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Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Gene

Rpn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.UniRule annotation

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1UniRule annotation (EC:2.4.99.18UniRule annotation)
Gene namesi
Name:Rpn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98084. Rpn1.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei113 – 132HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ99LY0.
PeptideAtlasiQ99LY0.
PRIDEiQ99LY0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030062.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032143.

Family & Domainsi

Sequence similaritiesi

Belongs to the OST1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2291. Eukaryota.
ENOG410XQVZ. LUCA.
HOVERGENiHBG012864.

Family and domain databases

InterProiIPR007676. Ribophorin_I.
[Graphical view]
PANTHERiPTHR21049. PTHR21049. 1 hit.
PfamiPF04597. Ribophorin_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99LY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
THYIVGYNLP SYEYLYNLGD QYALKMRFVD HVFDEQVIDS LTVKIILPEG
60 70 80 90 100
AKNIQVDSPY DISRAPDELH YTYLDTFGRP VIVAYKKNLV EQHIQDIVVH
110 120 130 140 150
YTFNKVLMLQ EPLLVVAAFY ILFFTVIIYV RLDFSITKDP AAEARMKVAC
160 170 180 190 200
ITEQVLTLVN KRLGLYRHFD ETVNRYKQSR DISTLNSGKK SLETEHKAVT
210 220 230 240 250
SEIAVLQSRL KTEGSDLCDR VSEMQKLDAQ VKELVLKSAV EAERLVAGKL
260 270 280
KKDTYLENEK LSSGKRQELV TKIDHILDAL
Length:280
Mass (Da):32,166
Last modified:June 1, 2001 - v1
Checksum:iF707C43DDAB88236
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002175 mRNA. Translation: AAH02175.1.
UniGeneiMm.188544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002175 mRNA. Translation: AAH02175.1.
UniGeneiMm.188544.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032143.

Proteomic databases

PaxDbiQ99LY0.
PeptideAtlasiQ99LY0.
PRIDEiQ99LY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98084. Rpn1.

Phylogenomic databases

eggNOGiKOG2291. Eukaryota.
ENOG410XQVZ. LUCA.
HOVERGENiHBG012864.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

ChiTaRSiRpn1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030062.

Family and domain databases

InterProiIPR007676. Ribophorin_I.
[Graphical view]
PANTHERiPTHR21049. PTHR21049. 1 hit.
PfamiPF04597. Ribophorin_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ99LY0_MOUSE
AccessioniPrimary (citable) accession number: Q99LY0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.