Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial fission regulator 1

Gene

Mtfr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission.1 Publication

GO - Biological processi

  • aerobic respiration Source: UniProtKB
  • mitochondrial fission Source: UniProtKB
  • mitochondrion organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission regulator 1
Alternative name(s):
Chondrocyte protein with a poly-proline region
Gene namesi
Name:Mtfr1
Synonyms:Chppr, Kiaa0009
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914722. Mtfr1.

Subcellular locationi

  • Mitochondrion By similarity

  • Note: May be associated with the inner and the outer mitochondrial membrane.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. However, oxidative DNA damages appear in the testis, associated with a reduced expression of genes encoding enzymes with oxidoreductase activity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionSequence analysisAdd BLAST48
ChainiPRO_000009662349 – 328Mitochondrial fission regulator 1Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99MB2.
PaxDbiQ99MB2.
PRIDEiQ99MB2.

PTM databases

iPTMnetiQ99MB2.
PhosphoSitePlusiQ99MB2.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027601.
CleanExiMM_MTFR1.
ExpressionAtlasiQ99MB2. baseline and differential.
GenevisibleiQ99MB2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112752.

Structurei

3D structure databases

ProteinModelPortaliQ99MB2.
SMRiQ99MB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 299Necessary and sufficient to promote mitochondrial fissionBy similarityAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 167Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 196Pro-richAdd BLAST13

Sequence similaritiesi

Belongs to the MTFR1 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiENOG410IEID. Eukaryota.
ENOG4111K5H. LUCA.
GeneTreeiENSGT00530000063223.
HOGENOMiHOG000013162.
HOVERGENiHBG056951.
InParanoidiQ99MB2.
OMAiDMPNMLE.
OrthoDBiEOG091G0DDL.
PhylomeDBiQ99MB2.
TreeFamiTF331404.

Family and domain databases

InterProiIPR007972. Mtfr1.
[Graphical view]
PANTHERiPTHR14215. PTHR14215. 1 hit.
PfamiPF05308. Mito_fiss_reg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99MB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGWIKCLMR MWFQRVGVSM QSVLWSGKPY GSSRSIVRKI GTNLSLIQCP
60 70 80 90 100
RVQFQLTSHA TEWSPAHSGE DAVASFADVG LVATEEGECS IRLRAEVSSK
110 120 130 140 150
PPHEDDPPCF EKPPSRHTSF PSLSQDKPSP ERTLASEEAL QKISALENEL
160 170 180 190 200
AALRAQIAKI VTLQEQQSPS AGCLDSSTSV TVAPPPPPPP PPPPLPLVLH
210 220 230 240 250
QSTSALDLIK ERREQRLSAG KTLATGHPKK PDMPNMLEIL KDMNSVKLRS
260 270 280 290 300
VKRSEKDVKP RPADTDHAAF IAEALKKKFA YRHNSQGETE RGIPKPESEA
310 320
TSEPALFGPH ILKSTGKMKA LIENVPDS
Length:328
Mass (Da):35,905
Last modified:June 1, 2001 - v1
Checksum:i69C9352E2654B653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354708 mRNA. Translation: AAK26434.1.
AK004846 mRNA. Translation: BAB23612.2.
AK006952 mRNA. Translation: BAB24802.2.
AK075822 mRNA. Translation: BAC35988.1.
AK075992 mRNA. Translation: BAC36103.1.
BC019971 mRNA. Translation: AAH19971.1.
CCDSiCCDS17256.1.
RefSeqiNP_001240319.1. NM_001253390.1.
NP_001240320.1. NM_001253391.1.
NP_080458.1. NM_026182.5.
XP_006535589.1. XM_006535526.2.
XP_011248010.1. XM_011249708.2.
UniGeneiMm.45125.

Genome annotation databases

EnsembliENSMUST00000117529; ENSMUSP00000112824; ENSMUSG00000027601.
ENSMUST00000119865; ENSMUSP00000112752; ENSMUSG00000027601.
ENSMUST00000130645; ENSMUSP00000119724; ENSMUSG00000027601.
GeneIDi67472.
KEGGimmu:67472.
UCSCiuc008orp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354708 mRNA. Translation: AAK26434.1.
AK004846 mRNA. Translation: BAB23612.2.
AK006952 mRNA. Translation: BAB24802.2.
AK075822 mRNA. Translation: BAC35988.1.
AK075992 mRNA. Translation: BAC36103.1.
BC019971 mRNA. Translation: AAH19971.1.
CCDSiCCDS17256.1.
RefSeqiNP_001240319.1. NM_001253390.1.
NP_001240320.1. NM_001253391.1.
NP_080458.1. NM_026182.5.
XP_006535589.1. XM_006535526.2.
XP_011248010.1. XM_011249708.2.
UniGeneiMm.45125.

3D structure databases

ProteinModelPortaliQ99MB2.
SMRiQ99MB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112752.

PTM databases

iPTMnetiQ99MB2.
PhosphoSitePlusiQ99MB2.

Proteomic databases

MaxQBiQ99MB2.
PaxDbiQ99MB2.
PRIDEiQ99MB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117529; ENSMUSP00000112824; ENSMUSG00000027601.
ENSMUST00000119865; ENSMUSP00000112752; ENSMUSG00000027601.
ENSMUST00000130645; ENSMUSP00000119724; ENSMUSG00000027601.
GeneIDi67472.
KEGGimmu:67472.
UCSCiuc008orp.2. mouse.

Organism-specific databases

CTDi9650.
MGIiMGI:1914722. Mtfr1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IEID. Eukaryota.
ENOG4111K5H. LUCA.
GeneTreeiENSGT00530000063223.
HOGENOMiHOG000013162.
HOVERGENiHBG056951.
InParanoidiQ99MB2.
OMAiDMPNMLE.
OrthoDBiEOG091G0DDL.
PhylomeDBiQ99MB2.
TreeFamiTF331404.

Miscellaneous databases

PROiQ99MB2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027601.
CleanExiMM_MTFR1.
ExpressionAtlasiQ99MB2. baseline and differential.
GenevisibleiQ99MB2. MM.

Family and domain databases

InterProiIPR007972. Mtfr1.
[Graphical view]
PANTHERiPTHR14215. PTHR14215. 1 hit.
PfamiPF05308. Mito_fiss_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTFR1_MOUSE
AccessioniPrimary (citable) accession number: Q99MB2
Secondary accession number(s): Q9CQZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.