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Q99MR3

- S12A9_MOUSE

UniProt

Q99MR3 - S12A9_MOUSE

Protein

Solute carrier family 12 member 9

Gene

Slc12a9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function By similarity.By similarity

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 12 member 9
    Alternative name(s):
    Cation-chloride cotransporter-interacting protein 1
    Potassium-chloride transporter 9
    Gene namesi
    Name:Slc12a9
    Synonyms:Cip1, Slc12a8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1933532. Slc12a9.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: MGI
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 914914Solute carrier family 12 member 9PRO_0000331416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi218 – 2181N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi228 – 2281N-linked (GlcNAc...)1 Publication
    Glycosylationi243 – 2431N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ99MR3.
    PRIDEiQ99MR3.

    PTM databases

    PhosphoSiteiQ99MR3.

    Expressioni

    Gene expression databases

    BgeeiQ99MR3.
    GenevestigatoriQ99MR3.

    Interactioni

    Subunit structurei

    Interacts with SLC12A1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 7215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini94 – 11926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 1935CytoplasmicSequence Analysis
    Topological domaini215 – 26248ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 37617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 41617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini438 – 46629CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini488 – 740253ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini762 – 914153CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei741 – 76121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi715 – 7184Poly-Ser
    Compositional biasi811 – 8166Poly-Glu

    Sequence similaritiesi

    Belongs to the SLC12A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00560000077088.
    HOGENOMiHOG000018183.
    HOVERGENiHBG106223.
    InParanoidiQ99MR3.
    KOiK14429.
    OMAiGHFTGFN.
    OrthoDBiEOG7GN2M6.
    TreeFamiTF313191.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    [Graphical view]
    PfamiPF00324. AA_permease. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99MR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASESSPLLA YRLLGEEGAA FPPNGAGVSG VPSSRKLSTF LGVVVPTVLS    50
    MFSIVVFLRI GFVVGHAGLL QALAMLLVAY IILALTVLSV CAIATNGAVR 100
    GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESILDVFGAD 150
    ATGSSGIQVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV 200
    SGSLASVLVS FVAVGPRNIP LAPRPGTNAS SVPHRHGHFT GFNGSTLRDN 250
    LGAGYAEDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL 300
    GTIIAVAYTF FIYILLFFLS SFTCDRALLQ EDYGFFRDIS LWPPLVLIGI 350
    YATALSASMS SLIGASRILH ALAQDDLFGV ILAPAKVVSG GGNPWGAVLY 400
    SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT 450
    FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLSA LLTARGGPSS 500
    WGYVSQALLF HQVRKYLLRL DVRKEHVKFW RPQLLLLVGN PRGALPLLRL 550
    ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD LAQVKAFVDL 600
    TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP 650
    AEGTREGGSP ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA 700
    RACGALPPER LSRGSSSSAQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ 750
    MATILSMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE 800
    VVWGEGAETG EPEEEEGDFV NGGRGDEEAE ALACSANALV RAQQGRGTVG 850
    GPGGPEGRDG EEGPTTALTF LYLPRPPADP ARYPRYLALL ETLSRDLGPT 900
    LLIHGVTPVT CTDL 914
    Length:914
    Mass (Da):96,330
    Last modified:July 27, 2011 - v2
    Checksum:i769EA9EB4BD40E00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341S → A in AAK28822. (PubMed:11239002)Curated
    Sequence conflicti34 – 341S → A in AAL26866. 1 PublicationCurated
    Sequence conflicti34 – 341S → A in AAH46982. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312033 Genomic DNA. Translation: AAK28822.1.
    AF314957 mRNA. Translation: AAL26866.1.
    AC150682 Genomic DNA. No translation available.
    BC046982 mRNA. Translation: AAH46982.1.
    CCDSiCCDS19766.1.
    RefSeqiNP_113583.2. NM_031406.3.
    XP_006504696.1. XM_006504633.1.
    UniGeneiMm.235625.

    Genome annotation databases

    EnsembliENSMUST00000039991; ENSMUSP00000038106; ENSMUSG00000037344.
    GeneIDi83704.
    KEGGimmu:83704.
    UCSCiuc009ace.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312033 Genomic DNA. Translation: AAK28822.1 .
    AF314957 mRNA. Translation: AAL26866.1 .
    AC150682 Genomic DNA. No translation available.
    BC046982 mRNA. Translation: AAH46982.1 .
    CCDSi CCDS19766.1.
    RefSeqi NP_113583.2. NM_031406.3.
    XP_006504696.1. XM_006504633.1.
    UniGenei Mm.235625.

    3D structure databases

    ProteinModelPortali Q99MR3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99MR3.

    Proteomic databases

    PaxDbi Q99MR3.
    PRIDEi Q99MR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039991 ; ENSMUSP00000038106 ; ENSMUSG00000037344 .
    GeneIDi 83704.
    KEGGi mmu:83704.
    UCSCi uc009ace.2. mouse.

    Organism-specific databases

    CTDi 56996.
    MGIi MGI:1933532. Slc12a9.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00560000077088.
    HOGENOMi HOG000018183.
    HOVERGENi HBG106223.
    InParanoidi Q99MR3.
    KOi K14429.
    OMAi GHFTGFN.
    OrthoDBi EOG7GN2M6.
    TreeFami TF313191.

    Miscellaneous databases

    NextBioi 350746.
    PROi Q99MR3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99MR3.
    Genevestigatori Q99MR3.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    [Graphical view ]
    Pfami PF00324. AA_permease. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
      Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Cloning of mouse Slc12a8, a new member of the cation-chloride cotransporter gene family."
      Mount D.B.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-218; ASN-228 AND ASN-243.

    Entry informationi

    Entry nameiS12A9_MOUSE
    AccessioniPrimary (citable) accession number: Q99MR3
    Secondary accession number(s): E9QNN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3