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Protein
Submitted name:

Map kinase phosphatase-M A1 isoform

Gene

Dusp16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • inactivation of MAPK activity Source: MGI
  • negative regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Map kinase phosphatase-M A1 isoformImported
Gene namesi
Name:Dusp16Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ99MG6.
PRIDEiQ99MG6.

Structurei

3D structure databases

ProteinModelPortaliQ99MG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 137116RhodaneseInterPro annotationAdd
BLAST
Domaini158 – 299142Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini227 – 28155TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000082452.
HOVERGENiHBG005541.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHEMIGTQI VTESLVALLE SGTEKVLLID SRPFVEYNTS HILEAININC
60 70 80 90 100
SKLMKRRLQQ DRVLITELIQ HSAKHKVDID CNQKVVVYDQ SSQDVGSLSS
110 120 130 140 150
DCFLTVLLGK LERSFNSVHL LAGGFAEFSR CFPGLCEGKS TLVPTCISQP
160 170 180 190 200
CLPVANIGPT RILPNLYLGC QRDVLNKDLM QQNGIGYVLN ASNTCPKPDF
210 220 230 240 250
IPESHFLRVP VNDSFCEKIL PWLDKSVDFI EKAKASNGCV LIHCLAGISR
260 270 280 290 300
SATIAIAYIM KRMDMSLDEA YRFVKEKRPT ISPNFNFMGQ LMDYEKTINN
310 320 330 340 350
QTGMSGPKSK LKLLHLDKPS EPVPAASEGG WKSALSLSPP CANSTSEASG
360 370 380 390 400
QRLVHPASVP SLQPSLLEDS PLVQALSGLQ LSSEKLEDST KLKRSFSLDI
410 420 430 440 450
KSVSYSASMA ASLHGFSSEE ALDYCKPSAT LDGTNKLCQF SPVQEVSEQS
460 470 480 490 500
PETSPDKEEA HIPKQPQPPR PSESQVTRLH SVRTGSSGST QRPFFSPLHR
510 520 530 540 550
SGSVEDNYHT NFLFGPFHQP ATPHQVCRAW LKGWHSDILA PQSSAPSLTS
560 570 580 590 600
SWYFATEPSH LYSASAIYGG NSSYSAYSCG QLPTCSDQIY SVRRRQKPTD
610 620 630 640 650
RADSRRTGMK RAPLKSSLNA EAAKWNLERA LCRRTGPGRS WARWAASPAS
660 670
PAAWRSSRSL EKTSSLLLTV LFPVHKK
Length:677
Mass (Da):74,551
Last modified:June 1, 2001 - v1
Checksum:i8B6D5B7096CEC2FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345951 mRNA. Translation: AAK35052.1.
UniGeneiMm.491182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345951 mRNA. Translation: AAK35052.1.
UniGeneiMm.491182.

3D structure databases

ProteinModelPortaliQ99MG6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ99MG6.
PRIDEiQ99MG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Phylogenomic databases

HOGENOMiHOG000082452.
HOVERGENiHBG005541.

Miscellaneous databases

ChiTaRSiDusp16. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Novel MKP is an Important Negative Regulator of LPS-mediated JNK Activation in Macrophages."
    Matsuguchi T., Musikacharoen T., Johnson T.R., Kraft A.S., Yoshikai Y.
    Mol. Cell. Biol. 20:6999-7009(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.

Entry informationi

Entry nameiQ99MG6_MOUSE
AccessioniPrimary (citable) accession number: Q99MG6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.