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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene

Ndufs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Alternative name(s):
Complex I-15 kDa
Short name:
CI-15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
Cleaved into the following chain:
Gene namesi
Name:Ndufs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1890889. Ndufs5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106NADH dehydrogenase [ubiquinone] iron-sulfur protein 5PRO_0000118787Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 106105NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, N-terminally processedPRO_0000421790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 66Sequence analysis
Disulfide bondi43 ↔ 56Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ99LY9.
MaxQBiQ99LY9.
PaxDbiQ99LY9.
PeptideAtlasiQ99LY9.
PRIDEiQ99LY9.

PTM databases

iPTMnetiQ99LY9.
PhosphoSiteiQ99LY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028648.
ExpressionAtlasiQ99LY9. baseline and differential.
GenevisibleiQ99LY9. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

BioGridi546774. 1 interaction.
IntActiQ99LY9. 3 interactions.
MINTiMINT-1861965.
STRINGi10090.ENSMUSP00000030401.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4311C-X9-C motif 1Add
BLAST
Motifi56 – 6611C-X9-C motif 2Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFS5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ99LY9.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG091G1CDO.
PhylomeDBiQ99LY9.
TreeFamiTF332111.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLDIQKKL GISLDRHFMF LSAEQPYKNA ARCHAFEKEW IECAHGIGGT
60 70 80 90 100
RAKKECKIEF DDFEECLLRY KTMRRMHDIK KQREKLMKEG KYTPPPHHSG

REEPRP
Length:106
Mass (Da):12,648
Last modified:January 23, 2007 - v3
Checksum:iDA74C0EEE1EB5C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148505 mRNA. Translation: BAE28590.1.
AK152845 mRNA. Translation: BAE31538.1.
AL606932 Genomic DNA. Translation: CAM18556.1.
CH466521 Genomic DNA. Translation: EDK98017.1.
CH466552 Genomic DNA. Translation: EDL30376.1.
BC081434 mRNA. Translation: AAH81434.1.
CCDSiCCDS18618.1.
RefSeqiNP_001025445.1. NM_001030274.1.
XP_006544269.1. XM_006544206.2.
UniGeneiMm.375824.
Mm.42805.

Genome annotation databases

EnsembliENSMUST00000030401; ENSMUSP00000030401; ENSMUSG00000028648.
ENSMUST00000106206; ENSMUSP00000101812; ENSMUSG00000028648.
ENSMUST00000106207; ENSMUSP00000101813; ENSMUSG00000028648.
GeneIDi102641315.
595136.
KEGGimmu:102641315.
mmu:595136.
UCSCiuc008upu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148505 mRNA. Translation: BAE28590.1.
AK152845 mRNA. Translation: BAE31538.1.
AL606932 Genomic DNA. Translation: CAM18556.1.
CH466521 Genomic DNA. Translation: EDK98017.1.
CH466552 Genomic DNA. Translation: EDL30376.1.
BC081434 mRNA. Translation: AAH81434.1.
CCDSiCCDS18618.1.
RefSeqiNP_001025445.1. NM_001030274.1.
XP_006544269.1. XM_006544206.2.
UniGeneiMm.375824.
Mm.42805.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi546774. 1 interaction.
IntActiQ99LY9. 3 interactions.
MINTiMINT-1861965.
STRINGi10090.ENSMUSP00000030401.

PTM databases

iPTMnetiQ99LY9.
PhosphoSiteiQ99LY9.

Proteomic databases

EPDiQ99LY9.
MaxQBiQ99LY9.
PaxDbiQ99LY9.
PeptideAtlasiQ99LY9.
PRIDEiQ99LY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030401; ENSMUSP00000030401; ENSMUSG00000028648.
ENSMUST00000106206; ENSMUSP00000101812; ENSMUSG00000028648.
ENSMUST00000106207; ENSMUSP00000101813; ENSMUSG00000028648.
GeneIDi102641315.
595136.
KEGGimmu:102641315.
mmu:595136.
UCSCiuc008upu.1. mouse.

Organism-specific databases

CTDi4725.
MGIiMGI:1890889. Ndufs5.

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ99LY9.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG091G1CDO.
PhylomeDBiQ99LY9.
TreeFamiTF332111.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ99LY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028648.
ExpressionAtlasiQ99LY9. baseline and differential.
GenevisibleiQ99LY9. MM.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS5_MOUSE
AccessioniPrimary (citable) accession number: Q99LY9
Secondary accession number(s): Q3U734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.