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Q99LY0

- Q99LY0_MOUSE

UniProt

Q99LY0 - Q99LY0_MOUSE

Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Gene

Rpn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.UniRule annotation

    Catalytic activityi

    Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro

    GO - Biological processi

    1. protein glycosylation Source: InterPro

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotation, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1UniRule annotation (EC:2.4.99.18UniRule annotation)
    Gene namesi
    Name:Rpn1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98084. Rpn1.

    Subcellular locationi

    Endoplasmic reticulum membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: MGI
    2. integral component of membrane Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulumUniRule annotation, Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ99LY0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99LY0.
    BgeeiQ99LY0.
    GenevestigatoriQ99LY0.

    Interactioni

    Subunit structurei

    Component of the oligosaccharyltransferase (OST) complex.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OST1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG012864.
    InParanoidiQ99LY0.

    Family and domain databases

    InterProiIPR007676. Ribophorin_I.
    [Graphical view]
    PANTHERiPTHR21049. PTHR21049. 1 hit.
    PfamiPF04597. Ribophorin_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99LY0-1 [UniParc]FASTAAdd to Basket

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    THYIVGYNLP SYEYLYNLGD QYALKMRFVD HVFDEQVIDS LTVKIILPEG    50
    AKNIQVDSPY DISRAPDELH YTYLDTFGRP VIVAYKKNLV EQHIQDIVVH 100
    YTFNKVLMLQ EPLLVVAAFY ILFFTVIIYV RLDFSITKDP AAEARMKVAC 150
    ITEQVLTLVN KRLGLYRHFD ETVNRYKQSR DISTLNSGKK SLETEHKAVT 200
    SEIAVLQSRL KTEGSDLCDR VSEMQKLDAQ VKELVLKSAV EAERLVAGKL 250
    KKDTYLENEK LSSGKRQELV TKIDHILDAL 280
    Length:280
    Mass (Da):32,166
    Last modified:June 1, 2001 - v1
    Checksum:iF707C43DDAB88236
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002175 mRNA. Translation: AAH02175.1.
    UniGeneiMm.188544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002175 mRNA. Translation: AAH02175.1 .
    UniGenei Mm.188544.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q99LY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98084. Rpn1.

    Phylogenomic databases

    HOVERGENi HBG012864.
    InParanoidi Q99LY0.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    ChiTaRSi RPN1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99LY0.
    Bgeei Q99LY0.
    Genevestigatori Q99LY0.

    Family and domain databases

    InterProi IPR007676. Ribophorin_I.
    [Graphical view ]
    PANTHERi PTHR21049. PTHR21049. 1 hit.
    Pfami PF04597. Ribophorin_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Mix FVB/NImported.
      Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

    Entry informationi

    Entry nameiQ99LY0_MOUSE
    AccessioniPrimary (citable) accession number: Q99LY0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)