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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

Ptprt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1065SubstrateBy similarity1
Active sitei1097Phosphocysteine intermediateBy similarity1
Binding sitei1141SubstrateBy similarity1
Active sitei1391Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • alpha-actinin binding Source: MGI
  • alpha-catenin binding Source: MGI
  • beta-catenin binding Source: MGI
  • cadherin binding Source: MGI
  • delta-catenin binding Source: MGI
  • gamma-catenin binding Source: MGI
  • protein tyrosine phosphatase activity Source: MGI
  • thiolester hydrolase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
RPTPmam4
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Short name:
mRPTPrho
Gene namesi
Name:Ptprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1321152 Ptprt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 770ExtracellularSequence analysisAdd BLAST741
Transmembranei771 – 791HelicalSequence analysisAdd BLAST21
Topological domaini792 – 1454CytoplasmicSequence analysisAdd BLAST663

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002546430 – 1454Receptor-type tyrosine-protein phosphatase TAdd BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 271PROSITE-ProRule annotation
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1221PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99M80
PRIDEiQ99M80

PTM databases

iPTMnetiQ99M80
PhosphoSitePlusiQ99M80

Expressioni

Tissue specificityi

Expression is restricted to the CNS. Distributed throughout the brain and spinal cord.1 Publication

Developmental stagei

Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6.

Gene expression databases

BgeeiENSMUSG00000053141
CleanExiMM_PTPRT
ExpressionAtlasiQ99M80 baseline and differential
GenevisibleiQ99M80 MM

Interactioni

GO - Molecular functioni

  • alpha-actinin binding Source: MGI
  • alpha-catenin binding Source: MGI
  • beta-catenin binding Source: MGI
  • cadherin binding Source: MGI
  • delta-catenin binding Source: MGI
  • gamma-catenin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105071

Structurei

3D structure databases

ProteinModelPortaliQ99M80
SMRiQ99M80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 195MAMPROSITE-ProRule annotationAdd BLAST162
Domaini197 – 288Ig-like C2-typeAdd BLAST92
Domaini295 – 388Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini393 – 487Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini488 – 594Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini670 – 767Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini902 – 1156Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1188 – 1450Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1097 – 1103Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG062785
InParanoidiQ99M80
KOiK13297
OMAiQYEAEEV
OrthoDBiEOG091G00CK
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 3 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99M80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSLGGLALC LLRLLLLGLQ RPPLPGAGAQ SAAGGCSFDE HYSNCGYSVA
60 70 80 90 100
LGTNGFTWEQ INTWEKPMLD PAVPTGSFMM VNSSGRASGQ KAHLLLPTLK
110 120 130 140 150
ENDTHCIDFH YYFSSRDRSS PGALNVYVKV NGGPQGNPVW NVSGVVTEGW
160 170 180 190 200
VKAELAISTF WPHFYQVIFE SVSLKGHPGY IAVDEVRVLA HPCRKAPHFL
210 220 230 240 250
RLQNVEVNVG QNATFQCIAG GKWSQHDKLW LQQWNGRDTA LMVTRVVNHR
260 270 280 290 300
RFSATVSVAD TSQRSISKYR CVIRSDGGSG VSNYAELIVK EPPTPIAPPE
310 320 330 340 350
LLAVGATYLW IKPNANSIIG DGPIILKEVE YRTTTGTWAE THIVDSPNYK
360 370 380 390 400
LWHLDPDVEY EIRVLLTRPG EGGTGPPGPP LTTRTKCADP VHGPQNVEIV
410 420 430 440 450
DIRARQLTLQ WEPFGYAVTR CHSYNLTVQY QYVFNQQQYE AEEVIQTSSH
460 470 480 490 500
YTLRGLRPFM TIRLRLLLSN PEGRMESEEL VVQTEEDVPG AVPLESIQGG
510 520 530 540 550
PFEEKIYIQW KPPNETNGVI TLYEINYKAV GSLDPSADLS SQRGKVFKLR
560 570 580 590 600
NETHHLFVGL YPGTTYSFTI KASTAKGFGP PVTTRIATKI SAPSMPEYDA
610 620 630 640 650
DTPLNETDTT ITVMLKPAQS RGAPVSVYQL VVKEERLQKS RRAADIIECF
660 670 680 690 700
SVPVSYRNAS NLDSLHYFAA ELKPSNLPVT QPFTVGDNKT YNGYWNPPLS
710 720 730 740 750
PLKSYSIYFQ ALSKANGETK INCVRLATKG APMGSAQVTP GTPLCLLTTA
760 770 780 790 800
STQNSNTVEP EKQVDNTVKM AGVIAGLLMF IIILLGVMLT IKRRKLAKKQ
810 820 830 840 850
KETQSGAQRE MGPVASTDKP TAKLGTNRND EGFSSSSQDV NGFTDGSRGE
860 870 880 890 900
LSQPTLTIQT HPYRTCDPVE MSYPRDQFQP AIRVADLLQH ITQMKRGQGY
910 920 930 940 950
GFKEEYEALP EGQTASWDTA KEDENRNKNR YGNIISYDHS RVRLLVLDGD
960 970 980 990 1000
PHSDYINANY IDGYHRPRHY IATQGPMQET VKDFWRMIWQ ENSASIVMVT
1010 1020 1030 1040 1050
NLVEVGRVKC VRYWPDDTEV YGDIKVTLIE TEPLAEYVIR TFTVQKKGYH
1060 1070 1080 1090 1100
EIRELRLFHF TSWPDHGVPC YATGLLGFVR QVKFLNPPEA GPIVVHCSAG
1110 1120 1130 1140 1150
AGRTGCFIAI DTMLDMAENE GVVDIFNCVR ELRAQRVNLV QTEEQYVFVH
1160 1170 1180 1190 1200
DAILEACLCG NTAIPVCEFR SLYYNISRLD PQTNSSQIKD EFQTLNIVTP
1210 1220 1230 1240 1250
RVRPEDCSIG LLPRNHDKNR SMDVLPLDRC LPFLISVDGE SSNYINAALM
1260 1270 1280 1290 1300
DSHKQPAAFV VTQHPLPNTV ADFWRLVFDY NCSSVVMLNE MDTAQLCMQY
1310 1320 1330 1340 1350
WPEKTSGCYG PIQVEFVSAD IDEDIIHRIF RICNMARPQD GYRIVQHLQY
1360 1370 1380 1390 1400
IGWPAYRDTP PSKRSLLKVV RRLEKWQEQY DGREGRTVVH CLNGGGRSGT
1410 1420 1430 1440 1450
FCAICSVCEM IQQQNIIDVF HIVKTLRNNK SNMVETLEQY KFVYEVALEY

