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Protein

MutS protein homolog 4

Gene

Msh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi702 – 7098ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • female gamete generation Source: MGI
  • meiotic nuclear division Source: MGI
  • mismatch repair Source: GO_Central
  • ovarian follicle development Source: MGI
  • reciprocal meiotic recombination Source: GO_Central
  • spermatogenesis Source: MGI
  • synapsis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-912446. Meiotic recombination.
R-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 4
Short name:
mMsh4
Gene namesi
Name:Msh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1860077. Msh4.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome Source: MGI
  • condensed nuclear chromosome Source: MGI
  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
  • synaptonemal complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958MutS protein homolog 4PRO_0000115198Add
BLAST

Proteomic databases

PaxDbiQ99MT2.
PRIDEiQ99MT2.

PTM databases

iPTMnetiQ99MT2.
PhosphoSiteiQ99MT2.

Expressioni

Tissue specificityi

Predominantly expressed in testis.

Gene expression databases

BgeeiQ99MT2.
CleanExiMM_MSH4.
ExpressionAtlasiQ99MT2. baseline and differential.
GenevisibleiQ99MT2. MM.

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005630.

Structurei

3D structure databases

ProteinModelPortaliQ99MT2.
SMRiQ99MT2. Positions 152-884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0220. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074897.
HOGENOMiHOG000290656.
HOVERGENiHBG036910.
InParanoidiQ99MT2.
KOiK08740.
OMAiWTPQMGY.
OrthoDBiEOG7DRJ2N.
PhylomeDBiQ99MT2.
TreeFamiTF300572.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 2 hits.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCCLFLRLRD YSTAHALSLP PCQRCGLQPW SARSHARRTL GVRKAGEMLR
60 70 80 90 100
QEAASLSSSP RWTPSRRDAP CGRTLASASR PSTEGAMADR SSSSSSSPAP
110 120 130 140 150
ASAPGSSFGN KRSYAIHRAA SSFPVGTSSS SARDTTYPHT FRTPLSAGNP
160 170 180 190 200
QRSGHKSWTP QVGYSATSSA VSAHAPSVIV AVVEGRGLAR GEIGMASIDL
210 220 230 240 250
KSPQIMLSQF ADNTTYAKVI TKLQVLSPLE IIMSNTACVV GNSTKLFTLI
260 270 280 290 300
TENFKNVNFT TVQRKYFNET KGLEYIEQLC IAEFSSVLME VQSRYYCLAA
310 320 330 340 350
AAALLKYVEF IQNSVYAPKS LKIYFQGSEQ TAMIDSSSAQ NLELLVNNQD
360 370 380 390 400
YRSNHTLFGV LNYTKTAGGS RRLRSNILEP LVDVETISMR LDCVQELLQD
410 420 430 440 450
EELFFGLQSV ISRFLDTEQL LSVLVQIPKQ DTVNAAESKI TNLIYLKHTL
460 470 480 490 500
ELVEPLKVTL KNCSTPLLRA YYGSLEDHRF GLILDKIKTV INDDARYMKG
510 520 530 540 550
CLNMRTQKCY AVRSNISEFL DIARRTYTEI VDDIAGMIAQ LAEKYSLPLR
560 570 580 590 600
TSFSSSRGFF IQMTTDCAAL SSDQLPSEFI KISKVKNSYS FTSADLIKMN
610 620 630 640 650
ERCQESLREI YHMTYMIVCK LLSEIYEHIH CLYKLSDTVS MLDMLLSFAH
660 670 680 690 700
ACTLSDYVRP EFTDTLAIKQ GWHPILEKIS AEKPVANNTY ITEGSNVLII
710 720 730 740 750
TGPNMSGKST YLKQIALCQI MAQIGSYVPA EYASFRIAAQ IFTRISTDDD
760 770 780 790 800
IETNSSTFMK EMKEIAYILH NANDKSLILI DELGRGTNTE EGIGISYAVC
810 820 830 840 850
EHLLSIKAFT LFTTHFLELC HLDALYLNVE NMHFEVQHVK NTSRNKDAIL
860 870 880 890 900
YTYKLSRGLT EEKNYGLKAA EASSLPSSIV LDARDITTQI TRQILQNQRS
910 920 930 940 950
SPEMDRQRAV YHLATRLVQA ARNSQLEPDR LRTYLSNLKK KYAGDFPRAV

GLPEKTEE
Length:958
Mass (Da):107,006
Last modified:June 1, 2001 - v1
Checksum:i936962E370C4B240
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 9018RTLAS…AMADR → GPWPRVQAEYGRRHGRQ in AAL18350 (PubMed:11553915).CuratedAdd
BLAST
Sequence conflicti125 – 1251V → I in AAL18350 (PubMed:11553915).Curated
Sequence conflicti372 – 3732RL → TV in AAL18350 (PubMed:11553915).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298655 mRNA. Translation: AAK15620.1.
AF178957 mRNA. Translation: AAL18350.1.
CCDSiCCDS38678.1.
RefSeqiNP_114076.1. NM_031870.3.
UniGeneiMm.272226.

Genome annotation databases

EnsembliENSMUST00000005630; ENSMUSP00000005630; ENSMUSG00000005493.
GeneIDi55993.
KEGGimmu:55993.
UCSCiuc008rue.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298655 mRNA. Translation: AAK15620.1.
AF178957 mRNA. Translation: AAL18350.1.
CCDSiCCDS38678.1.
RefSeqiNP_114076.1. NM_031870.3.
UniGeneiMm.272226.

3D structure databases

ProteinModelPortaliQ99MT2.
SMRiQ99MT2. Positions 152-884.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005630.

PTM databases

iPTMnetiQ99MT2.
PhosphoSiteiQ99MT2.

Proteomic databases

PaxDbiQ99MT2.
PRIDEiQ99MT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005630; ENSMUSP00000005630; ENSMUSG00000005493.
GeneIDi55993.
KEGGimmu:55993.
UCSCiuc008rue.2. mouse.

Organism-specific databases

CTDi4438.
MGIiMGI:1860077. Msh4.

Phylogenomic databases

eggNOGiKOG0220. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074897.
HOGENOMiHOG000290656.
HOVERGENiHBG036910.
InParanoidiQ99MT2.
KOiK08740.
OMAiWTPQMGY.
OrthoDBiEOG7DRJ2N.
PhylomeDBiQ99MT2.
TreeFamiTF300572.

Enzyme and pathway databases

ReactomeiR-MMU-912446. Meiotic recombination.
R-MMU-912497. Meiotic Recombination.

Miscellaneous databases

ChiTaRSiMsh4. mouse.
PROiQ99MT2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99MT2.
CleanExiMM_MSH4.
ExpressionAtlasiQ99MT2. baseline and differential.
GenevisibleiQ99MT2. MM.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 2 hits.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5."
    Her C., Wu X., Bailey S.M., Doggett N.A.
    Mamm. Genome 12:73-76(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4 (MutS Homolog 4) gene expression."
    Santucci-Darmanin S., Vidal F., Scimeca J.C., Turc-Carel C., Paquis-Flucklinger V.
    Mol. Reprod. Dev. 60:172-180(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-958.

Entry informationi

Entry nameiMSH4_MOUSE
AccessioniPrimary (citable) accession number: Q99MT2
Secondary accession number(s): Q920J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.