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Protein

Myoneurin

Gene

Mynn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri302 – 324C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri387 – 409C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 522C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myoneurin
Gene namesi
Name:Mynn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1931415. Mynn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482181 – 610MyoneurinAdd BLAST610

Proteomic databases

PaxDbiQ99MD8.
PeptideAtlasiQ99MD8.
PRIDEiQ99MD8.

PTM databases

iPTMnetiQ99MD8.
PhosphoSitePlusiQ99MD8.

Expressioni

Tissue specificityi

Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the cerebellum, testis, heart, brain and liver.2 Publications

Developmental stagei

Expression is developmentally regulated in muscle and is associated with neuromuscular junctions during the late embryonic period.1 Publication

Gene expression databases

BgeeiENSMUSG00000037730.
CleanExiMM_MYNN.
GenevisibleiQ99MD8. MM.

Interactioni

Protein-protein interaction databases

BioGridi219802. 1 interactor.
STRINGi10090.ENSMUSP00000041034.

Structurei

3D structure databases

ProteinModelPortaliQ99MD8.
SMRiQ99MD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 89BTBPROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 190Nuclear localization signalSequence analysisAdd BLAST17
Motifi257 – 262Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 184Poly-Lys5

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri302 – 324C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri387 – 409C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 522C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOGENOMiHOG000059547.
HOVERGENiHBG055746.
InParanoidiQ99MD8.
OMAiHCALKEH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ99MD8.
TreeFamiTF330787.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99MD8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQYSHHCEHL LERLNKQREA GFLCDCTVVI GEFQFKAHRN VLASFSEYFG
60 70 80 90 100
AIYRSTSENN VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD
110 120 130 140 150
YLKVEEVVTK CKIKMEDFAF IASPSSTEIS SITGNIELNQ QACLLTLRDY
160 170 180 190 200
NNREKSEVST DSVQANPKPR ALTKKSSQSK KKKKAFSSQK PGQSKAVQYP
210 220 230 240 250
SDVLESASVE LFLETSKLSS PVVEQIIQGN DSSELELTSV VENTFPTQDI
260 270 280 290 300
VQTVTVKRKR RKSQSHCALK EHSMSNIASV KSPYELENAG EELDARFSKA
310 320 330 340 350
KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR
360 370 380 390 400
THTGERPYKC ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS
410 420 430 440 450
NLKIHARKHS GEKPYVCDRC GQRFAQASTL TYHVRRHTGE KPYVCDTCGK
460 470 480 490 500
AFAVSSSLIT HSRKHTGEKP YICGICGKSF ISSGELNKHF RSHTGERPFI
510 520 530 540 550
CELCGNSYTD IKNLKKHKTK VHSGTDKNPD CSVDDHAVSE QDSVQRSPLS
560 570 580 590 600
ETLDVKPSDM TLPLALPLGT EDHQMLLPVT DSQSPASDTL LRSTVNGYSE
610
PQLIFLQQLY
Length:610
Mass (Da):68,593
Last modified:September 5, 2006 - v2
Checksum:i0FB8DC19C0501935
GO
Isoform 2 (identifier: Q99MD8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-495: Missing.

Show »
Length:582
Mass (Da):65,514
Checksum:iAE928F4674CB13EE
GO
Isoform 3 (identifier: Q99MD8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-60: SEYFGAIYRSTSENN → IGMLKKSIRLLTISK
     61-610: Missing.

