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Protein

WD repeat-containing protein 6

Gene

Wdr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 6
Short name:
mWDR6
Gene namesi
Name:Wdr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930140. Wdr6.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Colocalizes in the cytoplasm with STK11/LKB1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934601 – 1125WD repeat-containing protein 6Add BLAST1125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99ME2.
MaxQBiQ99ME2.
PaxDbiQ99ME2.
PRIDEiQ99ME2.

PTM databases

iPTMnetiQ99ME2.
PhosphoSitePlusiQ99ME2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066357.
GenevisibleiQ99ME2. MM.

Interactioni

Subunit structurei

Interacts with STK11/LKB1. Interacts with IRS4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070927.

Structurei

3D structure databases

ProteinModelPortaliQ99ME2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 109WD 1Add BLAST40
Repeati114 – 151WD 2Add BLAST38
Repeati155 – 197WD 3Add BLAST43
Repeati207 – 246WD 4Add BLAST40
Repeati256 – 294WD 5Add BLAST39
Repeati295 – 335WD 6Add BLAST41
Repeati346 – 384WD 7Add BLAST39
Repeati433 – 475WD 8Add BLAST43
Repeati489 – 528WD 9Add BLAST40
Repeati567 – 605WD 10Add BLAST39
Repeati611 – 650WD 11Add BLAST40
Repeati652 – 692WD 12Add BLAST41
Repeati725 – 765WD 13Add BLAST41
Repeati767 – 798WD 14Add BLAST32
Repeati860 – 905WD 15Add BLAST46
Repeati912 – 958WD 16Add BLAST47
Repeati982 – 1024WD 17Add BLAST43
Repeati1047 – 1085WD 18Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated
Contains 18 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0974. Eukaryota.
ENOG410ZJ6J. LUCA.
GeneTreeiENSGT00420000029923.
HOGENOMiHOG000008701.
HOVERGENiHBG004019.
InParanoidiQ99ME2.
OMAiCAKRWLT.
OrthoDBiEOG091G010D.
PhylomeDBiQ99ME2.
TreeFamiTF313984.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ME2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDLGGHL
60 70 80 90 100
RMVKRVQNLL GHFLIHGFRV RPEPKGDLDS EAMIAVFGSK GLKVVKVSWG
110 120 130 140 150
QSHLRELWRS GLWNMSDWIW DVRWIEGNVA VALGHNSVVL YDPVIGCMLQ
160 170 180 190 200
DVPCTDRCTL SSACLVGDTW KELTIVAGAV SNELLIWYPA TALTDNKPVA
210 220 230 240 250
PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRLWKVGD LRVPGGRVQN
260 270 280 290 300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHRGRG
310 320 330 340 350
IRAIATHERQ AWVVTGGDDS GIRLWHLAGR GYPGLGVSSL SFKSPSRPGA
360 370 380 390 400
LKAVTLAGSW RVLAVTDVGS LYLYDLEVKS WEQLLEDNRF RSYCLLEAAP
410 420 430 440 450
GPEGFGLCAL ANGEGLVKVV PINTPTAAVE QKLFQGKVHS LSWALRGYEE
460 470 480 490 500
LLLLASGPGG VIACLEISAA PTGKAIFVKE RCRYLLPPSK QRWHTCSAFL
510 520 530 540 550
PPGDFLVCGD RRGSVMLFPV RPCLFKKPGA GSKAITAAEA PGAGSGSGGS
560 570 580 590 600
ESVPTGIGPV STLHSLHGKQ GVTSVTCHGG YLYSTGRDSS YFQLFVHGGH
610 620 630 640 650
LQPVLRQKAC RGMNWVAGLR MVPDGSMVIL GFHANEFVVW SPRSHEKLHI
660 670 680 690 700
VNCGGGHRSW AFSDTEAAMA FTYLKDGEVM LYRALGGCIR PNVILREGLH
710 720 730 740 750
GREITCVKRV GTVTLGPEFE VPNLEHPDSL EPGSEGPGLI DIVITGSEDT
760 770 780 790 800
TVCVLALPTT TGSAHALTSV CNHISSVRAL AVWAVGTPGG PQDTRPGLTA
810 820 830 840 850
QVVSAGGRAE IHCFSVMVTP DASTPSRLAC HVMHLSSHRL DEYWDRQRNK
860 870 880 890 900
HKMIKVDPET RYMSLAICEL DNDRPGLGPG PLVAAACSDG AVRLFLLQDS
910 920 930 940 950
GRILHLLAES FHHKRCVLKV HSFTHEAPNQ RRRLILCSAA TDGSLAFWDL
960 970 980 990 1000
TTAMDKGSTT LELPAHPGLP YQMGTPSMTV QAHSCGVNSL HTLPTPEGHH
1010 1020 1030 1040 1050
LVASGSEDGS LHVFTLAVKM PEPEEADGEA ELVPQLCVLE EYSVPCAHAA
1060 1070 1080 1090 1100
HVTGVKILSP KLMVSASIDQ RLTFWRLGQG EPTFMNSTVY HVPDVADMDC
1110 1120
WPVSPEFGHR CALAGQGLEV YNWYD
Length:1,125
Mass (Da):121,898
Last modified:June 1, 2001 - v1
Checksum:iF228CE5D71554766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348591 mRNA. Translation: AAK31166.1.
AK037181 mRNA. Translation: BAC29740.1.
AK146617 mRNA. Translation: BAE27306.1.
AK163752 mRNA. Translation: BAE37480.1.
CH466560 Genomic DNA. Translation: EDL21306.1.
BC050894 mRNA. Translation: AAH50894.1.
BC054367 mRNA. Translation: AAH54367.1.
CCDSiCCDS23532.2.
RefSeqiNP_113569.1. NM_031392.2.
UniGeneiMm.335454.
Mm.458081.

