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Protein

Protein phosphatase 1 regulatory subunit 3A

Gene

Ppp1r3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.1 Publication

GO - Molecular functioni

GO - Biological processi

  • glycogen metabolic process Source: MGI

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3A
Alternative name(s):
Protein phosphatase 1 glycogen-associated regulatory subunit
Protein phosphatase type-1 glycogen targeting subunit
Short name:
RG1
Gene namesi
Name:Ppp1r3a
Synonyms:Pp1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2153588. Ppp1r3a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1047 – 1067HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715011 – 1089Protein phosphatase 1 regulatory subunit 3AAdd BLAST1089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Phosphoserine; by GSK3By similarity1
Modified residuei44Phosphoserine; by GSK3By similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei58PhosphothreonineCombined sources1
Modified residuei67Phosphoserine; by PKABy similarity1
Modified residuei821PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99MR9.
PaxDbiQ99MR9.
PRIDEiQ99MR9.

PTM databases

iPTMnetiQ99MR9.
PhosphoSitePlusiQ99MR9.

Expressioni

Tissue specificityi

Skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000042717.
GenevisibleiQ99MR9. MM.

Interactioni

Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.By similarity

Protein-protein interaction databases

IntActiQ99MR9. 2 interactors.
MINTiMINT-4108485.
STRINGi10090.ENSMUSP00000049054.

Structurei

3D structure databases

ProteinModelPortaliQ99MR9.
SMRiQ99MR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 231CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 67PP1-binding motif4

Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000115667.
HOVERGENiHBG053657.
InParanoidiQ99MR9.
KOiK07189.
OMAiLFTCQET.
OrthoDBiEOG091G00OC.
TreeFamiTF105537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR005036. CBM21_dom.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF03370. CBM_21. 1 hit.
PROSITEiView protein in PROSITE
PS51159. CBM21. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99MR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAEEPGQI SKDNFLEVPN LSDSVCEDEE VKATFKPGFS PQPSRRGSGS
60 70 80 90 100
SEDMYLDTPT SASRRVSFAD SLGFSLVSVK EFDCWELPSV STDFDLSGDV
110 120 130 140 150
FHTDEYVLSP LFDLPSSKEK LMEQLQVQKA VLESAEHLPG SSMKGIIRVL
160 170 180 190 200
NISFEKLVYV RMSLDDWQTH YDILAEYVPN SCDGETDQFS FKISLVPPYQ
210 220 230 240 250
KEGGKVEFCI RYETSAGTFW SNNNGTNYIL VCQKKRKEPE PVKPLEEAPS
260 270 280 290 300
RQIKGCLKVK SRSKEEPLLA PEENKFETLK FTESYIPTII CSHEDKDDLG
310 320 330 340 350
ANHPNVDDIN KKHDEHNGKE LDLMINQRLI TSQDEKNTFA TDTVNFTNKA
360 370 380 390 400
EGSEKKQAYH EINTDLFMGP LSPSLSAESS LKRDFYHSRS SSPGNEYGHP
410 420 430 440 450
HSEEIISDMG EKGPSLGDTS SDELMQLELC SKEDLDDNAN PANGSGRVCS
460 470 480 490 500
SFDQRMACGL KNNEAGIKKT GIQDYKYSHG DSTKLEESNA SSRDDYAKVD
510 520 530 540 550
NKKEKQTCLG VNENPSKNFQ SVFQTQEGHM GYPKISTEGD KANNQDLTSL
560 570 580 590 600
LSKDITANTW AVTVDPCPST NAKRSWREVG SGSNLEPGTS DLSSPRNFSP
610 620 630 640 650
LTDDHLFQAD RENSDSSNPE NQNMNTRHRK KWNVLETQSE TSETESDIAK
660 670 680 690 700
HTKEQAEYKD MWEKTDNSRN LKATPTEHLF TCRETECYGL SSLADHGITE
710 720 730 740 750
KAQAVTAYII KTTLESTPES ASARGKAIIA KLPQETAGND RPIEVKETAF
760 770 780 790 800
DPHEGRKDDS HYSLCHGDTA GVIHDNDFER ESHLDICNLR VDEMKKEKTT
810 820 830 840 850
STCFPQKTYD KEKHGIGSVT SIDEPSQVIT GNQKATSKLD LHLGVLPTDR
860 870 880 890 900
AIFQANADLE LLQELSRRTD FNAVPSAFNS DTASASRDSS QVYRHCSKKS
910 920 930 940 950
VPSYGEEKAV TNTTLQSIPT KSEYNWHPES EVLGHAMSKP EDVFKSSEIM
960 970 980 990 1000
KSGSGGERGG GPILQQKEGS LENSQGPMFF TNEPLENLDE ASSENEGLMH
1010 1020 1030 1040 1050
SGQSQCYLGD KGLVSSASAT VSTQELEAQG RESLLSISTN SKIPYFLLFL
1060 1070 1080
IFLATVYYYD LMIGLAFYLF SLYWLYWEGG RQRESVKKK
Length:1,089
Mass (Da):121,435
Last modified:July 27, 2011 - v2
Checksum:i85EC67FD90CC8FD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti959G → S in AAK31072 (PubMed:11361130).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309629, AF309628 Genomic DNA. Translation: AAK31072.1.
CH466533 Genomic DNA. Translation: EDL13902.1.
BC109007 mRNA. Translation: AAI09008.1.
AK084518 mRNA. Translation: BAC39208.2.
AK084719 mRNA. Translation: BAC39262.2.
CCDSiCCDS19917.1.
RefSeqiNP_536712.2. NM_080464.2.
UniGeneiMm.209429.

Genome annotation databases

EnsembliENSMUST00000045096; ENSMUSP00000049054; ENSMUSG00000042717.
GeneIDi140491.
KEGGimmu:140491.
UCSCiuc009ayw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPPR3A_MOUSE
AccessioniPrimary (citable) accession number: Q99MR9
Secondary accession number(s): Q32MS0, Q8BUJ4, Q8BUL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot