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Q99MF3

- Q99MF3_RAT

UniProt

Q99MF3 - Q99MF3_RAT

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Protein
Submitted name: Wnt5a protein
Gene
Wnt5a
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: Ensembl
  2. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. Wnt signaling pathway, calcium modulating pathway Source: Ensembl
  2. activation of JUN kinase activity Source: Ensembl
  3. activation of protein kinase B activity Source: Ensembl
  4. ameboidal cell migration Source: Ensembl
  5. anterior/posterior axis specification, embryo Source: Ensembl
  6. axon guidance Source: Ensembl
  7. canonical Wnt signaling pathway Source: Ensembl
  8. cellular protein localization Source: Ensembl
  9. cellular response to calcium ion Source: Ensembl
  10. cellular response to interferon-gamma Source: Ensembl
  11. cellular response to lipopolysaccharide Source: Ensembl
  12. cellular response to transforming growth factor beta stimulus Source: Ensembl
  13. cervix development Source: Ensembl
  14. cochlea morphogenesis Source: Ensembl
  15. convergent extension involved in organogenesis Source: Ensembl
  16. dopaminergic neuron differentiation Source: Ensembl
  17. embryonic digit morphogenesis Source: Ensembl
  18. embryonic skeletal system development Source: Ensembl
  19. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  20. epithelial to mesenchymal transition Source: Ensembl
  21. establishment of planar polarity Source: Ensembl
  22. face development Source: Ensembl
  23. heart looping Source: Ensembl
  24. hematopoietic stem cell proliferation Source: Ensembl
  25. hindgut morphogenesis Source: Ensembl
  26. hypophysis morphogenesis Source: Ensembl
  27. keratinocyte differentiation Source: Ensembl
  28. lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
  29. lung development Source: Ensembl
  30. male gonad development Source: Ensembl
  31. mammary gland branching involved in thelarche Source: Ensembl
  32. mesenchymal-epithelial cell signaling Source: Ensembl
  33. midgut development Source: Ensembl
  34. negative chemotaxis Source: Ensembl
  35. negative regulation of BMP signaling pathway Source: Ensembl
  36. negative regulation of apoptotic process Source: Ensembl
  37. negative regulation of axon extension involved in axon guidance Source: Ensembl
  38. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  39. negative regulation of epithelial cell proliferation Source: Ensembl
  40. negative regulation of fat cell differentiation Source: Ensembl
  41. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  42. negative regulation of mesenchymal cell proliferation Source: Ensembl
  43. negative regulation of prostatic bud formation Source: Ensembl
  44. negative regulation of synapse assembly Source: Ensembl
  45. negative regulation of transcription, DNA-templated Source: Ensembl
  46. neural tube closure Source: Ensembl
  47. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
  48. olfactory bulb interneuron development Source: Ensembl
  49. palate development Source: Ensembl
  50. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
  51. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
  52. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  53. planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
  54. planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
  55. planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
  56. positive regulation of JNK cascade Source: Ensembl
  57. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  58. positive regulation of T cell chemotaxis Source: Ensembl
  59. positive regulation of angiogenesis Source: Ensembl
  60. positive regulation of cGMP metabolic process Source: Ensembl
  61. positive regulation of cartilage development Source: Ensembl
  62. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
  63. positive regulation of chemokine biosynthetic process Source: Ensembl
  64. positive regulation of cytokine secretion involved in immune response Source: Ensembl
  65. positive regulation of endothelial cell migration Source: Ensembl
  66. positive regulation of endothelial cell proliferation Source: Ensembl
  67. positive regulation of fibroblast proliferation Source: Ensembl
  68. positive regulation of inflammatory response Source: Ensembl
  69. positive regulation of interferon-gamma production Source: Ensembl
  70. positive regulation of interleukin-1 beta secretion Source: Ensembl
  71. positive regulation of interleukin-6 production Source: Ensembl
  72. positive regulation of interleukin-8 secretion Source: Ensembl
  73. positive regulation of macrophage activation Source: Ensembl
  74. positive regulation of macrophage cytokine production Source: Ensembl
  75. positive regulation of meiosis Source: Ensembl
  76. positive regulation of mesenchymal cell proliferation Source: Ensembl
  77. positive regulation of neuron projection development Source: Ensembl
  78. positive regulation of ossification Source: Ensembl
  79. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  80. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  81. positive regulation of protein catabolic process Source: Ensembl
  82. positive regulation of protein kinase C signaling Source: Ensembl
  83. positive regulation of thymocyte apoptotic process Source: Ensembl
  84. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  85. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
  86. post-anal tail morphogenesis Source: Ensembl
  87. primitive streak formation Source: Ensembl
  88. protein phosphorylation Source: Ensembl
  89. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  90. somitogenesis Source: Ensembl
  91. type B pancreatic cell development Source: Ensembl
  92. urinary bladder development Source: Ensembl
  93. uterus development Source: Ensembl
  94. vagina development Source: Ensembl
  95. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_194690. Ca2+ pathway.
REACT_198373. WNT ligand biogenesis and trafficking.
REACT_198389. PCP/CE pathway.
REACT_198397. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_198398. WNT5A-dependent internalization of FZD4.
REACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_212065. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Submitted name:
Wnt5a proteinImported
Gene namesi
Name:Wnt5aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi69250. Wnt5a.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99MF3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021164.

Family & Domainsi

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99MF3-1 [UniParc]FASTAAdd to Basket

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GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG MNNPVQMSEV   50
YIIGAQ 56
Length:56
Mass (Da):5,948
Last modified:June 1, 2001 - v1
Checksum:i307278761ED6B8D2
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei56 – 561Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348139 Genomic DNA. Translation: AAK29626.1.
UniGeneiRn.48749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348139 Genomic DNA. Translation: AAK29626.1 .
UniGenei Rn.48749.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 69250. Wnt5a.

Enzyme and pathway databases

Reactomei REACT_194690. Ca2+ pathway.
REACT_198373. WNT ligand biogenesis and trafficking.
REACT_198389. PCP/CE pathway.
REACT_198397. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_198398. WNT5A-dependent internalization of FZD4.
REACT_205336. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_212065. TCF dependent signaling in response to WNT.

Gene expression databases

Genevestigatori Q99MF3.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026538. Wnt5a.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Partial genomic structure of rat Wnt5a."
    Peters S., Knoblich R., Mix E., Rolfs A.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99MF3_RAT
AccessioniPrimary (citable) accession number: Q99MF3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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