Genome annotation databases

EnsembliENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357.
GeneIDi83669.
KEGGimmu:83669.
UCSCiuc009rqj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348591 mRNA. Translation: AAK31166.1.
AK037181 mRNA. Translation: BAC29740.1.
AK146617 mRNA. Translation: BAE27306.1.
AK163752 mRNA. Translation: BAE37480.1.
CH466560 Genomic DNA. Translation: EDL21306.1.
BC050894 mRNA. Translation: AAH50894.1.
BC054367 mRNA. Translation: AAH54367.1.
CCDSiCCDS23532.2.
RefSeqiNP_113569.1. NM_031392.2.
UniGeneiMm.335454.
Mm.458081.

3D structure databases

ProteinModelPortaliQ99ME2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070927.

PTM databases

iPTMnetiQ99ME2.
PhosphoSitePlusiQ99ME2.

Proteomic databases

EPDiQ99ME2.
MaxQBiQ99ME2.
PaxDbiQ99ME2.
PRIDEiQ99ME2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068700; ENSMUSP00000070927; ENSMUSG00000066357.
GeneIDi83669.
KEGGimmu:83669.
UCSCiuc009rqj.1. mouse.

Organism-specific databases

CTDi11180.
MGIiMGI:1930140. Wdr6.

Phylogenomic databases

eggNOGiKOG0974. Eukaryota.
ENOG410ZJ6J. LUCA.
GeneTreeiENSGT00420000029923.
HOGENOMiHOG000008701.
HOVERGENiHBG004019.
InParanoidiQ99ME2.
OMAiCAKRWLT.
OrthoDBiEOG091G010D.
PhylomeDBiQ99ME2.
TreeFamiTF313984.

Miscellaneous databases

ChiTaRSiWdr6. mouse.
PROiQ99ME2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066357.
GenevisibleiQ99ME2. MM.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR6_MOUSE
AccessioniPrimary (citable) accession number: Q99ME2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.