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Q99MQ5 (COPA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXV) chain
Alternative name(s):
CLAC-P

Cleaved into the following chain:

  1. Collagen-like Alzheimer amyloid plaque component
    Short name=CLAC
Gene names
Name:Col25a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin By similarity. UniProtKB Q9BXS0

Subunit structure

Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 By similarity. UniProtKB Q9BXS0

Subcellular location

Membrane; Single-pass type II membrane protein Potential. Note: After proteolytic cleavage, CLAC is secreted By similarity.

Tissue specificity

Expressed predominantly in neurons with low levels also detected in heart, testis and eye. Ref.1

Post-translational modification

Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component By similarity. UniProtKB Q9BXS0

Glycosylated By similarity. UniProtKB Q9BXS0

Hydroxylated on proline and lysine residues By similarity. UniProtKB Q9BXS0

Sequence similarities

Contains 8 collagen-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 666666Collagen alpha-1(XXV) chain
PRO_0000259613
Chain113 – 654542Collagen-like Alzheimer amyloid plaque component By similarity UniProtKB Q9BXS0
PRO_0000259614

Regions

Topological domain1 – 3333Cytoplasmic Potential
Transmembrane34 – 5421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain55 – 666612Extracellular Potential
Domain121 – 16444Collagen-like 1
Domain192 – 24756Collagen-like 2
Domain249 – 30860Collagen-like 3
Domain311 – 37060Collagen-like 4
Domain373 – 42553Collagen-like 5
Domain455 – 51460Collagen-like 6
Domain529 – 58860Collagen-like 7
Domain589 – 64860Collagen-like 8
Region181 – 1888Interaction with beta amyloid peptide By similarity UniProtKB Q9BXS0

Sites

Site112 – 1132Cleavage; by furin By similarity UniProtKB Q9BXS0

Experimental info

Sequence conflict641A → V in AAK37475. Ref.1
Sequence conflict1041H → Y in AAK37475. Ref.1
Sequence conflict1111A → V in AAK37475. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99MQ5 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: DD8F5CAADE401366

FASTA66665,377
        10         20         30         40         50         60 
MLVKKLAGKG GGRESGSEDP RPLGQRCAGT MPSCTALATL LSVVAVAFCF YLGVKTNDLQ 

        70         80         90        100        110        120 
ARIAALESAK GTPSFHPLSD TVDELKAMVQ EKVERLLAQK SYEHMAKIRT AREAPLECNC 

       130        140        150        160        170        180 
PAGPPGKRGK RGRRGESGPP GQPGPQGPPG PKGDKGEQGD QGPRMVFPKI NHGFLSADQQ 

       190        200        210        220        230        240 
LIKRRLIKGD QGQAGPPGPP GPPGPRGPPG DTGKDGPRGM PGVPGEPGKP GEQGLMGPLG 

       250        260        270        280        290        300 
PPGQKGSIGA PGTPGMDGQK GEPGSPGAAG QSGLPGPKGE PGKEGEKGDA GENGPKGDTG 

       310        320        330        340        350        360 
EKGDPGSSAA GIKGEPGESG RPGQKGEPGL PGLPGLPGIK GEPGFIGPQG EPGLPGLPGT 

       370        380        390        400        410        420 
KGDRGEAGPP GRGERGDPGA PGPKGKQGES GARGPKGSKG DRGDKGDSGA LGPRGPPGQK 

       430        440        450        460        470        480 
GDPGATEIID YNGNLHEALQ RITTLTVTGP PGPPGPQGLQ GPKGEQGSPG IPGVDGEQGL 

       490        500        510        520        530        540 
KGSKGDMGDP GVPGEKGGLG LPGLPGANGV KGEKGDTGLP GPQGPSIIGP PGPPGPHGPP 

       550        560        570        580        590        600 
GPMGPHGLPG PKGASGLDGK PGSRGADGPI GPHGPAGPKG ERGEKGAMGE PGPRGPYGLP 

       610        620        630        640        650        660 
GKDGEPGLDG FPGPRGEKGD LGEKGEKGFR GVKGEKGEPG QPGLDGLDAP CQLGPDGLPM 


PGCWQK 

« Hide

References

« Hide 'large scale' references
[1]"CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV."
Hashimoto T., Wakabayashi T., Watanabe A., Kowa H., Hosoda R., Nakamura A., Kanazawa I., Arai T., Takio K., Mann D.M.A., Iwatsubo T.
EMBO J. 21:1524-1534(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF315290 mRNA. Translation: AAK37475.1.
AC091312 Genomic DNA. No translation available.
AC110540 Genomic DNA. No translation available.
AC114642 Genomic DNA. No translation available.
AC164078 Genomic DNA. No translation available.
CH466532 Genomic DNA. Translation: EDL12220.1.
CCDSCCDS38637.1.
RefSeqNP_084114.2. NM_029838.4.
UniGeneMm.91728.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ99MQ5.

Proteomic databases

PRIDEQ99MQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080335; ENSMUSP00000079210; ENSMUSG00000058897.
GeneID77018.
KEGGmmu:77018.
UCSCuc008riw.2. mouse.
uc008riz.1. mouse.

Organism-specific databases

CTD84570.
MGIMGI:1924268. Col25a1.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00750000117303.
HOGENOMHOG000085653.
HOVERGENHBG101380.
InParanoidQ99MQ5.
OMAGRRGESX.
OrthoDBEOG7D59P1.
TreeFamTF338175.

Gene expression databases

CleanExMM_COL25A1.
GenevestigatorQ99MQ5.

Family and domain databases

InterProIPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio13888081.
PROQ99MQ5.
SOURCESearch...

Entry information

Entry nameCOPA1_MOUSE
AccessionPrimary (citable) accession number: Q99MQ5
Secondary accession number(s): G3X9H6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot