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Q99MF3

- Q99MF3_RAT

UniProt

Q99MF3 - Q99MF3_RAT

Protein
Submitted name:

Wnt5a protein

Gene

Wnt5a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: Ensembl
    2. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. activation of JUN kinase activity Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. ameboidal cell migration Source: Ensembl
    4. anterior/posterior axis specification, embryo Source: Ensembl
    5. axon guidance Source: Ensembl
    6. canonical Wnt signaling pathway Source: Ensembl
    7. cellular protein localization Source: Ensembl
    8. cellular response to calcium ion Source: Ensembl
    9. cellular response to interferon-gamma Source: Ensembl
    10. cellular response to lipopolysaccharide Source: Ensembl
    11. cellular response to transforming growth factor beta stimulus Source: Ensembl
    12. cervix development Source: Ensembl
    13. cochlea morphogenesis Source: Ensembl
    14. convergent extension involved in organogenesis Source: Ensembl
    15. dopaminergic neuron differentiation Source: Ensembl
    16. embryonic digit morphogenesis Source: Ensembl
    17. embryonic skeletal system development Source: Ensembl
    18. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    19. epithelial to mesenchymal transition Source: Ensembl
    20. establishment of planar polarity Source: Ensembl
    21. face development Source: Ensembl
    22. heart looping Source: Ensembl
    23. hematopoietic stem cell proliferation Source: Ensembl
    24. hindgut morphogenesis Source: Ensembl
    25. hypophysis morphogenesis Source: Ensembl
    26. keratinocyte differentiation Source: Ensembl
    27. lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
    28. lung development Source: Ensembl
    29. male gonad development Source: Ensembl
    30. mammary gland branching involved in thelarche Source: Ensembl
    31. mesenchymal-epithelial cell signaling Source: Ensembl
    32. midgut development Source: Ensembl
    33. negative chemotaxis Source: Ensembl
    34. negative regulation of apoptotic process Source: Ensembl
    35. negative regulation of axon extension involved in axon guidance Source: Ensembl
    36. negative regulation of BMP signaling pathway Source: Ensembl
    37. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    38. negative regulation of epithelial cell proliferation Source: Ensembl
    39. negative regulation of fat cell differentiation Source: Ensembl
    40. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    41. negative regulation of mesenchymal cell proliferation Source: Ensembl
    42. negative regulation of prostatic bud formation Source: Ensembl
    43. negative regulation of synapse assembly Source: Ensembl
    44. negative regulation of transcription, DNA-templated Source: Ensembl
    45. neural tube closure Source: Ensembl
    46. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
    47. olfactory bulb interneuron development Source: Ensembl
    48. palate development Source: Ensembl
    49. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
    50. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
    51. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    52. planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
    53. planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
    54. planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
    55. positive regulation of angiogenesis Source: Ensembl
    56. positive regulation of cartilage development Source: Ensembl
    57. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
    58. positive regulation of cGMP metabolic process Source: Ensembl
    59. positive regulation of chemokine biosynthetic process Source: Ensembl
    60. positive regulation of cytokine secretion involved in immune response Source: Ensembl
    61. positive regulation of endothelial cell migration Source: Ensembl
    62. positive regulation of endothelial cell proliferation Source: Ensembl
    63. positive regulation of fibroblast proliferation Source: Ensembl
    64. positive regulation of inflammatory response Source: Ensembl
    65. positive regulation of interferon-gamma production Source: Ensembl
    66. positive regulation of interleukin-1 beta secretion Source: Ensembl
    67. positive regulation of interleukin-6 production Source: Ensembl
    68. positive regulation of interleukin-8 secretion Source: Ensembl
    69. positive regulation of JNK cascade Source: Ensembl
    70. positive regulation of macrophage activation Source: Ensembl
    71. positive regulation of macrophage cytokine production Source: Ensembl
    72. positive regulation of meiosis Source: Ensembl
    73. positive regulation of mesenchymal cell proliferation Source: Ensembl
    74. positive regulation of neuron projection development Source: Ensembl
    75. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    76. positive regulation of ossification Source: Ensembl
    77. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    78. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    79. positive regulation of protein catabolic process Source: Ensembl
    80. positive regulation of protein kinase C signaling Source: Ensembl
    81. positive regulation of T cell chemotaxis Source: Ensembl
    82. positive regulation of thymocyte apoptotic process Source: Ensembl
    83. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    84. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
    85. post-anal tail morphogenesis Source: Ensembl
    86. primitive streak formation Source: Ensembl
    87. protein phosphorylation Source: Ensembl
    88. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
    89. somitogenesis Source: Ensembl
    90. type B pancreatic cell development Source: Ensembl
    91. urinary bladder development Source: Ensembl
    92. uterus development Source: Ensembl
    93. vagina development Source: Ensembl
    94. Wnt signaling pathway, calcium modulating pathway Source: Ensembl
    95. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_194690. Ca2+ pathway.
    REACT_198373. WNT ligand biogenesis and trafficking.
    REACT_198389. PCP/CE pathway.
    REACT_198397. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_198398. WNT5A-dependent internalization of FZD4.
    REACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_212065. TCF dependent signaling in response to WNT.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Wnt5a proteinImported
    Gene namesi
    Name:Wnt5aImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi69250. Wnt5a.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular matrix Source: Ensembl
    3. extracellular space Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ99MF3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021164.

    Family & Domainsi

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026538. Wnt5a.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q99MF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG MNNPVQMSEV   50
    YIIGAQ 56
    Length:56
    Mass (Da):5,948
    Last modified:June 1, 2001 - v1
    Checksum:i307278761ED6B8D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei56 – 561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348139 Genomic DNA. Translation: AAK29626.1.
    UniGeneiRn.48749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348139 Genomic DNA. Translation: AAK29626.1 .
    UniGenei Rn.48749.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 69250. Wnt5a.

    Enzyme and pathway databases

    Reactomei REACT_194690. Ca2+ pathway.
    REACT_198373. WNT ligand biogenesis and trafficking.
    REACT_198389. PCP/CE pathway.
    REACT_198397. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_198398. WNT5A-dependent internalization of FZD4.
    REACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_212065. TCF dependent signaling in response to WNT.

    Gene expression databases

    Genevestigatori Q99MF3.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026538. Wnt5a.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Partial genomic structure of rat Wnt5a."
      Peters S., Knoblich R., Mix E., Rolfs A.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99MF3_RAT
    AccessioniPrimary (citable) accession number: Q99MF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)