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Q99MC6

- Q99MC6_RAT

UniProt

Q99MC6 - Q99MC6_RAT

Protein
Submitted name:

V-raf murine sarcoma viral oncogene B1-like protein

Gene

Braf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. calcium ion binding Source: Ensembl
    3. MAP kinase kinase kinase activity Source: RGD
    4. mitogen-activated protein kinase kinase binding Source: RGD
    5. protein binding Source: RGD
    6. protein heterodimerization activity Source: RGD
    7. protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. activation of MAPKK activity Source: GOC
    2. cellular response to calcium ion Source: Ensembl
    3. MAPK cascade Source: RGD
    4. negative regulation of neuron apoptotic process Source: RGD
    5. positive regulation of ERK1 and ERK2 cascade Source: RGD
    6. positive regulation of gene expression Source: Ensembl
    7. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    8. protein heterooligomerization Source: RGD
    9. protein phosphorylation Source: RGD
    10. response to cAMP Source: RGD
    11. response to epidermal growth factor Source: Ensembl
    12. response to peptide hormone Source: RGD

    Enzyme and pathway databases

    ReactomeiREACT_196391. CREB phosphorylation through the activation of Ras.
    REACT_199007. Spry regulation of FGF signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    V-raf murine sarcoma viral oncogene B1-like proteinImported
    Gene namesi
    Name:BrafImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi619908. Braf.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. membrane Source: RGD
    3. neuron projection Source: RGD
    4. nucleus Source: RGD
    5. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PaxDbiQ99MC6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99MC6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000252972.
    InParanoidiQ99MC6.
    PhylomeDBiQ99MC6.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99MC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    LNVTAPTPQQ LQAFKNEVGV LRKTRHVNIL LFMGYSTKPQ LAIVTQWCEG    50
    SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL 100
    HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS 150
    FQSDVYAFGI VLYELMTGQL PYSNINNRDQ 180
    Length:180
    Mass (Da):20,680
    Last modified:June 1, 2001 - v1
    Checksum:i3B4297488F6489C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei180 – 1801Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352172 mRNA. Translation: AAK32708.1.
    UniGeneiRn.205813.

    Genome annotation databases

    UCSCiRGD:619908. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352172 mRNA. Translation: AAK32708.1 .
    UniGenei Rn.205813.

    3D structure databases

    ProteinModelPortali Q99MC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014604.

    Chemistry

    BindingDBi Q99MC6.

    Proteomic databases

    PaxDbi Q99MC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:619908. rat.

    Organism-specific databases

    RGDi 619908. Braf.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000252972.
    InParanoidi Q99MC6.
    PhylomeDBi Q99MC6.

    Enzyme and pathway databases

    Reactomei REACT_196391. CREB phosphorylation through the activation of Ras.
    REACT_199007. Spry regulation of FGF signaling.

    Gene expression databases

    Genevestigatori Q99MC6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse."
      Walentinsson A., Helou K., Levan G.
      Mamm. Genome 12:900-908(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ99MC6_RAT
    AccessioniPrimary (citable) accession number: Q99MC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)