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Protein

Keratin, type II cuticular Hb4

Gene

Krt84

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

  • regulation of keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb4
Alternative name(s):
65 kDa type II keratin
Keratin-84
Short name:
K84
Type II hair keratin Hb4
Type-II keratin Kb24
Gene namesi
Name:Krt84
Synonyms:Krt2-16, Krthb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96700. Krt84.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • intermediate filament cytoskeleton Source: UniProtKB
  • keratin filament Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Keratin, type II cuticular Hb4PRO_0000063701Add
BLAST

Proteomic databases

MaxQBiQ99M73.
PaxDbiQ99M73.
PeptideAtlasiQ99M73.
PRIDEiQ99M73.

PTM databases

iPTMnetiQ99M73.
PhosphoSiteiQ99M73.

Expressioni

Tissue specificityi

In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.1 Publication

Inductioni

mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis.1 Publication

Gene expression databases

BgeeiQ99M73.
CleanExiMM_KRT84.
GenevisibleiQ99M73. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023720.

Structurei

3D structure databases

ProteinModelPortaliQ99M73.
SMRiQ99M73. Positions 172-309, 337-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 173173HeadAdd
BLAST
Regioni174 – 480307RodAdd
BLAST
Regioni174 – 20835Coil 1AAdd
BLAST
Regioni209 – 21810Linker 1
Regioni219 – 319101Coil 1BAdd
BLAST
Regioni320 – 33617Linker 12Add
BLAST
Regioni337 – 480144Coil 2Add
BLAST
Regioni481 – 603123TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ99M73.
KOiK07605.
OMAiEEIRICE.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 4 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99M73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRSYRVSS GRRVGSFSSC SAMAPQHLNR FRSSSVSCRS GPGFRGLGGF
60 70 80 90 100
GSRSVINFGS SSPRIAVGCS RPVRCGVGFG AGSGMAFGSG DGLGFRASSG
110 120 130 140 150
VGLGFGAGGC PSYGFGGPGF GGPGFGGPGF GYRIGGIGGP SAPAITAVTV
160 170 180 190 200
NQSLLTPLNL EIDPNAQRVK RDEKEQIKTL NNKFASFIDK VRFLEQQNKL
210 220 230 240 250
LETKWSFLQE QKCARSNLEP LFDNYITNLR RQLDVLSSDQ ARLQAERNHL
260 270 280 290 300
QDILEGFKKK YEEEVVFRAN AENEFVALKK DVDAAFLNKS DLEANVDTLI
310 320 330 340 350
QETEFLKALY HEEIEMLQSH ISETSVIVKM DNSRDLNLDG IIAEVKAQYE
360 370 380 390 400
EVARRSRADV ESWYQTKYEE MRVTAGQHCD NLRSTRDEIN ELTRLIQRLK
410 420 430 440 450
AEIEHTKAQC AKLEAAVAEA EQQGEAALND AKCKLADLEG ALQQAKQDMA
460 470 480 490 500
RQLREYQELM NVKLALDIEI VTYRRLLEGE EIRICEGVGP VNISVSSSRG
510 520 530 540 550
GVLCGPELVS GSSLSHNGGV TFSTSSSIRA TGGVLASSSL RAGGDLLSSG
560 570 580 590 600
SRGGSVLVGD ACAPSIPCAL PTEGGFSSCS GGRGNRSSSV RFSSTTTSRR

TRY
Length:603
Mass (Da):64,983
Last modified:July 27, 2011 - v2
Checksum:i63B1DCC4A0A8B95A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111P → T in AAK26233 (PubMed:12399393).Curated
Sequence conflicti111 – 1111P → T in AAI14972 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028607 mRNA. Translation: AAK26233.1.
AC103674 Genomic DNA. No translation available.
BC114971 mRNA. Translation: AAI14972.1.
X65505 mRNA. Translation: CAA46479.1.
CCDSiCCDS27853.1.
RefSeqiNP_032500.2. NM_008474.2.
UniGeneiMm.25292.

Genome annotation databases

EnsembliENSMUST00000023720; ENSMUSP00000023720; ENSMUSG00000044294.
GeneIDi16680.
KEGGimmu:16680.
UCSCiuc007xtm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028607 mRNA. Translation: AAK26233.1.
AC103674 Genomic DNA. No translation available.
BC114971 mRNA. Translation: AAI14972.1.
X65505 mRNA. Translation: CAA46479.1.
CCDSiCCDS27853.1.
RefSeqiNP_032500.2. NM_008474.2.
UniGeneiMm.25292.

3D structure databases

ProteinModelPortaliQ99M73.
SMRiQ99M73. Positions 172-309, 337-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023720.

PTM databases

iPTMnetiQ99M73.
PhosphoSiteiQ99M73.

Proteomic databases

MaxQBiQ99M73.
PaxDbiQ99M73.
PeptideAtlasiQ99M73.
PRIDEiQ99M73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023720; ENSMUSP00000023720; ENSMUSG00000044294.
GeneIDi16680.
KEGGimmu:16680.
UCSCiuc007xtm.2. mouse.

Organism-specific databases

CTDi3890.
MGIiMGI:96700. Krt84.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ99M73.
KOiK07605.
OMAiEEIRICE.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Miscellaneous databases

PROiQ99M73.
SOURCEiSearch...

Gene expression databases

BgeeiQ99M73.
CleanExiMM_KRT84.
GenevisibleiQ99M73. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 4 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hague (Hag): a new mouse hair mutation with an unstable semidominant allele."
    Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.
    Genetics 162:831-840(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeN.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation."
    Tobiasch E., Winter H., Schweizer J.
    Differentiation 50:163-178(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 306-603, TISSUE SPECIFICITY, INDUCTION.
    Strain: NMRI.
    Tissue: Tail epidermis.

Entry informationi

Entry nameiKRT84_MOUSE
AccessioniPrimary (citable) accession number: Q99M73
Secondary accession number(s): E9QMQ6, Q1RME6, Q61862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.