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Protein

Mitochondrial fission regulator 1

Gene

Mtfr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission.1 Publication

GO - Biological processi

  • aerobic respiration Source: UniProtKB
  • mitochondrial fission Source: UniProtKB
  • mitochondrion organization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission regulator 1
Alternative name(s):
Chondrocyte protein with a poly-proline region
Gene namesi
Name:Mtfr1
Synonyms:Chppr, Kiaa0009
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1914722 Mtfr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. However, oxidative DNA damages appear in the testis, associated with a reduced expression of genes encoding enzymes with oxidoreductase activity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionSequence analysisAdd BLAST48
ChainiPRO_000009662349 – 328Mitochondrial fission regulator 1Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99MB2
PaxDbiQ99MB2
PRIDEiQ99MB2

PTM databases

iPTMnetiQ99MB2
PhosphoSitePlusiQ99MB2

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027601
CleanExiMM_MTFR1
ExpressionAtlasiQ99MB2 baseline and differential
GenevisibleiQ99MB2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112752

Structurei

3D structure databases

ProteinModelPortaliQ99MB2
SMRiQ99MB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 299Necessary and sufficient to promote mitochondrial fissionBy similarityAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 167Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 196Pro-richAdd BLAST13

Sequence similaritiesi

Belongs to the MTFR1 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiENOG410IEID Eukaryota
ENOG4111K5H LUCA
GeneTreeiENSGT00530000063223
HOGENOMiHOG000013162
HOVERGENiHBG056951
InParanoidiQ99MB2
OMAiALQKICA
OrthoDBiEOG091G0DDL
PhylomeDBiQ99MB2
TreeFamiTF331404

Family and domain databases

InterProiView protein in InterPro
IPR007972 Mtfr1
PANTHERiPTHR14215 PTHR14215, 1 hit
PfamiView protein in Pfam
PF05308 Mito_fiss_reg, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGWIKCLMR MWFQRVGVSM QSVLWSGKPY GSSRSIVRKI GTNLSLIQCP
60 70 80 90 100
RVQFQLTSHA TEWSPAHSGE DAVASFADVG LVATEEGECS IRLRAEVSSK
110 120 130 140 150
PPHEDDPPCF EKPPSRHTSF PSLSQDKPSP ERTLASEEAL QKISALENEL
160 170 180 190 200
AALRAQIAKI VTLQEQQSPS AGCLDSSTSV TVAPPPPPPP PPPPLPLVLH
210 220 230 240 250
QSTSALDLIK ERREQRLSAG KTLATGHPKK PDMPNMLEIL KDMNSVKLRS
260 270 280 290 300
VKRSEKDVKP RPADTDHAAF IAEALKKKFA YRHNSQGETE RGIPKPESEA
310 320
TSEPALFGPH ILKSTGKMKA LIENVPDS
Length:328
Mass (Da):35,905
Last modified:June 1, 2001 - v1
Checksum:i69C9352E2654B653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354708 mRNA Translation: AAK26434.1
AK004846 mRNA Translation: BAB23612.2
AK006952 mRNA Translation: BAB24802.2
AK075822 mRNA Translation: BAC35988.1
AK075992 mRNA Translation: BAC36103.1
BC019971 mRNA Translation: AAH19971.1
CCDSiCCDS17256.1
RefSeqiNP_001240319.1, NM_001253390.1
NP_001240320.1, NM_001253391.1
NP_080458.1, NM_026182.5
XP_006535589.1, XM_006535526.2
XP_011248010.1, XM_011249708.2
UniGeneiMm.45125

Genome annotation databases

EnsembliENSMUST00000117529; ENSMUSP00000112824; ENSMUSG00000027601
ENSMUST00000119865; ENSMUSP00000112752; ENSMUSG00000027601
ENSMUST00000130645; ENSMUSP00000119724; ENSMUSG00000027601
GeneIDi67472
KEGGimmu:67472
UCSCiuc008orp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMTFR1_MOUSE
AccessioniPrimary (citable) accession number: Q99MB2
Secondary accession number(s): Q9CQZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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