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Protein

Transcriptional repressor scratch 1

Gene

Scrt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of neuron migration Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 1
Alternative name(s):
Scratch homolog 1 zinc finger protein
Short name:
SCRT
Short name:
Scratch 1
Short name:
mScrt
Gene namesi
Name:Scrt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2176606. Scrt1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Transcriptional repressor scratch 1PRO_0000047037Add
BLAST

Proteomic databases

MaxQBiQ99M85.
PaxDbiQ99M85.
PRIDEiQ99M85.

PTM databases

iPTMnetiQ99M85.
PhosphoSiteiQ99M85.

Expressioni

Developmental stagei

Detected throughout the spinal cord except in the ventricular zone surrounding the central canal, which contains proliferating neurons, and dorsal root ganglia at E11.5. At E12.5, detected in the telencephalon, and by E14.5 a distinct laminar pattern of expression was seen in regions adjacent to the ventricular zone. In the developing eye, expression was detected in the inner nuclear layer of the retina beginning at E13.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000048385.
GenevisibleiQ99M85. MM.

Interactioni

Subunit structurei

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094093.

Structurei

3D structure databases

ProteinModelPortaliQ99M85.
SMRiQ99M85. Positions 191-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Domaini

The N-terminal non zinc-finger region mediates the repressor activity.By similarity

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ99M85.
KOiK09219.
OMAiRCHKAFA.
OrthoDBiEOG091G0Q0V.
PhylomeDBiQ99M85.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99M85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKKV KLDTFSSADL DSSYGRARSD LGVRLQDKGY LSDYVGPASV
60 70 80 90 100
YDGDAEAALL KGPSPEPMYA AAVRGELGPA ASGSAPPPTP RPELATAAGG
110 120 130 140 150
YINGDAAVSE GYAADAFFIT DGRSRRKAAN ANAAAAPSTA SVAAPDSDAG
160 170 180 190 200
GGGGPGTRGS GSGSASRGGT RVGAGTEARA GSGATGAGGR HACGECGKTY
210 220 230 240 250
ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH LLTHDLRHKC
260 270 280 290 300
GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA
310 320 330 340
FKHFQCKRCK KSFALKSYLN KHYESACFKG GASGPATPAP PQLSPVQA
Length:348
Mass (Da):35,919
Last modified:June 1, 2001 - v1
Checksum:i98734743D56C204F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014997 mRNA. Translation: AAK01468.1.
BC057562 mRNA. Translation: AAH57562.1.
CCDSiCCDS37123.1.
RefSeqiNP_570963.1. NM_130893.3.
UniGeneiMm.218747.

Genome annotation databases

EnsembliENSMUST00000096365; ENSMUSP00000094093; ENSMUSG00000048385.
ENSMUST00000164703; ENSMUSP00000131152; ENSMUSG00000048385.
GeneIDi170729.
KEGGimmu:170729.
UCSCiuc007wko.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014997 mRNA. Translation: AAK01468.1.
BC057562 mRNA. Translation: AAH57562.1.
CCDSiCCDS37123.1.
RefSeqiNP_570963.1. NM_130893.3.
UniGeneiMm.218747.

3D structure databases

ProteinModelPortaliQ99M85.
SMRiQ99M85. Positions 191-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094093.

PTM databases

iPTMnetiQ99M85.
PhosphoSiteiQ99M85.

Proteomic databases

MaxQBiQ99M85.
PaxDbiQ99M85.
PRIDEiQ99M85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096365; ENSMUSP00000094093; ENSMUSG00000048385.
ENSMUST00000164703; ENSMUSP00000131152; ENSMUSG00000048385.
GeneIDi170729.
KEGGimmu:170729.
UCSCiuc007wko.1. mouse.

Organism-specific databases

CTDi83482.
MGIiMGI:2176606. Scrt1.

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ99M85.
KOiK09219.
OMAiRCHKAFA.
OrthoDBiEOG091G0Q0V.
PhylomeDBiQ99M85.
TreeFamiTF315515.

Miscellaneous databases

ChiTaRSiScrt1. mouse.
PROiQ99M85.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048385.
GenevisibleiQ99M85. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCRT1_MOUSE
AccessioniPrimary (citable) accession number: Q99M85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.