Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bardet-Biedl syndrome 2 protein homolog

Gene

Bbs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5620922. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 2 protein homolog
Gene namesi
Name:Bbs2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi71091. Bbs2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Bardet-Biedl syndrome 2 protein homologPRO_0000064845Add
BLAST

Proteomic databases

PaxDbiQ99MH9.
PRIDEiQ99MH9.

PTM databases

PhosphoSiteiQ99MH9.

Expressioni

Gene expression databases

GenevisibleiQ99MH9. RN.

Interactioni

Subunit structurei

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (via C-terminus) with BBS7. Interacts (via coiled coil domain) with MKKS. Interacts with CCDC28B (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026076.

Structurei

3D structure databases

ProteinModelPortaliQ99MH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili325 – 36945Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF6W. Eukaryota.
ENOG410XPDF. LUCA.
GeneTreeiENSGT00390000017113.
HOGENOMiHOG000007549.
HOVERGENiHBG031114.
InParanoidiQ99MH9.
KOiK16747.
OMAiSHVVHPS.
OrthoDBiEOG7TMZRK.
PhylomeDBiQ99MH9.
TreeFamiTF313236.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016616. Bardet-Biedl_syndrome_2_prot.
IPR029333. BBS2_C.
IPR029429. BBS2_Mid.
IPR029430. BBS2_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR32465:SF0. PTHR32465:SF0. 1 hit.
PfamiPF14782. BBS2_C. 1 hit.
PF14783. BBS2_Mid. 1 hit.
PF14781. BBS2_N. 1 hit.
[Graphical view]
PIRSFiPIRSF013684. BBS2. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q99MH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPVFTLKL RHKISPRMVA IGRYDGTHPC LAAATQAGKV FIHNPHMRSQ
60 70 80 90 100
HFSTSRVFQS PLESDVSLLN INQTVSCLGA GVLNPELGYD TLLVGTQTSL
110 120 130 140 150
LAYDIYNNSD LFYREVADGA NALVLGTLGD IAPPLAIIGG NCALQGFDHE
160 170 180 190 200
GNDLFWTVTG DNVHSLALCD FDGDGKSELL VGSEDFDIRV FKEDEIVAEM
210 220 230 240 250
TETEIVTSLC PMYGSRFGYA LSNGTVGVYD KTARYWRIKS KNHAMSIHAF
260 270 280 290 300
DINSDGVCEL ITGWSNGKVD ARSDRTGEVI FKDNFSSAVA GVVEGDYRMD
310 320 330 340 350
GHVQLICCSV DGEIRGYLPG TAEMKGNLLD TSVEQGLIRE LSQKKQNLLL
360 370 380 390 400
ELRNYEENTK AELSSPLNEA DGQKGIIPAN TKLHTALSVN LGNDAQDAHA
410 420 430 440 450
ELRISTSNDT IIRAVLIFAE GIFAGESHVV HPSTHNLSSS IRVPITPPKD
460 470 480 490 500
VPVDLHLKTF VGYRSSTQFH VFELIRQLPR FTMYALTSPD AASEPVSFVN
510 520 530 540 550
FIVVERAQRM VTWLNQNFLL PEDSNIQNAP FHVCFTSLRN GGQLYIKMKP
560 570 580 590 600
SGEITVNTDD IDLAGDIIQS MASFFAIEDL QVEADFPVYF EELRKVLLKV
610 620 630 640 650
DEYHSVHQKL SANMADNSNL IRSLLVRAED ARLMRDMKTM KTRYMELYDL
660 670 680 690 700
NKDLLNGYKI RCNNHTELLG NLKAVNQAIQ RAGRLRVGKP KNQVISACRD
710 720
AIRSNNINTL FRIMRVGTAP S
Length:721
Mass (Da):79,918
Last modified:June 1, 2001 - v1
Checksum:i55935DE19C0509DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF342738 mRNA. Translation: AAK28554.1.
RefSeqiNP_446070.1. NM_053618.1.
UniGeneiRn.15987.

Genome annotation databases

EnsembliENSRNOT00000026076; ENSRNOP00000026076; ENSRNOG00000019020.
GeneIDi113948.
KEGGirno:113948.
UCSCiRGD:71091. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF342738 mRNA. Translation: AAK28554.1.
RefSeqiNP_446070.1. NM_053618.1.
UniGeneiRn.15987.

3D structure databases

ProteinModelPortaliQ99MH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026076.

PTM databases

PhosphoSiteiQ99MH9.

Proteomic databases

PaxDbiQ99MH9.
PRIDEiQ99MH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026076; ENSRNOP00000026076; ENSRNOG00000019020.
GeneIDi113948.
KEGGirno:113948.
UCSCiRGD:71091. rat.

Organism-specific databases

CTDi583.
RGDi71091. Bbs2.

Phylogenomic databases

eggNOGiENOG410IF6W. Eukaryota.
ENOG410XPDF. LUCA.
GeneTreeiENSGT00390000017113.
HOGENOMiHOG000007549.
HOVERGENiHBG031114.
InParanoidiQ99MH9.
KOiK16747.
OMAiSHVVHPS.
OrthoDBiEOG7TMZRK.
PhylomeDBiQ99MH9.
TreeFamiTF313236.

Enzyme and pathway databases

ReactomeiR-RNO-5620922. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

NextBioi618075.
PROiQ99MH9.

Gene expression databases

GenevisibleiQ99MH9. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016616. Bardet-Biedl_syndrome_2_prot.
IPR029333. BBS2_C.
IPR029429. BBS2_Mid.
IPR029430. BBS2_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR32465:SF0. PTHR32465:SF0. 1 hit.
PfamiPF14782. BBS2_C. 1 hit.
PF14783. BBS2_Mid. 1 hit.
PF14781. BBS2_N. 1 hit.
[Graphical view]
PIRSFiPIRSF013684. BBS2. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiBBS2_RAT
AccessioniPrimary (citable) accession number: Q99MH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.