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Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

Ppp1r14a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).By similarity

GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: RGD

GO - Biological processi

  • negative regulation of catalytic activity Source: GOC
  • regulation of phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiREACT_360855. RHO GTPases activate PKNs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name:
CPI-17
Gene namesi
Name:Ppp1r14a
Synonyms:Cpi, Cpi17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620536. Ppp1r14a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Protein phosphatase 1 regulatory subunit 14APRO_0000071489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity
Modified residuei38 – 381PhosphothreonineBy similarity
Modified residuei136 – 1361PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99MC0.
PRIDEiQ99MC0.

PTM databases

PhosphoSiteiQ99MC0.

Expressioni

Gene expression databases

GenevisibleiQ99MC0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028070.

Structurei

3D structure databases

ProteinModelPortaliQ99MC0.
SMRiQ99MC0. Positions 22-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 12086InhibitoryAdd
BLAST

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiNOG78020.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ99MC0.
KOiK12328.
OMAiLHKQPGF.
OrthoDBiEOG7RNK21.
PhylomeDBiQ99MC0.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99MC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL
60 70 80 90 100
DVEKWIDGRL EELYRGREAD MPDEVNIDEL LELDSEEERC RKIRGLLEAC
110 120 130 140
LNPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD PAHTAPP
Length:147
Mass (Da):16,697
Last modified:June 1, 2001 - v1
Checksum:i116B39AA2FA1CD12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352572 mRNA. Translation: AAK35213.1.
AY050673 mRNA. Translation: AAL25831.1.
RefSeqiNP_569087.1. NM_130403.1.
UniGeneiRn.73852.

Genome annotation databases

EnsembliENSRNOT00000028070; ENSRNOP00000028070; ENSRNOG00000020676.
GeneIDi114004.
KEGGirno:114004.
UCSCiRGD:620536. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352572 mRNA. Translation: AAK35213.1.
AY050673 mRNA. Translation: AAL25831.1.
RefSeqiNP_569087.1. NM_130403.1.
UniGeneiRn.73852.

3D structure databases

ProteinModelPortaliQ99MC0.
SMRiQ99MC0. Positions 22-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028070.

PTM databases

PhosphoSiteiQ99MC0.

Proteomic databases

PaxDbiQ99MC0.
PRIDEiQ99MC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028070; ENSRNOP00000028070; ENSRNOG00000020676.
GeneIDi114004.
KEGGirno:114004.
UCSCiRGD:620536. rat.

Organism-specific databases

CTDi94274.
RGDi620536. Ppp1r14a.

Phylogenomic databases

eggNOGiNOG78020.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ99MC0.
KOiK12328.
OMAiLHKQPGF.
OrthoDBiEOG7RNK21.
PhylomeDBiQ99MC0.
TreeFamiTF105546.

Enzyme and pathway databases

ReactomeiREACT_360855. RHO GTPases activate PKNs.

Miscellaneous databases

NextBioi618150.
PROiQ99MC0.

Gene expression databases

GenevisibleiQ99MC0. RN.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Yu L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."
    Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J., Uhl G.R.
    Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Smooth muscle.

Entry informationi

Entry nameiPP14A_RAT
AccessioniPrimary (citable) accession number: Q99MC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.