UniProtKB - Q99MI5 (Q99MI5_RAT)
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Protein
Submitted name:
Spermidine synthase
Gene
LOC100912604
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 173 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
- spermidine synthase activity Source: RGD
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: RGD
- spermidine biosynthetic process Source: RGD
Keywordsi
Molecular function | TransferasePROSITE-ProRule annotation |
Biological process | Polyamine biosynthesisPROSITE-ProRule annotation |
Enzyme and pathway databases
Reactomei | R-RNO-351202. Metabolism of polyamines. |
Names & Taxonomyi
Protein namesi | Submitted name: Spermidine synthaseImportedSubmitted name: Spermidine synthase-likeImported |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 6485978. LOC100912604. 620796. Srm. |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067465. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 253 | PABSInterPro annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the spermidine/spermine synthase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG410ITKE. Eukaryota. COG0421. LUCA. |
GeneTreei | ENSGT00870000136521. |
HOGENOMi | HOG000256147. |
HOVERGENi | HBG000834. |
KOi | K00797. |
OMAi | LWPGQSF. |
OrthoDBi | EOG091G07LZ. |
TreeFami | TF314466. |
Family and domain databases
Gene3Di | 2.30.140.10. 1 hit. |
HAMAPi | MF_00198. Spermidine_synth. 1 hit. |
InterProi | View protein in InterPro IPR030374. PABS. IPR030373. PABS_CS. IPR029063. SAM-dependent_MTases. IPR001045. Spermi_synthase. IPR030668. Spermi_synthase_euk. IPR035246. Spermidine_synt_N. IPR037163. Spermidine_synt_N_sf. |
Pfami | View protein in Pfam PF17284. Spermine_synt_N. 1 hit. |
PIRSFi | PIRSF000502. Spermidine_synth. 1 hit. |
SUPFAMi | SSF53335. SSF53335. 1 hit. |
TIGRFAMsi | TIGR00417. speE. 1 hit. |
PROSITEi | View protein in PROSITE PS01330. PABS_1. 1 hit. PS51006. PABS_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q99MI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPGPDGPAA PGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD
60 70 80 90 100
ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII
110 120 130 140 150
GGGDGGVLRE VVKHPSVESV VQCEIDEDVI EVSKKFLPGM AVGYSSSKLT
160 170 180 190 200
LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED
210 220 230 240 250
GILCCQGECQ WLHLDLIKEM RHFCKSLFPV VSYAYCTIPT YPSGQIGFML
260 270 280 290 300
CSKNPSTNFR EPVQQLTQAQ VEQMQLKYYN SDMHRAAFVL PEFTRKALND
IS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07050449 Genomic DNA. No translation available. AABR07051514 Genomic DNA. No translation available. BC128733 mRNA. Translation: AAI28734.1. AF337636 mRNA. Translation: AAK21288.1. |
RefSeqi | NP_445916.1. NM_053464.2. XP_003749506.1. XM_003749458.2. |
UniGenei | Rn.22258. |
Genome annotation databases
Ensembli | ENSRNOT00000014934; ENSRNOP00000014934; ENSRNOG00000011078. ENSRNOT00000071712; ENSRNOP00000067465; ENSRNOG00000046379. |
GeneIDi | 100912604. 84596. |
KEGGi | rno:100912604. rno:84596. |
UCSCi | RGD:620796. rat. |
Similar proteinsi
Entry informationi
Entry namei | Q99MI5_RAT | |
Accessioni | Q99MI5Primary (citable) accession number: Q99MI5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | March 28, 2018 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |