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Protein
Submitted name:

V-raf murine sarcoma viral oncogene B1-like protein

Gene

Braf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. calcium ion binding Source: Ensembl
  3. MAP kinase kinase kinase activity Source: RGD
  4. mitogen-activated protein kinase kinase binding Source: RGD
  5. protein heterodimerization activity Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: GOC
  2. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. cellular response to drug Source: Ensembl
  5. long-term synaptic potentiation Source: Ensembl
  6. MAPK cascade Source: RGD
  7. myeloid progenitor cell differentiation Source: Ensembl
  8. negative regulation of endothelial cell apoptotic process Source: Ensembl
  9. negative regulation of fibroblast migration Source: Ensembl
  10. negative regulation of neuron apoptotic process Source: RGD
  11. negative regulation of synaptic vesicle exocytosis Source: Ensembl
  12. positive regulation of ERK1 and ERK2 cascade Source: RGD
  13. positive regulation of gene expression Source: Ensembl
  14. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  15. positive regulation of stress fiber assembly Source: Ensembl
  16. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  17. positive T cell selection Source: Ensembl
  18. protein heterooligomerization Source: RGD
  19. protein phosphorylation Source: RGD
  20. regulation of cell proliferation Source: Ensembl
  21. response to cAMP Source: RGD
  22. response to peptide hormone Source: RGD
  23. somatic stem cell maintenance Source: Ensembl
  24. visual learning Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_287614. CREB phosphorylation through the activation of Ras.
REACT_307725. Spry regulation of FGF signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
V-raf murine sarcoma viral oncogene B1-like proteinImported
Gene namesi
Name:BrafImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619908. Braf.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. membrane Source: RGD
  3. mitochondrion Source: Ensembl
  4. neuron projection Source: RGD
  5. nucleus Source: RGD
  6. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ99MC6.

Expressioni

Gene expression databases

ExpressionAtlasiQ99MC6. baseline.
GenevestigatoriQ99MC6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014604.

Structurei

3D structure databases

ProteinModelPortaliQ99MC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000252972.
PhylomeDBiQ99MC6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99MC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG
60 70 80 90 100
SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL
110 120 130 140 150
HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS
160 170 180
FQSDVYAFGI VLYELMTGQL PYSNINNRDQ
Length:180
Mass (Da):20,680
Last modified:June 1, 2001 - v1
Checksum:i3B4297488F6489C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei180 – 1801Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352172 mRNA. Translation: AAK32708.1.
UniGeneiRn.205813.

Genome annotation databases

UCSCiRGD:619908. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352172 mRNA. Translation: AAK32708.1.
UniGeneiRn.205813.

3D structure databases

ProteinModelPortaliQ99MC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014604.

Chemistry

BindingDBiQ99MC6.

Proteomic databases

PaxDbiQ99MC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619908. rat.

Organism-specific databases

RGDi619908. Braf.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000252972.
PhylomeDBiQ99MC6.

Enzyme and pathway databases

ReactomeiREACT_287614. CREB phosphorylation through the activation of Ras.
REACT_307725. Spry regulation of FGF signaling.

Gene expression databases

ExpressionAtlasiQ99MC6. baseline.
GenevestigatoriQ99MC6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse."
    Walentinsson A., Helou K., Levan G.
    Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ99MC6_RAT
AccessioniPrimary (citable) accession number: Q99MC6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.