LOC100912604

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	173	Proton acceptorPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

identical protein binding
Source: RGD
Inferred from sequence orthologyⁱ
- 17585781
protein homodimerization activity
Source: RGD
Inferred from sequence orthologyⁱ
- 17585781
spermidine synthase activity
Source: RGD
Inferred from direct assayⁱ
- 12843627
- 16931179

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to leukemia inhibitory factor
Source: RGD
Inferred from sequence orthologyⁱ
- 20439489
spermidine biosynthetic process
Source: RGD
Inferred from direct assayⁱ
- 12843627
- 16931179

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	TransferasePROSITE-ProRule annotation
Biological process	Polyamine biosynthesisPROSITE-ProRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-351202. Metabolism of polyamines.

Reactomeⁱ

R-RNO-351202. Metabolism of polyamines.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Spermidine synthaseImported Submitted name: Spermidine synthase-likeImported
Gene namesⁱ	Name:LOC100912604Imported Synonyms:LOC100364487Imported, SrmImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	6485978. LOC100912604. 620796. Srm.

RGDⁱ

6485978. LOC100912604.
620796. Srm.

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2429.

ChEMBLⁱ

CHEMBL2429.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000011078.

Bgeeⁱ

ENSRNOG00000011078.

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000067465.

STRINGⁱ

10116.ENSRNOP00000067465.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 253	PABSInterPro annotationAdd BLAST		236

Sequence similaritiesⁱ

Belongs to the spermidine/spermine synthase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410ITKE. Eukaryota. COG0421. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136521.
HOGENOMⁱ	HOG000256147.
HOVERGENⁱ	HBG000834.
KEGG Orthology (KO) More...KOⁱ	K00797.
OMAⁱ	LWPGQSF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07LZ.
TreeFamⁱ	TF314466.

Family and domain databases

Gene3Dⁱ	2.30.140.10. 1 hit.
HAMAPⁱ	MF_00198. Spermidine_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR030374. PABS. IPR030373. PABS_CS. IPR029063. SAM-dependent_MTases. IPR001045. Spermi_synthase. IPR030668. Spermi_synthase_euk. IPR035246. Spermidine_synt_N. IPR037163. Spermidine_synt_N_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17284. Spermine_synt_N. 1 hit.
PIRSFⁱ	PIRSF000502. Spermidine_synth. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 1 hit.
TIGRFAMsⁱ	TIGR00417. speE. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01330. PABS_1. 1 hit. PS51006. PABS_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99MI5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPGPDGPAA PGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD 
        60         70         80         90        100
ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII 
       110        120        130        140        150
GGGDGGVLRE VVKHPSVESV VQCEIDEDVI EVSKKFLPGM AVGYSSSKLT 
       160        170        180        190        200
LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED 
       210        220        230        240        250
GILCCQGECQ WLHLDLIKEM RHFCKSLFPV VSYAYCTIPT YPSGQIGFML 
       260        270        280        290        300
CSKNPSTNFR EPVQQLTQAQ VEQMQLKYYN SDMHRAAFVL PEFTRKALND 

IS

Length:302

Mass (Da):33,997

Last modified:June 1, 2001 - v1

Checksum:ⁱEDB401A122B43C99

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07050449 Genomic DNA. No translation available. AABR07051514 Genomic DNA. No translation available. BC128733 mRNA. Translation: AAI28734.1. AF337636 mRNA. Translation: AAK21288.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_445916.1. NM_053464.2. XP_003749506.1. XM_003749458.2.
UniGeneⁱ	Rn.22258.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014934; ENSRNOP00000014934; ENSRNOG00000011078. ENSRNOT00000071712; ENSRNOP00000067465; ENSRNOG00000046379.
GeneIDⁱ	100912604. 84596.
KEGGⁱ	rno:100912604. rno:84596.
UCSC genome browser More...UCSCⁱ	RGD:620796. rat.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99MI5	Q64674 Q543H0 UPI00045D7630 K9IHX0 UPI00057A10E5 UPI00057B8EB7 UPI0009422E86 UPI000B5007D8 G3RPZ5 M3WN08 +55	Mus musculus (Mouse) Orycteropus afer afer Desmodus rotundus (Vampire bat) Camelus bactrianus (Bactrian camel) Camelus dromedarius (Dromedary) (Arabian camel) Rhinolophus sinicus (Chinese rufous horseshoe bat) Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi) Gorilla gorilla gorilla (Western lowland gorilla) Felis catus (Cat) (Felis silvestris catus) Loxodonta africana (African elephant) And more	302	UniRef90_Q64674	Cluster: Spermidine synthase	66

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q99MI5	P19623 A0A2J8USF6 A0A0D9S8N0 A0A2K6BI63 G1REE6 H2N948 UPI00045DE215 H2PY02 UPI0007DBEE9D UPI000C2AAA3D +188	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca nemestrina (Pig-tailed macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan troglodytes (Chimpanzee) Piliocolobus tephrosceles (Ugandan red Colobus) Aotus nancymaae (Ma's night monkey) Chrysochloris asiatica (Cape golden mole) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) And more	302	UniRef50_P19623	Cluster: Spermidine synthase	199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07050449 Genomic DNA. No translation available. AABR07051514 Genomic DNA. No translation available. BC128733 mRNA. Translation: AAI28734.1. AF337636 mRNA. Translation: AAK21288.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_445916.1. NM_053464.2. XP_003749506.1. XM_003749458.2.
UniGeneⁱ	Rn.22258.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000067465.

STRINGⁱ

10116.ENSRNOP00000067465.

Chemistry databases

ChEMBLⁱ	CHEMBL2429.

ChEMBLⁱ

CHEMBL2429.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014934; ENSRNOP00000014934; ENSRNOG00000011078. ENSRNOT00000071712; ENSRNOP00000067465; ENSRNOG00000046379.
GeneIDⁱ	100912604. 84596.
KEGGⁱ	rno:100912604. rno:84596.
UCSC genome browser More...UCSCⁱ	RGD:620796. rat.

Organism-specific databases

CTDⁱ	6723.
Rat genome database More...RGDⁱ	6485978. LOC100912604. 620796. Srm.

Phylogenomic databases

eggNOGⁱ	ENOG410ITKE. Eukaryota. COG0421. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136521.
HOGENOMⁱ	HOG000256147.
HOVERGENⁱ	HBG000834.
KEGG Orthology (KO) More...KOⁱ	K00797.
OMAⁱ	LWPGQSF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07LZ.
TreeFamⁱ	TF314466.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-351202. Metabolism of polyamines.

Reactomeⁱ

R-RNO-351202. Metabolism of polyamines.

Gene expression databases

Bgeeⁱ	ENSRNOG00000011078.

Bgeeⁱ

ENSRNOG00000011078.

Family and domain databases

Gene3Dⁱ	2.30.140.10. 1 hit.
HAMAPⁱ	MF_00198. Spermidine_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR030374. PABS. IPR030373. PABS_CS. IPR029063. SAM-dependent_MTases. IPR001045. Spermi_synthase. IPR030668. Spermi_synthase_euk. IPR035246. Spermidine_synt_N. IPR037163. Spermidine_synt_N_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17284. Spermine_synt_N. 1 hit.
PIRSFⁱ	PIRSF000502. Spermidine_synth. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 1 hit.
TIGRFAMsⁱ	TIGR00417. speE. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01330. PABS_1. 1 hit. PS51006. PABS_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q99MI5_RAT
Accessionⁱ	Q99MI5Primary (citable) accession number: Q99MI5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2001
	Last sequence update:	June 1, 2001
	Last modified:	March 28, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99MI5 (Q99MI5_RAT)

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Spermidine synthase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