UniProtKB - Q99MR9 (PPR3A_MOUSE)
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Protein
Protein phosphatase 1 regulatory subunit 3A
Gene
Ppp1r3a
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.1 Publication
GO - Molecular functioni
- protein serine/threonine phosphatase activity Source: MGI
GO - Biological processi
- glycogen metabolic process Source: MGI
Keywordsi
Biological process | Carbohydrate metabolism, Glycogen metabolism |
Protein family/group databases
CAZyi | CBM21. Carbohydrate-Binding Module Family 21. |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 3AAlternative name(s): Protein phosphatase 1 glycogen-associated regulatory subunit Protein phosphatase type-1 glycogen targeting subunit Short name: RG1 |
Gene namesi | Name:Ppp1r3a Synonyms:Pp1g |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2153588. Ppp1r3a. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1047 – 1067 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071501 | 1 – 1089 | Protein phosphatase 1 regulatory subunit 3AAdd BLAST | 1089 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | Phosphoserine; by GSK3By similarity | 1 | |
Modified residuei | 44 | Phosphoserine; by GSK3By similarity | 1 | |
Modified residuei | 48 | PhosphoserineCombined sources | 1 | |
Modified residuei | 51 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 67 | Phosphoserine; by PKABy similarity | 1 | |
Modified residuei | 821 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q99MR9. |
PaxDbi | Q99MR9. |
PRIDEi | Q99MR9. |
PTM databases
iPTMneti | Q99MR9. |
PhosphoSitePlusi | Q99MR9. |
Expressioni
Tissue specificityi
Skeletal muscle and heart.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000042717. |
Genevisiblei | Q99MR9. MM. |
Interactioni
Subunit structurei
Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.By similarity
Protein-protein interaction databases
IntActi | Q99MR9. 3 interactors. |
MINTi | Q99MR9. |
STRINGi | 10090.ENSMUSP00000049054. |
Structurei
3D structure databases
ProteinModelPortali | Q99MR9. |
SMRi | Q99MR9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 123 – 231 | CBM21PROSITE-ProRule annotationAdd BLAST | 109 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 64 – 67 | PP1-binding motif | 4 |
Domaini
The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3986. Eukaryota. ENOG4111FT1. LUCA. |
GeneTreei | ENSGT00530000062978. |
HOGENOMi | HOG000115667. |
HOVERGENi | HBG053657. |
InParanoidi | Q99MR9. |
KOi | K07189. |
OMAi | LFTCQET. |
OrthoDBi | EOG091G00OC. |
TreeFami | TF105537. |
Family and domain databases
Gene3Di | 2.60.40.2440. 1 hit. |
InterProi | View protein in InterPro IPR005036. CBM21_dom. IPR038175. CBM21_dom_sf. |
Pfami | View protein in Pfam PF03370. CBM_21. 1 hit. |
PROSITEi | View protein in PROSITE PS51159. CBM21. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q99MR9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPAEEPGQI SKDNFLEVPN LSDSVCEDEE VKATFKPGFS PQPSRRGSGS
60 70 80 90 100
SEDMYLDTPT SASRRVSFAD SLGFSLVSVK EFDCWELPSV STDFDLSGDV
110 120 130 140 150
FHTDEYVLSP LFDLPSSKEK LMEQLQVQKA VLESAEHLPG SSMKGIIRVL
160 170 180 190 200
NISFEKLVYV RMSLDDWQTH YDILAEYVPN SCDGETDQFS FKISLVPPYQ
210 220 230 240 250
KEGGKVEFCI RYETSAGTFW SNNNGTNYIL VCQKKRKEPE PVKPLEEAPS
260 270 280 290 300
RQIKGCLKVK SRSKEEPLLA PEENKFETLK FTESYIPTII CSHEDKDDLG
310 320 330 340 350
ANHPNVDDIN KKHDEHNGKE LDLMINQRLI TSQDEKNTFA TDTVNFTNKA
360 370 380 390 400
EGSEKKQAYH EINTDLFMGP LSPSLSAESS LKRDFYHSRS SSPGNEYGHP
410 420 430 440 450
HSEEIISDMG EKGPSLGDTS SDELMQLELC SKEDLDDNAN PANGSGRVCS
460 470 480 490 500
SFDQRMACGL KNNEAGIKKT GIQDYKYSHG DSTKLEESNA SSRDDYAKVD
510 520 530 540 550
NKKEKQTCLG VNENPSKNFQ SVFQTQEGHM GYPKISTEGD KANNQDLTSL
560 570 580 590 600
LSKDITANTW AVTVDPCPST NAKRSWREVG SGSNLEPGTS DLSSPRNFSP
610 620 630 640 650
LTDDHLFQAD RENSDSSNPE NQNMNTRHRK KWNVLETQSE TSETESDIAK
660 670 680 690 700
HTKEQAEYKD MWEKTDNSRN LKATPTEHLF TCRETECYGL SSLADHGITE
710 720 730 740 750
KAQAVTAYII KTTLESTPES ASARGKAIIA KLPQETAGND RPIEVKETAF
760 770 780 790 800
DPHEGRKDDS HYSLCHGDTA GVIHDNDFER ESHLDICNLR VDEMKKEKTT
810 820 830 840 850
STCFPQKTYD KEKHGIGSVT SIDEPSQVIT GNQKATSKLD LHLGVLPTDR
860 870 880 890 900
AIFQANADLE LLQELSRRTD FNAVPSAFNS DTASASRDSS QVYRHCSKKS
910 920 930 940 950
VPSYGEEKAV TNTTLQSIPT KSEYNWHPES EVLGHAMSKP EDVFKSSEIM
960 970 980 990 1000
KSGSGGERGG GPILQQKEGS LENSQGPMFF TNEPLENLDE ASSENEGLMH
1010 1020 1030 1040 1050
SGQSQCYLGD KGLVSSASAT VSTQELEAQG RESLLSISTN SKIPYFLLFL
1060 1070 1080
IFLATVYYYD LMIGLAFYLF SLYWLYWEGG RQRESVKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 959 | G → S in AAK31072 (PubMed:11361130).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF309629, AF309628 Genomic DNA. Translation: AAK31072.1. CH466533 Genomic DNA. Translation: EDL13902.1. BC109007 mRNA. Translation: AAI09008.1. AK084518 mRNA. Translation: BAC39208.2. AK084719 mRNA. Translation: BAC39262.2. |
CCDSi | CCDS19917.1. |
RefSeqi | NP_536712.2. NM_080464.2. |
UniGenei | Mm.209429. |
Genome annotation databases
Ensembli | ENSMUST00000045096; ENSMUSP00000049054; ENSMUSG00000042717. |
GeneIDi | 140491. |
KEGGi | mmu:140491. |
UCSCi | uc009ayw.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | PPR3A_MOUSE | |
Accessioni | Q99MR9Primary (citable) accession number: Q99MR9 Secondary accession number(s): Q32MS0, Q8BUJ4, Q8BUL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | July 27, 2011 | |
Last modified: | March 28, 2018 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |