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Q99M80

- PTPRT_MOUSE

UniProt

Q99M80 - PTPRT_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase T

Gene
Ptprt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1065 – 10651Substrate By similarity
Active sitei1097 – 10971Phosphocysteine intermediate By similarity
Binding sitei1141 – 11411Substrate By similarity
Active sitei1391 – 13911Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. alpha-actinin binding Source: MGI
  2. alpha-catenin binding Source: MGI
  3. beta-catenin binding Source: MGI
  4. cadherin binding Source: MGI
  5. delta-catenin binding Source: MGI
  6. gamma-catenin binding Source: MGI
  7. protein tyrosine phosphatase activity Source: MGI
  8. thiolester hydrolase activity Source: MGI

GO - Biological processi

  1. homophilic cell adhesion Source: Ensembl
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: MGI
  4. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
RPTPmam4
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Short name:
mRPTPrho
Gene namesi
Name:Ptprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1321152. Ptprt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 770741Extracellular Reviewed predictionAdd
BLAST
Transmembranei771 – 79121Helical; Reviewed predictionAdd
BLAST
Topological domaini792 – 1454663Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 14541425Receptor-type tyrosine-protein phosphatase TPRO_0000025464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi217 ↔ 271 Reviewed prediction
Glycosylationi425 – 4251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi551 – 5511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi605 – 6051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi658 – 6581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi688 – 6881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99M80.
PRIDEiQ99M80.

PTM databases

PhosphoSiteiQ99M80.

Expressioni

Tissue specificityi

Expression is restricted to the CNS. Distributed throughout the brain and spinal cord.1 Publication

Developmental stagei

Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6.

Gene expression databases

ArrayExpressiQ99M80.
BgeeiQ99M80.
CleanExiMM_PTPRT.
GenevestigatoriQ99M80.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105067.

Structurei

3D structure databases

ProteinModelPortaliQ99M80.
SMRiQ99M80. Positions 33-595, 879-1454.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 195162MAMAdd
BLAST
Domaini197 – 28892Ig-like C2-typeAdd
BLAST
Domaini295 – 38894Fibronectin type-III 1Add
BLAST
Domaini393 – 48795Fibronectin type-III 2Add
BLAST
Domaini488 – 594107Fibronectin type-III 3Add
BLAST
Domaini670 – 76798Fibronectin type-III 4Add
BLAST
Domaini902 – 1156255Tyrosine-protein phosphatase 1Add
BLAST
Domaini1188 – 1450263Tyrosine-protein phosphatase 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1097 – 11037Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00640000091300.
HOVERGENiHBG062785.
KOiK13297.
OMAiTHPYRTC.
OrthoDBiEOG70KGNP.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99M80-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSLGGLALC LLRLLLLGLQ RPPLPGAGAQ SAAGGCSFDE HYSNCGYSVA     50
LGTNGFTWEQ INTWEKPMLD PAVPTGSFMM VNSSGRASGQ KAHLLLPTLK 100
ENDTHCIDFH YYFSSRDRSS PGALNVYVKV NGGPQGNPVW NVSGVVTEGW 150
VKAELAISTF WPHFYQVIFE SVSLKGHPGY IAVDEVRVLA HPCRKAPHFL 200
RLQNVEVNVG QNATFQCIAG GKWSQHDKLW LQQWNGRDTA LMVTRVVNHR 250
RFSATVSVAD TSQRSISKYR CVIRSDGGSG VSNYAELIVK EPPTPIAPPE 300
LLAVGATYLW IKPNANSIIG DGPIILKEVE YRTTTGTWAE THIVDSPNYK 350
LWHLDPDVEY EIRVLLTRPG EGGTGPPGPP LTTRTKCADP VHGPQNVEIV 400
DIRARQLTLQ WEPFGYAVTR CHSYNLTVQY QYVFNQQQYE AEEVIQTSSH 450
YTLRGLRPFM TIRLRLLLSN PEGRMESEEL VVQTEEDVPG AVPLESIQGG 500
PFEEKIYIQW KPPNETNGVI TLYEINYKAV GSLDPSADLS SQRGKVFKLR 550
NETHHLFVGL YPGTTYSFTI KASTAKGFGP PVTTRIATKI SAPSMPEYDA 600
DTPLNETDTT ITVMLKPAQS RGAPVSVYQL VVKEERLQKS RRAADIIECF 650
SVPVSYRNAS NLDSLHYFAA ELKPSNLPVT QPFTVGDNKT YNGYWNPPLS 700
PLKSYSIYFQ ALSKANGETK INCVRLATKG APMGSAQVTP GTPLCLLTTA 750
STQNSNTVEP EKQVDNTVKM AGVIAGLLMF IIILLGVMLT IKRRKLAKKQ 800
KETQSGAQRE MGPVASTDKP TAKLGTNRND EGFSSSSQDV NGFTDGSRGE 850
LSQPTLTIQT HPYRTCDPVE MSYPRDQFQP AIRVADLLQH ITQMKRGQGY 900
GFKEEYEALP EGQTASWDTA KEDENRNKNR YGNIISYDHS RVRLLVLDGD 950
PHSDYINANY IDGYHRPRHY IATQGPMQET VKDFWRMIWQ ENSASIVMVT 1000
NLVEVGRVKC VRYWPDDTEV YGDIKVTLIE TEPLAEYVIR TFTVQKKGYH 1050
EIRELRLFHF TSWPDHGVPC YATGLLGFVR QVKFLNPPEA GPIVVHCSAG 1100
AGRTGCFIAI DTMLDMAENE GVVDIFNCVR ELRAQRVNLV QTEEQYVFVH 1150
DAILEACLCG NTAIPVCEFR SLYYNISRLD PQTNSSQIKD EFQTLNIVTP 1200
RVRPEDCSIG LLPRNHDKNR SMDVLPLDRC LPFLISVDGE SSNYINAALM 1250
DSHKQPAAFV VTQHPLPNTV ADFWRLVFDY NCSSVVMLNE MDTAQLCMQY 1300
WPEKTSGCYG PIQVEFVSAD IDEDIIHRIF RICNMARPQD GYRIVQHLQY 1350
IGWPAYRDTP PSKRSLLKVV RRLEKWQEQY DGREGRTVVH CLNGGGRSGT 1400
FCAICSVCEM IQQQNIIDVF HIVKTLRNNK SNMVETLEQY KFVYEVALEY 1450
LSSF 1454
Length:1,454
Mass (Da):163,012
Last modified:July 19, 2003 - v2
Checksum:iC60464F7B423F8A8
GO
Isoform 2 (identifier: Q99M80-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     1007-1007: R → RHPAEHTVGTATLGRAASPGM

Show »
Length:1,455
Mass (Da):163,115
Checksum:i95293974FAEA85A0
GO
Isoform 3 (identifier: Q99M80-3) [UniParc]FASTAAdd to Basket

Also known as: RPTPrho2

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYL

Show »
Length:1,445
Mass (Da):162,453
Checksum:i1879E76330FE2329
GO
Isoform 4 (identifier: Q99M80-4) [UniParc]FASTAAdd to Basket

Also known as: RPTPrho1

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.

Show »
Length:1,435
Mass (Da):161,172
Checksum:i37E558F82049F50C
GO
Isoform 5 (identifier: Q99M80-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYLSQR

Show »
Length:1,448
Mass (Da):162,825
Checksum:iAF638DD3EA12DC5A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei731 – 74919Missing in isoform 2, isoform 3, isoform 4 and isoform 5. VSP_007803Add
BLAST
Alternative sequencei794 – 7941R → RRNAYSYSYYL in isoform 3. VSP_007804
Alternative sequencei794 – 7941R → RRNAYSYSYYLSQR in isoform 5. VSP_007805
Alternative sequencei1007 – 10071R → RHPAEHTVGTATLGRAASPG M in isoform 2. VSP_007806

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 164Missing in AAD34158. 1 Publication
Sequence conflicti21 – 211R → P in AAD34158. 1 Publication
Sequence conflicti34 – 374GGCS → RGVF in AAD34158. 1 Publication
Sequence conflicti87 – 871A → T in AAF82401. 1 Publication
Sequence conflicti254 – 2541A → S in AAF82401. 1 Publication
Sequence conflicti266 – 2661I → V in AAF82401. 1 Publication
Sequence conflicti602 – 6021T → S in AAF82401. 1 Publication
Sequence conflicti822 – 8221A → T in AAF82401. 1 Publication
Sequence conflicti825 – 8251G → S in AAF82401. 1 Publication
Sequence conflicti844 – 8452TD → N in AAF82401. 1 Publication
Sequence conflicti1016 – 10161D → A in AAF82401. 1 Publication
Sequence conflicti1049 – 10491Y → H in AAD34158. 1 Publication
Sequence conflicti1050 – 10501H → N in AAF82401. 1 Publication
Sequence conflicti1076 – 10761L → V in AAF82401. 1 Publication
Sequence conflicti1103 – 11031R → K in AAD34158. 1 Publication
Sequence conflicti1259 – 12591F → L in AAF82401. 1 Publication
Sequence conflicti1266 – 12661L → I in AAF82401. 1 Publication
Sequence conflicti1269 – 12691T → S in AAF82401. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152556 mRNA. Translation: AAD34158.4.
AY026861 mRNA. Translation: AAK18741.1.
AY026862 mRNA. Translation: AAK18742.1.
AY026863 mRNA. Translation: AAK18743.1.
AF244125 mRNA. Translation: AAF44712.1.
AF162856 mRNA. Translation: AAF82400.2.
AF162857 mRNA. Translation: AAF82401.1.
CCDSiCCDS17001.1. [Q99M80-4]
CCDS71182.1. [Q99M80-2]
CCDS71183.1. [Q99M80-3]
RefSeqiNP_001278078.1. NM_001291149.1. [Q99M80-2]
NP_001278079.1. NM_001291150.1. [Q99M80-3]
NP_067439.1. NM_021464.5. [Q99M80-4]
UniGeneiMm.235807.
Mm.381206.

