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Q99ME3

- SNCAP_MOUSE

UniProt

Q99ME3 - SNCAP_MOUSE

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Protein
Synphilin-1
Gene
Sncaip
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. dopamine metabolic process Source: Ensembl
  2. regulation of inclusion body assembly Source: Ensembl
  3. regulation of neurotransmitter secretion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synphilin-1
Alternative name(s):
Alpha-synuclein-interacting protein
Gene namesi
Name:Sncaip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915097. Sncaip.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleolus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Synphilin-1
PRO_0000320071Add
BLAST

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ99ME3.
PRIDEiQ99ME3.

PTM databases

PhosphoSiteiQ99ME3.

Expressioni

Gene expression databases

CleanExiMM_SNCAIP.
GenevestigatoriQ99ME3.

Interactioni

Subunit structurei

Associates with SNCA, RNF19A AND PARK2 By similarity.

Protein-protein interaction databases

IntActiQ99ME3. 3 interactions.
MINTiMINT-2739947.

Structurei

3D structure databases

ProteinModelPortaliQ99ME3.
SMRiQ99ME3. Positions 321-509, 511-556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati348 – 37932ANK 1
Add
BLAST
Repeati383 – 41230ANK 2
Add
BLAST
Repeati418 – 44730ANK 3
Add
BLAST
Repeati455 – 48430ANK 4
Add
BLAST
Repeati602 – 63130ANK 5
Add
BLAST
Repeati698 – 72831ANK 6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili522 – 54827 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG297616.
HOVERGENiHBG061375.
InParanoidiQ99ME3.
KOiK04558.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ME3-1 [UniParc]FASTAAdd to Basket

« Hide

MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN    50
CGVSTLITNP QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN 100
TVEYQKGGET DQGPQPEELS PEDGVGGLPG KGSEPSQALG ELEHYDLDMD 150
EILDVPYIKS SQQLAPLTKV TSEKRILGLC TTINGLSAKT CPIASTENST 200
PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA LGKCGPAYES 250
ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM 300
NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN 350
NLLHIAASKG HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV 400
RWMVSETEAI AELSCSKDFP SLIHYAGCYG QEKILLWLLQ FMQEQGISLD 450
EVDREGNSAV HVASQHGYLG CIQTLVEYGA NVTMQNHAGE KPSQSAERHG 500
HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS QLQQLLEAQK 550
SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL 600
SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN 650
SKKIPLEKRE LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP 700
QPIVESVENV DSAESLHLMI KKHSLASGRR FPFGMKASKS LDGHSPSPTS 750
ESSEPDLDSH GPGLGMTPPT QPSTEATQSS PDSTAAQKVA TSPKSALKSP 800
SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR APQRTSESGE 850
QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK 900
GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY 950
HMKHTAEPEP RE 962
Length:962
Mass (Da):105,607
Last modified:September 18, 2013 - v2
Checksum:iAD8980FA1F8E8BCB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti805 – 8051R → G in AAK30156. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130225 mRNA. Translation: AAI30226.1.
AF348447 mRNA. Translation: AAK30156.1.
RefSeqiNP_001186080.1. NM_001199151.1.
NP_001186082.1. NM_001199153.1.
UniGeneiMm.292168.

Genome annotation databases

GeneIDi67847.
KEGGimmu:67847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130225 mRNA. Translation: AAI30226.1 .
AF348447 mRNA. Translation: AAK30156.1 .
RefSeqi NP_001186080.1. NM_001199151.1.
NP_001186082.1. NM_001199153.1.
UniGenei Mm.292168.

3D structure databases

ProteinModelPortali Q99ME3.
SMRi Q99ME3. Positions 321-509, 511-556.
ModBasei Search...

Protein-protein interaction databases

IntActi Q99ME3. 3 interactions.
MINTi MINT-2739947.

PTM databases

PhosphoSitei Q99ME3.

Proteomic databases

PaxDbi Q99ME3.
PRIDEi Q99ME3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 67847.
KEGGi mmu:67847.

Organism-specific databases

CTDi 9627.
MGIi MGI:1915097. Sncaip.

Phylogenomic databases

eggNOGi NOG297616.
HOVERGENi HBG061375.
InParanoidi Q99ME3.
KOi K04558.

Miscellaneous databases

NextBioi 325703.
PROi Q99ME3.
SOURCEi Search...

Gene expression databases

CleanExi MM_SNCAIP.
Genevestigatori Q99ME3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cloning of the mouse homolog of synphilin-1."
    Cookson M.R., O'Farrell C.A., Vink L., Singleton A.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-915.
    Strain: BALB/c.
    Tissue: Brain.

Entry informationi

Entry nameiSNCAP_MOUSE
AccessioniPrimary (citable) accession number: Q99ME3
Secondary accession number(s): A2BDD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 18, 2013
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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