Q99MC6 (Q99MC6_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
V-raf murine sarcoma viral oncogene B1-like protein EMBL AAK32708.1

Gene names

Name:

Braf RGD 619908

Organism

Rattus norvegicus (Rat) EMBL AAK32708.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	180 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	cellular response to calcium ion Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 18194435. Source: RGD positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 19720729. Source: RGD positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from physical interaction PubMed 15917294. Source: RGD response to cAMP Inferred from mutant phenotype PubMed 19720729. Source: RGD response to epidermal growth factor stimulus Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from mutant phenotype PubMed 19720729. Source: RGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara membrane Inferred from direct assay PubMed 10336669. Source: RGD neuron projection Inferred from direct assay PubMed 10336669. Source: RGD nucleus Inferred from direct assay PubMed 10336669. Source: RGD plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro MAP kinase kinase kinase activity Inferred from direct assay PubMed 10648842. Source: RGD calcium ion binding Inferred from electronic annotation. Source: Compara mitogen-activated protein kinase kinase binding Inferred from mutant phenotype PubMed 16508002. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAK32708.1
	Non-terminal residue	180	1	EMBL AAK32708.1

Sequences

	Sequence		Length	Mass (Da)
	Q99MC6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3B4297488F6489C8	FASTA	180	20,680
	10 20 30 40 50 60 LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG SSLYHHLHII 70 80 90 100 110 120 ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL HEDLTVKIGD FGLATVKSRW 130 140 150 160 170 180 SGSHQFEQLS GSILWMAPEV IRMQDKNPYS FQSDVYAFGI VLYELMTGQL PYSNINNRDQ

References

[1]	"A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse." Walentinsson A., Helou K., Levan G. Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL AAK32708.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF352172 mRNA. Translation: AAK32708.1.
IPI	IPI00373550.
UniGene	Rn.205813.
3D structure databases
ProteinModelPortal	Q99MC6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014604.
Proteomic databases
PaxDb	Q99MC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:619908. rat.
Organism-specific databases
RGD	619908. Braf.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000252972.
InParanoid	Q99MC6.
OrthoDB	EOG41G33M.
Gene expression databases
ArrayExpress	Q99MC6.
Genevestigator	Q99MC6.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q99MC6.

Entry information

Entry name

Q99MC6_RAT

Accession

Primary (citable) accession number: Q99MC6

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)