ID   UCN2_MOUSE              Reviewed;         113 AA.
AC   Q99ML8; F8WIL4;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 2.
DT   24-JAN-2024, entry version 137.
DE   RecName: Full=Urocortin-2;
DE   AltName: Full=Urocortin II;
DE            Short=Ucn II;
DE   Flags: Precursor;
GN   Name=Ucn2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2-113.
RC   STRAIN=BALB/cJ;
RX   PubMed=11226328; DOI=10.1073/pnas.051626398;
RA   Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A.,
RA   Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., Sawchenko P.E.;
RT   "Urocortin II: a member of the corticotropin-releasing factor (CRF)
RT   neuropeptide family that is selectively bound by type 2 CRF receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:2843-2848(2001).
RN   [3]
RP   PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, SIGNAL SEQUENCE
RP   CLEAVAGE SITE, GLYCOSYLATION, AND AMIDATION AT VAL-110.
RX   PubMed=23493376; DOI=10.1210/en.2012-2011;
RA   Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E.,
RA   Sawchenko P.E., Vale W.W.;
RT   "Posttranslational processing of human and mouse urocortin 2:
RT   characterization and bioactivity of gene products.";
RL   Endocrinology 154:1553-1564(2013).
CC   -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC       heat-induced edema. Might represent an endogenous ligand for
CC       maintaining homeostasis after stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23493376}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:23493376}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AC140383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF331517; AAK16157.1; -; mRNA.
DR   CCDS; CCDS52929.1; -.
DR   RefSeq; NP_659543.1; NM_145077.1.
DR   AlphaFoldDB; Q99ML8; -.
DR   SMR; Q99ML8; -.
DR   BioGRID; 228607; 2.
DR   STRING; 10090.ENSMUSP00000060405; -.
DR   PaxDb; 10090-ENSMUSP00000060405; -.
DR   Antibodypedia; 55296; 207 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000052724.5; ENSMUSP00000060405.4; ENSMUSG00000049699.5.
DR   GeneID; 171530; -.
DR   KEGG; mmu:171530; -.
DR   UCSC; uc012hax.1; mouse.
DR   AGR; MGI:2176375; -.
DR   CTD; 90226; -.
DR   MGI; MGI:2176375; Ucn2.
DR   VEuPathDB; HostDB:ENSMUSG00000049699; -.
DR   eggNOG; ENOG502R23K; Eukaryota.
DR   GeneTree; ENSGT00940000160568; -.
DR   HOGENOM; CLU_2145078_0_0_1; -.
DR   InParanoid; Q99ML8; -.
DR   OMA; TWPWAAQ; -.
DR   OrthoDB; 5266489at2759; -.
DR   PhylomeDB; Q99ML8; -.
DR   TreeFam; TF330723; -.
DR   Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
DR   BioGRID-ORCS; 171530; 4 hits in 79 CRISPR screens.
DR   PRO; PR:Q99ML8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q99ML8; Protein.
DR   Bgee; ENSMUSG00000049699; Expressed in saccule of membranous labyrinth and 30 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; ISO:MGI.
DR   GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IDA:MGI.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042562; F:hormone binding; ISO:MGI.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0046882; P:negative regulation of follicle-stimulating hormone secretion; ISO:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR   GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; ISO:MGI.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR024270; Urocortin_II/III.
DR   PANTHER; PTHR17575:SF0; UROCORTIN-2; 1.
DR   PANTHER; PTHR17575; UROCORTIN-2 AND 3; 1.
DR   Pfam; PF00473; CRF; 1.
DR   Genevisible; Q99ML8; MM.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:23493376"
FT   PROPEP          24..71
FT                   /evidence="ECO:0000269|PubMed:23493376"
FT                   /id="PRO_0000006241"
FT   CHAIN           73..110
FT                   /note="Urocortin-2"
FT                   /id="PRO_0000006242"
FT   REGION          37..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         110
FT                   /note="Valine amide; partial"
FT                   /evidence="ECO:0000269|PubMed:23493376"
SQ   SEQUENCE   113 AA;  12310 MW;  9C55EB416C7D5B25 CRC64;
     MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS GTTTGPSASW
     SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA ATNAQILAHV GRR
//