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Q99ME7

- TBX19_MOUSE

UniProt

Q99ME7 - TBX19_MOUSE

Protein

T-box transcription factor TBX19

Gene

Tbx19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi43 – 216174T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. enhancer sequence-specific DNA binding Source: MGI
    3. protein binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell fate commitment Source: MGI
    2. pituitary gland development Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. regulation of cell differentiation Source: MGI
    5. regulation of cell proliferation Source: MGI
    6. regulation of transcription, DNA-templated Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX19
    Short name:
    T-box protein 19
    Alternative name(s):
    T-box factor, pituitary
    Gene namesi
    Name:Tbx19
    Synonyms:Tpit
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1891158. Tbx19.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446T-box transcription factor TBX19PRO_0000184450Add
    BLAST

    Proteomic databases

    PRIDEiQ99ME7.

    PTM databases

    PhosphoSiteiQ99ME7.

    Expressioni

    Gene expression databases

    BgeeiQ99ME7.
    CleanExiMM_TBX19.
    GenevestigatoriQ99ME7.

    Interactioni

    Protein-protein interaction databases

    BioGridi219993. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ME7.
    SMRiQ99ME7. Positions 38-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257463.
    GeneTreeiENSGT00750000117513.
    HOGENOMiHOG000063663.
    HOVERGENiHBG004599.
    InParanoidiQ0VBH2.
    KOiK10184.
    OMAiQHVAYSH.
    OrthoDBiEOG7GN2PM.
    PhylomeDBiQ99ME7.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99ME7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ    50
    RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK 100
    YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN 150
    GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI 200
    TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD 250
    GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH 300
    SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP 350
    YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS 400
    AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS 446
    Length:446
    Mass (Da):48,037
    Last modified:June 1, 2001 - v1
    Checksum:i9BA0995D30547753
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348321 mRNA. Translation: AAK27153.1.
    AF345520 mRNA. Translation: AAK64365.1.
    AK038666 mRNA. Translation: BAC30088.1.
    BC120635 mRNA. Translation: AAI20636.1.
    BC137731 mRNA. Translation: AAI37732.1.
    CCDSiCCDS15439.1.
    RefSeqiNP_114394.1. NM_032005.4.
    UniGeneiMm.190649.

    Genome annotation databases

    EnsembliENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572.
    GeneIDi83993.
    KEGGimmu:83993.
    UCSCiuc007diw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348321 mRNA. Translation: AAK27153.1 .
    AF345520 mRNA. Translation: AAK64365.1 .
    AK038666 mRNA. Translation: BAC30088.1 .
    BC120635 mRNA. Translation: AAI20636.1 .
    BC137731 mRNA. Translation: AAI37732.1 .
    CCDSi CCDS15439.1.
    RefSeqi NP_114394.1. NM_032005.4.
    UniGenei Mm.190649.

    3D structure databases

    ProteinModelPortali Q99ME7.
    SMRi Q99ME7. Positions 38-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219993. 1 interaction.

    PTM databases

    PhosphoSitei Q99ME7.

    Proteomic databases

    PRIDEi Q99ME7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027859 ; ENSMUSP00000027859 ; ENSMUSG00000026572 .
    GeneIDi 83993.
    KEGGi mmu:83993.
    UCSCi uc007diw.1. mouse.

    Organism-specific databases

    CTDi 9095.
    MGIi MGI:1891158. Tbx19.

    Phylogenomic databases

    eggNOGi NOG257463.
    GeneTreei ENSGT00750000117513.
    HOGENOMi HOG000063663.
    HOVERGENi HBG004599.
    InParanoidi Q0VBH2.
    KOi K10184.
    OMAi QHVAYSH.
    OrthoDBi EOG7GN2PM.
    PhylomeDBi Q99ME7.
    TreeFami TF106341.

    Miscellaneous databases

    NextBioi 350850.
    PROi Q99ME7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99ME7.
    CleanExi MM_TBX19.
    Genevestigatori Q99ME7.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins."
      Lamolet B., Pulichino A.-M., Lamonerie T., Gauthier Y., Brue T., Enjalbert A., Drouin J.
      Cell 104:849-859(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: LAF1.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTBX19_MOUSE
    AccessioniPrimary (citable) accession number: Q99ME7
    Secondary accession number(s): Q0VBH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3