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Q99MR9

- PPR3A_MOUSE

UniProt

Q99MR9 - PPR3A_MOUSE

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Protein
Protein phosphatase 1 regulatory subunit 3A
Gene
Ppp1r3a, Pp1g
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.1 Publication

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. glycogen metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3A
Alternative name(s):
Protein phosphatase 1 glycogen-associated regulatory subunit
Protein phosphatase type-1 glycogen targeting subunit
Short name:
RG1
Gene namesi
Name:Ppp1r3a
Synonyms:Pp1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2153588. Ppp1r3a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1047 – 106721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10891089Protein phosphatase 1 regulatory subunit 3A
PRO_0000071501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401Phosphoserine; by GSK3 By similarity
Modified residuei44 – 441Phosphoserine; by GSK3 By similarity
Modified residuei48 – 481Phosphoserine; by PKA and ISPK By similarity
Modified residuei67 – 671Phosphoserine; by PKA By similarity

Post-translational modificationi

Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99MR9.
PaxDbiQ99MR9.
PRIDEiQ99MR9.

PTM databases

PhosphoSiteiQ99MR9.

Expressioni

Tissue specificityi

Skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiQ99MR9.
GenevestigatoriQ99MR9.

Interactioni

Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen By similarity.

Protein-protein interaction databases

IntActiQ99MR9. 2 interactions.
MINTiMINT-4108485.

Structurei

3D structure databases

ProteinModelPortaliQ99MR9.
SMRiQ99MR9. Positions 124-244.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 231109CBM21
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 674PP1-binding motif

Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288354.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000115667.
HOVERGENiHBG053657.
InParanoidiQ32MS0.
KOiK07189.
OMAiAFDPHEG.
OrthoDBiEOG769ZKR.
TreeFamiTF105537.

Family and domain databases

InterProiIPR005036. CBM_21.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MR9-1 [UniParc]FASTAAdd to Basket

« Hide

MEPAEEPGQI SKDNFLEVPN LSDSVCEDEE VKATFKPGFS PQPSRRGSGS     50
SEDMYLDTPT SASRRVSFAD SLGFSLVSVK EFDCWELPSV STDFDLSGDV 100
FHTDEYVLSP LFDLPSSKEK LMEQLQVQKA VLESAEHLPG SSMKGIIRVL 150
NISFEKLVYV RMSLDDWQTH YDILAEYVPN SCDGETDQFS FKISLVPPYQ 200
KEGGKVEFCI RYETSAGTFW SNNNGTNYIL VCQKKRKEPE PVKPLEEAPS 250
RQIKGCLKVK SRSKEEPLLA PEENKFETLK FTESYIPTII CSHEDKDDLG 300
ANHPNVDDIN KKHDEHNGKE LDLMINQRLI TSQDEKNTFA TDTVNFTNKA 350
EGSEKKQAYH EINTDLFMGP LSPSLSAESS LKRDFYHSRS SSPGNEYGHP 400
HSEEIISDMG EKGPSLGDTS SDELMQLELC SKEDLDDNAN PANGSGRVCS 450
SFDQRMACGL KNNEAGIKKT GIQDYKYSHG DSTKLEESNA SSRDDYAKVD 500
NKKEKQTCLG VNENPSKNFQ SVFQTQEGHM GYPKISTEGD KANNQDLTSL 550
LSKDITANTW AVTVDPCPST NAKRSWREVG SGSNLEPGTS DLSSPRNFSP 600
LTDDHLFQAD RENSDSSNPE NQNMNTRHRK KWNVLETQSE TSETESDIAK 650
HTKEQAEYKD MWEKTDNSRN LKATPTEHLF TCRETECYGL SSLADHGITE 700
KAQAVTAYII KTTLESTPES ASARGKAIIA KLPQETAGND RPIEVKETAF 750
DPHEGRKDDS HYSLCHGDTA GVIHDNDFER ESHLDICNLR VDEMKKEKTT 800
STCFPQKTYD KEKHGIGSVT SIDEPSQVIT GNQKATSKLD LHLGVLPTDR 850
AIFQANADLE LLQELSRRTD FNAVPSAFNS DTASASRDSS QVYRHCSKKS 900
VPSYGEEKAV TNTTLQSIPT KSEYNWHPES EVLGHAMSKP EDVFKSSEIM 950
KSGSGGERGG GPILQQKEGS LENSQGPMFF TNEPLENLDE ASSENEGLMH 1000
SGQSQCYLGD KGLVSSASAT VSTQELEAQG RESLLSISTN SKIPYFLLFL 1050
IFLATVYYYD LMIGLAFYLF SLYWLYWEGG RQRESVKKK 1089
Length:1,089
Mass (Da):121,435
Last modified:July 27, 2011 - v2
Checksum:i85EC67FD90CC8FD2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti959 – 9591G → S in AAK31072. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309629, AF309628 Genomic DNA. Translation: AAK31072.1.
CH466533 Genomic DNA. Translation: EDL13902.1.
BC109007 mRNA. Translation: AAI09008.1.
AK084518 mRNA. Translation: BAC39208.2.
AK084719 mRNA. Translation: BAC39262.2.
CCDSiCCDS19917.1.
RefSeqiNP_536712.2. NM_080464.2.
UniGeneiMm.209429.

