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Q99ME3

- SNCAP_MOUSE

UniProt

Q99ME3 - SNCAP_MOUSE

Protein

Synphilin-1

Gene

Sncaip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. dopamine metabolic process Source: Ensembl
    2. regulation of inclusion body assembly Source: Ensembl
    3. regulation of neurotransmitter secretion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synphilin-1
    Alternative name(s):
    Alpha-synuclein-interacting protein
    Gene namesi
    Name:Sncaip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1915097. Sncaip.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleolus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Synphilin-1PRO_0000320071Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ99ME3.
    PRIDEiQ99ME3.

    PTM databases

    PhosphoSiteiQ99ME3.

    Expressioni

    Gene expression databases

    CleanExiMM_SNCAIP.
    GenevestigatoriQ99ME3.

    Interactioni

    Subunit structurei

    Associates with SNCA, RNF19A AND PARK2.By similarity

    Protein-protein interaction databases

    IntActiQ99ME3. 3 interactions.
    MINTiMINT-2739947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ME3.
    SMRiQ99ME3. Positions 321-509, 511-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati348 – 37932ANK 1Add
    BLAST
    Repeati383 – 41230ANK 2Add
    BLAST
    Repeati418 – 44730ANK 3Add
    BLAST
    Repeati455 – 48430ANK 4Add
    BLAST
    Repeati602 – 63130ANK 5Add
    BLAST
    Repeati698 – 72831ANK 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili522 – 54827Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG297616.
    HOVERGENiHBG061375.
    InParanoidiQ99ME3.
    KOiK04558.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99ME3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN    50
    CGVSTLITNP QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN 100
    TVEYQKGGET DQGPQPEELS PEDGVGGLPG KGSEPSQALG ELEHYDLDMD 150
    EILDVPYIKS SQQLAPLTKV TSEKRILGLC TTINGLSAKT CPIASTENST 200
    PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA LGKCGPAYES 250
    ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM 300
    NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN 350
    NLLHIAASKG HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV 400
    RWMVSETEAI AELSCSKDFP SLIHYAGCYG QEKILLWLLQ FMQEQGISLD 450
    EVDREGNSAV HVASQHGYLG CIQTLVEYGA NVTMQNHAGE KPSQSAERHG 500
    HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS QLQQLLEAQK 550
    SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL 600
    SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN 650
    SKKIPLEKRE LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP 700
    QPIVESVENV DSAESLHLMI KKHSLASGRR FPFGMKASKS LDGHSPSPTS 750
    ESSEPDLDSH GPGLGMTPPT QPSTEATQSS PDSTAAQKVA TSPKSALKSP 800
    SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR APQRTSESGE 850
    QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK 900
    GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY 950
    HMKHTAEPEP RE 962
    Length:962
    Mass (Da):105,607
    Last modified:September 18, 2013 - v2
    Checksum:iAD8980FA1F8E8BCB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti805 – 8051R → G in AAK30156. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130225 mRNA. Translation: AAI30226.1.
    AF348447 mRNA. Translation: AAK30156.1.
    RefSeqiNP_001186080.1. NM_001199151.1.
    NP_001186082.1. NM_001199153.1.
    UniGeneiMm.292168.

    Genome annotation databases

    GeneIDi67847.
    KEGGimmu:67847.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130225 mRNA. Translation: AAI30226.1 .
    AF348447 mRNA. Translation: AAK30156.1 .
    RefSeqi NP_001186080.1. NM_001199151.1.
    NP_001186082.1. NM_001199153.1.
    UniGenei Mm.292168.

    3D structure databases

    ProteinModelPortali Q99ME3.
    SMRi Q99ME3. Positions 321-509, 511-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99ME3. 3 interactions.
    MINTi MINT-2739947.

    PTM databases

    PhosphoSitei Q99ME3.

    Proteomic databases

    PaxDbi Q99ME3.
    PRIDEi Q99ME3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 67847.
    KEGGi mmu:67847.

    Organism-specific databases

    CTDi 9627.
    MGIi MGI:1915097. Sncaip.

    Phylogenomic databases

    eggNOGi NOG297616.
    HOVERGENi HBG061375.
    InParanoidi Q99ME3.
    KOi K04558.

    Miscellaneous databases

    NextBioi 325703.
    PROi Q99ME3.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SNCAIP.
    Genevestigatori Q99ME3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Cloning of the mouse homolog of synphilin-1."
      Cookson M.R., O'Farrell C.A., Vink L., Singleton A.B.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-915.
      Strain: BALB/c.
      Tissue: Brain.

    Entry informationi

    Entry nameiSNCAP_MOUSE
    AccessioniPrimary (citable) accession number: Q99ME3
    Secondary accession number(s): A2BDD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3