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Q99MC6 (Q99MC6_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Braf RGD 619908
OrganismRattus norvegicus (Rat) EMBL AAK32708.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length180 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from mutant phenotype PubMed 17310240. Source: RGD

activation of MAPKK activity

Inferred from direct assay PubMed 10648842. Source: GOC

cellular response to calcium ion

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 18194435. Source: RGD

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 19720729. Source: RGD

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

protein heterooligomerization

Inferred from physical interaction PubMed 15917294. Source: RGD

protein phosphorylation

Inferred from direct assay PubMed 10648842PubMed 15150271. Source: RGD

response to cAMP

Inferred from mutant phenotype PubMed 19720729. Source: RGD

response to epidermal growth factor

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from mutant phenotype PubMed 19720729. Source: RGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

membrane

Inferred from direct assay PubMed 10336669. Source: RGD

neuron projection

Inferred from direct assay PubMed 10336669. Source: RGD

nucleus

Inferred from direct assay PubMed 10336669. Source: RGD

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

MAP kinase kinase kinase activity

Inferred from direct assay PubMed 10648842. Source: RGD

calcium ion binding

Inferred from electronic annotation. Source: Ensembl

mitogen-activated protein kinase kinase binding

Inferred from mutant phenotype PubMed 16508002. Source: RGD

protein binding

Inferred from physical interaction PubMed 15150271. Source: RGD

protein heterodimerization activity

Inferred from physical interaction PubMed 16508002. Source: RGD

protein serine/threonine kinase activity

Inferred from direct assay PubMed 15150271. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAK32708.1
Non-terminal residue1801 EMBL AAK32708.1

Sequences

Sequence LengthMass (Da)Tools
Q99MC6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3B4297488F6489C8

FASTA18020,680
        10         20         30         40         50         60 
LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG SSLYHHLHII 

        70         80         90        100        110        120 
ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL HEDLTVKIGD FGLATVKSRW 

       130        140        150        160        170        180 
SGSHQFEQLS GSILWMAPEV IRMQDKNPYS FQSDVYAFGI VLYELMTGQL PYSNINNRDQ 

« Hide

References

[1]"A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse."
Walentinsson A., Helou K., Levan G.
Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Brown Norway EMBL AAK32708.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF352172 mRNA. Translation: AAK32708.1.
UniGeneRn.205813.

3D structure databases

ProteinModelPortalQ99MC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014604.

Chemistry

BindingDBQ99MC6.

Proteomic databases

PaxDbQ99MC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:619908. rat.

Organism-specific databases

RGD619908. Braf.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000252972.
InParanoidQ99MC6.
PhylomeDBQ99MC6.

Gene expression databases

GenevestigatorQ99MC6.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ99MC6_RAT
AccessionPrimary (citable) accession number: Q99MC6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)