Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XXV) chain

Gene

Col25a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXV) chain
Alternative name(s):
CLAC-P
Cleaved into the following chain:
Gene namesi
Name:Col25a1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924268. Col25a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 666ExtracellularSequence analysisAdd BLAST612

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596131 – 666Collagen alpha-1(XXV) chainAdd BLAST666
ChainiPRO_0000259614113 – 654Collagen-like Alzheimer amyloid plaque componentBy similarityAdd BLAST542

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.By similarity
Glycosylated.By similarity
Hydroxylated on proline and lysine residues.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei112 – 113Cleavage; by furinBy similarity2

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ99MQ5.
PRIDEiQ99MQ5.

PTM databases

iPTMnetiQ99MQ5.
PhosphoSitePlusiQ99MQ5.

Expressioni

Tissue specificityi

Expressed predominantly in neurons with low levels also detected in heart, testis and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000058897.
CleanExiMM_COL25A1.
ExpressionAtlasiQ99MQ5. baseline and differential.
GenevisibleiQ99MQ5. MM.

Interactioni

Subunit structurei

Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079210.

Structurei

3D structure databases

ProteinModelPortaliQ99MQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 164Collagen-like 1Sequence analysisAdd BLAST44
Domaini192 – 247Collagen-like 2Sequence analysisAdd BLAST56
Domaini249 – 308Collagen-like 3Sequence analysisAdd BLAST60
Domaini311 – 370Collagen-like 4Sequence analysisAdd BLAST60
Domaini373 – 425Collagen-like 5Sequence analysisAdd BLAST53
Domaini455 – 514Collagen-like 6Sequence analysisAdd BLAST60
Domaini529 – 588Collagen-like 7Sequence analysisAdd BLAST60
Domaini589 – 648Collagen-like 8Sequence analysisAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 188Interaction with beta amyloid peptideBy similarity8

Sequence similaritiesi

Contains 8 collagen-like domains.Sequence analysis

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410ZYTY. LUCA.
GeneTreeiENSGT00840000129701.
HOGENOMiHOG000085653.
HOVERGENiHBG101380.
InParanoidiQ99MQ5.
OMAiDENFFFP.
OrthoDBiEOG091G0G3Y.
TreeFamiTF338175.

Family and domain databases

InterProiIPR029575. CLAC-P.
IPR008160. Collagen.
[Graphical view]
PANTHERiPTHR24023:SF605. PTHR24023:SF605. 2 hits.
PfamiPF01391. Collagen. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKKLAGKG GGRESGSEDP RPLGQRCAGT MPSCTALATL LSVVAVAFCF
60 70 80 90 100
YLGVKTNDLQ ARIAALESAK GTPSFHPLSD TVDELKAMVQ EKVERLLAQK
110 120 130 140 150
SYEHMAKIRT AREAPLECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG
160 170 180 190 200
PKGDKGEQGD QGPRMVFPKI NHGFLSADQQ LIKRRLIKGD QGQAGPPGPP
210 220 230 240 250
GPPGPRGPPG DTGKDGPRGM PGVPGEPGKP GEQGLMGPLG PPGQKGSIGA
260 270 280 290 300
PGTPGMDGQK GEPGSPGAAG QSGLPGPKGE PGKEGEKGDA GENGPKGDTG
310 320 330 340 350
EKGDPGSSAA GIKGEPGESG RPGQKGEPGL PGLPGLPGIK GEPGFIGPQG
360 370 380 390 400
EPGLPGLPGT KGDRGEAGPP GRGERGDPGA PGPKGKQGES GARGPKGSKG
410 420 430 440 450
DRGDKGDSGA LGPRGPPGQK GDPGATEIID YNGNLHEALQ RITTLTVTGP
460 470 480 490 500
PGPPGPQGLQ GPKGEQGSPG IPGVDGEQGL KGSKGDMGDP GVPGEKGGLG
510 520 530 540 550
LPGLPGANGV KGEKGDTGLP GPQGPSIIGP PGPPGPHGPP GPMGPHGLPG
560 570 580 590 600
PKGASGLDGK PGSRGADGPI GPHGPAGPKG ERGEKGAMGE PGPRGPYGLP
610 620 630 640 650
GKDGEPGLDG FPGPRGEKGD LGEKGEKGFR GVKGEKGEPG QPGLDGLDAP
660
CQLGPDGLPM PGCWQK
Length:666
Mass (Da):65,377
Last modified:October 3, 2012 - v2
Checksum:iDD8F5CAADE401366
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → V in AAK37475 (PubMed:11927537).Curated1
Sequence conflicti104H → Y in AAK37475 (PubMed:11927537).Curated1
Sequence conflicti111A → V in AAK37475 (PubMed:11927537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315290 mRNA. Translation: AAK37475.1.
AC091312 Genomic DNA. No translation available.
AC110540 Genomic DNA. No translation available.
AC114642 Genomic DNA. No translation available.
AC164078 Genomic DNA. No translation available.
CH466532 Genomic DNA. Translation: EDL12220.1.
CCDSiCCDS38637.1.
RefSeqiNP_084114.2. NM_029838.4.
UniGeneiMm.91728.

Genome annotation databases

EnsembliENSMUST00000080335; ENSMUSP00000079210; ENSMUSG00000058897.
GeneIDi77018.
KEGGimmu:77018.
UCSCiuc008riz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315290 mRNA. Translation: AAK37475.1.
AC091312 Genomic DNA. No translation available.
AC110540 Genomic DNA. No translation available.
AC114642 Genomic DNA. No translation available.
AC164078 Genomic DNA. No translation available.
CH466532 Genomic DNA. Translation: EDL12220.1.
CCDSiCCDS38637.1.
RefSeqiNP_084114.2. NM_029838.4.
UniGeneiMm.91728.

3D structure databases

ProteinModelPortaliQ99MQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079210.

PTM databases

iPTMnetiQ99MQ5.
PhosphoSitePlusiQ99MQ5.

Proteomic databases

PaxDbiQ99MQ5.
PRIDEiQ99MQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080335; ENSMUSP00000079210; ENSMUSG00000058897.
GeneIDi77018.
KEGGimmu:77018.
UCSCiuc008riz.1. mouse.

Organism-specific databases

CTDi84570.
MGIiMGI:1924268. Col25a1.

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410ZYTY. LUCA.
GeneTreeiENSGT00840000129701.
HOGENOMiHOG000085653.
HOVERGENiHBG101380.
InParanoidiQ99MQ5.
OMAiDENFFFP.
OrthoDBiEOG091G0G3Y.
TreeFamiTF338175.

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

ChiTaRSiCol25a1. mouse.
PROiQ99MQ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058897.
CleanExiMM_COL25A1.
ExpressionAtlasiQ99MQ5. baseline and differential.
GenevisibleiQ99MQ5. MM.

Family and domain databases

InterProiIPR029575. CLAC-P.
IPR008160. Collagen.
[Graphical view]
PANTHERiPTHR24023:SF605. PTHR24023:SF605. 2 hits.
PfamiPF01391. Collagen. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPA1_MOUSE
AccessioniPrimary (citable) accession number: Q99MQ5
Secondary accession number(s): G3X9H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.