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Protein

Synphilin-1

Gene

Sncaip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. identical protein binding Source: ParkinsonsUK-UCL
  2. ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. dopamine metabolic process Source: ParkinsonsUK-UCL
  2. regulation of inclusion body assembly Source: ParkinsonsUK-UCL
  3. regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synphilin-1
Alternative name(s):
Alpha-synuclein-interacting protein
Gene namesi
Name:Sncaip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915097. Sncaip.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ParkinsonsUK-UCL
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Synphilin-1PRO_0000320071Add
BLAST

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ99ME3.
PRIDEiQ99ME3.

PTM databases

PhosphoSiteiQ99ME3.

Expressioni

Gene expression databases

CleanExiMM_SNCAIP.
ExpressionAtlasiQ99ME3. baseline and differential.
GenevestigatoriQ99ME3.

Interactioni

Subunit structurei

Associates with SNCA, RNF19A AND PARK2.By similarity

Protein-protein interaction databases

IntActiQ99ME3. 3 interactions.
MINTiMINT-2739947.

Structurei

3D structure databases

ProteinModelPortaliQ99ME3.
SMRiQ99ME3. Positions 321-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati348 – 37932ANK 1Add
BLAST
Repeati383 – 41230ANK 2Add
BLAST
Repeati418 – 44730ANK 3Add
BLAST
Repeati455 – 48430ANK 4Add
BLAST
Repeati602 – 63130ANK 5Add
BLAST
Repeati698 – 72831ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili522 – 54827Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG297616.
HOVERGENiHBG061375.
InParanoidiQ99ME3.
KOiK04558.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ME3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPEYLDLD EIDFSDDISY SVTSLKTIPA LCRRCDSQNE DRSVSSSGWN
60 70 80 90 100
CGVSTLITNP QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNENEDQKNN
110 120 130 140 150
TVEYQKGGET DQGPQPEELS PEDGVGGLPG KGSEPSQALG ELEHYDLDMD
160 170 180 190 200
EILDVPYIKS SQQLAPLTKV TSEKRILGLC TTINGLSAKT CPIASTENST
210 220 230 240 250
PNMTPFCVLS PVKSPHLRKA PTALRDQHKL STEDSESSPA LGKCGPAYES
260 270 280 290 300
ENHSKDFLNK VFSDPHSRKI EKSGPDCKLR SFHLQSSAAG AKTEEPINGM
310 320 330 340 350
NWTNTQGTEE RTEYLKKVRS ILNIVNEGQI SLLPHLAADN LDKIHDENGN
360 370 380 390 400
NLLHIAASKG HAECLQHLTS LMGEDCLNER NTEQLTPAGL AIKNGQLECV
410 420 430 440 450
RWMVSETEAI AELSCSKDFP SLIHYAGCYG QEKILLWLLQ FMQEQGISLD
460 470 480 490 500
EVDREGNSAV HVASQHGYLG CIQTLVEYGA NVTMQNHAGE KPSQSAERHG
510 520 530 540 550
HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTVERVTLQS QLQQLLEAQK
560 570 580 590 600
SEGKSLPSSP SSPSSPASTK SQWKALDTDE ESTGKSKVGA QEGIQVLGSL
610 620 630 640 650
SVSSRARTKG KDEDSDKILR QLLGKEISEN VCTQEKLSLE FQDAQASSRN
660 670 680 690 700
SKKIPLEKRE LKLARLRQLM QRSLSESDTD SNNSEDPKNT PVKRADRPRP
710 720 730 740 750
QPIVESVENV DSAESLHLMI KKHSLASGRR FPFGMKASKS LDGHSPSPTS
760 770 780 790 800
ESSEPDLDSH GPGLGMTPPT QPSTEATQSS PDSTAAQKVA TSPKSALKSP
810 820 830 840 850
SSKRRTSQNS KLRVTFEEPV VQMEQTGLEL NGEKDKDKGR APQRTSESGE
860 870 880 890 900
QMKRPFGTFR SIMESLSGNQ NNNNNYQPAS QLKTCTLPLT SLGRKTADAK
910 920 930 940 950
GNPVSPASKG KNKAAMYSSC IHLPSNALVE EHLRDYARHN DIKRNATKTY
960
HMKHTAEPEP RE
Length:962
Mass (Da):105,607
Last modified:September 18, 2013 - v2
Checksum:iAD8980FA1F8E8BCB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti805 – 8051R → G in AAK30156 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130225 mRNA. Translation: AAI30226.1.
AF348447 mRNA. Translation: AAK30156.1.
RefSeqiNP_001186080.1. NM_001199151.1.
NP_001186082.1. NM_001199153.1.
UniGeneiMm.292168.

Genome annotation databases

GeneIDi67847.
KEGGimmu:67847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130225 mRNA. Translation: AAI30226.1.
AF348447 mRNA. Translation: AAK30156.1.
RefSeqiNP_001186080.1. NM_001199151.1.
NP_001186082.1. NM_001199153.1.
UniGeneiMm.292168.

3D structure databases

ProteinModelPortaliQ99ME3.
SMRiQ99ME3. Positions 321-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99ME3. 3 interactions.
MINTiMINT-2739947.

PTM databases

PhosphoSiteiQ99ME3.

Proteomic databases

PaxDbiQ99ME3.
PRIDEiQ99ME3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67847.
KEGGimmu:67847.

Organism-specific databases

CTDi9627.
MGIiMGI:1915097. Sncaip.

Phylogenomic databases

eggNOGiNOG297616.
HOVERGENiHBG061375.
InParanoidiQ99ME3.
KOiK04558.

Miscellaneous databases

NextBioi325703.
PROiQ99ME3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SNCAIP.
ExpressionAtlasiQ99ME3. baseline and differential.
GenevestigatoriQ99ME3.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cloning of the mouse homolog of synphilin-1."
    Cookson M.R., O'Farrell C.A., Vink L., Singleton A.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-915.
    Strain: BALB/c.
    Tissue: Brain.

Entry informationi

Entry nameiSNCAP_MOUSE
AccessioniPrimary (citable) accession number: Q99ME3
Secondary accession number(s): A2BDD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 18, 2013
Last modified: February 4, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.