Solute carrier family 12 member 9 - Mus musculus (Mouse)

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Q99MR3 (S12A9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 77. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 12 member 9

Alternative name(s):
Cation-chloride cotransporter-interacting protein 1
Potassium-chloride transporter 9

Gene names

Name:	Slc12a9
Synonyms:	Cip1, Slc12a8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	914 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function By similarity.
Subunit structure	Interacts with SLC12A1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the SLC12A transporter family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from sequence orthology Ref.1. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 914

914

Solute carrier family 12 member 9

PRO_0000331416

Regions

Topological domain

1 – 36

Cytoplasmic Potential

Transmembrane

37 – 57

Helical; Potential

Topological domain

58 – 72

Extracellular Potential

Transmembrane

73 – 93

Helical; Potential

Topological domain

94 – 119

Cytoplasmic Potential

Transmembrane

120 – 140

Helical; Potential

Topological domain

141 – 167

Extracellular Potential

Transmembrane

168 – 188

Helical; Potential

Topological domain

189 – 193

Cytoplasmic Potential

Transmembrane

194 – 214

Helical; Potential

Topological domain

215 – 262

Extracellular Potential

Transmembrane

263 – 283

Helical; Potential

Topological domain

284 – 297

Cytoplasmic Potential

Transmembrane

298 – 318

Helical; Potential

Topological domain

319 – 338

Extracellular Potential

Transmembrane

339 – 359

Helical; Potential

Topological domain

360 – 376

Cytoplasmic Potential

Transmembrane

377 – 399

Helical; Potential

Topological domain

400 – 416

Extracellular Potential

Transmembrane

417 – 437

Helical; Potential

Topological domain

438 – 466

Cytoplasmic Potential

Transmembrane

467 – 487

Helical; Potential

Topological domain

488 – 740

253

Extracellular Potential

Transmembrane

741 – 761

Helical; Potential

Topological domain

762 – 914

153

Cytoplasmic Potential

Compositional bias

715 – 718

Poly-Ser

Compositional bias

811 – 816

Poly-Glu

Amino acid modifications

Glycosylation

218

N-linked (GlcNAc...) Ref.5

Glycosylation

228

N-linked (GlcNAc...) Ref.5

Glycosylation

243

N-linked (GlcNAc...) Ref.5

Experimental info

Sequence conflict

S → A in AAK28822. Ref.1

Sequence conflict

S → A in AAL26866. Ref.2

Sequence conflict

S → A in AAH46982. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q99MR3 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 769EA9EB4BD40E00
Show »

FASTA

914

96,330

        10         20         30         40         50         60 
MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS MFSIVVFLRI 

        70         80         90        100        110        120 
GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR GGGAYFMISR TLGPEVGGSI 

       130        140        150        160        170        180 
GLMFYLANVC GCAVSLLGLV ESILDVFGAD ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG 

       190        200        210        220        230        240 
VCTLGAGLYA RASFLTFLLV SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT 

       250        260        270        280        290        300 
GFNGSTLRDN LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL 

       310        320        330        340        350        360 
GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI YATALSASMS 

       370        380        390        400        410        420 
SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY SWGLVQLVLL AGKLNTLAAV 

       430        440        450        460        470        480 
VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FSLFSWHTCL LGVASCLLMM FLISPGAAGG 

       490        500        510        520        530        540 
SLLLMGLLSA LLTARGGPSS WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN 

       550        560        570        580        590        600 
PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL 

       610        620        630        640        650        660 
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP AEGTREGGSP 

       670        680        690        700        710        720 
ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA RACGALPPER LSRGSSSSAQ 

       730        740        750        760        770        780 
LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILSMVPA WHSARLRIFL CLGPREAPGA 

       790        800        810        820        830        840 
AEGRLRALLS QLRIRAEVQE VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV 

       850        860        870        880        890        900 
RAQQGRGTVG GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT 

       910 
LLIHGVTPVT CTDL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F. Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"Cloning of mouse Slc12a8, a new member of the cation-chloride cotransporter gene family." Mount D.B. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB/N.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[5]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-218; ASN-228 AND ASN-243, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF312033 Genomic DNA. Translation: AAK28822.1. AF314957 mRNA. Translation: AAL26866.1. AC150682 Genomic DNA. No translation available. BC046982 mRNA. Translation: AAH46982.1.
IPI	IPI00117986.
RefSeq	NP_113583.2. NM_031406.3.
UniGene	Mm.235625.
3D structure databases
ProteinModelPortal	Q99MR3.
ModBase	Search...
PTM databases
PhosphoSite	Q99MR3.
Proteomic databases
PaxDb	Q99MR3.
PRIDE	Q99MR3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
GeneID	83704.
KEGG	mmu:83704.
UCSC	uc009ace.2. mouse.
Organism-specific databases
CTD	56996.
MGI	MGI:1933532. Slc12a9.
Phylogenomic databases
eggNOG	COG0531.
GeneTree	ENSGT00560000076892.
HOGENOM	HOG000018183.
HOVERGEN	HBG106223.
InParanoid	Q99MR3.
KO	K14429.
OMA	GHFTGFN.
OrthoDB	EOG4B2SWJ.
Gene expression databases
ArrayExpress	Q99MR3.
Bgee	Q99MR3.
Genevestigator	Q99MR3.
Family and domain databases
InterPro	IPR004841. AA-permease_dom. [Graphical view]
Pfam	PF00324. AA_permease. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	350746.
SOURCE	Search...

Entry information

Entry name

S12A9_MOUSE

Accession

Primary (citable) accession number: Q99MR3
Secondary accession number(s): E9QNN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents