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Protein

DNA replication complex GINS protein SLD5

Gene

Gins4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974 Unwinding of DNA

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein SLD5
Alternative name(s):
GINS complex subunit 4
Cleaved into the following chain:
Gene namesi
Name:Gins4
Synonyms:Sld5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923847 Gins4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276211 – 223DNA replication complex GINS protein SLD5Add BLAST223
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004217952 – 223DNA replication complex GINS protein SLD5, N-terminally processedAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processedBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99LZ3
MaxQBiQ99LZ3
PaxDbiQ99LZ3
PeptideAtlasiQ99LZ3
PRIDEiQ99LZ3

PTM databases

iPTMnetiQ99LZ3
PhosphoSitePlusiQ99LZ3

Expressioni

Tissue specificityi

Highly abundant in testis. Weakly expressed in thymus and bone marrow.1 Publication

Gene expression databases

BgeeiENSMUSG00000031546
GenevisibleiQ99LZ3 MM

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

BioGridi224572, 1 interactor
IntActiQ99LZ3, 1 interactor
MINTiQ99LZ3
STRINGi10090.ENSMUSP00000033950

Structurei

3D structure databases

ProteinModelPortaliQ99LZ3
SMRiQ99LZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 223Important for GINS complex assemblyBy similarityAdd BLAST58

Sequence similaritiesi

Belongs to the GINS4/SLD5 family.Curated

Phylogenomic databases

eggNOGiKOG3176 Eukaryota
COG5086 LUCA
GeneTreeiENSGT00390000003246
HOGENOMiHOG000215319
HOVERGENiHBG059490
InParanoidiQ99LZ3
KOiK10735
OMAiVSIHRME
OrthoDBiEOG091G0ULR
PhylomeDBiQ99LZ3
TreeFamiTF105863

Family and domain databases

CDDicd11711 GINS_A_Sld5, 1 hit
InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR008591 GINS_Sld5
IPR031633 SLD5_C
IPR038749 Sld5_GINS_A
PANTHERiPTHR21206 PTHR21206, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PF16922 SLD5_C, 1 hit
PIRSFiPIRSF007764 Sld5, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLDLHGQ DSDGGSEEMV LTPAELIEKL EQAWMNEKFA PELLESKAEI
60 70 80 90 100
VECVMEQLEH MEENLRRAKK GDLKVSIHRM EMERIRYVLS SYLRCRLMKI
110 120 130 140 150
EKFFPHILEK EKVRSEGEPS SLSPEEFVFA KEYMDHTETH FKNVALKHMP
160 170 180 190 200
PNLQKVDLLR AVPKPDLDSY VFLRVKERQE NILVEPEADE QRDYVIDLEV
210 220
GSQHLIRYKT IAPLVASGAV QLI
Length:223
Mass (Da):25,961
Last modified:June 1, 2001 - v1
Checksum:iA6E1B88E95F6DF1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076104 mRNA Translation: BAC36185.1
AK164815 mRNA Translation: BAE37931.1
BC002156 mRNA Translation: AAH02156.1
CCDSiCCDS22190.1
RefSeqiNP_077202.1, NM_024240.6
UniGeneiMm.27945

Genome annotation databases

EnsembliENSMUST00000033950; ENSMUSP00000033950; ENSMUSG00000031546
GeneIDi109145
KEGGimmu:109145
UCSCiuc009ler.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSLD5_MOUSE
AccessioniPrimary (citable) accession number: Q99LZ3
Secondary accession number(s): Q3TP06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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