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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene

Ndufs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Alternative name(s):
Complex I-15 kDa
Short name:
CI-15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
Cleaved into the following chain:
Gene namesi
Name:Ndufs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1890889. Ndufs5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106NADH dehydrogenase [ubiquinone] iron-sulfur protein 5PRO_0000118787Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 106105NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, N-terminally processedPRO_0000421790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 66Sequence analysis
Disulfide bondi43 ↔ 56Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ99LY9.
MaxQBiQ99LY9.
PaxDbiQ99LY9.
PRIDEiQ99LY9.

PTM databases

iPTMnetiQ99LY9.
PhosphoSiteiQ99LY9.

Expressioni

Gene expression databases

BgeeiQ99LY9.
ExpressionAtlasiQ99LY9. baseline and differential.
GenevisibleiQ99LY9. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

BioGridi546774. 1 interaction.
IntActiQ99LY9. 3 interactions.
MINTiMINT-1861965.
STRINGi10090.ENSMUSP00000030401.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4311C-X9-C motif 1Add
BLAST
Motifi56 – 6611C-X9-C motif 2Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFS5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ99LY9.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG7C8GKB.
PhylomeDBiQ99LY9.
TreeFamiTF332111.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLDIQKKL GISLDRHFMF LSAEQPYKNA ARCHAFEKEW IECAHGIGGT
60 70 80 90 100
RAKKECKIEF DDFEECLLRY KTMRRMHDIK KQREKLMKEG KYTPPPHHSG

REEPRP
Length:106
Mass (Da):12,648
Last modified:January 23, 2007 - v3
Checksum:iDA74C0EEE1EB5C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148505 mRNA. Translation: BAE28590.1.
AK152845 mRNA. Translation: BAE31538.1.
AL606932 Genomic DNA. Translation: CAM18556.1.
CH466521 Genomic DNA. Translation: EDK98017.1.
CH466552 Genomic DNA. Translation: EDL30376.1.
BC081434 mRNA. Translation: AAH81434.1.
CCDSiCCDS18618.1.
RefSeqiNP_001025445.1. NM_001030274.1.
XP_006544269.1. XM_006544206.2.
UniGeneiMm.375824.
Mm.42805.

Genome annotation databases

EnsembliENSMUST00000030401; ENSMUSP00000030401; ENSMUSG00000028648.
ENSMUST00000106206; ENSMUSP00000101812; ENSMUSG00000028648.
ENSMUST00000106207; ENSMUSP00000101813; ENSMUSG00000028648.
GeneIDi102641315.
595136.
KEGGimmu:102641315.
mmu:595136.
UCSCiuc008upu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148505 mRNA. Translation: BAE28590.1.
AK152845 mRNA. Translation: BAE31538.1.
AL606932 Genomic DNA. Translation: CAM18556.1.
CH466521 Genomic DNA. Translation: EDK98017.1.
CH466552 Genomic DNA. Translation: EDL30376.1.
BC081434 mRNA. Translation: AAH81434.1.
CCDSiCCDS18618.1.
RefSeqiNP_001025445.1. NM_001030274.1.
XP_006544269.1. XM_006544206.2.
UniGeneiMm.375824.
Mm.42805.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi546774. 1 interaction.
IntActiQ99LY9. 3 interactions.
MINTiMINT-1861965.
STRINGi10090.ENSMUSP00000030401.

PTM databases

iPTMnetiQ99LY9.
PhosphoSiteiQ99LY9.

Proteomic databases

EPDiQ99LY9.
MaxQBiQ99LY9.
PaxDbiQ99LY9.
PRIDEiQ99LY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030401; ENSMUSP00000030401; ENSMUSG00000028648.
ENSMUST00000106206; ENSMUSP00000101812; ENSMUSG00000028648.
ENSMUST00000106207; ENSMUSP00000101813; ENSMUSG00000028648.
GeneIDi102641315.
595136.
KEGGimmu:102641315.
mmu:595136.
UCSCiuc008upu.1. mouse.

Organism-specific databases

CTDi4725.
MGIiMGI:1890889. Ndufs5.

Phylogenomic databases

eggNOGiKOG4110. Eukaryota.
ENOG41123TD. LUCA.
GeneTreeiENSGT00390000002919.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiQ99LY9.
KOiK03938.
OMAiFEDFYEC.
OrthoDBiEOG7C8GKB.
PhylomeDBiQ99LY9.
TreeFamiTF332111.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ99LY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LY9.
ExpressionAtlasiQ99LY9. baseline and differential.
GenevisibleiQ99LY9. MM.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-7; 16-27 AND 57-68, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUS5_MOUSE
AccessioniPrimary (citable) accession number: Q99LY9
Secondary accession number(s): Q3U734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.