SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99MC6

- Q99MC6_RAT

UniProt

Q99MC6 - Q99MC6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: V-raf murine sarcoma viral oncogene B1-like protein
Gene
Braf
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. MAP kinase kinase kinase activity Source: RGD
  3. calcium ion binding Source: Ensembl
  4. mitogen-activated protein kinase kinase binding Source: RGD
  5. protein binding Source: RGD
  6. protein heterodimerization activity Source: RGD
  7. protein serine/threonine kinase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. MAPK cascade Source: RGD
  2. activation of MAPKK activity Source: GOC
  3. cellular response to calcium ion Source: Ensembl
  4. negative regulation of neuron apoptotic process Source: RGD
  5. positive regulation of ERK1 and ERK2 cascade Source: RGD
  6. positive regulation of gene expression Source: Ensembl
  7. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  8. protein heterooligomerization Source: RGD
  9. protein phosphorylation Source: RGD
  10. response to cAMP Source: RGD
  11. response to epidermal growth factor Source: Ensembl
  12. response to peptide hormone Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196391. CREB phosphorylation through the activation of Ras.
REACT_199007. Spry regulation of FGF signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
V-raf murine sarcoma viral oncogene B1-like proteinImported
Gene namesi
Name:BrafImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619908. Braf.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. membrane Source: RGD
  3. neuron projection Source: RGD
  4. nucleus Source: RGD
  5. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ99MC6.

Expressioni

Gene expression databases

GenevestigatoriQ99MC6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014604.

Structurei

3D structure databases

ProteinModelPortaliQ99MC6.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000252972.
InParanoidiQ99MC6.
PhylomeDBiQ99MC6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99MC6-1 [UniParc]FASTAAdd to Basket

« Hide

LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG    50
SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL 100
HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS 150
FQSDVYAFGI VLYELMTGQL PYSNINNRDQ 180
Length:180
Mass (Da):20,680
Last modified:June 1, 2001 - v1
Checksum:i3B4297488F6489C8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei180 – 1801Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352172 mRNA. Translation: AAK32708.1.
UniGeneiRn.205813.

Genome annotation databases

UCSCiRGD:619908. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352172 mRNA. Translation: AAK32708.1 .
UniGenei Rn.205813.

3D structure databases

ProteinModelPortali Q99MC6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014604.

Chemistry

BindingDBi Q99MC6.

Proteomic databases

PaxDbi Q99MC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:619908. rat.

Organism-specific databases

RGDi 619908. Braf.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000252972.
InParanoidi Q99MC6.
PhylomeDBi Q99MC6.

Enzyme and pathway databases

Reactomei REACT_196391. CREB phosphorylation through the activation of Ras.
REACT_199007. Spry regulation of FGF signaling.

Gene expression databases

Genevestigatori Q99MC6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse."
    Walentinsson A., Helou K., Levan G.
    Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ99MC6_RAT
AccessioniPrimary (citable) accession number: Q99MC6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi