LOC100912604

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	173	Proton acceptorPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

spermidine synthase activity
Source: RGD
Inferred from direct assayⁱ
- 12843627
- 16931179

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

spermidine biosynthetic process
Source: RGD
Inferred from direct assayⁱ
- 12843627
- 16931179

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	TransferasePROSITE-ProRule annotation
Biological process	Polyamine biosynthesisPROSITE-ProRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-351202 Metabolism of polyamines

Reactomeⁱ

R-RNO-351202 Metabolism of polyamines

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Spermidine synthaseImported
Gene namesⁱ	Name:LOC100912604Imported Synonyms:LOC100364487Imported, SrmImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	6485978 LOC100912604 620796 Srm

RGDⁱ

6485978 LOC100912604
620796 Srm

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2429

ChEMBLⁱ

CHEMBL2429

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000011078

Bgeeⁱ

ENSRNOG00000011078

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000067465

STRINGⁱ

10116.ENSRNOP00000067465

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 253	PABSInterPro annotationAdd BLAST		236

Sequence similaritiesⁱ

Belongs to the spermidine/spermine synthase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410ITKE Eukaryota COG0421 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136521
HOGENOMⁱ	HOG000256147
HOVERGENⁱ	HBG000834
KEGG Orthology (KO) More...KOⁱ	K00797
OMAⁱ	LWPGQSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07LZ
TreeFamⁱ	TF314466

Family and domain databases

Gene3Dⁱ	2.30.140.10, 1 hit
HAMAPⁱ	MF_00198 Spermidine_synth, 1 hit
InterProⁱ	View protein in InterPro IPR030374 PABS IPR030373 PABS_CS IPR029063 SAM-dependent_MTases IPR001045 Spermi_synthase IPR030668 Spermi_synthase_euk IPR035246 Spermidine_synt_N IPR037163 Spermidine_synt_N_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17284 Spermine_synt_N, 1 hit
PIRSFⁱ	PIRSF000502 Spermidine_synth, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
TIGRFAMsⁱ	TIGR00417 speE, 1 hit
PROSITEⁱ	View protein in PROSITE PS01330 PABS_1, 1 hit PS51006 PABS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99MI5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPGPDGPAA PGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD 
        60         70         80         90        100
ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII 
       110        120        130        140        150
GGGDGGVLRE VVKHPSVESV VQCEIDEDVI EVSKKFLPGM AVGYSSSKLT 
       160        170        180        190        200
LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED 
       210        220        230        240        250
GILCCQGECQ WLHLDLIKEM RHFCKSLFPV VSYAYCTIPT YPSGQIGFML 
       260        270        280        290        300
CSKNPSTNFR EPVQQLTQAQ VEQMQLKYYN SDMHRAAFVL PEFTRKALND 

IS

Length:302

Mass (Da):33,997

Last modified:June 1, 2001 - v1

Checksum:ⁱEDB401A122B43C99

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07050449 Genomic DNA No translation available. AABR07051514 Genomic DNA No translation available. BC128733 mRNA Translation: AAI28734.1 AF337636 mRNA Translation: AAK21288.1
NCBI Reference Sequences More...RefSeqⁱ	NP_445916.1, NM_053464.2 XP_003749506.1, XM_003749458.2
UniGeneⁱ	Rn.22258

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014934; ENSRNOP00000014934; ENSRNOG00000011078 ENSRNOT00000071712; ENSRNOP00000067465; ENSRNOG00000046379
GeneIDⁱ	100912604 84596
KEGGⁱ	rno:100912604 rno:84596
UCSC genome browser More...UCSCⁱ	RGD:620796 rat

Protein	Similar proteins		Species	Score	Length
Q99MI5	Spermidine synthase		MOUSE		302
UPI00045D7630		Orycteropus afer afer		374
Spermidine synthase		CALJA		302
UPI00038C0248		MICOH		302
Spermidine synthase		PROCO		302
+59

Protein	Similar proteins		Species	Score	Length
Q99MI5	Spermidine synthase	)	HUMAN		302
SRM isoform 1		PONAB		302
Spermidine synthase		CHLSB		302
Uncharacterized protein		MACNE		302
Uncharacterized protein		NOMLE		247
+219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07050449 Genomic DNA No translation available. AABR07051514 Genomic DNA No translation available. BC128733 mRNA Translation: AAI28734.1 AF337636 mRNA Translation: AAK21288.1
NCBI Reference Sequences More...RefSeqⁱ	NP_445916.1, NM_053464.2 XP_003749506.1, XM_003749458.2
UniGeneⁱ	Rn.22258

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000067465

STRINGⁱ

10116.ENSRNOP00000067465

Chemistry databases

ChEMBLⁱ	CHEMBL2429

ChEMBLⁱ

CHEMBL2429

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014934; ENSRNOP00000014934; ENSRNOG00000011078 ENSRNOT00000071712; ENSRNOP00000067465; ENSRNOG00000046379
GeneIDⁱ	100912604 84596
KEGGⁱ	rno:100912604 rno:84596
UCSC genome browser More...UCSCⁱ	RGD:620796 rat

Organism-specific databases

CTDⁱ	6723
Rat genome database More...RGDⁱ	6485978 LOC100912604 620796 Srm

Phylogenomic databases

eggNOGⁱ	ENOG410ITKE Eukaryota COG0421 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136521
HOGENOMⁱ	HOG000256147
HOVERGENⁱ	HBG000834
KEGG Orthology (KO) More...KOⁱ	K00797
OMAⁱ	LWPGQSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07LZ
TreeFamⁱ	TF314466

Enzyme and pathway databases

Reactomeⁱ	R-RNO-351202 Metabolism of polyamines

Reactomeⁱ

R-RNO-351202 Metabolism of polyamines

Gene expression databases

Bgeeⁱ	ENSRNOG00000011078

Bgeeⁱ

ENSRNOG00000011078

Family and domain databases

Gene3Dⁱ	2.30.140.10, 1 hit
HAMAPⁱ	MF_00198 Spermidine_synth, 1 hit
InterProⁱ	View protein in InterPro IPR030374 PABS IPR030373 PABS_CS IPR029063 SAM-dependent_MTases IPR001045 Spermi_synthase IPR030668 Spermi_synthase_euk IPR035246 Spermidine_synt_N IPR037163 Spermidine_synt_N_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17284 Spermine_synt_N, 1 hit
PIRSFⁱ	PIRSF000502 Spermidine_synth, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
TIGRFAMsⁱ	TIGR00417 speE, 1 hit
PROSITEⁱ	View protein in PROSITE PS01330 PABS_1, 1 hit PS51006 PABS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q99MI5_RAT
Accessionⁱ	Q99MI5Primary (citable) accession number: Q99MI5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2001
	Last sequence update:	June 1, 2001
	Last modified:	June 20, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q99MI5 (Q99MI5_RAT)

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Spermidine synthase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