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Protein

Solute carrier family 12 member 9

Gene

Slc12a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 9
Alternative name(s):
Cation-chloride cotransporter-interacting protein 1
Potassium-chloride transporter 9
Gene namesi
Name:Slc12a9
Synonyms:Cip1, Slc12a8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933532. Slc12a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 72ExtracellularSequence analysisAdd BLAST15
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 119CytoplasmicSequence analysisAdd BLAST26
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 167ExtracellularSequence analysisAdd BLAST27
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 193CytoplasmicSequence analysis5
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 262ExtracellularSequence analysisAdd BLAST48
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 297CytoplasmicSequence analysisAdd BLAST14
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 338ExtracellularSequence analysisAdd BLAST20
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 376CytoplasmicSequence analysisAdd BLAST17
Transmembranei377 – 399HelicalSequence analysisAdd BLAST23
Topological domaini400 – 416ExtracellularSequence analysisAdd BLAST17
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 466CytoplasmicSequence analysisAdd BLAST29
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 740ExtracellularSequence analysisAdd BLAST253
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 914CytoplasmicSequence analysisAdd BLAST153

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314161 – 914Solute carrier family 12 member 9Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Glycosylationi218N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi228N-linked (GlcNAc...)1 Publication1
Glycosylationi243N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99MR3.
MaxQBiQ99MR3.
PaxDbiQ99MR3.
PeptideAtlasiQ99MR3.
PRIDEiQ99MR3.

PTM databases

iPTMnetiQ99MR3.
PhosphoSitePlusiQ99MR3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037344.
ExpressionAtlasiQ99MR3. baseline and differential.
GenevisibleiQ99MR3. MM.

Interactioni

Subunit structurei

Interacts with SLC12A1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038106.

Structurei

3D structure databases

ProteinModelPortaliQ99MR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi715 – 718Poly-Ser4
Compositional biasi811 – 816Poly-Glu6

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1288. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000018183.
HOVERGENiHBG106223.
InParanoidiQ99MR3.
KOiK14429.
OMAiISGCTEG.
OrthoDBiEOG091G02RC.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR018491. SLC12_C.
IPR030345. SLC12A9.
[Graphical view]
PANTHERiPTHR11827:SF52. PTHR11827:SF52. 2 hits.
PfamiPF00324. AA_permease. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS
60 70 80 90 100
MFSIVVFLRI GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR
110 120 130 140 150
GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESILDVFGAD
160 170 180 190 200
ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV
210 220 230 240 250
SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT GFNGSTLRDN
260 270 280 290 300
LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
310 320 330 340 350
GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI
360 370 380 390 400
YATALSASMS SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY
410 420 430 440 450
SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT
460 470 480 490 500
FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLSA LLTARGGPSS
510 520 530 540 550
WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN PRGALPLLRL
560 570 580 590 600
ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL
610 620 630 640 650
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP
660 670 680 690 700
AEGTREGGSP ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA
710 720 730 740 750
RACGALPPER LSRGSSSSAQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ
760 770 780 790 800
MATILSMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE
810 820 830 840 850
VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV RAQQGRGTVG
860 870 880 890 900
GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT
910
LLIHGVTPVT CTDL
Length:914
Mass (Da):96,330
Last modified:July 27, 2011 - v2
Checksum:i769EA9EB4BD40E00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → A in AAK28822 (PubMed:11239002).Curated1
Sequence conflicti34S → A in AAL26866 (Ref. 2) Curated1
Sequence conflicti34S → A in AAH46982 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1.
AF314957 mRNA. Translation: AAL26866.1.
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1.
CCDSiCCDS19766.1.
RefSeqiNP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.3.
UniGeneiMm.235625.

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
GeneIDi83704.
KEGGimmu:83704.
UCSCiuc009ace.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1.
AF314957 mRNA. Translation: AAL26866.1.
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1.
CCDSiCCDS19766.1.
RefSeqiNP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.3.
UniGeneiMm.235625.

3D structure databases

ProteinModelPortaliQ99MR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038106.

PTM databases

iPTMnetiQ99MR3.
PhosphoSitePlusiQ99MR3.

Proteomic databases

EPDiQ99MR3.
MaxQBiQ99MR3.
PaxDbiQ99MR3.
PeptideAtlasiQ99MR3.
PRIDEiQ99MR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
GeneIDi83704.
KEGGimmu:83704.
UCSCiuc009ace.2. mouse.

Organism-specific databases

CTDi56996.
MGIiMGI:1933532. Slc12a9.

Phylogenomic databases

eggNOGiKOG1288. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000018183.
HOVERGENiHBG106223.
InParanoidiQ99MR3.
KOiK14429.
OMAiISGCTEG.
OrthoDBiEOG091G02RC.
TreeFamiTF313191.

Miscellaneous databases

PROiQ99MR3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037344.
ExpressionAtlasiQ99MR3. baseline and differential.
GenevisibleiQ99MR3. MM.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR018491. SLC12_C.
IPR030345. SLC12A9.
[Graphical view]
PANTHERiPTHR11827:SF52. PTHR11827:SF52. 2 hits.
PfamiPF00324. AA_permease. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS12A9_MOUSE
AccessioniPrimary (citable) accession number: Q99MR3
Secondary accession number(s): E9QNN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.