LSSF
Length:1,454
Mass (Da):163,012
Last modified:July 19, 2003 - v2
Checksum:iC60464F7B423F8A8
GO
Isoform 2 (identifier: Q99M80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     1007-1007: R → RHPAEHTVGTATLGRAASPGM

Show »
Length:1,455
Mass (Da):163,115
Checksum:i95293974FAEA85A0
GO
Isoform 3 (identifier: Q99M80-3) [UniParc]FASTAAdd to basket
Also known as: RPTPrho2

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYL

Show »
Length:1,445
Mass (Da):162,453
Checksum:i1879E76330FE2329
GO
Isoform 4 (identifier: Q99M80-4) [UniParc]FASTAAdd to basket
Also known as: RPTPrho1

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.

Show »
Length:1,435
Mass (Da):161,172
Checksum:i37E558F82049F50C
GO
Isoform 5 (identifier: Q99M80-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-749: Missing.
     794-794: R → RRNAYSYSYYLSQR

Show »
Length:1,448
Mass (Da):162,825
Checksum:iAF638DD3EA12DC5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 16Missing in AAD34158 (PubMed:11423001).Curated4
Sequence conflicti21R → P in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti34 – 37GGCS → RGVF in AAD34158 (PubMed:11423001).Curated4
Sequence conflicti87A → T in AAF82401 (Ref. 3) Curated1
Sequence conflicti254A → S in AAF82401 (Ref. 3) Curated1
Sequence conflicti266I → V in AAF82401 (Ref. 3) Curated1
Sequence conflicti602T → S in AAF82401 (Ref. 3) Curated1
Sequence conflicti822A → T in AAF82401 (Ref. 3) Curated1
Sequence conflicti825G → S in AAF82401 (Ref. 3) Curated1
Sequence conflicti844 – 845TD → N in AAF82401 (Ref. 3) Curated2
Sequence conflicti1016D → A in AAF82401 (Ref. 3) Curated1
Sequence conflicti1049Y → H in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti1050H → N in AAF82401 (Ref. 3) Curated1
Sequence conflicti1076L → V in AAF82401 (Ref. 3) Curated1
Sequence conflicti1103R → K in AAD34158 (PubMed:11423001).Curated1
Sequence conflicti1259F → L in AAF82401 (Ref. 3) Curated1
Sequence conflicti1266L → I in AAF82401 (Ref. 3) Curated1
Sequence conflicti1269T → S in AAF82401 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007803731 – 749Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_007804794R → RRNAYSYSYYL in isoform 3. 2 Publications1
Alternative sequenceiVSP_007805794R → RRNAYSYSYYLSQR in isoform 5. 1 Publication1
Alternative sequenceiVSP_0078061007R → RHPAEHTVGTATLGRAASPG M in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152556 mRNA Translation: AAD34158.4
AY026861 mRNA Translation: AAK18741.1
AY026862 mRNA Translation: AAK18742.1
AY026863 mRNA Translation: AAK18743.1
AF244125 mRNA Translation: AAF44712.1
AF162856 mRNA Translation: AAF82400.2
AF162857 mRNA Translation: AAF82401.1
CCDSiCCDS17001.1 [Q99M80-4]
CCDS71182.1 [Q99M80-2]
CCDS71183.1 [Q99M80-3]
RefSeqiNP_001278078.1, NM_001291149.1 [Q99M80-2]
NP_001278079.1, NM_001291150.1 [Q99M80-3]
NP_067439.1, NM_021464.5 [Q99M80-4]
XP_011237686.1, XM_011239384.2 [Q99M80-5]
UniGeneiMm.235807
Mm.381206

Genome annotation databases

EnsembliENSMUST00000109441; ENSMUSP00000105067; ENSMUSG00000053141 [Q99M80-2]
ENSMUST00000109443; ENSMUSP00000105069; ENSMUSG00000053141 [Q99M80-3]
ENSMUST00000109445; ENSMUSP00000105071; ENSMUSG00000053141 [Q99M80-4]
GeneIDi19281
KEGGimmu:19281
UCSCiuc008nrw.2 mouse [Q99M80-4]
uc008nrx.2 mouse [Q99M80-3]
uc008nrz.2 mouse [Q99M80-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTPRT_MOUSE
AccessioniPrimary (citable) accession number: Q99M80
Secondary accession number(s): Q99M81
, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health