Genome annotation databases

EnsembliENSMUST00000045096; ENSMUSP00000049054; ENSMUSG00000042717.
GeneIDi140491.
KEGGimmu:140491.
UCSCiuc009ayw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309629 , AF309628 Genomic DNA. Translation: AAK31072.1 .
CH466533 Genomic DNA. Translation: EDL13902.1 .
BC109007 mRNA. Translation: AAI09008.1 .
AK084518 mRNA. Translation: BAC39208.2 .
AK084719 mRNA. Translation: BAC39262.2 .
CCDSi CCDS19917.1.
RefSeqi NP_536712.2. NM_080464.2.
UniGenei Mm.209429.

3D structure databases

ProteinModelPortali Q99MR9.
SMRi Q99MR9. Positions 124-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99MR9. 2 interactions.
MINTi MINT-4108485.

Protein family/group databases

CAZyi CBM21. Carbohydrate-Binding Module Family 21.

PTM databases

PhosphoSitei Q99MR9.

Proteomic databases

MaxQBi Q99MR9.
PaxDbi Q99MR9.
PRIDEi Q99MR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045096 ; ENSMUSP00000049054 ; ENSMUSG00000042717 .
GeneIDi 140491.
KEGGi mmu:140491.
UCSCi uc009ayw.1. mouse.

Organism-specific databases

CTDi 5506.
MGIi MGI:2153588. Ppp1r3a.

Phylogenomic databases

eggNOGi NOG288354.
GeneTreei ENSGT00530000062978.
HOGENOMi HOG000115667.
HOVERGENi HBG053657.
InParanoidi Q32MS0.
KOi K07189.
OMAi AFDPHEG.
OrthoDBi EOG769ZKR.
TreeFami TF105537.

Miscellaneous databases

NextBioi 369808.
PROi Q99MR9.
SOURCEi Search...

Gene expression databases

Bgeei Q99MR9.
Genevestigatori Q99MR9.

Family and domain databases

InterProi IPR005036. CBM_21.
[Graphical view ]
Pfami PF03370. CBM_21. 1 hit.
[Graphical view ]
PROSITEi PS51159. CBM21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G."
    Lanner C., Suzuki Y., Bi C., Zhang H., Cooper L.D., Bowker-Kinley M.M., DePaoli-Roach A.A.
    Arch. Biochem. Biophys. 388:135-145(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-626.
    Strain: C57BL/6J.
    Tissue: Embryonic heart.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 259-264, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL."
    Suzuki Y., Lanner C., Kim J.-H., Vilardo P.G., Zhang H., Yang J., Cooper L.D., Steele M., Kennedy A., Bock C.B., Scrimgeour A., Lawrence J.C. Jr., DePaoli-Roach A.A.
    Mol. Cell. Biol. 21:2683-2694(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 129/Sv.

Entry informationi

Entry nameiPPR3A_MOUSE
AccessioniPrimary (citable) accession number: Q99MR9
Secondary accession number(s): Q32MS0, Q8BUJ4, Q8BUL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi