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Protein

Bardet-Biedl syndrome 2 protein homolog

Gene

Bbs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 2 protein homolog
Gene namesi
Name:Bbs2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi71091 Bbs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648451 – 721Bardet-Biedl syndrome 2 protein homologAdd BLAST721

Proteomic databases

PaxDbiQ99MH9
PRIDEiQ99MH9

PTM databases

iPTMnetiQ99MH9
PhosphoSitePlusiQ99MH9

Expressioni

Gene expression databases

BgeeiENSRNOG00000019020
GenevisibleiQ99MH9 RN

Interactioni

Subunit structurei

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (via C-terminus) with BBS7. Interacts (via coiled coil domain) with MKKS. Interacts with CCDC28B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026076

Structurei

3D structure databases

ProteinModelPortaliQ99MH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili325 – 369Sequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF6W Eukaryota
ENOG410XPDF LUCA
GeneTreeiENSGT00390000017113
HOGENOMiHOG000007549
HOVERGENiHBG031114
InParanoidiQ99MH9
KOiK16747
OMAiHSVHQKL
OrthoDBiEOG091G03EK
PhylomeDBiQ99MH9
TreeFamiTF313236

Family and domain databases

InterProiView protein in InterPro
IPR016616 Bardet-Biedl_syndrome_2_prot
IPR029333 BBS2_C
IPR029429 BBS2_Mid
IPR029430 BBS2_N
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF14782 BBS2_C, 1 hit
PF14783 BBS2_Mid, 1 hit
PF14781 BBS2_N, 1 hit
PIRSFiPIRSF013684 BBS2, 1 hit
SUPFAMiSSF50978 SSF50978, 2 hits

Sequencei

Sequence statusi: Complete.

Q99MH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPVFTLKL RHKISPRMVA IGRYDGTHPC LAAATQAGKV FIHNPHMRSQ
60 70 80 90 100
HFSTSRVFQS PLESDVSLLN INQTVSCLGA GVLNPELGYD TLLVGTQTSL
110 120 130 140 150
LAYDIYNNSD LFYREVADGA NALVLGTLGD IAPPLAIIGG NCALQGFDHE
160 170 180 190 200
GNDLFWTVTG DNVHSLALCD FDGDGKSELL VGSEDFDIRV FKEDEIVAEM
210 220 230 240 250
TETEIVTSLC PMYGSRFGYA LSNGTVGVYD KTARYWRIKS KNHAMSIHAF
260 270 280 290 300
DINSDGVCEL ITGWSNGKVD ARSDRTGEVI FKDNFSSAVA GVVEGDYRMD
310 320 330 340 350
GHVQLICCSV DGEIRGYLPG TAEMKGNLLD TSVEQGLIRE LSQKKQNLLL
360 370 380 390 400
ELRNYEENTK AELSSPLNEA DGQKGIIPAN TKLHTALSVN LGNDAQDAHA
410 420 430 440 450
ELRISTSNDT IIRAVLIFAE GIFAGESHVV HPSTHNLSSS IRVPITPPKD
460 470 480 490 500
VPVDLHLKTF VGYRSSTQFH VFELIRQLPR FTMYALTSPD AASEPVSFVN
510 520 530 540 550
FIVVERAQRM VTWLNQNFLL PEDSNIQNAP FHVCFTSLRN GGQLYIKMKP
560 570 580 590 600
SGEITVNTDD IDLAGDIIQS MASFFAIEDL QVEADFPVYF EELRKVLLKV
610 620 630 640 650
DEYHSVHQKL SANMADNSNL IRSLLVRAED ARLMRDMKTM KTRYMELYDL
660 670 680 690 700
NKDLLNGYKI RCNNHTELLG NLKAVNQAIQ RAGRLRVGKP KNQVISACRD
710 720
AIRSNNINTL FRIMRVGTAP S
Length:721
Mass (Da):79,918
Last modified:June 1, 2001 - v1
Checksum:i55935DE19C0509DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF342738 mRNA Translation: AAK28554.1
RefSeqiNP_446070.1, NM_053618.1
UniGeneiRn.15987

Genome annotation databases

EnsembliENSRNOT00000026076; ENSRNOP00000026076; ENSRNOG00000019020
GeneIDi113948
KEGGirno:113948
UCSCiRGD:71091 rat

Similar proteinsi

Entry informationi

Entry nameiBBS2_RAT
AccessioniPrimary (citable) accession number: Q99MH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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