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Q99MC0

- PP14A_RAT

UniProt

Q99MC0 - PP14A_RAT

Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

Ppp1r14a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction By similarity.By similarity

    GO - Molecular functioni

    1. protein phosphatase inhibitor activity Source: RGD

    GO - Biological processi

    1. negative regulation of catalytic activity Source: GOC
    2. regulation of phosphorylation Source: InterPro

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14A
    Alternative name(s):
    17 kDa PKC-potentiated inhibitory protein of PP1
    Protein kinase C-potentiated inhibitor protein of 17 kDa
    Short name:
    CPI-17
    Gene namesi
    Name:Ppp1r14a
    Synonyms:Cpi, Cpi17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620536. Ppp1r14a.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Protein phosphatase 1 regulatory subunit 14APRO_0000071489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261PhosphoserineBy similarity
    Modified residuei38 – 381PhosphothreonineBy similarity
    Modified residuei128 – 1281PhosphoserineBy similarity
    Modified residuei130 – 1301PhosphoserineBy similarity
    Modified residuei134 – 1341PhosphoserineBy similarity
    Modified residuei136 – 1361PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ99MC0.
    PRIDEiQ99MC0.

    PTM databases

    PhosphoSiteiQ99MC0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99MC0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99MC0.
    SMRiQ99MC0. Positions 22-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 12086InhibitoryAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP1 inhibitor family.Curated

    Phylogenomic databases

    eggNOGiNOG78020.
    GeneTreeiENSGT00390000003608.
    HOGENOMiHOG000231993.
    HOVERGENiHBG054419.
    InParanoidiQ99MC0.
    KOiK12328.
    OMAiLHKQPGF.
    OrthoDBiEOG7RNK21.
    PhylomeDBiQ99MC0.
    TreeFamiTF105546.

    Family and domain databases

    Gene3Di1.10.150.220. 1 hit.
    InterProiIPR008025. PP1_inhibitor.
    [Graphical view]
    PANTHERiPTHR16188. PTHR16188. 1 hit.
    PfamiPF05361. PP1_inhibitor. 1 hit.
    [Graphical view]
    SUPFAMiSSF81790. SSF81790. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99MC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL    50
    DVEKWIDGRL EELYRGREAD MPDEVNIDEL LELDSEEERC RKIRGLLEAC 100
    LNPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD PAHTAPP 147
    Length:147
    Mass (Da):16,697
    Last modified:June 1, 2001 - v1
    Checksum:i116B39AA2FA1CD12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352572 mRNA. Translation: AAK35213.1.
    AY050673 mRNA. Translation: AAL25831.1.
    RefSeqiNP_569087.1. NM_130403.1.
    XP_006228706.1. XM_006228644.1.
    XP_006228707.1. XM_006228645.1.
    UniGeneiRn.73852.

    Genome annotation databases

    EnsembliENSRNOT00000028070; ENSRNOP00000028070; ENSRNOG00000020676.
    GeneIDi114004.
    KEGGirno:114004.
    UCSCiRGD:620536. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352572 mRNA. Translation: AAK35213.1 .
    AY050673 mRNA. Translation: AAL25831.1 .
    RefSeqi NP_569087.1. NM_130403.1.
    XP_006228706.1. XM_006228644.1.
    XP_006228707.1. XM_006228645.1.
    UniGenei Rn.73852.

    3D structure databases

    ProteinModelPortali Q99MC0.
    SMRi Q99MC0. Positions 22-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028070.

    PTM databases

    PhosphoSitei Q99MC0.

    Proteomic databases

    PaxDbi Q99MC0.
    PRIDEi Q99MC0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028070 ; ENSRNOP00000028070 ; ENSRNOG00000020676 .
    GeneIDi 114004.
    KEGGi rno:114004.
    UCSCi RGD:620536. rat.

    Organism-specific databases

    CTDi 94274.
    RGDi 620536. Ppp1r14a.

    Phylogenomic databases

    eggNOGi NOG78020.
    GeneTreei ENSGT00390000003608.
    HOGENOMi HOG000231993.
    HOVERGENi HBG054419.
    InParanoidi Q99MC0.
    KOi K12328.
    OMAi LHKQPGF.
    OrthoDBi EOG7RNK21.
    PhylomeDBi Q99MC0.
    TreeFami TF105546.

    Miscellaneous databases

    NextBioi 618150.
    PROi Q99MC0.

    Gene expression databases

    Genevestigatori Q99MC0.

    Family and domain databases

    Gene3Di 1.10.150.220. 1 hit.
    InterProi IPR008025. PP1_inhibitor.
    [Graphical view ]
    PANTHERi PTHR16188. PTHR16188. 1 hit.
    Pfami PF05361. PP1_inhibitor. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81790. SSF81790. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Yu L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."
      Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J., Uhl G.R.
      Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Smooth muscle.

    Entry informationi

    Entry nameiPP14A_RAT
    AccessioniPrimary (citable) accession number: Q99MC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3