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Protein

Hepcidin

Gene

Hamp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: RGD
  • aging Source: RGD
  • cellular iron ion homeostasis Source: RGD
  • cellular response to bile acid Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • cellular response to X-ray Source: RGD
  • defense response to bacterium Source: GO_Central
  • liver regeneration Source: RGD
  • multicellular organismal iron ion homeostasis Source: Ensembl
  • negative regulation of ferrous iron export Source: Ensembl
  • negative regulation of intestinal absorption Source: Ensembl
  • negative regulation of iron channel activity Source: Ensembl
  • negative regulation of iron ion transmembrane transport Source: GO_Central
  • positive regulation of cell growth involved in cardiac muscle cell development Source: RGD
  • positive regulation of protein polyubiquitination Source: Ensembl
  • positive regulation of receptor catabolic process Source: Ensembl
  • positive regulation of receptor internalization Source: Ensembl
  • response to erythropoietin Source: RGD
  • response to ethanol Source: RGD
  • response to iron ion Source: Ensembl
  • response to iron ion starvation Source: RGD
  • response to vitamin A Source: RGD
  • response to zinc ion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:Hamp
Synonyms:Hepc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi70971. Hamp.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: RGD
  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • intercalated disc Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 5431Sequence analysisPRO_0000013385Add
BLAST
Peptidei60 – 8425HepcidinPRO_0000013386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 82By similarity
Disulfide bondi69 ↔ 72By similarity
Disulfide bondi70 ↔ 78By similarity
Disulfide bondi73 ↔ 81By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ99MH3.
PRIDEiQ99MH3.

Expressioni

Gene expression databases

GenevisibleiQ99MH3. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028545.

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ99MH3.
OMAiCGICCKT.
OrthoDBiEOG7N8ZZ3.
PhylomeDBiQ99MH3.
TreeFamiTF330932.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTRIQAA CLLLLLLASL SSGAYLRQQT RQTTALQPWH GAESKTDDSA
60 70 80
LLMLKRRKRD TNFPICLFCC KCCKNSSCGL CCIT
Length:84
Mass (Da):9,286
Last modified:June 1, 2001 - v1
Checksum:i65E0D5FE4F44A0B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344185 mRNA. Translation: AAK12966.1.
RefSeqiNP_445921.1. NM_053469.1.
UniGeneiRn.7865.

Genome annotation databases

EnsembliENSRNOT00000028545; ENSRNOP00000028545; ENSRNOG00000021029.
GeneIDi84604.
KEGGirno:84604.
UCSCiRGD:70971. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344185 mRNA. Translation: AAK12966.1.
RefSeqiNP_445921.1. NM_053469.1.
UniGeneiRn.7865.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028545.

Proteomic databases

PaxDbiQ99MH3.
PRIDEiQ99MH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028545; ENSRNOP00000028545; ENSRNOG00000021029.
GeneIDi84604.
KEGGirno:84604.
UCSCiRGD:70971. rat.

Organism-specific databases

CTDi57817.
RGDi70971. Hamp.

Phylogenomic databases

GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ99MH3.
OMAiCGICCKT.
OrthoDBiEOG7N8ZZ3.
PhylomeDBiQ99MH3.
TreeFamiTF330932.

Miscellaneous databases

PROiQ99MH3.

Gene expression databases

GenevisibleiQ99MH3. RN.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload."
    Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., Loreal O.
    J. Biol. Chem. 276:7811-7819(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiHEPC_RAT
AccessioniPrimary (citable) accession number: Q99MH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.