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Q99ML8

- UCN2_MOUSE

UniProt

Q99ML8 - UCN2_MOUSE

Protein

Urocortin-2

Gene

Ucn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor binding Source: MGI
    2. hormone binding Source: Ensembl
    3. protein binding Source: MGI
    4. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cAMP biosynthetic process Source: UniProtKB
    2. cell proliferation Source: Ensembl
    3. cellular response to glucocorticoid stimulus Source: Ensembl
    4. cellular response to hypoxia Source: Ensembl
    5. digestion Source: InterPro
    6. negative regulation of follicle-stimulating hormone secretion Source: Ensembl
    7. negative regulation of gene expression Source: Ensembl
    8. negative regulation of luteinizing hormone secretion Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocortin-2
    Alternative name(s):
    Urocortin II
    Short name:
    Ucn II
    Gene namesi
    Name:Ucn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2176375. Ucn2.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Propeptidei24 – 71481 PublicationPRO_0000006241Add
    BLAST
    Chaini73 – 11038Urocortin-2PRO_0000006242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101Valine amide; partial1 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Amidation, Glycoprotein

    Proteomic databases

    PRIDEiQ99ML8.

    Expressioni

    Gene expression databases

    BgeeiQ99ML8.
    CleanExiMM_UCN2.
    GenevestigatoriQ99ML8.

    Interactioni

    Subunit structurei

    Binds with high affinity to CRF receptors 2-alpha and 2-beta.By similarity

    Protein-protein interaction databases

    BioGridi228607. 2 interactions.
    STRINGi10090.ENSMUSP00000060405.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ML8.
    SMRiQ99ML8. Positions 73-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43191.
    GeneTreeiENSGT00390000004650.
    HOGENOMiHOG000154768.
    HOVERGENiHBG036242.
    InParanoidiQ99ML8.
    KOiK05257.
    OMAiQNSPQTT.
    OrthoDBiEOG73BVGS.
    TreeFamiTF330723.

    Family and domain databases

    InterProiIPR024273. Urocortin_II.
    IPR024270. Urocortin_II/III.
    [Graphical view]
    PANTHERiPTHR17575. PTHR17575. 1 hit.
    PTHR17575:SF0. PTHR17575:SF0. 1 hit.
    PfamiPF11613. UCN2. 1 hit.
    [Graphical view]
    ProDomiPD455741. PD455741. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99ML8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS    50
    GTTTGPSASW SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA 100
    ATNAQILAHV GRR 113
    Length:113
    Mass (Da):12,310
    Last modified:September 18, 2013 - v2
    Checksum:i9C55EB416C7D5B25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140383 Genomic DNA. No translation available.
    AF331517 mRNA. Translation: AAK16157.1.
    CCDSiCCDS52929.1.
    RefSeqiNP_659543.1. NM_145077.1.
    UniGeneiMm.388865.

    Genome annotation databases

    EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699.
    GeneIDi171530.
    KEGGimmu:171530.
    UCSCiuc012hax.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140383 Genomic DNA. No translation available.
    AF331517 mRNA. Translation: AAK16157.1 .
    CCDSi CCDS52929.1.
    RefSeqi NP_659543.1. NM_145077.1.
    UniGenei Mm.388865.

    3D structure databases

    ProteinModelPortali Q99ML8.
    SMRi Q99ML8. Positions 73-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228607. 2 interactions.
    STRINGi 10090.ENSMUSP00000060405.

    Proteomic databases

    PRIDEi Q99ML8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052724 ; ENSMUSP00000060405 ; ENSMUSG00000049699 .
    GeneIDi 171530.
    KEGGi mmu:171530.
    UCSCi uc012hax.1. mouse.

    Organism-specific databases

    CTDi 90226.
    MGIi MGI:2176375. Ucn2.

    Phylogenomic databases

    eggNOGi NOG43191.
    GeneTreei ENSGT00390000004650.
    HOGENOMi HOG000154768.
    HOVERGENi HBG036242.
    InParanoidi Q99ML8.
    KOi K05257.
    OMAi QNSPQTT.
    OrthoDBi EOG73BVGS.
    TreeFami TF330723.

    Miscellaneous databases

    NextBioi 371032.
    PROi Q99ML8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99ML8.
    CleanExi MM_UCN2.
    Genevestigatori Q99ML8.

    Family and domain databases

    InterProi IPR024273. Urocortin_II.
    IPR024270. Urocortin_II/III.
    [Graphical view ]
    PANTHERi PTHR17575. PTHR17575. 1 hit.
    PTHR17575:SF0. PTHR17575:SF0. 1 hit.
    Pfami PF11613. UCN2. 1 hit.
    [Graphical view ]
    ProDomi PD455741. PD455741. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors."
      Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., Sawchenko P.E.
      Proc. Natl. Acad. Sci. U.S.A. 98:2843-2848(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-113.
      Strain: BALB/c.
    3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
      Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
      Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION, AMIDATION AT VAL-110.

    Entry informationi

    Entry nameiUCN2_MOUSE
    AccessioniPrimary (citable) accession number: Q99ML8
    Secondary accession number(s): F8WIL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3