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Protein
Submitted name:

Map kinase phosphatase-M A2 isoform

Gene

Dusp16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dephosphorylation Source: MGI
  • inactivation of MAPK activity Source: MGI
  • negative regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Map kinase phosphatase-M A2 isoformImported
Gene namesi
Name:Dusp16Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ99MG5.

Structurei

3D structure databases

ProteinModelPortaliQ99MG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 127RhodaneseInterPro annotationAdd BLAST106
Domaini106 – 244Tyrosine-protein phosphataseInterPro annotationAdd BLAST139
Domaini172 – 226TYR_PHOSPHATASE_2InterPro annotationAdd BLAST55

Phylogenomic databases

HOGENOMiHOG000082452.
HOVERGENiHBG005541.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHEMIGTQI VTESLVALLE SGTEKVLLID SRPFVEYNTS HILEAININC
60 70 80 90 100
SKLMKRRLQQ DRVLITELIQ HSAKHKVDID CNQKVVVYDQ SSQDVGSLSS
110 120 130 140 150
DCFLTVLLGK LERSFNSVHL LADLMQQNGI GYVLNASNTC PKPDFIPESH
160 170 180 190 200
FLRVPVNDSF CEKILPWLDK SVDFIEKAKA SNGCVLIHCL AGISRSATIA
210 220 230 240 250
IAYIMKRMDM SLDEAYRFVK EKRPTISPNF NFMGQLMDYE KTINNQTGMS
260 270 280 290 300
GPKSKLKLLH LDKPSEPVPA ASEGGWKSAL SLSPPCANST SEASGQRLVH
310 320 330 340 350
PASVPSLQPS LLEDSPLVQA LSGLQLSSEK LEDSTKLKRS FSLDIKSVSY
360 370 380 390 400
SASMAASLHG FSSEEALDYC KPSATLDGTN KLCQFSPVQE VSEQSPETSP
410 420 430 440 450
DKEEAHIPKQ PQPPRPSESQ VTRLHSVRTG SSGSTQRPFF SPLHRSGSVE
460 470 480 490 500
DNYHTNFLFG PFHQPATPHQ VCRAWLKGWH SDILAPQSSA PSLTSSWYFA
510 520 530 540 550
TEPSHLYSAS AIYGGNSSYS AYSCGQLPTC SDQIYSVRRR QKPTDRADSR
560 570 580 590 600
RTGMKRAPLK SSLNAEAAKW NLERALCRRT GPGRSWARWA ASPASPAAWR
610 620
SSRSLEKTSS LLLTVLFPVH KK
Length:622
Mass (Da):68,673
Last modified:June 1, 2001 - v1
Checksum:i6C0CA4E6E9099B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345952 mRNA. Translation: AAK35053.1.
UniGeneiMm.491182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345952 mRNA. Translation: AAK35053.1.
UniGeneiMm.491182.

3D structure databases

ProteinModelPortaliQ99MG5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ99MG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Phylogenomic databases

HOGENOMiHOG000082452.
HOVERGENiHBG005541.

Miscellaneous databases

ChiTaRSiDusp16. mouse.
SOURCEiSearch...

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ99MG5_MOUSE
AccessioniPrimary (citable) accession number: Q99MG5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.