Q99ME3 (SNCAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synphilin-1

Alternative name(s):
Alpha-synuclein-interacting protein

Gene names

Name:

Sncaip

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Associates with SNCA, RNF19A AND PARK2 By similarity.
Post-translational modification	Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation By similarity.
Sequence similarities	Contains 6 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Coiled coil Repeat
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 915	915	Synphilin-1		PRO_0000320071
Regions
	Repeat	348 – 379	32	ANK 1
	Repeat	383 – 412	30	ANK 2
	Repeat	418 – 447	30	ANK 3
	Repeat	455 – 484	30	ANK 4
	Repeat	602 – 631	30	ANK 5
	Repeat	698 – 728	31	ANK 6
	Coiled coil	522 – 548	27	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q99ME3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: DE47B52447C24BA2	FASTA	915	99,935
	10 20 30 40 50 60 MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN CGVSTLITNP 70 80 90 100 110 120 QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN TVEYQKGGET DQGPQPEELS 130 140 150 160 170 180 PEDGVGGLPG KGSEPSQALG ELEHYDLDMD EILDVPYIKS SQQLAPLTKV TSEKRILGLC 190 200 210 220 230 240 TTINGLSAKT CPIASTENST PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA 250 260 270 280 290 300 LGKCGPAYES ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM 310 320 330 340 350 360 NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN NLLHIAASKG 370 380 390 400 410 420 HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV RWMVSETEAI AELSCSKDFP 430 440 450 460 470 480 SLIHYAGCYG QEKILLWLLQ FMQEQGISLD EVDREGNSAV HVASQHGYLG CIQTLVEYGA 490 500 510 520 530 540 NVTMQNHAGE KPSQSAERHG HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS 550 560 570 580 590 600 QLQQLLEAQK SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL 610 620 630 640 650 660 SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN SKKIPLEKRE 670 680 690 700 710 720 LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP QPIVESVENV DSAESLHLMI 730 740 750 760 770 780 KKHSLASGRR FPFGMKASKS LDGHSPSPTS ESSEPDLDSH GPGLGMTPPT QPSTEATQSS 790 800 810 820 830 840 PDSTAAQKVA TSPKSALKSP SSKRGTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR 850 860 870 880 890 900 APQRTSESGE QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK 910 GNPVSPASKG KNKAA

References

[1]	"Cloning of the mouse homolog of synphilin-1." Cookson M.R., O'Farrell C.A., Vink L., Singleton A.B. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF348447 mRNA. Translation: AAK30156.1.
IPI	IPI00316865.
UniGene	Mm.292168.
3D structure databases
ProteinModelPortal	Q99ME3.
SMR	Q99ME3. Positions 276-556.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2739947.
STRING	Q99ME3.
PTM databases
PhosphoSite	Q99ME3.
Proteomic databases
PRIDE	Q99ME3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1915097. Sncaip.
Phylogenomic databases
HOVERGEN	HBG061375.
InParanoid	Q99ME3.
OrthoDB	EOG4X3H0T.
Gene expression databases
ArrayExpress	Q99ME3.
Bgee	Q99ME3.
CleanEx	MM_SNCAIP.
Genevestigator	Q99ME3.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 2 hits. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

SNCAP_MOUSE

Accession

Primary (citable) accession number: Q99ME3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2001
Last modified:	October 19, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program