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Protein

RING finger protein 141

Gene

Rnf141

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 19238RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • ubiquitin-protein transferase activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein autoubiquitination Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 141
Alternative name(s):
Zinc finger protein 230
Gene namesi
Name:Rnf141
Synonyms:Znf230
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914400. Rnf141.

Subcellular locationi

  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 230229RING finger protein 141PRO_0000056102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ99MB7.
PaxDbiQ99MB7.
PRIDEiQ99MB7.

PTM databases

iPTMnetiQ99MB7.
PhosphoSiteiQ99MB7.

Expressioni

Tissue specificityi

Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney, pancreas, lung, liver and testis. Isoform 3 is expressed in heart, liver, and kidney.1 Publication

Developmental stagei

Expression was first detected at postnatal day 6, and reached the adult level between postnatal day 14 and 21.1 Publication

Gene expression databases

BgeeiQ99MB7.
CleanExiMM_RNF141.
ExpressionAtlasiQ99MB7. baseline and differential.
GenevisibleiQ99MB7. MM.

Interactioni

Protein-protein interaction databases

BioGridi211978. 1 interaction.
STRINGi10090.ENSMUSP00000102293.

Structurei

3D structure databases

ProteinModelPortaliQ99MB7.
SMRiQ99MB7. Positions 144-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 19238RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1039. Eukaryota.
ENOG410XRM0. LUCA.
GeneTreeiENSGT00390000003145.
HOGENOMiHOG000247058.
HOVERGENiHBG055763.
InParanoidiQ99MB7.
OMAiVAVRVVC.
TreeFamiTF323284.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99MB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQQISDQTQ LVINKLPEKV AKHVTLVRES GSLTYEEFLG RVAELNDVTA
60 70 80 90 100
KVAAGQEKHL LFEVQPGSDS SAFWKVVVRV VCTKINKSSG IVEASRIMNL
110 120 130 140 150
YQFIQLYKDI TSQAAGVLAQ SSTSEEPDEN PSSVTSCQAS LWMGRVKQLT
160 170 180 190 200
DEEECCICMD GRADLILPCA HSFCQKCIDK WSDRHRNCPI CRLQMTGANE
210 220 230
SWVVSDAPTE DDMANYILNM ADEAGQPHRP
Length:230
Mass (Da):25,529
Last modified:September 13, 2005 - v2
Checksum:iD2196217AB2973E6
GO
Isoform 2 (identifier: Q99MB7-2)

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q99MB7-3)

Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 112QL → HV in BAB27871 (PubMed:16141072).Curated
Sequence conflicti139 – 1391A → S in AAK31205 (PubMed:12804569).Curated
Sequence conflicti148 – 1481Q → R in BAB24742 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353167 mRNA. Translation: AAK31205.1.
AK006791 mRNA. Translation: BAB24742.1.
AK011839 mRNA. Translation: BAB27871.1.
AK015505 mRNA. Translation: BAB29874.1.
BC018553 mRNA. Translation: AAH18553.1.
CCDSiCCDS40086.1. [Q99MB7-1]
RefSeqiNP_080275.2. NM_025999.3. [Q99MB7-1]
XP_006508186.1. XM_006508123.2. [Q99MB7-1]
XP_006508187.1. XM_006508124.2. [Q99MB7-1]
UniGeneiMm.486738.
Mm.96867.

Genome annotation databases

EnsembliENSMUST00000106682; ENSMUSP00000102293; ENSMUSG00000030788. [Q99MB7-1]
ENSMUST00000177236; ENSMUSP00000134781; ENSMUSG00000030788. [Q99MB7-1]
GeneIDi67150.
KEGGimmu:67150.
UCSCiuc009jfp.1. mouse. [Q99MB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353167 mRNA. Translation: AAK31205.1.
AK006791 mRNA. Translation: BAB24742.1.
AK011839 mRNA. Translation: BAB27871.1.
AK015505 mRNA. Translation: BAB29874.1.
BC018553 mRNA. Translation: AAH18553.1.
CCDSiCCDS40086.1. [Q99MB7-1]
RefSeqiNP_080275.2. NM_025999.3. [Q99MB7-1]
XP_006508186.1. XM_006508123.2. [Q99MB7-1]
XP_006508187.1. XM_006508124.2. [Q99MB7-1]
UniGeneiMm.486738.
Mm.96867.

3D structure databases

ProteinModelPortaliQ99MB7.
SMRiQ99MB7. Positions 144-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211978. 1 interaction.
STRINGi10090.ENSMUSP00000102293.

PTM databases

iPTMnetiQ99MB7.
PhosphoSiteiQ99MB7.

Proteomic databases

MaxQBiQ99MB7.
PaxDbiQ99MB7.
PRIDEiQ99MB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106682; ENSMUSP00000102293; ENSMUSG00000030788. [Q99MB7-1]
ENSMUST00000177236; ENSMUSP00000134781; ENSMUSG00000030788. [Q99MB7-1]
GeneIDi67150.
KEGGimmu:67150.
UCSCiuc009jfp.1. mouse. [Q99MB7-1]

Organism-specific databases

CTDi50862.
MGIiMGI:1914400. Rnf141.

Phylogenomic databases

eggNOGiKOG1039. Eukaryota.
ENOG410XRM0. LUCA.
GeneTreeiENSGT00390000003145.
HOGENOMiHOG000247058.
HOVERGENiHBG055763.
InParanoidiQ99MB7.
OMAiVAVRVVC.
TreeFamiTF323284.

Miscellaneous databases

PROiQ99MB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ99MB7.
CleanExiMM_RNF141.
ExpressionAtlasiQ99MB7. baseline and differential.
GenevisibleiQ99MB7. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230."
    Qiu W., Zhang S., Xiao C., Xu W., Ma Y., Liu Y., Wu Q.
    Biochem. Biophys. Res. Commun. 306:347-353(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ALTERNATIVE SPLICING.
    Strain: Kunming.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiRN141_MOUSE
AccessioniPrimary (citable) accession number: Q99MB7
Secondary accession number(s): Q9D040, Q9D5C4, Q9D9L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.