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Protein

Interleukin-11 receptor subunit alpha

Gene

Il11ra1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

GO - Molecular functioni

  • interleukin-11 binding Source: RGD
  • interleukin-11 receptor activity Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • embryo implantation Source: RGD
  • head development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11 receptor subunit alpha
Short name:
IL-11 receptor subunit alpha
Short name:
IL-11R subunit alpha
Short name:
IL-11R-alpha
Short name:
IL-11RA
Gene namesi
Name:Il11ra1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621332. Il11ra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 371348ExtracellularSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Topological domaini393 – 43139CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 431408Interleukin-11 receptor subunit alphaPRO_0000010916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 94PROSITE-ProRule annotation
Disulfide bondi120 ↔ 130PROSITE-ProRule annotation
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi170 ↔ 180PROSITE-ProRule annotation
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99MF4.
PRIDEiQ99MF4.

Expressioni

Gene expression databases

GenevisibleiQ99MF4. RN.

Interactioni

Subunit structurei

On ligand binding, forms a multimer complex with IL6ST/gp130.By similarity

GO - Molecular functioni

  • interleukin-11 binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020885.

Structurei

3D structure databases

ProteinModelPortaliQ99MF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11084Ig-like C2-typeAdd
BLAST
Domaini112 – 219108Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini220 – 31798Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi304 – 3085WSXWS motif

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ7D. Eukaryota.
ENOG4111N1H. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000231670.
HOVERGENiHBG063427.
InParanoidiQ99MF4.
KOiK05056.
OMAiWFRDGET.
OrthoDBiEOG72NRQF.
PhylomeDBiQ99MF4.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRSGLTR VLVAVATALV SSSTPCPQAW GPPGVQYGQP GRPVMLCCPG
60 70 80 90 100
VNAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSRDEG TYVCRTLDGV
110 120 130 140 150
FGGMVTLKLG SPPARPEVSC QAVDYENFSC TWSPGRVSGL PTRYLTSYRK
160 170 180 190 200
KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP
210 220 230 240 250
LGASTCLLDV RLQRILRPDP PQGLRVESVP GYPRRLHASW TYPASWRRQP
260 270 280 290 300
HFLLKFRLQY RPAQHPAWST VEPIGLEELI TDAVAGLPHA VRVSARDFLD
310 320 330 340 350
AGTWSAWSPE AWGTPSTGPL RDEVPDGSRG HEQKLEAAAQ EDSPAPPSPS
360 370 380 390 400
LQPDPRPLDH RDPLEQVAVL ASLGIFSFLG LAVGALALGL WLRLRRSGKD
410 420 430
GPQKPGFLAP MIPGDKLPGI PNLQRTPENF S
Length:431
Mass (Da):46,784
Last modified:June 1, 2001 - v1
Checksum:iE086FD6B1688180B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347936 mRNA. Translation: AAK29624.1.
BC070921 mRNA. Translation: AAH70921.1.
RefSeqiNP_620816.1. NM_139116.1.
XP_006238085.1. XM_006238023.2.
UniGeneiRn.29849.

Genome annotation databases

EnsembliENSRNOT00000020885; ENSRNOP00000020885; ENSRNOG00000015068.
GeneIDi245983.
KEGGirno:245983.
UCSCiRGD:621332. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347936 mRNA. Translation: AAK29624.1.
BC070921 mRNA. Translation: AAH70921.1.
RefSeqiNP_620816.1. NM_139116.1.
XP_006238085.1. XM_006238023.2.
UniGeneiRn.29849.

3D structure databases

ProteinModelPortaliQ99MF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020885.

Proteomic databases

PaxDbiQ99MF4.
PRIDEiQ99MF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020885; ENSRNOP00000020885; ENSRNOG00000015068.
GeneIDi245983.
KEGGirno:245983.
UCSCiRGD:621332. rat.

Organism-specific databases

CTDi16157.
RGDi621332. Il11ra1.

Phylogenomic databases

eggNOGiENOG410IJ7D. Eukaryota.
ENOG4111N1H. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000231670.
HOVERGENiHBG063427.
InParanoidiQ99MF4.
KOiK05056.
OMAiWFRDGET.
OrthoDBiEOG72NRQF.
PhylomeDBiQ99MF4.
TreeFamiTF331210.

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiQ99MF4.

Gene expression databases

GenevisibleiQ99MF4. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of interleukin-11 and interleukin-11 receptor alpha chain in the rat uterus in the peri-implantation period."
    Li R., Hartley L., Robb L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiI11RA_RAT
AccessioniPrimary (citable) accession number: Q99MF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.