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Q99ML8 (UCN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name=Ucn II
Gene names
Name:Ucn2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress By similarity.

Subunit structure

Binds with high affinity to CRF receptors 2-alpha and 2-beta By similarity.

Subcellular location

Secreted Ref.3.

Post-translational modification

Glycosylated. Ref.3

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.3
Propeptide24 – 7148
PRO_0000006241
Chain73 – 11038Urocortin-2
PRO_0000006242

Amino acid modifications

Modified residue1101Valine amide; partial Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q99ML8 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: 9C55EB416C7D5B25

FASTA11312,310
        10         20         30         40         50         60 
MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS GTTTGPSASW 

        70         80         90        100        110 
SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA ATNAQILAHV GRR 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors."
Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., Sawchenko P.E.
Proc. Natl. Acad. Sci. U.S.A. 98:2843-2848(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-113.
Strain: BALB/c.
[3]"Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION, AMIDATION AT VAL-110.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC140383 Genomic DNA. No translation available.
AF331517 mRNA. Translation: AAK16157.1.
CCDSCCDS52929.1.
RefSeqNP_659543.1. NM_145077.1.
UniGeneMm.388865.

3D structure databases

ProteinModelPortalQ99ML8.
SMRQ99ML8. Positions 73-110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid228607. 2 interactions.
STRING10090.ENSMUSP00000060405.

Proteomic databases

PRIDEQ99ML8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699.
GeneID171530.
KEGGmmu:171530.
UCSCuc012hax.1. mouse.

Organism-specific databases

CTD90226.
MGIMGI:2176375. Ucn2.

Phylogenomic databases

eggNOGNOG43191.
GeneTreeENSGT00390000004650.
HOGENOMHOG000154768.
HOVERGENHBG036242.
InParanoidQ99ML8.
KOK05257.
OMAQNSPQTT.
OrthoDBEOG73BVGS.
TreeFamTF330723.

Gene expression databases

BgeeQ99ML8.
CleanExMM_UCN2.
GenevestigatorQ99ML8.

Family and domain databases

InterProIPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamPF11613. UCN2. 1 hit.
[Graphical view]
ProDomPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio371032.
PROQ99ML8.
SOURCESearch...

Entry information

Entry nameUCN2_MOUSE
AccessionPrimary (citable) accession number: Q99ML8
Secondary accession number(s): F8WIL4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot