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Protein

Cbp/p300-interacting transactivator 4

Gene

Cited4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 4
Alternative name(s):
MSG1-related protein 2
Short name:
MRG-2
Gene namesi
Name:Cited4Imported
Synonyms:Mrg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620113. Cited4.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Cbp/p300-interacting transactivator 4PRO_0000233311Add
BLAST

Proteomic databases

PaxDbiQ99MA0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046607.
GenevisibleiQ99MA0. RN.

Interactioni

Subunit structurei

Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99MA0.
SMRiQ99MA0. Positions 122-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 122106Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CITED family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOVERGENiHBG075182.
InParanoidiQ99MA0.
OMAiSFQPFPA.
OrthoDBiEOG091G11W9.
PhylomeDBiQ99MA0.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99MA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHLMLAEG YCLLQVPHAP RTLQPYPGPG LDSGLRPRGA PLGPPPPSGT
60 70 80 90 100
LAYGSFGSPV SFQPFPVSQP PGAGNAHLQS AATPSPGRMP APPSAAGGPS
110 120 130 140 150
PLQPAPGAAS PLPLPPPPPL PPALGCMDAE LIDEEALTSL ELELGLHRVR
160 170
ELPELFLGQS EFDCFSDLGS VPAAGSVSC
Length:179
Mass (Da):18,158
Last modified:June 1, 2001 - v1
Checksum:i7B1A819DE7865284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361477 mRNA. Translation: AAK30622.1.
RefSeqiNP_446151.1. NM_053699.1.
UniGeneiRn.40380.

Genome annotation databases

EnsembliENSRNOT00000072427; ENSRNOP00000064826; ENSRNOG00000046607.
GeneIDi114491.
KEGGirno:114491.
UCSCiRGD:620113. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361477 mRNA. Translation: AAK30622.1.
RefSeqiNP_446151.1. NM_053699.1.
UniGeneiRn.40380.

3D structure databases

ProteinModelPortaliQ99MA0.
SMRiQ99MA0. Positions 122-168.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ99MA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072427; ENSRNOP00000064826; ENSRNOG00000046607.
GeneIDi114491.
KEGGirno:114491.
UCSCiRGD:620113. rat.

Organism-specific databases

CTDi163732.
RGDi620113. Cited4.

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOVERGENiHBG075182.
InParanoidiQ99MA0.
OMAiSFQPFPA.
OrthoDBiEOG091G11W9.
PhylomeDBiQ99MA0.

Miscellaneous databases

PROiQ99MA0.

Gene expression databases

BgeeiENSRNOG00000046607.
GenevisibleiQ99MA0. RN.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCITE4_RAT
AccessioniPrimary (citable) accession number: Q99MA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.