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Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Gene

Rpn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1UniRule annotation
Gene namesi
Name:Rpn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98084. Rpn1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei113 – 132HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ99LY0.
PeptideAtlasiQ99LY0.
PRIDEiQ99LY0.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the OST1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2291. Eukaryota.
ENOG410XQVZ. LUCA.
HOVERGENiHBG012864.

Family and domain databases

InterProiView protein in InterPro
IPR007676. Ribophorin_I.
PANTHERiPTHR21049. PTHR21049. 1 hit.
PfamiView protein in Pfam
PF04597. Ribophorin_I. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99LY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
THYIVGYNLP SYEYLYNLGD QYALKMRFVD HVFDEQVIDS LTVKIILPEG
60 70 80 90 100
AKNIQVDSPY DISRAPDELH YTYLDTFGRP VIVAYKKNLV EQHIQDIVVH
110 120 130 140 150
YTFNKVLMLQ EPLLVVAAFY ILFFTVIIYV RLDFSITKDP AAEARMKVAC
160 170 180 190 200
ITEQVLTLVN KRLGLYRHFD ETVNRYKQSR DISTLNSGKK SLETEHKAVT
210 220 230 240 250
SEIAVLQSRL KTEGSDLCDR VSEMQKLDAQ VKELVLKSAV EAERLVAGKL
260 270 280
KKDTYLENEK LSSGKRQELV TKIDHILDAL
Length:280
Mass (Da):32,166
Last modified:June 1, 2001 - v1
Checksum:iF707C43DDAB88236
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002175 mRNA. Translation: AAH02175.1.
UniGeneiMm.188544.

Similar proteinsi

Entry informationi

Entry nameiQ99LY0_MOUSE
AccessioniPrimary (citable) accession number: Q99LY0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)