Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q99MC0 (PP14A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name=CPI-17
Gene names
Name:Ppp1r14a
Synonyms:Cpi, Cpi17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PP1 inhibitor family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 147147Protein phosphatase 1 regulatory subunit 14A
PRO_0000071489

Regions

Region35 – 12086Inhibitory

Amino acid modifications

Modified residue261Phosphoserine By similarity
Modified residue381Phosphothreonine By similarity
Modified residue1281Phosphoserine By similarity
Modified residue1301Phosphoserine By similarity
Modified residue1341Phosphoserine By similarity
Modified residue1361Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99MC0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 116B39AA2FA1CD12

FASTA14716,697
        10         20         30         40         50         60 
MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL 

        70         80         90        100        110        120 
EELYRGREAD MPDEVNIDEL LELDSEEERC RKIRGLLEAC LNPTEDFVQE LLAKLRGLHK 

       130        140 
QPGFPQPSPS DDPSLSPRQD PAHTAPP 

« Hide

References

[1]Yu L.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."
Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J., Uhl G.R.
Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Smooth muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF352572 mRNA. Translation: AAK35213.1.
AY050673 mRNA. Translation: AAL25831.1.
RefSeqNP_569087.1. NM_130403.1.
XP_006228706.1. XM_006228644.1.
XP_006228707.1. XM_006228645.1.
UniGeneRn.73852.

3D structure databases

ProteinModelPortalQ99MC0.
SMRQ99MC0. Positions 22-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028070.

PTM databases

PhosphoSiteQ99MC0.

Proteomic databases

PaxDbQ99MC0.
PRIDEQ99MC0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028070; ENSRNOP00000028070; ENSRNOG00000020676.
GeneID114004.
KEGGrno:114004.
UCSCRGD:620536. rat.

Organism-specific databases

CTD94274.
RGD620536. Ppp1r14a.

Phylogenomic databases

eggNOGNOG78020.
GeneTreeENSGT00390000003608.
HOGENOMHOG000231993.
HOVERGENHBG054419.
InParanoidQ99MC0.
KOK12328.
OMALHKQPGF.
OrthoDBEOG7RNK21.
PhylomeDBQ99MC0.
TreeFamTF105546.

Gene expression databases

GenevestigatorQ99MC0.

Family and domain databases

Gene3D1.10.150.220. 1 hit.
InterProIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERPTHR16188. PTHR16188. 1 hit.
PfamPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMSSF81790. SSF81790. 1 hit.
ProtoNetSearch...

Other

NextBio618150.
PROQ99MC0.

Entry information

Entry namePP14A_RAT
AccessionPrimary (citable) accession number: Q99MC0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families