Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate receptor 1

Gene

Sucnr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for succinate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate receptor 1
Alternative name(s):
G-protein coupled receptor 91
Gene namesi
Name:Sucnr1
Synonyms:Gpr91
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1934135 Sucnr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 101ExtracellularSequence analysisAdd BLAST25
Transmembranei102 – 119Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini120 – 133CytoplasmicSequence analysisAdd BLAST14
Transmembranei134 – 157Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini158 – 180ExtracellularSequence analysisAdd BLAST23
Transmembranei181 – 204Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini205 – 228CytoplasmicSequence analysisAdd BLAST24
Transmembranei229 – 246Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini247 – 277ExtracellularSequence analysisAdd BLAST31
Transmembranei278 – 294Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini295 – 317CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Abolition of succinate-induced hypertension.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701351 – 317Succinate receptor 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99MT6
PRIDEiQ99MT6

PTM databases

iPTMnetiQ99MT6
PhosphoSitePlusiQ99MT6

Expressioni

Tissue specificityi

Predominantly expressed in the kidney (proximal and distal tubules and the juxtaglomerular apparatus). Weakly expressed in liver, spleen and small intestine.2 Publications

Gene expression databases

BgeeiENSMUSG00000027762
CleanExiMM_SUCNR1
GenevisibleiQ99MT6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029326

Structurei

3D structure databases

ProteinModelPortaliQ99MT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJKI Eukaryota
ENOG410YANU LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG095590
InParanoidiQ99MT6
KOiK10042
OMAiLMGDHFR
OrthoDBiEOG091G0FDD
PhylomeDBiQ99MT6
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99MT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNLSCENW LATEAILNKY YLSAFYAIEF IFGLLGNVTV VFGYLFCMKN
60 70 80 90 100
WNSSNVYLFN LSISDFAFLC TLPILIKSYA NDKGTYGDVL CISNRYVLHT
110 120 130 140 150
NLYTSILFLT FISMDRYLLM KYPFREHFLQ KKEFAILISL AVWALVTLEV
160 170 180 190 200
LPMLTFINSV PKEEGSNCID YASSGNPEHN LIYSLCLTLL GFLIPLSVMC
210 220 230 240 250
FFYYKMVVFL KRRSQQQATA LPLDKPQRLV VLAVVIFSIL FTPYHIMRNL
260 270 280 290 300
RIASRLDSWP QGCTQKAIKS IYTLTRPLAF LNSAINPIFY FLMGDHYREM
310
LISKFRQYFK SLTSFRT
Length:317
Mass (Da):36,765
Last modified:September 22, 2009 - v2
Checksum:i378C0738E108B3A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106I → M in AAK01867 (PubMed:11273702).Curated1
Sequence conflicti108F → L in AAK01867 (PubMed:11273702).Curated1
Sequence conflicti111F → V in AAK01867 (PubMed:11273702).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295367 mRNA Translation: AAK01867.1
BC096665 mRNA Translation: AAH96665.1
CCDSiCCDS38442.1
RefSeqiNP_115776.2, NM_032400.2
UniGeneiMm.125110

Genome annotation databases

EnsembliENSMUST00000029326; ENSMUSP00000029326; ENSMUSG00000027762
GeneIDi84112
KEGGimmu:84112
UCSCiuc008pja.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSUCR1_MOUSE
AccessioniPrimary (citable) accession number: Q99MT6
Secondary accession number(s): Q4V9V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health