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Q99MR3

- S12A9_MOUSE

UniProt

Q99MR3 - S12A9_MOUSE

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Protein

Solute carrier family 12 member 9

Gene

Slc12a9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity).By similarity

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 9
Alternative name(s):
Cation-chloride cotransporter-interacting protein 1
Potassium-chloride transporter 9
Gene namesi
Name:Slc12a9
Synonyms:Cip1, Slc12a8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1933532. Slc12a9.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: MGI
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Solute carrier family 12 member 9PRO_0000331416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi218 – 2181N-linked (GlcNAc...); atypical1 Publication
Glycosylationi228 – 2281N-linked (GlcNAc...)1 Publication
Glycosylationi243 – 2431N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99MR3.
PaxDbiQ99MR3.
PRIDEiQ99MR3.

PTM databases

PhosphoSiteiQ99MR3.

Expressioni

Gene expression databases

BgeeiQ99MR3.
ExpressionAtlasiQ99MR3. baseline and differential.
GenevestigatoriQ99MR3.

Interactioni

Subunit structurei

Interacts with SLC12A1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99MR3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini58 – 7215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini94 – 11926CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini141 – 16727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 1935CytoplasmicSequence Analysis
Topological domaini215 – 26248ExtracellularSequence AnalysisAdd
BLAST
Topological domaini284 – 29714CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini319 – 33820ExtracellularSequence AnalysisAdd
BLAST
Topological domaini360 – 37617CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini400 – 41617ExtracellularSequence AnalysisAdd
BLAST
Topological domaini438 – 46629CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini488 – 740253ExtracellularSequence AnalysisAdd
BLAST
Topological domaini762 – 914153CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei377 – 39923HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST
Transmembranei741 – 76121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi715 – 7184Poly-Ser
Compositional biasi811 – 8166Poly-Glu

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000018183.
HOVERGENiHBG106223.
InParanoidiQ99MR3.
KOiK14429.
OMAiGHFTGFN.
OrthoDBiEOG7GN2M6.
TreeFamiTF313191.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MR3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS
60 70 80 90 100
MFSIVVFLRI GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR
110 120 130 140 150
GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESILDVFGAD
160 170 180 190 200
ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV
210 220 230 240 250
SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT GFNGSTLRDN
260 270 280 290 300
LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
310 320 330 340 350
GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI
360 370 380 390 400
YATALSASMS SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY
410 420 430 440 450
SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT
460 470 480 490 500
FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLSA LLTARGGPSS
510 520 530 540 550
WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN PRGALPLLRL
560 570 580 590 600
ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL
610 620 630 640 650
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP
660 670 680 690 700
AEGTREGGSP ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA
710 720 730 740 750
RACGALPPER LSRGSSSSAQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ
760 770 780 790 800
MATILSMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE
810 820 830 840 850
VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV RAQQGRGTVG
860 870 880 890 900
GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT
910
LLIHGVTPVT CTDL
Length:914
Mass (Da):96,330
Last modified:July 27, 2011 - v2
Checksum:i769EA9EB4BD40E00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341S → A in AAK28822. (PubMed:11239002)Curated
Sequence conflicti34 – 341S → A in AAL26866. 1 PublicationCurated
Sequence conflicti34 – 341S → A in AAH46982. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1.
AF314957 mRNA. Translation: AAL26866.1.
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1.
CCDSiCCDS19766.1.
RefSeqiNP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.1.
UniGeneiMm.235625.

Genome annotation databases

EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
GeneIDi83704.
KEGGimmu:83704.
UCSCiuc009ace.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28822.1 .
AF314957 mRNA. Translation: AAL26866.1 .
AC150682 Genomic DNA. No translation available.
BC046982 mRNA. Translation: AAH46982.1 .
CCDSi CCDS19766.1.
RefSeqi NP_113583.2. NM_031406.3.
XP_006504696.1. XM_006504633.1.
UniGenei Mm.235625.

3D structure databases

ProteinModelPortali Q99MR3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99MR3.

Proteomic databases

MaxQBi Q99MR3.
PaxDbi Q99MR3.
PRIDEi Q99MR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039991 ; ENSMUSP00000038106 ; ENSMUSG00000037344 .
GeneIDi 83704.
KEGGi mmu:83704.
UCSCi uc009ace.2. mouse.

Organism-specific databases

CTDi 56996.
MGIi MGI:1933532. Slc12a9.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119053.
HOGENOMi HOG000018183.
HOVERGENi HBG106223.
InParanoidi Q99MR3.
KOi K14429.
OMAi GHFTGFN.
OrthoDBi EOG7GN2M6.
TreeFami TF313191.

Miscellaneous databases

NextBioi 350746.
PROi Q99MR3.
SOURCEi Search...

Gene expression databases

Bgeei Q99MR3.
ExpressionAtlasi Q99MR3. baseline and differential.
Genevestigatori Q99MR3.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Cloning of mouse Slc12a8, a new member of the cation-chloride cotransporter gene family."
    Mount D.B.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-218; ASN-228 AND ASN-243.

Entry informationi

Entry nameiS12A9_MOUSE
AccessioniPrimary (citable) accession number: Q99MR3
Secondary accession number(s): E9QNN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3