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Q99MR3

- S12A9_MOUSE

UniProt

Q99MR3 - S12A9_MOUSE

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Protein

Solute carrier family 12 member 9

Gene
Slc12a9, Cip1, Slc12a8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function By similarity.

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 9
Alternative name(s):
Cation-chloride cotransporter-interacting protein 1
Potassium-chloride transporter 9
Gene namesi
Name:Slc12a9
Synonyms:Cip1, Slc12a8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1933532. Slc12a9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei37 – 5721Helical; Reviewed predictionAdd
BLAST
Topological domaini58 – 7215Extracellular Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Topological domaini94 – 11926Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST
Topological domaini141 – 16727Extracellular Reviewed predictionAdd
BLAST
Transmembranei168 – 18821Helical; Reviewed predictionAdd
BLAST
Topological domaini189 – 1935Cytoplasmic Reviewed prediction
Transmembranei194 – 21421Helical; Reviewed predictionAdd
BLAST
Topological domaini215 – 26248Extracellular Reviewed predictionAdd
BLAST
Transmembranei263 – 28321Helical; Reviewed predictionAdd
BLAST
Topological domaini284 – 29714Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Reviewed predictionAdd
BLAST
Topological domaini319 – 33820Extracellular Reviewed predictionAdd
BLAST
Transmembranei339 – 35921Helical; Reviewed predictionAdd
BLAST
Topological domaini360 – 37617Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei377 – 39923Helical; Reviewed predictionAdd
BLAST
Topological domaini400 – 41617Extracellular Reviewed predictionAdd
BLAST
Transmembranei417 – 43721Helical; Reviewed predictionAdd
BLAST
Topological domaini438 – 46629Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei467 – 48721Helical; Reviewed predictionAdd
BLAST
Topological domaini488 – 740253Extracellular Reviewed predictionAdd
BLAST
Transmembranei741 – 76121Helical; Reviewed predictionAdd
BLAST
Topological domaini762 – 914153Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Solute carrier family 12 member 9PRO_0000331416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi218 – 2181N-linked (GlcNAc...); atypical1 Publication
Glycosylationi228 – 2281N-linked (GlcNAc...)1 Publication
Glycosylationi243 – 2431N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99MR3.
PRIDEiQ99MR3.

PTM databases

PhosphoSiteiQ99MR3.

Expressioni

Gene expression databases

BgeeiQ99MR3.
GenevestigatoriQ99MR3.

Interactioni

Subunit structurei

Interacts with SLC12A1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99MR3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi715 – 7184Poly-Ser
Compositional biasi811 – 8166Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00560000077088.
HOGENOMiHOG000018183.
HOVERGENiHBG106223.
InParanoidiQ99MR3.
KOiK14429.
OMAiGHFTGFN.
OrthoDBiEOG7GN2M6.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MR3-1 [UniParc]FASTAAdd to Basket

« Hide

MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS    50
MFSIVVFLRI GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR 100
GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESILDVFGAD 150
ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV 200
SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT GFNGSTLRDN 250
LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL 300
GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI 350
YATALSASMS SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY 400
SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT 450
FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLSA LLTARGGPSS 500
WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN PRGALPLLRL 550
ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL 600
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP 650
AEGTREGGSP ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA 700
RACGALPPER LSRGSSSSAQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ 750
MATILSMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE 800
VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV RAQQGRGTVG 850
GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT 900
LLIHGVTPVT CTDL 914
Length:914
Mass (Da):96,330
Last modified:July 27, 2011 - v2
Checksum:i769EA9EB4BD40E00
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341S → A in AAK28822. 1 Publication
Sequence conflicti34 – 341S → A in AAL26866. 1 Publication
Sequence conflicti34 – 341S → A in AAH46982. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1.
AF314957 mRNA. Translation: AAL26866.1.
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1.
CCDSiCCDS19766.1.
RefSeqiNP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.1.
UniGeneiMm.235625.

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
GeneIDi83704.
KEGGimmu:83704.
UCSCiuc009ace.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1 .
AF314957 mRNA. Translation: AAL26866.1 .
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1 .
CCDSi CCDS19766.1.
RefSeqi NP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.1.
UniGenei Mm.235625.

3D structure databases

ProteinModelPortali Q99MR3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99MR3.

Proteomic databases

PaxDbi Q99MR3.
PRIDEi Q99MR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039991 ; ENSMUSP00000038106 ; ENSMUSG00000037344 .
GeneIDi 83704.
KEGGi mmu:83704.
UCSCi uc009ace.2. mouse.

Organism-specific databases

CTDi 56996.
MGIi MGI:1933532. Slc12a9.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00560000077088.
HOGENOMi HOG000018183.
HOVERGENi HBG106223.
InParanoidi Q99MR3.
KOi K14429.
OMAi GHFTGFN.
OrthoDBi EOG7GN2M6.
TreeFami TF313191.

Miscellaneous databases

NextBioi 350746.
PROi Q99MR3.
SOURCEi Search...

Gene expression databases

Bgeei Q99MR3.
Genevestigatori Q99MR3.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Cloning of mouse Slc12a8, a new member of the cation-chloride cotransporter gene family."
    Mount D.B.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-218; ASN-228 AND ASN-243.

Entry informationi

Entry nameiS12A9_MOUSE
AccessioniPrimary (citable) accession number: Q99MR3
Secondary accession number(s): E9QNN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi