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Protein

Collagen alpha-1(XXV) chain

Gene

Col25a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: MGI

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXV) chain
Alternative name(s):
CLAC-P
Cleaved into the following chain:
Gene namesi
Name:Col25a1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924268 Col25a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 666ExtracellularSequence analysisAdd BLAST612

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596131 – 666Collagen alpha-1(XXV) chainAdd BLAST666
ChainiPRO_0000259614113 – 654Collagen-like Alzheimer amyloid plaque componentBy similarityAdd BLAST542

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.By similarity
Glycosylated.By similarity
Hydroxylated on proline and lysine residues.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei112 – 113Cleavage; by furinBy similarity2

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ99MQ5
PRIDEiQ99MQ5

PTM databases

iPTMnetiQ99MQ5
PhosphoSitePlusiQ99MQ5

Expressioni

Tissue specificityi

Expressed predominantly in neurons with low levels also detected in heart, testis and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000058897
CleanExiMM_COL25A1
ExpressionAtlasiQ99MQ5 baseline and differential
GenevisibleiQ99MQ5 MM

Interactioni

Subunit structurei

Forms homodimers and homotrimers. Binds to the fibrillized forms of amyloid-beta protein 40 (beta-APP40) and amyloid-betad protein 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079210

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 164Collagen-like 1Sequence analysisAdd BLAST44
Domaini192 – 247Collagen-like 2Sequence analysisAdd BLAST56
Domaini249 – 308Collagen-like 3Sequence analysisAdd BLAST60
Domaini311 – 370Collagen-like 4Sequence analysisAdd BLAST60
Domaini373 – 425Collagen-like 5Sequence analysisAdd BLAST53
Domaini455 – 514Collagen-like 6Sequence analysisAdd BLAST60
Domaini529 – 588Collagen-like 7Sequence analysisAdd BLAST60
Domaini589 – 648Collagen-like 8Sequence analysisAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 188Interaction with amyloid-beta peptideBy similarity8

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410ZYTY LUCA
GeneTreeiENSGT00900000140850
HOGENOMiHOG000085653
HOVERGENiHBG101380
InParanoidiQ99MQ5
OMAiGRRGESX
OrthoDBiEOG091G0G3Y
TreeFamiTF338175

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKKLAGKG GGRESGSEDP RPLGQRCAGT MPSCTALATL LSVVAVAFCF
60 70 80 90 100
YLGVKTNDLQ ARIAALESAK GTPSFHPLSD TVDELKAMVQ EKVERLLAQK
110 120 130 140 150
SYEHMAKIRT AREAPLECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG
160 170 180 190 200
PKGDKGEQGD QGPRMVFPKI NHGFLSADQQ LIKRRLIKGD QGQAGPPGPP
210 220 230 240 250
GPPGPRGPPG DTGKDGPRGM PGVPGEPGKP GEQGLMGPLG PPGQKGSIGA
260 270 280 290 300
PGTPGMDGQK GEPGSPGAAG QSGLPGPKGE PGKEGEKGDA GENGPKGDTG
310 320 330 340 350
EKGDPGSSAA GIKGEPGESG RPGQKGEPGL PGLPGLPGIK GEPGFIGPQG
360 370 380 390 400
EPGLPGLPGT KGDRGEAGPP GRGERGDPGA PGPKGKQGES GARGPKGSKG
410 420 430 440 450
DRGDKGDSGA LGPRGPPGQK GDPGATEIID YNGNLHEALQ RITTLTVTGP
460 470 480 490 500
PGPPGPQGLQ GPKGEQGSPG IPGVDGEQGL KGSKGDMGDP GVPGEKGGLG
510 520 530 540 550
LPGLPGANGV KGEKGDTGLP GPQGPSIIGP PGPPGPHGPP GPMGPHGLPG
560 570 580 590 600
PKGASGLDGK PGSRGADGPI GPHGPAGPKG ERGEKGAMGE PGPRGPYGLP
610 620 630 640 650
GKDGEPGLDG FPGPRGEKGD LGEKGEKGFR GVKGEKGEPG QPGLDGLDAP
660
CQLGPDGLPM PGCWQK
Length:666
Mass (Da):65,377
Last modified:October 3, 2012 - v2
Checksum:iDD8F5CAADE401366
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → V in AAK37475 (PubMed:11927537).Curated1
Sequence conflicti104H → Y in AAK37475 (PubMed:11927537).Curated1
Sequence conflicti111A → V in AAK37475 (PubMed:11927537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315290 mRNA Translation: AAK37475.1
AC091312 Genomic DNA No translation available.
AC110540 Genomic DNA No translation available.
AC114642 Genomic DNA No translation available.
AC164078 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL12220.1
CCDSiCCDS38637.1
RefSeqiNP_084114.2, NM_029838.4
UniGeneiMm.91728

Genome annotation databases

EnsembliENSMUST00000080335; ENSMUSP00000079210; ENSMUSG00000058897
GeneIDi77018
KEGGimmu:77018
UCSCiuc008riz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOPA1_MOUSE
AccessioniPrimary (citable) accession number: Q99MQ5
Secondary accession number(s): G3X9H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 3, 2012
Last modified: February 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome