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Protein

Protein ATP1B4

Gene

Atp1b4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:Atp1b4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1915071 Atp1b4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 109NuclearSequence analysisAdd BLAST109
Transmembranei110 – 130Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini131 – 356Perinuclear spaceSequence analysisAdd BLAST226

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191231 – 356Protein ATP1B4Add BLAST356

Proteomic databases

PaxDbiQ99ME6
PRIDEiQ99ME6

PTM databases

PhosphoSitePlusiQ99ME6

Expressioni

Tissue specificityi

Expressed in skeletal muscle (at protein level). Expressed during postnatal development in skeletal muscle and heart.1 Publication

Developmental stagei

Expressed in embryo 15.5 dpc, onward.1 Publication

Gene expression databases

BgeeiENSMUSG00000016327
CleanExiMM_ATP1B4
ExpressionAtlasiQ99ME6 baseline and differential
GenevisibleiQ99ME6 MM

Interactioni

Subunit structurei

Associates with a SMAD7-transcriptional complex. Interacts with TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Interacts with SNW1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-60965N
IntActiQ99ME6, 3 interactors
STRINGi10090.ENSMUSP00000016471

Structurei

3D structure databases

ProteinModelPortaliQ99ME6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 71Glu-richAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiQ99ME6
KOiK01540
OMAiAWWQKLQ
OrthoDBiEOG091G0DJ4
PhylomeDBiQ99ME6
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q99ME6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRQLRSRRA PAFPYGYRYR LDDQDEANHN YLADEEEEAE EEAQVMMVPG
60 70 80 90 100
LEEEEEEEEG KEEEEEREEE EGQGQSTGSA WWRKLQIVNE YLWDPEKRMS
110 120 130 140 150
LARTGQSRSL ILVIYFFFYA SLAAVITLFI YMLFLAISPY MPTFTEQVKP
160 170 180 190 200
PGVMIRPFAH SLNFNFNVSE PETWQRYVIS LNGFLQGYND SLQEEMNIDC
210 220 230 240 250
PPGRYFIQDG DEDEDKKACQ FKRSFLKNCS GLEDPTFGYS TGQPCILLKM
260 270 280 290 300
NRIVGFRPEF GDPVKVSCKV QKGDENDIRS INYYPESASF DLRYYPYYGK
310 320 330 340 350
LTHVNYTSPL VAMHFTDVVK NQAVPVQCQL KGKGIVNDVI NDRFVGRIIF

TLNIET
Length:356
Mass (Da):41,401
Last modified:June 1, 2001 - v1
Checksum:i1AD12A8D7AA720F2
GO
Isoform B (identifier: Q99ME6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-109: Missing.

Show »
Length:352
Mass (Da):40,942
Checksum:iDBBE56CBF6A57ED7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000352106 – 109Missing in isoform B. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348324 mRNA Translation: AAK30148.1
AF348325 mRNA Translation: AAK30149.1
AK053500 mRNA Translation: BAC35406.1
AL513347 Genomic DNA Translation: CAM25391.1
CH466570 Genomic DNA Translation: EDL29013.1
BC137924 mRNA Translation: AAI37925.1
CCDSiCCDS30090.1 [Q99ME6-1]
CCDS72368.1 [Q99ME6-2]
RefSeqiNP_001277318.1, NM_001290389.1 [Q99ME6-2]
NP_598451.1, NM_133690.3 [Q99ME6-1]
UniGeneiMm.60134

Genome annotation databases

EnsembliENSMUST00000016471; ENSMUSP00000016471; ENSMUSG00000016327 [Q99ME6-1]
ENSMUST00000115134; ENSMUSP00000110787; ENSMUSG00000016327 [Q99ME6-2]
GeneIDi67821
KEGGimmu:67821
UCSCiuc009szt.2 mouse [Q99ME6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAT1B4_MOUSE
AccessioniPrimary (citable) accession number: Q99ME6
Secondary accession number(s): Q543D0, Q99ME5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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