Genome annotation databases

EnsembliENSMUST00000109441; ENSMUSP00000105067; ENSMUSG00000053141. [Q99M80-2]
ENSMUST00000109443; ENSMUSP00000105069; ENSMUSG00000053141. [Q99M80-3]
ENSMUST00000109445; ENSMUSP00000105071; ENSMUSG00000053141. [Q99M80-4]
GeneIDi19281.
KEGGimmu:19281.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152556 mRNA. Translation: AAD34158.4 .
AY026861 mRNA. Translation: AAK18741.1 .
AY026862 mRNA. Translation: AAK18742.1 .
AY026863 mRNA. Translation: AAK18743.1 .
AF244125 mRNA. Translation: AAF44712.1 .
AF162856 mRNA. Translation: AAF82400.2 .
AF162857 mRNA. Translation: AAF82401.1 .
CCDSi CCDS17001.1. [Q99M80-4 ]
CCDS71182.1. [Q99M80-2 ]
CCDS71183.1. [Q99M80-3 ]
RefSeqi NP_001278078.1. NM_001291149.1. [Q99M80-2 ]
NP_001278079.1. NM_001291150.1. [Q99M80-3 ]
NP_067439.1. NM_021464.5. [Q99M80-4 ]
UniGenei Mm.235807.
Mm.381206.

3D structure databases

ProteinModelPortali Q99M80.
SMRi Q99M80. Positions 33-595, 879-1454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000105067.

PTM databases

PhosphoSitei Q99M80.

Proteomic databases

PaxDbi Q99M80.
PRIDEi Q99M80.

Protocols and materials databases

DNASUi 19281.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109441 ; ENSMUSP00000105067 ; ENSMUSG00000053141 . [Q99M80-2 ]
ENSMUST00000109443 ; ENSMUSP00000105069 ; ENSMUSG00000053141 . [Q99M80-3 ]
ENSMUST00000109445 ; ENSMUSP00000105071 ; ENSMUSG00000053141 . [Q99M80-4 ]
GeneIDi 19281.
KEGGi mmu:19281.

Organism-specific databases

CTDi 11122.
MGIi MGI:1321152. Ptprt.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00640000091300.
HOVERGENi HBG062785.
KOi K13297.
OMAi THPYRTC.
OrthoDBi EOG70KGNP.
TreeFami TF312900.

Miscellaneous databases

ChiTaRSi PTPRT. mouse.
NextBioi 296196.
PROi Q99M80.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99M80.
Bgeei Q99M80.
CleanExi MM_PTPRT.
Genevestigatori Q99M80.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic organization and alternative splicing of the human and mouse RPTPrho genes."
    Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A.
    BMC Genomics 2:1-1(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ALTERNATIVE SPLICING.
    Strain: C57BL/6J.
  2. "RPTPmam4: a fourth member of the MAM family of receptor protein tyrosine phosphatases expressed in adult brain."
    Buchli A.D., Zimmermann D.R., Pfister F., Vaughan L.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
  3. "Molecular cloning and functional characterization on mouse receptor-like protein tyrosine phosphatase, mRPTPrho, which mediates cell-cell adhesion of pancreatic beta cells."
    Mizuta M., Bergman B., Miki T., Hutton J.C.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  4. "Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex."
    McAndrew P.E., Frostholm A., Evans J.E., Zdilar D., Goldowitz D., Chiu I.-M., Burghes A.H.M., Rotter A.
    J. Comp. Neurol. 391:444-455(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPTPRT_MOUSE
AccessioniPrimary (citable) accession number: Q99M80
Secondary accession number(s): Q99M81
, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi