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Protein

Anion exchange protein

Gene

Slc4a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:Slc4a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109351. Slc4a2.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4425HelicalUniRule annotationAdd
BLAST
Transmembranei51 – 6919HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14318HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 17921HelicalUniRule annotationAdd
BLAST
Transmembranei216 – 23520HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 28025HelicalUniRule annotationAdd
BLAST
Transmembranei341 – 36121HelicalUniRule annotationAdd
BLAST
Transmembranei388 – 40619HelicalUniRule annotationAdd
BLAST
Transmembranei412 – 43322HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ99LT5.
ExpressionAtlasiQ99LT5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078972.

Family & Domainsi

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01231. HCO3TRNSPORT.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99LT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EAFFSFCSSN ELEYLVGRVW IGFWLVFLAL LMVALEGSFL VRFVSRFTQE
60 70 80 90 100
IFAFLISLIF IYETFYKLIK IFQEHPLHGC SGSNDSEAGS SSSSNMTWAT
110 120 130 140 150
TILVPDNSSA SGQSGQEKPR GQPNTALLSL VLMAGTFFIA FFLRKFKNSR
160 170 180 190 200
FFPGRIRRVI GDFGVPIAIL IMVLVDYSIE DTYTQKLSVP SGFSVTAPDK
210 220 230 240 250
RGWVINPLGE KTPFPVWMMV ASLLPAVLVF ILIFMETQIT TLIISKKERM
260 270 280 290 300
LQKGSGFHLD LLLIVAMGGI CALFGLPWLA AATVRSVTHA NALTVMSKAV
310 320 330 340 350
APGDKPKIQE VKEQRVTGLL VALLVGLSMV IGDLLRQIPL AVLFGIFLYM
360 370 380 390 400
GVTSLNGIQF YERLHLLLMP PKHHPDVTYV KKVRTMRMHL FTALQLLCLA
410 420 430 440 450
LLWAVMSTAA SLAFPFILIL TVPLRMVVLT RIFTEREMKC LDANEAEPVF
460
DECEGVDEYN EMPMPV
Length:466
Mass (Da):52,004
Last modified:June 1, 2001 - v1
Checksum:i481C1108E28D03B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002234 mRNA. Translation: AAH02234.1.
UniGeneiMm.4580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002234 mRNA. Translation: AAH02234.1.
UniGeneiMm.4580.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109351. Slc4a2.

Phylogenomic databases

HOVERGENiHBG004326.

Miscellaneous databases

ChiTaRSiSlc4a2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LT5.
ExpressionAtlasiQ99LT5. baseline and differential.

Family and domain databases

InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01231. HCO3TRNSPORT.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ99LT5_MOUSE
AccessioniPrimary (citable) accession number: Q99LT5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.