Ppp1r3a

Functionⁱ

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.1 Publication

GO - Molecular functionⁱ

protein serine/threonine phosphatase activity
Source: MGI
Inferred from sequence orthologyⁱ
- 11361130

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycogen metabolic process
Source: MGI
Traceable author statementⁱ
- 11361130

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Carbohydrate metabolism, Glycogen metabolism

Biological process

Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	CBM21. Carbohydrate-Binding Module Family 21.

CAZyⁱ

CBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 3A Alternative name(s): Protein phosphatase 1 glycogen-associated regulatory subunit Protein phosphatase type-1 glycogen targeting subunit Short name: RG1
Gene namesⁱ	Name:Ppp1r3a Synonyms:Pp1g
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2153588. Ppp1r3a.

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	1047 – 1067	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071501	1 – 1089	Protein phosphatase 1 regulatory subunit 3AAdd BLAST		1089

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	40	Phosphoserine; by GSK3By similarity	1
Modified residueⁱ	44	Phosphoserine; by GSK3By similarity	1
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	51	PhosphoserineCombined sources	1
Modified residueⁱ	58	PhosphothreonineCombined sources	1
Modified residueⁱ	67	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	821	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation at Ser-48 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99MR9.
PaxDbⁱ	Q99MR9.
PRIDEⁱ	Q99MR9.

PTM databases

iPTMnetⁱ	Q99MR9.
PhosphoSitePlusⁱ	Q99MR9.

Expressionⁱ

Tissue specificityⁱ

Skeletal muscle and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000042717.
Genevisibleⁱ	Q99MR9. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen.By similarity

Protein-protein interaction databases

IntActⁱ	Q99MR9. 3 interactors.
Molecular INTeraction database More...MINTⁱ	Q99MR9.
STRINGⁱ	10090.ENSMUSP00000049054.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99MR9.
SMRⁱ	Q99MR9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	123 – 231	CBM21PROSITE-ProRule annotationAdd BLAST		109

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	64 – 67	PP1-binding motif		4

Domainⁱ

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3986. Eukaryota. ENOG4111FT1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062978.
HOGENOMⁱ	HOG000115667.
HOVERGENⁱ	HBG053657.
InParanoidⁱ	Q99MR9.
KEGG Orthology (KO) More...KOⁱ	K07189.
OMAⁱ	LFTCQET.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00OC.
TreeFamⁱ	TF105537.

Family and domain databases

Gene3Dⁱ	2.60.40.2440. 1 hit.
InterProⁱ	View protein in InterPro IPR005036. CBM21_dom. IPR038175. CBM21_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03370. CBM_21. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51159. CBM21. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99MR9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPAEEPGQI SKDNFLEVPN LSDSVCEDEE VKATFKPGFS PQPSRRGSGS 
        60         70         80         90        100
SEDMYLDTPT SASRRVSFAD SLGFSLVSVK EFDCWELPSV STDFDLSGDV 
       110        120        130        140        150
FHTDEYVLSP LFDLPSSKEK LMEQLQVQKA VLESAEHLPG SSMKGIIRVL 
       160        170        180        190        200
NISFEKLVYV RMSLDDWQTH YDILAEYVPN SCDGETDQFS FKISLVPPYQ 
       210        220        230        240        250
KEGGKVEFCI RYETSAGTFW SNNNGTNYIL VCQKKRKEPE PVKPLEEAPS 
       260        270        280        290        300
RQIKGCLKVK SRSKEEPLLA PEENKFETLK FTESYIPTII CSHEDKDDLG 
       310        320        330        340        350
ANHPNVDDIN KKHDEHNGKE LDLMINQRLI TSQDEKNTFA TDTVNFTNKA 
       360        370        380        390        400
EGSEKKQAYH EINTDLFMGP LSPSLSAESS LKRDFYHSRS SSPGNEYGHP 
       410        420        430        440        450
HSEEIISDMG EKGPSLGDTS SDELMQLELC SKEDLDDNAN PANGSGRVCS 
       460        470        480        490        500
SFDQRMACGL KNNEAGIKKT GIQDYKYSHG DSTKLEESNA SSRDDYAKVD 
       510        520        530        540        550
NKKEKQTCLG VNENPSKNFQ SVFQTQEGHM GYPKISTEGD KANNQDLTSL 
       560        570        580        590        600
LSKDITANTW AVTVDPCPST NAKRSWREVG SGSNLEPGTS DLSSPRNFSP 
       610        620        630        640        650
LTDDHLFQAD RENSDSSNPE NQNMNTRHRK KWNVLETQSE TSETESDIAK 
       660        670        680        690        700
HTKEQAEYKD MWEKTDNSRN LKATPTEHLF TCRETECYGL SSLADHGITE 
       710        720        730        740        750
KAQAVTAYII KTTLESTPES ASARGKAIIA KLPQETAGND RPIEVKETAF 
       760        770        780        790        800
DPHEGRKDDS HYSLCHGDTA GVIHDNDFER ESHLDICNLR VDEMKKEKTT 
       810        820        830        840        850
STCFPQKTYD KEKHGIGSVT SIDEPSQVIT GNQKATSKLD LHLGVLPTDR 
       860        870        880        890        900
AIFQANADLE LLQELSRRTD FNAVPSAFNS DTASASRDSS QVYRHCSKKS 
       910        920        930        940        950
VPSYGEEKAV TNTTLQSIPT KSEYNWHPES EVLGHAMSKP EDVFKSSEIM 
       960        970        980        990       1000
KSGSGGERGG GPILQQKEGS LENSQGPMFF TNEPLENLDE ASSENEGLMH 
      1010       1020       1030       1040       1050
SGQSQCYLGD KGLVSSASAT VSTQELEAQG RESLLSISTN SKIPYFLLFL 
      1060       1070       1080 
IFLATVYYYD LMIGLAFYLF SLYWLYWEGG RQRESVKKK