Show »
Length:60
Mass (Da):6,990
Checksum:i5C90CF6F5824CE36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127T → A in BAB28858 (PubMed:16141072).Curated1
Sequence conflicti130S → I in BAC25584 (PubMed:16141072).Curated1
Sequence conflicti168K → Q in BAB29266 (PubMed:16141072).Curated1
Sequence conflicti185A → G in BAB29266 (PubMed:16141072).Curated1
Sequence conflicti440E → G in AAK18605 (PubMed:10873615).Curated1
Sequence conflicti512K → E in BAC25584 (PubMed:16141072).Curated1
Sequence conflicti518K → E in BAC25584 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02021846 – 60SEYFG…TSENN → IGMLKKSIRLLTISK in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_02021961 – 610Missing in isoform 3. 1 PublicationAdd BLAST550
Alternative sequenceiVSP_020220468 – 495Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349561 mRNA. Translation: AAK18605.1.
AK014315 mRNA. Translation: BAB29266.1.
AK019238 mRNA. Translation: BAC25584.2.
AK013445 mRNA. Translation: BAB28858.1.
AK136107 mRNA. Translation: BAE22823.1.
BC007477 mRNA. Translation: AAH07477.1.
BC065084 mRNA. Translation: AAH65084.1.
CCDSiCCDS17284.1. [Q99MD8-1]
CCDS79891.1. [Q99MD8-2]
RefSeqiNP_001276550.1. NM_001289621.1. [Q99MD8-2]
NP_001276551.1. NM_001289622.1.
NP_001276552.1. NM_001289623.1.
NP_085034.2. NM_030557.3. [Q99MD8-1]
UniGeneiMm.200378.

Genome annotation databases

EnsembliENSMUST00000047502; ENSMUSP00000041034; ENSMUSG00000037730. [Q99MD8-2]
ENSMUST00000192715; ENSMUSP00000141951; ENSMUSG00000037730. [Q99MD8-1]
ENSMUST00000195396; ENSMUSP00000141623; ENSMUSG00000037730. [Q99MD8-3]
ENSMUST00000195751; ENSMUSP00000141450; ENSMUSG00000037730. [Q99MD8-3]
GeneIDi80732.
KEGGimmu:80732.
UCSCiuc008oux.2. mouse. [Q99MD8-1]
uc008ouz.2. mouse. [Q99MD8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349561 mRNA. Translation: AAK18605.1.
AK014315 mRNA. Translation: BAB29266.1.
AK019238 mRNA. Translation: BAC25584.2.
AK013445 mRNA. Translation: BAB28858.1.
AK136107 mRNA. Translation: BAE22823.1.
BC007477 mRNA. Translation: AAH07477.1.
BC065084 mRNA. Translation: AAH65084.1.
CCDSiCCDS17284.1. [Q99MD8-1]
CCDS79891.1. [Q99MD8-2]
RefSeqiNP_001276550.1. NM_001289621.1. [Q99MD8-2]
NP_001276551.1. NM_001289622.1.
NP_001276552.1. NM_001289623.1.
NP_085034.2. NM_030557.3. [Q99MD8-1]
UniGeneiMm.200378.

3D structure databases

ProteinModelPortaliQ99MD8.
SMRiQ99MD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219802. 1 interactor.
STRINGi10090.ENSMUSP00000041034.

PTM databases

iPTMnetiQ99MD8.
PhosphoSitePlusiQ99MD8.

Proteomic databases

PaxDbiQ99MD8.
PeptideAtlasiQ99MD8.
PRIDEiQ99MD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047502; ENSMUSP00000041034; ENSMUSG00000037730. [Q99MD8-2]
ENSMUST00000192715; ENSMUSP00000141951; ENSMUSG00000037730. [Q99MD8-1]
ENSMUST00000195396; ENSMUSP00000141623; ENSMUSG00000037730. [Q99MD8-3]
ENSMUST00000195751; ENSMUSP00000141450; ENSMUSG00000037730. [Q99MD8-3]
GeneIDi80732.
KEGGimmu:80732.
UCSCiuc008oux.2. mouse. [Q99MD8-1]
uc008ouz.2. mouse. [Q99MD8-2]

Organism-specific databases

CTDi55892.
MGIiMGI:1931415. Mynn.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOGENOMiHOG000059547.
HOVERGENiHBG055746.
InParanoidiQ99MD8.
OMAiHCALKEH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ99MD8.
TreeFamiTF330787.

Miscellaneous databases

ChiTaRSiMynn. mouse.
PROiQ99MD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037730.
CleanExiMM_MYNN.
GenevisibleiQ99MD8. MM.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYNN_MOUSE
AccessioniPrimary (citable) accession number: Q99MD8
Secondary accession number(s): Q6P1G7
, Q8BT55, Q922I4, Q9CSA0, Q9CXJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.