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Q99ME3 (SNCAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synphilin-1
Alternative name(s):
Alpha-synuclein-interacting protein
Gene names
Name:Sncaip
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Associates with SNCA, RNF19A AND PARK2 By similarity.

Post-translational modification

Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation By similarity.

Sequence similarities

Contains 6 ANK repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Synphilin-1
PRO_0000320071

Regions

Repeat348 – 37932ANK 1
Repeat383 – 41230ANK 2
Repeat418 – 44730ANK 3
Repeat455 – 48430ANK 4
Repeat602 – 63130ANK 5
Repeat698 – 72831ANK 6
Coiled coil522 – 54827 Potential

Experimental info

Sequence conflict8051R → G in AAK30156. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99ME3 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: AD8980FA1F8E8BCB

FASTA962105,607
        10         20         30         40         50         60 
MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN CGVSTLITNP 

        70         80         90        100        110        120 
QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN TVEYQKGGET DQGPQPEELS 

       130        140        150        160        170        180 
PEDGVGGLPG KGSEPSQALG ELEHYDLDMD EILDVPYIKS SQQLAPLTKV TSEKRILGLC 

       190        200        210        220        230        240 
TTINGLSAKT CPIASTENST PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA 

       250        260        270        280        290        300 
LGKCGPAYES ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM 

       310        320        330        340        350        360 
NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN NLLHIAASKG 

       370        380        390        400        410        420 
HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV RWMVSETEAI AELSCSKDFP 

       430        440        450        460        470        480 
SLIHYAGCYG QEKILLWLLQ FMQEQGISLD EVDREGNSAV HVASQHGYLG CIQTLVEYGA 

       490        500        510        520        530        540 
NVTMQNHAGE KPSQSAERHG HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS 

       550        560        570        580        590        600 
QLQQLLEAQK SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL 

       610        620        630        640        650        660 
SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN SKKIPLEKRE 

       670        680        690        700        710        720 
LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP QPIVESVENV DSAESLHLMI 

       730        740        750        760        770        780 
KKHSLASGRR FPFGMKASKS LDGHSPSPTS ESSEPDLDSH GPGLGMTPPT QPSTEATQSS 

       790        800        810        820        830        840 
PDSTAAQKVA TSPKSALKSP SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR 

       850        860        870        880        890        900 
APQRTSESGE QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK 

       910        920        930        940        950        960 
GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY HMKHTAEPEP 


RE 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Cloning of the mouse homolog of synphilin-1."
Cookson M.R., O'Farrell C.A., Vink L., Singleton A.B.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-915.
Strain: BALB/c.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC130225 mRNA. Translation: AAI30226.1.
AF348447 mRNA. Translation: AAK30156.1.
RefSeqNP_001186080.1. NM_001199151.1.
NP_001186082.1. NM_001199153.1.
UniGeneMm.292168.

3D structure databases

ProteinModelPortalQ99ME3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99ME3. 3 interactions.
MINTMINT-2739947.

PTM databases

PhosphoSiteQ99ME3.

Proteomic databases

PaxDbQ99ME3.
PRIDEQ99ME3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID67847.
KEGGmmu:67847.

Organism-specific databases

CTD9627.
MGIMGI:1915097. Sncaip.

Phylogenomic databases

eggNOGNOG297616.
HOVERGENHBG061375.
InParanoidQ99ME3.
KOK04558.

Gene expression databases

CleanExMM_SNCAIP.
GenevestigatorQ99ME3.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325703.
PROQ99ME3.
SOURCESearch...

Entry information

Entry nameSNCAP_MOUSE
AccessionPrimary (citable) accession number: Q99ME3
Secondary accession number(s): A2BDD1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 18, 2013
Last modified: April 16, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot