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Protein

Bcl-2-like protein 10

Gene

Bcl2l10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell survival. Suppresses apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Gene namesi
Name:Bcl2l10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621015. Bcl2l10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei160 – 18223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Bcl-2-like protein 10PRO_0000378194Add
BLAST

Proteomic databases

PaxDbiQ99M66.
PRIDEiQ99M66.

Expressioni

Tissue specificityi

Expressed in oligodendroglial lineage cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000009308.
GenevisibleiQ99M66. RN.

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012409.

Structurei

3D structure databases

ProteinModelPortaliQ99M66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 9520BH1Add
BLAST
Motifi138 – 14912BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PB. Eukaryota.
ENOG4112AS5. LUCA.
GeneTreeiENSGT00640000091607.
HOGENOMiHOG000059275.
InParanoidiQ99M66.
KOiK18451.
OMAiGYPGNRV.
OrthoDBiEOG091G0KGL.
PhylomeDBiQ99M66.
TreeFamiTF334762.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99M66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPLQDRTR RLLTDYILFC ARAPNTPEPL PTSVEAALLR SVTSQIQQEH
60 70 80 90 100
QDLFNSFRDY QGNRLELVTQ MADELLSNDQ EFNWGRLVML LAFVGTLMNQ
110 120 130 140 150
DRTVKRRRDQ RNRLLLERDC YLIVSLLYNR LTGRHRSWLE AHGGWDGFCQ
160 170 180
FFKNPLPPGF WRRLLIRAIL SCFFATAIFY IWKCL
Length:185
Mass (Da):21,859
Last modified:June 1, 2001 - v1
Checksum:i2EB9B94C8EC106A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029163 mRNA. Translation: AAK31792.1.
RefSeqiNP_446185.1. NM_053733.1.
UniGeneiRn.67084.

Genome annotation databases

EnsembliENSRNOT00000012409; ENSRNOP00000012409; ENSRNOG00000009308.
GeneIDi114552.
KEGGirno:114552.
UCSCiRGD:621015. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029163 mRNA. Translation: AAK31792.1.
RefSeqiNP_446185.1. NM_053733.1.
UniGeneiRn.67084.

3D structure databases

ProteinModelPortaliQ99M66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012409.

Proteomic databases

PaxDbiQ99M66.
PRIDEiQ99M66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012409; ENSRNOP00000012409; ENSRNOG00000009308.
GeneIDi114552.
KEGGirno:114552.
UCSCiRGD:621015. rat.

Organism-specific databases

CTDi10017.
RGDi621015. Bcl2l10.

Phylogenomic databases

eggNOGiENOG410J2PB. Eukaryota.
ENOG4112AS5. LUCA.
GeneTreeiENSGT00640000091607.
HOGENOMiHOG000059275.
InParanoidiQ99M66.
KOiK18451.
OMAiGYPGNRV.
OrthoDBiEOG091G0KGL.
PhylomeDBiQ99M66.
TreeFamiTF334762.

Miscellaneous databases

PROiQ99M66.

Gene expression databases

BgeeiENSRNOG00000009308.
GenevisibleiQ99M66. RN.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2L10_RAT
AccessioniPrimary (citable) accession number: Q99M66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.