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Protein

Urocortin-2

Gene

Ucn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI
  • hormone binding Source: MGI
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name:
Ucn II
Gene namesi
Name:Ucn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2176375. Ucn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Propeptidei24 – 71481 PublicationPRO_0000006241Add
BLAST
Chaini73 – 11038Urocortin-2PRO_0000006242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Valine amide; partial1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Amidation, Glycoprotein

Proteomic databases

PRIDEiQ99ML8.

Expressioni

Gene expression databases

BgeeiQ99ML8.
CleanExiMM_UCN2.
GenevisibleiQ99ML8. MM.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.By similarity

Protein-protein interaction databases

BioGridi228607. 2 interactions.
STRINGi10090.ENSMUSP00000060405.

Structurei

3D structure databases

ProteinModelPortaliQ99ML8.
SMRiQ99ML8. Positions 73-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ99ML8.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
TreeFamiTF330723.

Family and domain databases

InterProiIPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ML8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTRWALVVF VVLMLDRILF VPGTPIPTFQ LLPQNSLETT PSSVTSESSS
60 70 80 90 100
GTTTGPSASW SNSKASPYLD TRVILSLDVP IGLLRILLEQ ARYKAARNQA
110
ATNAQILAHV GRR
Length:113
Mass (Da):12,310
Last modified:September 18, 2013 - v2
Checksum:i9C55EB416C7D5B25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140383 Genomic DNA. No translation available.
AF331517 mRNA. Translation: AAK16157.1.
CCDSiCCDS52929.1.
RefSeqiNP_659543.1. NM_145077.1.
UniGeneiMm.388865.

Genome annotation databases

EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699.
GeneIDi171530.
KEGGimmu:171530.
UCSCiuc012hax.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140383 Genomic DNA. No translation available.
AF331517 mRNA. Translation: AAK16157.1.
CCDSiCCDS52929.1.
RefSeqiNP_659543.1. NM_145077.1.
UniGeneiMm.388865.

3D structure databases

ProteinModelPortaliQ99ML8.
SMRiQ99ML8. Positions 73-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228607. 2 interactions.
STRINGi10090.ENSMUSP00000060405.

Proteomic databases

PRIDEiQ99ML8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052724; ENSMUSP00000060405; ENSMUSG00000049699.
GeneIDi171530.
KEGGimmu:171530.
UCSCiuc012hax.1. mouse.

Organism-specific databases

CTDi90226.
MGIiMGI:2176375. Ucn2.

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ99ML8.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
TreeFamiTF330723.

Miscellaneous databases

NextBioi371032.
PROiQ99ML8.
SOURCEiSearch...

Gene expression databases

BgeeiQ99ML8.
CleanExiMM_UCN2.
GenevisibleiQ99ML8. MM.

Family and domain databases

InterProiIPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors."
    Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., Sawchenko P.E.
    Proc. Natl. Acad. Sci. U.S.A. 98:2843-2848(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-113.
    Strain: BALB/c.
  3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
    Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
    Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE, GLYCOSYLATION, AMIDATION AT VAL-110.

Entry informationi

Entry nameiUCN2_MOUSE
AccessioniPrimary (citable) accession number: Q99ML8
Secondary accession number(s): F8WIL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: September 18, 2013
Last modified: June 24, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.