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Q99ME7

- TBX19_MOUSE

UniProt

Q99ME7 - TBX19_MOUSE

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Protein

T-box transcription factor TBX19

Gene

Tbx19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi43 – 216174T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. enhancer sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell fate commitment Source: MGI
  2. pituitary gland development Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. regulation of cell differentiation Source: MGI
  5. regulation of cell proliferation Source: MGI
  6. regulation of transcription, DNA-templated Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX19
Short name:
T-box protein 19
Alternative name(s):
T-box factor, pituitary
Gene namesi
Name:Tbx19
Synonyms:Tpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1891158. Tbx19.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446T-box transcription factor TBX19PRO_0000184450Add
BLAST

Proteomic databases

PRIDEiQ99ME7.

PTM databases

PhosphoSiteiQ99ME7.

Expressioni

Gene expression databases

BgeeiQ99ME7.
CleanExiMM_TBX19.
GenevestigatoriQ99ME7.

Interactioni

Protein-protein interaction databases

BioGridi219993. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99ME7.
SMRiQ99ME7. Positions 38-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257463.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000063663.
HOVERGENiHBG004599.
InParanoidiQ99ME7.
KOiK10184.
OMAiQHVAYSH.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ99ME7.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ME7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELATQKAG EGTVSRLLNV VESELQAGRE KGDPTEKQLQ IILEDAPLWQ
60 70 80 90 100
RFKEVTNEMI VTKNGRRMFP VLKISVTGLD PNAMYSLLLD FVRTDSHRWK
110 120 130 140 150
YVNGEWVPAG KPEVSSHSCV YIHPDSPNFG AHWMKAPISF SKVKLTNKLN
160 170 180 190 200
GGGQIMLNSL HKYEPQVHIV RVGGAHRMVM NCSFPETQFI AVTAYQNEEI
210 220 230 240 250
TALKIKYNPF AKAFLDAKER NHLKDVPEAI SESQHVTYSH LGGWILSNPD
260 270 280 290 300
GVCTAANSNY QYATPLPLPA PHTHHGCEHY AGLRGHRQAP YPSAYMHRNH
310 320 330 340 350
SPSVNLIESS SNNLQVFSGP DSWTSLSSTP HASILSVPHS NGPINPGPSP
360 370 380 390 400
YPCLWTISNG GGGPVASGSE VHASTSGTIL LGNPAVTSPS SLLPTQATTS
410 420 430 440
AGVEVLGEPS LTSIAVSTWT AVASHPLPGW GGPGGAGRHS SSSLDS
Length:446
Mass (Da):48,037
Last modified:June 1, 2001 - v1
Checksum:i9BA0995D30547753
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348321 mRNA. Translation: AAK27153.1.
AF345520 mRNA. Translation: AAK64365.1.
AK038666 mRNA. Translation: BAC30088.1.
BC120635 mRNA. Translation: AAI20636.1.
BC137731 mRNA. Translation: AAI37732.1.
CCDSiCCDS15439.1.
RefSeqiNP_114394.1. NM_032005.4.
UniGeneiMm.190649.

Genome annotation databases

EnsembliENSMUST00000027859; ENSMUSP00000027859; ENSMUSG00000026572.
GeneIDi83993.
KEGGimmu:83993.
UCSCiuc007diw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348321 mRNA. Translation: AAK27153.1 .
AF345520 mRNA. Translation: AAK64365.1 .
AK038666 mRNA. Translation: BAC30088.1 .
BC120635 mRNA. Translation: AAI20636.1 .
BC137731 mRNA. Translation: AAI37732.1 .
CCDSi CCDS15439.1.
RefSeqi NP_114394.1. NM_032005.4.
UniGenei Mm.190649.

3D structure databases

ProteinModelPortali Q99ME7.
SMRi Q99ME7. Positions 38-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219993. 1 interaction.

PTM databases

PhosphoSitei Q99ME7.

Proteomic databases

PRIDEi Q99ME7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027859 ; ENSMUSP00000027859 ; ENSMUSG00000026572 .
GeneIDi 83993.
KEGGi mmu:83993.
UCSCi uc007diw.1. mouse.

Organism-specific databases

CTDi 9095.
MGIi MGI:1891158. Tbx19.

Phylogenomic databases

eggNOGi NOG257463.
GeneTreei ENSGT00760000118897.
HOGENOMi HOG000063663.
HOVERGENi HBG004599.
InParanoidi Q99ME7.
KOi K10184.
OMAi QHVAYSH.
OrthoDBi EOG7GN2PM.
PhylomeDBi Q99ME7.
TreeFami TF106341.

Miscellaneous databases

NextBioi 350850.
PROi Q99ME7.
SOURCEi Search...

Gene expression databases

Bgeei Q99ME7.
CleanExi MM_TBX19.
Genevestigatori Q99ME7.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00938. BRACHYURY.
PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins."
    Lamolet B., Pulichino A.-M., Lamonerie T., Gauthier Y., Brue T., Enjalbert A., Drouin J.
    Cell 104:849-859(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: LAF1.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTBX19_MOUSE
AccessioniPrimary (citable) accession number: Q99ME7
Secondary accession number(s): Q0VBH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3