Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cuticular Hb2

Gene

Krt82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb2
Alternative name(s):
Keratin-82
Short name:
K82
Type II hair keratin Hb2
Type-II keratin Kb22
Gene namesi
Name:Krt82
Synonyms:Krt2-20, Krthb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2149248. Krt82.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Keratin, type II cuticular Hb2PRO_0000063698Add
BLAST

Proteomic databases

EPDiQ99M74.
MaxQBiQ99M74.
PaxDbiQ99M74.
PRIDEiQ99M74.

PTM databases

PhosphoSiteiQ99M74.

Expressioni

Gene expression databases

BgeeiQ99M74.
CleanExiMM_KRT82.
GenevisibleiQ99M74. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

BioGridi227744. 1 interaction.
STRINGi10090.ENSMUSP00000023713.

Structurei

3D structure databases

ProteinModelPortaliQ99M74.
SMRiQ99M74. Positions 117-266, 282-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 118118HeadAdd
BLAST
Regioni119 – 425307RodAdd
BLAST
Regioni119 – 15335Coil 1AAdd
BLAST
Regioni154 – 16310Linker 1
Regioni164 – 264101Coil 1BAdd
BLAST
Regioni265 – 28117Linker 12Add
BLAST
Regioni282 – 425144Coil 2Add
BLAST
Regioni426 – 51691TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ99M74.
KOiK07605.
OMAiCDNLRNR.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99M74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRNFQLSP RCGNRSFSSC SAIMPRMVTH YEVSKAPCRS GGGGGLRALG
60 70 80 90 100
CLGSRSLCNV GFGRPRVASR CGMPGFGYRA GATCGSSACI TPVTINESLL
110 120 130 140 150
VPLELEIDPT VQRVKRDEKE QIKCLNNRFA SFINKVRFLE QKNKLLETKW
160 170 180 190 200
NFMQQQRSCQ SNMEPLFEGY ICALRRQLDC VSGDHGRLEA ELCSLQEALE
210 220 230 240 250
GYKKKYEEEL SLRPCAENEF VTLKKDVDTA FLVKADLETN LEALEHEIEF
260 270 280 290 300
LKALFEEEIG LLQSQISETS VIVKMDNSRE LDVDGIVAEI KAQYDDIASR
310 320 330 340 350
SKAEAEAWYQ CRYEELRLTA GNHCDNLRNR KNEILEMNKL IQRLQQDIEA
360 370 380 390 400
VKGQRCKLEG AIAQAEQQGE AALTDAKCKL AGLEEALQKA KQDMACLLKQ
410 420 430 440 450
YQEVMNCKLG LDIEIATYRR LLEGEEHRLC EGIGPVNISV SSSKGAVLYE
460 470 480 490 500
PCVMGTPMLR TEYCTGTTGV LRNSGGCNVV GTGELYIPCE PQGLLGCGNG
510
RSSSMKVGVG SNSCSR
Length:516
Mass (Da):57,140
Last modified:July 27, 2011 - v2
Checksum:iFCA08FB6BDFB7F6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti478 – 4781N → S in AAK26232 (PubMed:12399393).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028606 mRNA. Translation: AAK26232.1.
BC108971 mRNA. Translation: AAI08972.1.
CCDSiCCDS27854.1.
RefSeqiNP_444479.2. NM_053249.3.
UniGeneiMm.458432.

Genome annotation databases

EnsembliENSMUST00000023713; ENSMUSP00000023713; ENSMUSG00000049548.
GeneIDi114566.
KEGGimmu:114566.
UCSCiuc007xtn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028606 mRNA. Translation: AAK26232.1.
BC108971 mRNA. Translation: AAI08972.1.
CCDSiCCDS27854.1.
RefSeqiNP_444479.2. NM_053249.3.
UniGeneiMm.458432.

3D structure databases

ProteinModelPortaliQ99M74.
SMRiQ99M74. Positions 117-266, 282-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227744. 1 interaction.
STRINGi10090.ENSMUSP00000023713.

PTM databases

PhosphoSiteiQ99M74.

Proteomic databases

EPDiQ99M74.
MaxQBiQ99M74.
PaxDbiQ99M74.
PRIDEiQ99M74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023713; ENSMUSP00000023713; ENSMUSG00000049548.
GeneIDi114566.
KEGGimmu:114566.
UCSCiuc007xtn.3. mouse.

Organism-specific databases

CTDi3888.
MGIiMGI:2149248. Krt82.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ99M74.
KOiK07605.
OMAiCDNLRNR.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Miscellaneous databases

NextBioi368501.
PROiQ99M74.
SOURCEiSearch...

Gene expression databases

BgeeiQ99M74.
CleanExiMM_KRT82.
GenevisibleiQ99M74. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hague (Hag): a new mouse hair mutation with an unstable semidominant allele."
    Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.
    Genetics 162:831-840(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeN.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver and Lung.

Entry informationi

Entry nameiKRT82_MOUSE
AccessioniPrimary (citable) accession number: Q99M74
Secondary accession number(s): Q32MV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.