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Q99ML8

- UCN2_MOUSE

UniProt

Q99ML8 - UCN2_MOUSE

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Protein
Urocortin-2
Gene
Ucn2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI
  2. hormone binding Source: Ensembl
  3. protein binding Source: MGI
  4. receptor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cAMP biosynthetic process Source: UniProtKB
  2. cell proliferation Source: Ensembl
  3. cellular response to glucocorticoid stimulus Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. digestion Source: InterPro
  6. negative regulation of follicle-stimulating hormone secretion Source: Ensembl
  7. negative regulation of gene expression Source: Ensembl
  8. negative regulation of luteinizing hormone secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name:
Ucn II
Gene namesi
Name:Ucn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2176375. Ucn2.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Propeptidei24 – 7148
PRO_0000006241Add
BLAST
Chaini73 – 11038Urocortin-2
PRO_0000006242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Valine amide; partial1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Amidation, Glycoprotein

Proteomic databases

PRIDEiQ99ML8.

Expressioni

Gene expression databases

BgeeiQ99ML8.
CleanExiMM_UCN2.
GenevestigatoriQ99ML8.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta By similarity.

Protein-protein interaction databases

BioGridi228607. 2 interactions.
STRINGi10090.ENSMUSP00000060405.

Structurei

3D structure databases

ProteinModelPortaliQ99ML8.
SMRiQ99ML8. Positions 73-110.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ99ML8.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
TreeFamiTF330723.

Family and domain databases

InterProiIPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ML8-1 [UniParc]FASTAAdd to Basket

« Hide

MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS    50
GTTTGPSASW SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA 100
ATNAQILAHV GRR 113
Length:113
Mass (Da):12,310
Last modified:September 18, 2013 - v2
Checksum:i9C55EB416C7D5B25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC140383 Genomic DNA. No translation available.
AF331517 mRNA. Translation: AAK16157.1.
CCDSiCCDS52929.1.
RefSeqiNP_659543.1. NM_145077.1.
UniGeneiMm.388865.

Genome annotation databases

EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699.
GeneIDi171530.
KEGGimmu:171530.
UCSCiuc012hax.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC140383 Genomic DNA. No translation available.
AF331517 mRNA. Translation: AAK16157.1 .
CCDSi CCDS52929.1.
RefSeqi NP_659543.1. NM_145077.1.
UniGenei Mm.388865.

3D structure databases

ProteinModelPortali Q99ML8.
SMRi Q99ML8. Positions 73-110.
ModBasei Search...

Protein-protein interaction databases

BioGridi 228607. 2 interactions.
STRINGi 10090.ENSMUSP00000060405.

Proteomic databases

PRIDEi Q99ML8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052724 ; ENSMUSP00000060405 ; ENSMUSG00000049699 .
GeneIDi 171530.
KEGGi mmu:171530.
UCSCi uc012hax.1. mouse.

Organism-specific databases

CTDi 90226.
MGIi MGI:2176375. Ucn2.

Phylogenomic databases

eggNOGi NOG43191.
GeneTreei ENSGT00390000004650.
HOGENOMi HOG000154768.
HOVERGENi HBG036242.
InParanoidi Q99ML8.
KOi K05257.
OMAi QNSPQTT.
OrthoDBi EOG73BVGS.
TreeFami TF330723.

Miscellaneous databases

NextBioi 371032.
PROi Q99ML8.
SOURCEi Search...

Gene expression databases

Bgeei Q99ML8.
CleanExi MM_UCN2.
Genevestigatori Q99ML8.

Family and domain databases

InterProi IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view ]
PANTHERi PTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
Pfami PF11613. UCN2. 1 hit.
[Graphical view ]
ProDomi PD455741. PD455741. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors."
    Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., Sawchenko P.E.
    Proc. Natl. Acad. Sci. U.S.A. 98:2843-2848(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-113.
    Strain: BALB/c.
  3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
    Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
    Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION, AMIDATION AT VAL-110.

Entry informationi

Entry nameiUCN2_MOUSE
AccessioniPrimary (citable) accession number: Q99ML8
Secondary accession number(s): F8WIL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi