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Q99ME7 (TBX19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX19

Short name=T-box protein 19
Alternative name(s):
T-box factor, pituitary
Gene names
Name:Tbx19
Synonyms:Tpit
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. Ref.1

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 T-box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446T-box transcription factor TBX19
PRO_0000184450

Regions

DNA binding43 – 216174T-box

Sequences

Sequence LengthMass (Da)Tools
Q99ME7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9BA0995D30547753

FASTA44648,037
        10         20         30         40         50         60 
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ RFKEVTNEMI 

        70         80         90        100        110        120 
VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK YVNGEWVPAG KPEVSSHSCV 

       130        140        150        160        170        180 
YIHPDSPNFG AHWMKAPISF SKVKLTNKLN GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM 

       190        200        210        220        230        240 
NCSFPETQFI AVTAYQNEEI TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH 

       250        260        270        280        290        300 
LGGWILSNPD GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH 

       310        320        330        340        350        360 
SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP YPCLWTISNG 

       370        380        390        400        410        420 
GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS AGVEVLGEPS LTSIAVSTWT 

       430        440 
AVASHPLPGW GGPGGAGRHS SSSLDS 

« Hide

References

« Hide 'large scale' references
[1]"A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins."
Lamolet B., Pulichino A.-M., Lamonerie T., Gauthier Y., Brue T., Enjalbert A., Drouin J.
Cell 104:849-859(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: LAF1.
[2]"Tbx19, a tissue-selective regulator of POMC gene expression."
Liu J., Lin C., Gleiberman A., Ohgi K.A., Herman T., Huang H.P., Tsai M.J., Rosenfeld M.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8674-8679(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hypothalamus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF348321 mRNA. Translation: AAK27153.1.
AF345520 mRNA. Translation: AAK64365.1.
AK038666 mRNA. Translation: BAC30088.1.
BC120635 mRNA. Translation: AAI20636.1.
BC137731 mRNA. Translation: AAI37732.1.
CCDSCCDS15439.1.
RefSeqNP_114394.1. NM_032005.4.
UniGeneMm.190649.

3D structure databases

ProteinModelPortalQ99ME7.
SMRQ99ME7. Positions 38-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219993. 1 interaction.

PTM databases

PhosphoSiteQ99ME7.

Proteomic databases

PRIDEQ99ME7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572.
GeneID83993.
KEGGmmu:83993.
UCSCuc007diw.1. mouse.

Organism-specific databases

CTD9095.
MGIMGI:1891158. Tbx19.

Phylogenomic databases

eggNOGNOG257463.
GeneTreeENSGT00750000117513.
HOGENOMHOG000063663.
HOVERGENHBG004599.
InParanoidQ0VBH2.
KOK10184.
OMAQHVAYSH.
OrthoDBEOG7GN2PM.
PhylomeDBQ99ME7.
TreeFamTF106341.

Gene expression databases

BgeeQ99ME7.
CleanExMM_TBX19.
GenevestigatorQ99ME7.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00938. BRACHYURY.
PR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350850.
PROQ99ME7.
SOURCESearch...

Entry information

Entry nameTBX19_MOUSE
AccessionPrimary (citable) accession number: Q99ME7
Secondary accession number(s): Q0VBH2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot