Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Monoacylglycerol lipase ABHD12

Gene

Abhd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (PubMed:23297193). May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways (PubMed:18096503).2 Publications

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246NucleophileBy similarity1
Active sitei333Charge relay systemBy similarity1
Active sitei372Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • lysophospholipase activity Source: MGI
  • palmitoyl-(protein) hydrolase activity Source: UniProtKB

GO - Biological processi

  • acylglycerol catabolic process Source: UniProtKB
  • adult walking behavior Source: MGI
  • glycerophospholipid catabolic process Source: MGI
  • monoacylglycerol catabolic process Source: MGI
  • phosphatidylserine catabolic process Source: MGI
  • protein depalmitoylation Source: UniProtKB
  • response to auditory stimulus Source: MGI

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-426048 Arachidonate production from DAG

Protein family/group databases

ESTHERimouse-abd12 ABHD12-PHARC
MEROPSiS09.054

Chemistry databases

SwissLipidsiSLP:000001041

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.231 Publication)
Alternative name(s):
2-arachidonoylglycerol hydrolaseCurated
Abhydrolase domain-containing protein 12Curated
Gene namesi
Name:Abhd12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923442 Abhd12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74Cytoplasmic1 PublicationAdd BLAST74
Transmembranei75 – 95Helical1 PublicationAdd BLAST21
Topological domaini96 – 398Extracellular1 PublicationAdd BLAST303

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Mice are viable and were born at the expected Mendelian frequency. Young mice (less than 6 months old) are mostly normal in their behavior; however, as these animals age, they develop an array of phenotypes, including defective auditory and motor behavior, with concomitant cellular pathology indicative of a neuroinflammatory response. Metabolomic characterization of brain tissue show striking elevations in a series of lysophosphatidylserine (LPS) lipids that occur before the onset of neuroinflammatory and behavioral defects.1 Publication

Chemistry databases

ChEMBLiCHEMBL5972

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794141 – 398Monoacylglycerol lipase ABHD12Add BLAST398

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ99LR1
PaxDbiQ99LR1
PeptideAtlasiQ99LR1
PRIDEiQ99LR1

PTM databases

iPTMnetiQ99LR1
PhosphoSitePlusiQ99LR1
SwissPalmiQ99LR1

Expressioni

Gene expression databases

BgeeiENSMUSG00000032046
CleanExiMM_ABHD12
ExpressionAtlasiQ99LR1 baseline and differential
GenevisibleiQ99LR1 MM

Interactioni

Protein-protein interaction databases

BioGridi218015, 1 interactor
IntActiQ99LR1, 3 interactors
MINTiQ99LR1
STRINGi10090.ENSMUSP00000053558

Chemistry databases

BindingDBiQ99LR1

Structurei

3D structure databases

ProteinModelPortaliQ99LR1
SMRiQ99LR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Ser8
Compositional biasi26 – 29Poly-Ala4

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1552 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000006625
HOGENOMiHOG000230822
HOVERGENiHBG051152
InParanoidiQ99LR1
KOiK13704
OMAiWGPVEFH
OrthoDBiEOG091G0QYO
PhylomeDBiQ99LR1
TreeFamiTF315122

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR026605 ABHD12
IPR022742 Hydrolase_4
PANTHERiPTHR12277:SF61 PTHR12277:SF61, 1 hit
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99LR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP
60 70 80 90 100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK
160 170 180 190 200
NAQGKDQMWY EDALASNHAI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH
Length:398
Mass (Da):45,270
Last modified:November 28, 2003 - v2
Checksum:iB8B23FA97DB4FF45
GO
Isoform 2 (identifier: Q99LR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,880
Checksum:iE1606371821F87CC
GO

Sequence cautioni

The sequence AAH02138 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti386R → W in AAH02138 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574931 – 219Missing in isoform 2. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808125, AL954712 Genomic DNA Translation: CAM17128.1
AL954712, AL808125 Genomic DNA Translation: CAM18377.1
CH466519 Genomic DNA Translation: EDL28584.1
BC002138 mRNA Translation: AAH02138.1 Different initiation.
BC002263 mRNA Translation: AAH02263.1
CCDSiCCDS50742.1 [Q99LR1-1]
RefSeqiNP_077785.2, NM_024465.3 [Q99LR1-1]
UniGeneiMm.112632

Genome annotation databases

EnsembliENSMUST00000056149; ENSMUSP00000053558; ENSMUSG00000032046 [Q99LR1-1]
GeneIDi76192
KEGGimmu:76192
UCSCiuc008muo.2 mouse [Q99LR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABD12_MOUSE
AccessioniPrimary (citable) accession number: Q99LR1
Secondary accession number(s): A2ANB4, Q99M06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health