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Protein

Keratin, type II cuticular Hb4

Gene

Krt84

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

  • regulation of keratinocyte differentiation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb4
Alternative name(s):
65 kDa type II keratin
Keratin-84
Short name:
K84
Type II hair keratin Hb4
Type-II keratin Kb24
Gene namesi
Name:Krt84
Synonyms:Krt2-16, Krthb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96700 Krt84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637011 – 603Keratin, type II cuticular Hb4Add BLAST603

Proteomic databases

MaxQBiQ99M73
PaxDbiQ99M73
PeptideAtlasiQ99M73
PRIDEiQ99M73

PTM databases

iPTMnetiQ99M73
PhosphoSitePlusiQ99M73

Expressioni

Tissue specificityi

In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.1 Publication

Inductioni

mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000044294
CleanExiMM_KRT84
GenevisibleiQ99M73 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023720

Structurei

3D structure databases

ProteinModelPortaliQ99M73
SMRiQ99M73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 484IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 173HeadAdd BLAST173
Regioni174 – 208Coil 1AAdd BLAST35
Regioni209 – 218Linker 110
Regioni219 – 319Coil 1BAdd BLAST101
Regioni320 – 336Linker 12Add BLAST17
Regioni337 – 480Coil 2Add BLAST144
Regioni481 – 603TailAdd BLAST123

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ99M73
KOiK07605
OMAiLQEQKCA
OrthoDBiEOG091G09KR
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99M73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRSYRVSS GRRVGSFSSC SAMAPQHLNR FRSSSVSCRS GPGFRGLGGF
60 70 80 90 100
GSRSVINFGS SSPRIAVGCS RPVRCGVGFG AGSGMAFGSG DGLGFRASSG
110 120 130 140 150
VGLGFGAGGC PSYGFGGPGF GGPGFGGPGF GYRIGGIGGP SAPAITAVTV
160 170 180 190 200
NQSLLTPLNL EIDPNAQRVK RDEKEQIKTL NNKFASFIDK VRFLEQQNKL
210 220 230 240 250
LETKWSFLQE QKCARSNLEP LFDNYITNLR RQLDVLSSDQ ARLQAERNHL
260 270 280 290 300
QDILEGFKKK YEEEVVFRAN AENEFVALKK DVDAAFLNKS DLEANVDTLI
310 320 330 340 350
QETEFLKALY HEEIEMLQSH ISETSVIVKM DNSRDLNLDG IIAEVKAQYE
360 370 380 390 400
EVARRSRADV ESWYQTKYEE MRVTAGQHCD NLRSTRDEIN ELTRLIQRLK
410 420 430 440 450
AEIEHTKAQC AKLEAAVAEA EQQGEAALND AKCKLADLEG ALQQAKQDMA
460 470 480 490 500
RQLREYQELM NVKLALDIEI VTYRRLLEGE EIRICEGVGP VNISVSSSRG
510 520 530 540 550
GVLCGPELVS GSSLSHNGGV TFSTSSSIRA TGGVLASSSL RAGGDLLSSG
560 570 580 590 600
SRGGSVLVGD ACAPSIPCAL PTEGGFSSCS GGRGNRSSSV RFSSTTTSRR

TRY
Length:603
Mass (Da):64,983
Last modified:July 27, 2011 - v2
Checksum:i63B1DCC4A0A8B95A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111P → T in AAK26233 (PubMed:12399393).Curated1
Sequence conflicti111P → T in AAI14972 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028607 mRNA Translation: AAK26233.1
AC103674 Genomic DNA No translation available.
BC114971 mRNA Translation: AAI14972.1
X65505 mRNA Translation: CAA46479.1
CCDSiCCDS27853.1
RefSeqiNP_032500.2, NM_008474.2
UniGeneiMm.25292

Genome annotation databases

EnsembliENSMUST00000023720; ENSMUSP00000023720; ENSMUSG00000044294
GeneIDi16680
KEGGimmu:16680
UCSCiuc007xtm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKRT84_MOUSE
AccessioniPrimary (citable) accession number: Q99M73
Secondary accession number(s): E9QMQ6, Q1RME6, Q61862
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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