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Q99ML5

- PCYOX_RAT

UniProt

Q99ML5 - PCYOX_RAT

Protein

Prenylcysteine oxidase

Gene

Pcyox1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.By similarity

    Catalytic activityi

    An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

    Cofactori

    FAD.By similarity

    GO - Molecular functioni

    1. chloride-transporting ATPase activity Source: RGD
    2. prenylcysteine oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: RGD
    3. prenylated protein catabolic process Source: Ensembl
    4. prenylcysteine catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BRENDAi3.6.3.11. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prenylcysteine oxidase (EC:1.8.3.5)
    Alternative name(s):
    Chloride ion pump-associated 55 kDa protein
    Gene namesi
    Name:Pcyox1
    Synonyms:Clp55
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi628652. Pcyox1.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell
    2. plasma membrane Source: RGD
    3. very-low-density lipoprotein particle Source: Ensembl

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 504476Prenylcysteine oxidasePRO_0000023302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki162 – 162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ99ML5.
    PRIDEiQ99ML5.

    Expressioni

    Tissue specificityi

    Expressed mainly in cerebrum.1 Publication

    Gene expression databases

    GenevestigatoriQ99ML5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ML5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prenylcysteine oxidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG73316.
    GeneTreeiENSGT00390000011206.
    HOGENOMiHOG000241149.
    HOVERGENiHBG053532.
    InParanoidiQ99ML5.
    KOiK05906.
    OMAiNGIECAA.
    OrthoDBiEOG7VB2F5.
    PhylomeDBiQ99ML5.
    TreeFamiTF329001.

    Family and domain databases

    InterProiIPR010795. Prenylcys_lyase.
    IPR017046. Prenylcysteine_Oxase.
    [Graphical view]
    PfamiPF07156. Prenylcys_lyase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036292. Prenylcysteine_oxidase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99ML5-1 [UniParc]FASTAAdd to Basket

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    MGRFAATLVG SLFGLGLLLC GLGRLASAEP RAPPEKIAIV GAGIGGTSSA    50
    YYLRKKFGKD VKIDVFEREE IGGRLATLKV QGHDYEAGGS VIHPLNLHMK 100
    RFVKELGLSS VPASGGLVGV YNGKSLVFEE SSWFIINVIK LVWRYGFQSL 150
    RMHMWVEDLL DKFMRIYRYQ SHDYAFSSVE KLMYAIGGDD YVRLLNQTLR 200
    ENLKKAGFSE TFLNEMIAPV MKVNFGQSTD LNAFVGAVSM TAADSNLWAV 250
    EGGNKVVCSG LLQASNSNLI SGSVMSIEKT RTKQTGTPPK MYEVVYKTGS 300
    EIHSDFYDIV LVAAPLNRKM SNITFRNFDP PIEEFNDPYQ QLVTTLIKGE 350
    LNSTLFSSRH KDQFGLSAIL VTDDSDMFIN SLSIVASVSH KEGPPPAVDG 400
    MHVWKTFSKD ILTKEQISKL FLSYDYAVRK PWLSYPYYNP PQKCPSIILH 450
    DRLYYLNGIE FAASCMEMSA IAGYNAALLA YHRWNGNEDM IDQDDLYEKL 500
    KTEL 504
    Length:504
    Mass (Da):56,288
    Last modified:June 1, 2001 - v1
    Checksum:iD2778026128FE9D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332142 mRNA. Translation: AAK16548.1.
    BC078719 mRNA. Translation: AAH78719.1.
    PIRiJC7782.
    RefSeqiNP_659553.1. NM_145085.2.
    UniGeneiRn.34505.

    Genome annotation databases

    EnsembliENSRNOT00000022532; ENSRNOP00000022532; ENSRNOG00000016704.
    GeneIDi246302.
    KEGGirno:246302.
    UCSCiRGD:628652. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332142 mRNA. Translation: AAK16548.1 .
    BC078719 mRNA. Translation: AAH78719.1 .
    PIRi JC7782.
    RefSeqi NP_659553.1. NM_145085.2.
    UniGenei Rn.34505.

    3D structure databases

    ProteinModelPortali Q99ML5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022532.

    Proteomic databases

    PaxDbi Q99ML5.
    PRIDEi Q99ML5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022532 ; ENSRNOP00000022532 ; ENSRNOG00000016704 .
    GeneIDi 246302.
    KEGGi rno:246302.
    UCSCi RGD:628652. rat.

    Organism-specific databases

    CTDi 51449.
    RGDi 628652. Pcyox1.

    Phylogenomic databases

    eggNOGi NOG73316.
    GeneTreei ENSGT00390000011206.
    HOGENOMi HOG000241149.
    HOVERGENi HBG053532.
    InParanoidi Q99ML5.
    KOi K05906.
    OMAi NGIECAA.
    OrthoDBi EOG7VB2F5.
    PhylomeDBi Q99ML5.
    TreeFami TF329001.

    Enzyme and pathway databases

    BRENDAi 3.6.3.11. 5301.

    Miscellaneous databases

    NextBioi 623706.
    PROi Q99ML5.

    Gene expression databases

    Genevestigatori Q99ML5.

    Family and domain databases

    InterProi IPR010795. Prenylcys_lyase.
    IPR017046. Prenylcysteine_Oxase.
    [Graphical view ]
    Pfami PF07156. Prenylcys_lyase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036292. Prenylcysteine_oxidase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the Cl(-) pump-associated 55-kDa protein in rat brain."
      Kitagawa K., Yagyu K., Yamamoto A., Hattori N., Omori K., Zeng X.-T., Inagaki C.
      Biochem. Biophys. Res. Commun. 289:363-371(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 291-318 AND 420-429, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiPCYOX_RAT
    AccessioniPrimary (citable) accession number: Q99ML5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3