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Q99MC6

- Q99MC6_RAT

UniProt

Q99MC6 - Q99MC6_RAT

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Protein
Submitted name:

V-raf murine sarcoma viral oncogene B1-like protein

Gene

Braf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. calcium ion binding Source: Ensembl
  3. MAP kinase kinase kinase activity Source: RGD
  4. mitogen-activated protein kinase kinase binding Source: RGD
  5. protein heterodimerization activity Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: GOC
  2. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. cellular response to drug Source: Ensembl
  5. long-term synaptic potentiation Source: Ensembl
  6. MAPK cascade Source: RGD
  7. myeloid progenitor cell differentiation Source: Ensembl
  8. negative regulation of endothelial cell apoptotic process Source: Ensembl
  9. negative regulation of fibroblast migration Source: Ensembl
  10. negative regulation of neuron apoptotic process Source: RGD
  11. negative regulation of synaptic vesicle exocytosis Source: Ensembl
  12. positive regulation of ERK1 and ERK2 cascade Source: RGD
  13. positive regulation of gene expression Source: Ensembl
  14. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  15. positive regulation of stress fiber assembly Source: Ensembl
  16. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  17. positive T cell selection Source: Ensembl
  18. protein heterooligomerization Source: RGD
  19. protein phosphorylation Source: RGD
  20. regulation of cell proliferation Source: Ensembl
  21. response to cAMP Source: RGD
  22. response to epidermal growth factor Source: Ensembl
  23. response to peptide hormone Source: RGD
  24. somatic stem cell maintenance Source: Ensembl
  25. visual learning Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196391. CREB phosphorylation through the activation of Ras.
REACT_199007. Spry regulation of FGF signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
V-raf murine sarcoma viral oncogene B1-like proteinImported
Gene namesi
Name:BrafImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619908. Braf.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. membrane Source: RGD
  3. mitochondrion Source: Ensembl
  4. neuron projection Source: RGD
  5. nucleus Source: RGD
  6. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ99MC6.

Expressioni

Gene expression databases

ExpressionAtlasiQ99MC6. baseline.
GenevestigatoriQ99MC6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014604.

Structurei

3D structure databases

ProteinModelPortaliQ99MC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000252972.
PhylomeDBiQ99MC6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99MC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG
60 70 80 90 100
SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL
110 120 130 140 150
HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS
160 170 180
FQSDVYAFGI VLYELMTGQL PYSNINNRDQ
Length:180
Mass (Da):20,680
Last modified:June 1, 2001 - v1
Checksum:i3B4297488F6489C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei180 – 1801Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352172 mRNA. Translation: AAK32708.1.
UniGeneiRn.205813.

Genome annotation databases

UCSCiRGD:619908. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352172 mRNA. Translation: AAK32708.1 .
UniGenei Rn.205813.

3D structure databases

ProteinModelPortali Q99MC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014604.

Chemistry

BindingDBi Q99MC6.

Proteomic databases

PaxDbi Q99MC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:619908. rat.

Organism-specific databases

RGDi 619908. Braf.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000252972.
PhylomeDBi Q99MC6.

Enzyme and pathway databases

Reactomei REACT_196391. CREB phosphorylation through the activation of Ras.
REACT_199007. Spry regulation of FGF signaling.

Gene expression databases

ExpressionAtlasi Q99MC6. baseline.
Genevestigatori Q99MC6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse."
    Walentinsson A., Helou K., Levan G.
    Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ99MC6_RAT
AccessioniPrimary (citable) accession number: Q99MC6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)