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Protein

YY1-associated factor 2

Gene

Yaf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 48RanBP2-typePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
YY1-associated factor 2
Gene namesi
Name:Yaf2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914307 Yaf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000661141 – 179YY1-associated factor 2Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LW6
PaxDbiQ99LW6
PeptideAtlasiQ99LW6
PRIDEiQ99LW6

PTM databases

iPTMnetiQ99LW6
PhosphoSitePlusiQ99LW6

Expressioni

Tissue specificityi

In the mesoderm, expressed in the region close to the surface ectoderm.1 Publication

Developmental stagei

Expressed in both pre- and post-implantation embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000022634
CleanExiMM_YAF2
GenevisibleiQ99LW6 MM

Interactioni

Subunit structurei

Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.1 Publication

Protein-protein interaction databases

BioGridi211908, 2 interactors
IntActiQ99LW6, 3 interactors
STRINGi10090.ENSMUSP00000079179

Structurei

3D structure databases

ProteinModelPortaliQ99LW6
SMRiQ99LW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 48RanBP2-typePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4477 Eukaryota
ENOG4111PN1 LUCA
GeneTreeiENSGT00390000013995
HOGENOMiHOG000007553
HOVERGENiHBG001768
InParanoidiQ99LW6
KOiK11468
OMAiCTYRNNA
OrthoDBiEOG091G10HB
PhylomeDBiQ99LW6
TreeFamiTF350501

Family and domain databases

InterProiView protein in InterPro
IPR038039 YAF2
IPR033774 YAF2_RYBP
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR12920:SF2 PTHR12920:SF2, 1 hit
PfamiView protein in Pfam
PF17219 YAF2_RYBP, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q99LW6-1) [UniParc]FASTAAdd to basket
Also known as: YAF2-a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDKKSPTRP KRQPKPASDE GYWDCSVCTF RNSAEAFKCM MCDVRKGTST
60 70 80 90 100
RKPRPVSQLV AQQVTQQFVP PTQSKKEKKD RVEKDKSEKE AASKKNCHKK
110 120 130 140 150
TRPRLKNVDR SSAQHLEVTV GDLTVIITDF KEKAKSAPAS SAAGDQHSQG
160 170
SCSSDSTERG VSRSSSPRGE ASSLNGESH
Length:179
Mass (Da):19,655
Last modified:June 1, 2001 - v1
Checksum:i7DDB7B7F171CB547
GO
Isoform 21 Publication (identifier: Q99LW6-2) [UniParc]FASTAAdd to basket
Also known as: YAF2-b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     52-68: KPRPVSQLVAQQVTQQF → STFSEAIANALRTKGPL
     69-179: Missing.

Show »
Length:68
Mass (Da):7,548
Checksum:i1E9AB907CD05D5C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98H → S in BAB23741 (PubMed:16141072).Curated1
Sequence conflicti107N → Y in BAB23741 (PubMed:16141072).Curated1
Sequence conflicti162S → F in BAB23741 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05061952 – 68KPRPV…VTQQF → STFSEAIANALRTKGPL in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05062069 – 179Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100452 mRNA Translation: BAC97817.1
AB100453 mRNA Translation: BAC97818.1
AK005008 mRNA Translation: BAB23741.1
AK148634 mRNA Translation: BAE28627.1
BC002192 mRNA Translation: AAH02192.1
CCDSiCCDS27765.1 [Q99LW6-1]
RefSeqiNP_077151.3, NM_024189.6 [Q99LW6-1]
UniGeneiMm.4714

Genome annotation databases

EnsembliENSMUST00000080299; ENSMUSP00000079179; ENSMUSG00000022634 [Q99LW6-1]
GeneIDi67057
KEGGimmu:67057
UCSCiuc007xis.2 mouse [Q99LW6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiYAF2_MOUSE
AccessioniPrimary (citable) accession number: Q99LW6
Secondary accession number(s): Q3UFD4, Q9DBE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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