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Q99LY0

- Q99LY0_MOUSE

UniProt

Q99LY0 - Q99LY0_MOUSE

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Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Gene

Rpn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.UniRule annotation

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro
  2. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1UniRule annotation (EC:2.4.99.18UniRule annotation)
Gene namesi
Name:Rpn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98084. Rpn1.

Subcellular locationi

Endoplasmic reticulum membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ99LY0.

Expressioni

Gene expression databases

BgeeiQ99LY0.
ExpressionAtlasiQ99LY0. baseline and differential.
GenevestigatoriQ99LY0.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the OST1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG012864.

Family and domain databases

InterProiIPR007676. Ribophorin_I.
[Graphical view]
PANTHERiPTHR21049. PTHR21049. 1 hit.
PfamiPF04597. Ribophorin_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99LY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
THYIVGYNLP SYEYLYNLGD QYALKMRFVD HVFDEQVIDS LTVKIILPEG
60 70 80 90 100
AKNIQVDSPY DISRAPDELH YTYLDTFGRP VIVAYKKNLV EQHIQDIVVH
110 120 130 140 150
YTFNKVLMLQ EPLLVVAAFY ILFFTVIIYV RLDFSITKDP AAEARMKVAC
160 170 180 190 200
ITEQVLTLVN KRLGLYRHFD ETVNRYKQSR DISTLNSGKK SLETEHKAVT
210 220 230 240 250
SEIAVLQSRL KTEGSDLCDR VSEMQKLDAQ VKELVLKSAV EAERLVAGKL
260 270 280
KKDTYLENEK LSSGKRQELV TKIDHILDAL
Length:280
Mass (Da):32,166
Last modified:June 1, 2001 - v1
Checksum:iF707C43DDAB88236
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002175 mRNA. Translation: AAH02175.1.
UniGeneiMm.188544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002175 mRNA. Translation: AAH02175.1 .
UniGenei Mm.188544.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q99LY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98084. Rpn1.

Phylogenomic databases

HOVERGENi HBG012864.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

ChiTaRSi RPN1. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q99LY0.
ExpressionAtlasi Q99LY0. baseline and differential.
Genevestigatori Q99LY0.

Family and domain databases

InterProi IPR007676. Ribophorin_I.
[Graphical view ]
PANTHERi PTHR21049. PTHR21049. 1 hit.
Pfami PF04597. Ribophorin_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ99LY0_MOUSE
AccessioniPrimary (citable) accession number: Q99LY0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)