Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-box transcription factor TBX19

Gene

Tbx19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi43 – 216T-boxPROSITE-ProRule annotationAdd BLAST174

GO - Molecular functioni

  • DNA binding Source: MGI
  • enhancer sequence-specific DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • cell fate commitment Source: MGI
  • pituitary gland development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of cell differentiation Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX19
Short name:
T-box protein 19
Alternative name(s):
T-box factor, pituitary
Gene namesi
Name:Tbx19
Synonyms:Tpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891158. Tbx19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844501 – 446T-box transcription factor TBX19Add BLAST446

Proteomic databases

PaxDbiQ99ME7.
PRIDEiQ99ME7.

PTM databases

iPTMnetiQ99ME7.
PhosphoSitePlusiQ99ME7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026572.
CleanExiMM_TBX19.
ExpressionAtlasiQ99ME7. baseline and differential.
GenevisibleiQ99ME7. MM.

Interactioni

Protein-protein interaction databases

BioGridi219993. 1 interactor.
STRINGi10090.ENSMUSP00000027859.

Structurei

3D structure databases

ProteinModelPortaliQ99ME7.
SMRiQ99ME7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000063663.
HOVERGENiHBG004599.
InParanoidiQ99ME7.
KOiK10184.
OMAiQHVAYSH.
OrthoDBiEOG091G05OC.
PhylomeDBiQ99ME7.
TreeFamiTF106341.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiView protein in Pfam
PF00907. T-box. 1 hit.
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiView protein in SMART
SM00425. TBOX. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99ME7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ
60 70 80 90 100
RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK
110 120 130 140 150
YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN
160 170 180 190 200
GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI
210 220 230 240 250
TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD
260 270 280 290 300
GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH
310 320 330 340 350
SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP
360 370 380 390 400
YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS
410 420 430 440
AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS
Length:446
Mass (Da):48,037
Last modified:June 1, 2001 - v1
Checksum:i9BA0995D30547753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348321 mRNA. Translation: AAK27153.1.
AF345520 mRNA. Translation: AAK64365.1.
AK038666 mRNA. Translation: BAC30088.1.
BC120635 mRNA. Translation: AAI20636.1.
BC137731 mRNA. Translation: AAI37732.1.
CCDSiCCDS15439.1.
RefSeqiNP_114394.1. NM_032005.4.
UniGeneiMm.190649.

Genome annotation databases

EnsembliENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572.
GeneIDi83993.
KEGGimmu:83993.
UCSCiuc007diw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTBX19_MOUSE
AccessioniPrimary (citable) accession number: Q99ME7
Secondary accession number(s): Q0VBH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot