Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ATP1B4

Gene

Atp1b4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:Atp1b4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1915071. Atp1b4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 109109NuclearSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini131 – 356226Perinuclear spaceSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Protein ATP1B4PRO_0000219123Add
BLAST

Proteomic databases

PaxDbiQ99ME6.
PRIDEiQ99ME6.

PTM databases

PhosphoSiteiQ99ME6.

Expressioni

Tissue specificityi

Expressed in skeletal muscle (at protein level). Expressed during postnatal development in skeletal muscle and heart.1 Publication

Developmental stagei

Expressed in embryo 15.5 dpc, onward.1 Publication

Gene expression databases

BgeeiQ99ME6.
CleanExiMM_ATP1B4.
ExpressionAtlasiQ99ME6. baseline and differential.
GenevisibleiQ99ME6. MM.

Interactioni

Subunit structurei

Associates with a SMAD7-transcriptional complex. Interacts with TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity). Interacts with SNW1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-60965N.
STRINGi10090.ENSMUSP00000016471.

Structurei

3D structure databases

ProteinModelPortaliQ99ME6.
SMRiQ99ME6. Positions 94-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 7137Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ99ME6.
KOiK01540.
OMAiPTGNAWW.
OrthoDBiEOG7M6D85.
PhylomeDBiQ99ME6.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q99ME6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRQLRSRRA PAFPYGYRYR LDDQDEANHN YLADEEEEAE EEAQVMMVPG
60 70 80 90 100
LEEEEEEEEG KEEEEEREEE EGQGQSTGSA WWRKLQIVNE YLWDPEKRMS
110 120 130 140 150
LARTGQSRSL ILVIYFFFYA SLAAVITLFI YMLFLAISPY MPTFTEQVKP
160 170 180 190 200
PGVMIRPFAH SLNFNFNVSE PETWQRYVIS LNGFLQGYND SLQEEMNIDC
210 220 230 240 250
PPGRYFIQDG DEDEDKKACQ FKRSFLKNCS GLEDPTFGYS TGQPCILLKM
260 270 280 290 300
NRIVGFRPEF GDPVKVSCKV QKGDENDIRS INYYPESASF DLRYYPYYGK
310 320 330 340 350
LTHVNYTSPL VAMHFTDVVK NQAVPVQCQL KGKGIVNDVI NDRFVGRIIF

TLNIET
Length:356
Mass (Da):41,401
Last modified:June 1, 2001 - v1
Checksum:i1AD12A8D7AA720F2
GO
Isoform B (identifier: Q99ME6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-109: Missing.

Show »
Length:352
Mass (Da):40,942
Checksum:iDBBE56CBF6A57ED7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1094Missing in isoform B. 1 PublicationVSP_000352

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348324 mRNA. Translation: AAK30148.1.
AF348325 mRNA. Translation: AAK30149.1.
AK053500 mRNA. Translation: BAC35406.1.
AL513347 Genomic DNA. Translation: CAM25391.1.
CH466570 Genomic DNA. Translation: EDL29013.1.
BC137924 mRNA. Translation: AAI37925.1.
CCDSiCCDS30090.1. [Q99ME6-1]
CCDS72368.1. [Q99ME6-2]
RefSeqiNP_001277318.1. NM_001290389.1. [Q99ME6-2]
NP_598451.1. NM_133690.3. [Q99ME6-1]
UniGeneiMm.60134.

Genome annotation databases

EnsembliENSMUST00000016471; ENSMUSP00000016471; ENSMUSG00000016327. [Q99ME6-1]
ENSMUST00000115134; ENSMUSP00000110787; ENSMUSG00000016327. [Q99ME6-2]
GeneIDi67821.
KEGGimmu:67821.
UCSCiuc009szt.2. mouse. [Q99ME6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348324 mRNA. Translation: AAK30148.1.
AF348325 mRNA. Translation: AAK30149.1.
AK053500 mRNA. Translation: BAC35406.1.
AL513347 Genomic DNA. Translation: CAM25391.1.
CH466570 Genomic DNA. Translation: EDL29013.1.
BC137924 mRNA. Translation: AAI37925.1.
CCDSiCCDS30090.1. [Q99ME6-1]
CCDS72368.1. [Q99ME6-2]
RefSeqiNP_001277318.1. NM_001290389.1. [Q99ME6-2]
NP_598451.1. NM_133690.3. [Q99ME6-1]
UniGeneiMm.60134.

3D structure databases

ProteinModelPortaliQ99ME6.
SMRiQ99ME6. Positions 94-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60965N.
STRINGi10090.ENSMUSP00000016471.

PTM databases

PhosphoSiteiQ99ME6.

Proteomic databases

PaxDbiQ99ME6.
PRIDEiQ99ME6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016471; ENSMUSP00000016471; ENSMUSG00000016327. [Q99ME6-1]
ENSMUST00000115134; ENSMUSP00000110787; ENSMUSG00000016327. [Q99ME6-2]
GeneIDi67821.
KEGGimmu:67821.
UCSCiuc009szt.2. mouse. [Q99ME6-1]

Organism-specific databases

CTDi23439.
MGIiMGI:1915071. Atp1b4.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ99ME6.
KOiK01540.
OMAiPTGNAWW.
OrthoDBiEOG7M6D85.
PhylomeDBiQ99ME6.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-MMU-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Miscellaneous databases

PROiQ99ME6.
SOURCEiSearch...

Gene expression databases

BgeeiQ99ME6.
CleanExiMM_ATP1B4.
ExpressionAtlasiQ99ME6. baseline and differential.
GenevisibleiQ99ME6. MM.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Pestov N.B., Shakhparonov M.I., Modyanov N.N.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    Strain: ICR.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
    Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
    Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
    Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D., Roy S., Bibert S., Geering K., Modyanov N.N.
    Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNW1.

Entry informationi

Entry nameiAT1B4_MOUSE
AccessioniPrimary (citable) accession number: Q99ME6
Secondary accession number(s): Q543D0, Q99ME5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.