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Protein

Nucleolar GTP-binding protein 1

Gene

Gtpbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1828GTPPROSITE-ProRule annotation
Nucleotide bindingi221 – 2255GTPPROSITE-ProRule annotation
Nucleotide bindingi289 – 2924GTPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1
Alternative name(s):
Chronic renal failure gene protein
GTP-binding protein NGB
Gene namesi
Name:Gtpbp4
Synonyms:Crfg, Nog1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916487. Gtpbp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 634633Nucleolar GTP-binding protein 1PRO_0000195024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei103 – 1031N6-acetyllysineBy similarity
Modified residuei122 – 1221PhosphoserineBy similarity
Modified residuei468 – 4681PhosphoserineCombined sources
Modified residuei470 – 4701PhosphoserineCombined sources
Modified residuei472 – 4721PhosphoserineCombined sources
Modified residuei558 – 5581PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99ME9.
MaxQBiQ99ME9.
PaxDbiQ99ME9.
PeptideAtlasiQ99ME9.
PRIDEiQ99ME9.

PTM databases

iPTMnetiQ99ME9.
PhosphoSiteiQ99ME9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ99ME9.
CleanExiMM_GTPBP4.
GenevisibleiQ99ME9. MM.

Interactioni

Protein-protein interaction databases

BioGridi213310. 4 interactions.
IntActiQ99ME9. 3 interactions.
MINTiMINT-1853470.
STRINGi10090.ENSMUSP00000021574.

Structurei

3D structure databases

ProteinModelPortaliQ99ME9.
SMRiQ99ME9. Positions 6-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 340172OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1490. Eukaryota.
COG1084. LUCA.
GeneTreeiENSGT00390000018475.
HOGENOMiHOG000164071.
HOVERGENiHBG052642.
InParanoidiQ99ME9.
KOiK06943.
OMAiLQTEGFP.
OrthoDBiEOG72G175.
PhylomeDBiQ99ME9.
TreeFamiTF300430.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILSDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTI IKRQRQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLKEQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
310 320 330 340 350
EEDQKIFLDL QAEGFPVIET STLTEEGVIQ VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAVPNKRDD KERPPFIPEG VIARRKRMEI EEPKKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NSSEKYDKIP EIWEGHNVAD YIDPAIMKKL
460 470 480 490 500
EELEKEEELR TAAGEYDSDS ESEDEEMMEI RQLAKQIREK KKLKILQSKE
510 520 530 540 550
KNKQGPRMPR TAKKVQRADL ENEMRSLGVD MDDKNNAHYA VQARRSRSVT
560 570 580 590 600
RKRKREESVP PSSTARSRSC SRTPRDVSGL RDVKMVKKAK TMMKKAQKKM
610 620 630
NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
Length:634
Mass (Da):74,113
Last modified:January 23, 2007 - v3
Checksum:i642F42BF8C717D6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171D → E in AAH05514 (PubMed:15489334).Curated
Sequence conflicti221 – 2222DT → TY in AAK13445 (PubMed:11316846).Curated
Sequence conflicti270 – 2701E → K in AAK13445 (PubMed:11316846).Curated
Sequence conflicti288 – 2881A → T in AAK13445 (PubMed:11316846).Curated
Sequence conflicti293 – 2931V → A in AAK13445 (PubMed:11316846).Curated
Sequence conflicti302 – 3021E → K in AAK13445 (PubMed:11316846).Curated
Sequence conflicti341 – 3433AHR → THG in AAK13445 (PubMed:11316846).Curated
Sequence conflicti632 – 6321D → E in AAK13445 (PubMed:11316846).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348208 mRNA. Translation: AAK19749.1.
AF325354 mRNA. Translation: AAK13445.1.
BC005514 mRNA. Translation: AAH05514.1.
BC025431 mRNA. Translation: AAH25431.1.
AK011580 mRNA. Translation: BAB27714.1.
CCDSiCCDS26236.1.
RefSeqiNP_081276.2. NM_027000.4.
UniGeneiMm.41800.

Genome annotation databases

EnsembliENSMUST00000021574; ENSMUSP00000021574; ENSMUSG00000021149.
GeneIDi69237.
KEGGimmu:69237.
UCSCiuc007pkp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348208 mRNA. Translation: AAK19749.1.
AF325354 mRNA. Translation: AAK13445.1.
BC005514 mRNA. Translation: AAH05514.1.
BC025431 mRNA. Translation: AAH25431.1.
AK011580 mRNA. Translation: BAB27714.1.
CCDSiCCDS26236.1.
RefSeqiNP_081276.2. NM_027000.4.
UniGeneiMm.41800.

3D structure databases

ProteinModelPortaliQ99ME9.
SMRiQ99ME9. Positions 6-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213310. 4 interactions.
IntActiQ99ME9. 3 interactions.
MINTiMINT-1853470.
STRINGi10090.ENSMUSP00000021574.

PTM databases

iPTMnetiQ99ME9.
PhosphoSiteiQ99ME9.

Proteomic databases

EPDiQ99ME9.
MaxQBiQ99ME9.
PaxDbiQ99ME9.
PeptideAtlasiQ99ME9.
PRIDEiQ99ME9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021574; ENSMUSP00000021574; ENSMUSG00000021149.
GeneIDi69237.
KEGGimmu:69237.
UCSCiuc007pkp.1. mouse.

Organism-specific databases

CTDi23560.
MGIiMGI:1916487. Gtpbp4.

Phylogenomic databases

eggNOGiKOG1490. Eukaryota.
COG1084. LUCA.
GeneTreeiENSGT00390000018475.
HOGENOMiHOG000164071.
HOVERGENiHBG052642.
InParanoidiQ99ME9.
KOiK06943.
OMAiLQTEGFP.
OrthoDBiEOG72G175.
PhylomeDBiQ99ME9.
TreeFamiTF300430.

Miscellaneous databases

PROiQ99ME9.
SOURCEiSearch...

Gene expression databases

BgeeiQ99ME9.
CleanExiMM_GTPBP4.
GenevisibleiQ99ME9. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a mouse GTP-binding protein, NGB."
    Cheng J.Q.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease."
    Laping N.J., Olson B.A., Zhu Y.
    J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-347.
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468; SER-470 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNOG1_MOUSE
AccessioniPrimary (citable) accession number: Q99ME9
Secondary accession number(s): Q99K16, Q99P78, Q9CT02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.