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Protein

WD repeat-containing protein 6

Gene

Wdr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 6
Short name:
mWDR6
Gene namesi
Name:Wdr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930140 Wdr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934601 – 1125WD repeat-containing protein 6Add BLAST1125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99ME2
MaxQBiQ99ME2
PaxDbiQ99ME2
PRIDEiQ99ME2

PTM databases

iPTMnetiQ99ME2
PhosphoSitePlusiQ99ME2

Expressioni

Gene expression databases

BgeeiENSMUSG00000066357
GenevisibleiQ99ME2 MM

Interactioni

Subunit structurei

Interacts with STK11/LKB1. Interacts with IRS4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070927

Structurei

3D structure databases

ProteinModelPortaliQ99ME2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 97WD 1Add BLAST45
Repeati105 – 143WD 2Add BLAST39
Repeati147 – 189WD 3Add BLAST43
Repeati200 – 238WD 4Add BLAST39
Repeati247 – 285WD 5Add BLAST39
Repeati289 – 327WD 6Add BLAST39
Repeati335 – 376WD 7Add BLAST42
Repeati381 – 422WD 8Add BLAST42
Repeati425 – 470WD 9Add BLAST46
Repeati476 – 520WD 10Add BLAST45
Repeati559 – 598WD 11Add BLAST40
Repeati604 – 642WD 12Add BLAST39
Repeati645 – 684WD 13Add BLAST40
Repeati739 – 785WD 14Add BLAST47
Repeati848 – 897WD 15Add BLAST50
Repeati905 – 950WD 16Add BLAST46
Repeati974 – 1016WD 17Add BLAST43
Repeati1040 – 1077WD 18Add BLAST38
Repeati1083 – 1125WD 19Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0974 Eukaryota
ENOG410ZJ6J LUCA
GeneTreeiENSGT00420000029923
HOGENOMiHOG000008701
HOVERGENiHBG004019
InParanoidiQ99ME2
OMAiMHLSSHR
OrthoDBiEOG091G010D
PhylomeDBiQ99ME2
TreeFamiTF313984

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 6 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q99ME2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL
60 70 80 90 100
RMVKRVQNLL GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG
110 120 130 140 150
QSHLRELWRS GLWNMSDWIW DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ
160 170 180 190 200
DVPCTDRCTL SSACLVGDTW KELTIVAGAV SNELLIWYPA TALTDNKPVA
210 220 230 240 250
PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD LRVPGGRVQN
260 270 280 290 300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG
310 320 330 340 350
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA
360 370 380 390 400
LKAVTLAGSW RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP
410 420 430 440 450
GPEGFGLCAL ANGEGLVKVV PINTPTAAVE QKLFQGKVHS LSWALRGYEE
460 470 480 490 500
LLLLASGPGG VIACLEISAA PTGKAIFVKE RCRYLLPPSK QRWHTCSAFL
510 520 530 540 550
PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA PGAGSGSGGS
560 570 580 590 600
ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH
610 620 630 640 650
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI
660 670 680 690 700
VNCGGGHRSW AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH
710 720 730 740 750
GREITCVKRV GTVTLGPEFE VPNLEHPDSL EPGSEGPGLI DIVITGSEDT
760 770 780 790 800
TVCVLALPTT TGSAHALTSV CNHISSVRAL AVWAVGTPGG PQDTRPGLTA
810 820 830 840 850
QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL DEYWDRQRNK
860 870 880 890 900
HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS
910 920 930 940 950
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL
960 970 980 990 1000
TTAMDKGSTT LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH
1010 1020 1030 1040 1050
LVASGSEDGS LHVFTLAVKM PEPEEADGEA ELVPQLCVLE EYSVPCAHAA
1060 1070 1080 1090 1100
HVTGVKILSP KLMVSASIDQ RLTFWRLGQG EPTFMNSTVY HVPDVADMDC
1110 1120
WPVSPEFGHR CALAGQGLEV YNWYD
Length:1,125
Mass (Da):121,898
Last modified:June 1, 2001 - v1
Checksum:iF228CE5D71554766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348591 mRNA Translation: AAK31166.1
AK037181 mRNA Translation: BAC29740.1
AK146617 mRNA Translation: BAE27306.1
AK163752 mRNA Translation: BAE37480.1
CH466560 Genomic DNA Translation: EDL21306.1
BC050894 mRNA Translation: AAH50894.1
BC054367 mRNA Translation: AAH54367.1
CCDSiCCDS23532.2
RefSeqiNP_113569.1, NM_031392.2
UniGeneiMm.335454
Mm.458081

Genome annotation databases

EnsembliENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357
GeneIDi83669
KEGGimmu:83669
UCSCiuc009rqj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiWDR6_MOUSE
AccessioniPrimary (citable) accession number: Q99ME2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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