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Protein

Succinate receptor 1

Gene

Sucnr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for succinate.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate receptor 1
Alternative name(s):
G-protein coupled receptor 91
Gene namesi
Name:Sucnr1
Synonyms:Gpr91
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1934135. Sucnr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 10125ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 11918Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13314CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15724Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 18023ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20424Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini205 – 22824CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 24618Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini247 – 27731ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29417Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 31723CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Abolition of succinate-induced hypertension.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Succinate receptor 1PRO_0000070135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99MT6.
PRIDEiQ99MT6.

PTM databases

iPTMnetiQ99MT6.
PhosphoSiteiQ99MT6.

Expressioni

Tissue specificityi

Predominantly expressed in the kidney (proximal and distal tubules and the juxtaglomerular apparatus). Weakly expressed in liver, spleen and small intestine.2 Publications

Gene expression databases

BgeeiENSMUSG00000027762.
CleanExiMM_SUCNR1.
GenevisibleiQ99MT6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029326.

Structurei

3D structure databases

ProteinModelPortaliQ99MT6.
SMRiQ99MT6. Positions 20-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ99MT6.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG091G0FDD.
PhylomeDBiQ99MT6.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNLSCENW LATEAILNKY YLSAFYAIEF IFGLLGNVTV VFGYLFCMKN
60 70 80 90 100
WNSSNVYLFN LSISDFAFLC TLPILIKSYA NDKGTYGDVL CISNRYVLHT
110 120 130 140 150
NLYTSILFLT FISMDRYLLM KYPFREHFLQ KKEFAILISL AVWALVTLEV
160 170 180 190 200
LPMLTFINSV PKEEGSNCID YASSGNPEHN LIYSLCLTLL GFLIPLSVMC
210 220 230 240 250
FFYYKMVVFL KRRSQQQATA LPLDKPQRLV VLAVVIFSIL FTPYHIMRNL
260 270 280 290 300
RIASRLDSWP QGCTQKAIKS IYTLTRPLAF LNSAINPIFY FLMGDHYREM
310
LISKFRQYFK SLTSFRT
Length:317
Mass (Da):36,765
Last modified:September 22, 2009 - v2
Checksum:i378C0738E108B3A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061I → M in AAK01867 (PubMed:11273702).Curated
Sequence conflicti108 – 1081F → L in AAK01867 (PubMed:11273702).Curated
Sequence conflicti111 – 1111F → V in AAK01867 (PubMed:11273702).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295367 mRNA. Translation: AAK01867.1.
BC096665 mRNA. Translation: AAH96665.1.
CCDSiCCDS38442.1.
RefSeqiNP_115776.2. NM_032400.2.
UniGeneiMm.125110.

Genome annotation databases

EnsembliENSMUST00000029326; ENSMUSP00000029326; ENSMUSG00000027762.
GeneIDi84112.
KEGGimmu:84112.
UCSCiuc008pja.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295367 mRNA. Translation: AAK01867.1.
BC096665 mRNA. Translation: AAH96665.1.
CCDSiCCDS38442.1.
RefSeqiNP_115776.2. NM_032400.2.
UniGeneiMm.125110.

3D structure databases

ProteinModelPortaliQ99MT6.
SMRiQ99MT6. Positions 20-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029326.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99MT6.
PhosphoSiteiQ99MT6.

Proteomic databases

PaxDbiQ99MT6.
PRIDEiQ99MT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029326; ENSMUSP00000029326; ENSMUSG00000027762.
GeneIDi84112.
KEGGimmu:84112.
UCSCiuc008pja.2. mouse.

Organism-specific databases

CTDi56670.
MGIiMGI:1934135. Sucnr1.

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ99MT6.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG091G0FDD.
PhylomeDBiQ99MT6.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ99MT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027762.
CleanExiMM_SUCNR1.
GenevisibleiQ99MT6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUCR1_MOUSE
AccessioniPrimary (citable) accession number: Q99MT6
Secondary accession number(s): Q4V9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.