Length:1,089

Mass (Da):121,435

Last modified:July 27, 2011 - v2

Checksum:ⁱ85EC67FD90CC8FD2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	959	G → S in AAK31072 (PubMed:11361130).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF309629, AF309628 Genomic DNA. Translation: AAK31072.1. CH466533 Genomic DNA. Translation: EDL13902.1. BC109007 mRNA. Translation: AAI09008.1. AK084518 mRNA. Translation: BAC39208.2. AK084719 mRNA. Translation: BAC39262.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19917.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_536712.2. NM_080464.2.
UniGeneⁱ	Mm.209429.

Genome annotation databases

Ensemblⁱ	ENSMUST00000045096; ENSMUSP00000049054; ENSMUSG00000042717.
GeneIDⁱ	140491.
KEGGⁱ	mmu:140491.
UCSC genome browser More...UCSCⁱ	uc009ayw.1. mouse.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99MR9	UPI000A30AB04 UPI000A315FE1 UPI000A313F0C UPI000A31590F UPI00032B03C8 UPI00042AC2F8 UPI00042AF3BC UPI00033154BB A0A1U7R7B1 A0A1U7R4Q7 +10	Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Ochotona princeps (Southern American pika) Peromyscus maniculatus bairdii (Prairie deer mouse) Sorex araneus (Eurasian common shrew) (European shrew) Mesocricetus auratus (Golden hamster) Jaculus jaculus (Lesser Egyptian jerboa) Rattus norvegicus (Rat) Microtus ochrogaster (Prairie vole) Dipodomys ordii (Ord's kangaroo rat) And more	1,089	UniRef50_Q99MR9	Cluster: Protein phosphatase 1 regulatory subunit 3A	21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF309629, AF309628 Genomic DNA. Translation: AAK31072.1. CH466533 Genomic DNA. Translation: EDL13902.1. BC109007 mRNA. Translation: AAI09008.1. AK084518 mRNA. Translation: BAC39208.2. AK084719 mRNA. Translation: BAC39262.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19917.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_536712.2. NM_080464.2.
UniGeneⁱ	Mm.209429.

3D structure databases

ProteinModelPortalⁱ	Q99MR9.
SMRⁱ	Q99MR9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q99MR9. 3 interactors.
Molecular INTeraction database More...MINTⁱ	Q99MR9.
STRINGⁱ	10090.ENSMUSP00000049054.

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	CBM21. Carbohydrate-Binding Module Family 21.

CAZyⁱ

CBM21. Carbohydrate-Binding Module Family 21.

PTM databases

iPTMnetⁱ	Q99MR9.
PhosphoSitePlusⁱ	Q99MR9.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99MR9.
PaxDbⁱ	Q99MR9.
PRIDEⁱ	Q99MR9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000045096; ENSMUSP00000049054; ENSMUSG00000042717.
GeneIDⁱ	140491.
KEGGⁱ	mmu:140491.
UCSC genome browser More...UCSCⁱ	uc009ayw.1. mouse.

Organism-specific databases

CTDⁱ	5506.
MGIⁱ	MGI:2153588. Ppp1r3a.

Phylogenomic databases

eggNOGⁱ	KOG3986. Eukaryota. ENOG4111FT1. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062978.
HOGENOMⁱ	HOG000115667.
HOVERGENⁱ	HBG053657.
InParanoidⁱ	Q99MR9.
KEGG Orthology (KO) More...KOⁱ	K07189.
OMAⁱ	LFTCQET.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00OC.
TreeFamⁱ	TF105537.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q99MR9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042717.
Genevisibleⁱ	Q99MR9. MM.

Family and domain databases

Gene3Dⁱ	2.60.40.2440. 1 hit.
InterProⁱ	View protein in InterPro IPR005036. CBM21_dom. IPR038175. CBM21_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03370. CBM_21. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51159. CBM21. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPR3A_MOUSE
Accessionⁱ	Q99MR9Primary (citable) accession number: Q99MR9 Secondary accession number(s): Q32MS0, Q8BUJ4, Q8BUL0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
	Last sequence update:	July 27, 2011
	Last modified:	March 28, 2018
	This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

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Supporting data

UniProtKB - Q99MR9 (PPR3A_MOUSE)

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Protein phosphatase 1 regulatory subunit 3A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