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Protein

Transmembrane protein 189

Gene

Tmem189

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 189
Gene namesi
Name:Tmem189Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2142624. Tmem189.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199941 – 271Transmembrane protein 189Add BLAST271

Proteomic databases

PaxDbiQ99LQ7.
PeptideAtlasiQ99LQ7.
PRIDEiQ99LQ7.

PTM databases

PhosphoSitePlusiQ99LQ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000090213.
CleanExiMM_TMEM189.
GenevisibleiQ99LQ7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006587.

Structurei

3D structure databases

ProteinModelPortaliQ99LQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3011. Eukaryota.
ENOG410XRWR. LUCA.
GeneTreeiENSGT00740000115607.
HOGENOMiHOG000257103.
HOVERGENiHBG058716.
InParanoidiQ99LQ7.
KOiK20656.
OMAiALTNQIH.
OrthoDBiEOG091G0SMT.
PhylomeDBiQ99LQ7.
TreeFamiTF106147.

Family and domain databases

InterProiIPR019547. TMEM189_B_dmain.
[Graphical view]
PfamiPF10520. TMEM189_B_dmain. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAEDAPGR QPELDEDETA EGRRWGAQHA GARELAALYS PGKRFQEWCS
60 70 80 90 100
VILCFSLIAH NLVHLLLLAR WEHTPLVILG VVAGALVADF LSGLVHWGAD
110 120 130 140 150
TWGSVDLPIV GKAFIRPFRE HHIDPTAITR HDFIETNGDN CLVTLLPLLN
160 170 180 190 200
MAYKFRTQSP ETLEQLYPWE CFVFCLTIFG TFTNQIHKWS HTYLGLPYWV
210 220 230 240 250
TVLQDWHVIL PRKHHRIHHV APHETYFCIT TGWLNYPLEV IGFWRRLEDL
260 270
IQGLTGEKPR ADDMKWAQKI K
Length:271
Mass (Da):31,134
Last modified:June 1, 2001 - v1
Checksum:i4C37C838DBE5E15B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088196 mRNA. Translation: BAC40204.1.
AK151326 mRNA. Translation: BAE30306.1.
AL589870, CR626861 Genomic DNA. Translation: CAM13820.1.
CR626861, AL589870 Genomic DNA. Translation: CAM20694.1.
BC002270 mRNA. Translation: AAH02270.1.
CCDSiCCDS17104.1.
RefSeqiNP_663513.1. NM_145538.2.
UniGeneiMm.4863.

Genome annotation databases

EnsembliENSMUST00000006587; ENSMUSP00000006587; ENSMUSG00000090213.
GeneIDi407243.
KEGGimmu:407243.
UCSCiuc008oad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088196 mRNA. Translation: BAC40204.1.
AK151326 mRNA. Translation: BAE30306.1.
AL589870, CR626861 Genomic DNA. Translation: CAM13820.1.
CR626861, AL589870 Genomic DNA. Translation: CAM20694.1.
BC002270 mRNA. Translation: AAH02270.1.
CCDSiCCDS17104.1.
RefSeqiNP_663513.1. NM_145538.2.
UniGeneiMm.4863.

3D structure databases

ProteinModelPortaliQ99LQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006587.

PTM databases

PhosphoSitePlusiQ99LQ7.

Proteomic databases

PaxDbiQ99LQ7.
PeptideAtlasiQ99LQ7.
PRIDEiQ99LQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006587; ENSMUSP00000006587; ENSMUSG00000090213.
GeneIDi407243.
KEGGimmu:407243.
UCSCiuc008oad.1. mouse.

Organism-specific databases

CTDi387521.
MGIiMGI:2142624. Tmem189.

Phylogenomic databases

eggNOGiKOG3011. Eukaryota.
ENOG410XRWR. LUCA.
GeneTreeiENSGT00740000115607.
HOGENOMiHOG000257103.
HOVERGENiHBG058716.
InParanoidiQ99LQ7.
KOiK20656.
OMAiALTNQIH.
OrthoDBiEOG091G0SMT.
PhylomeDBiQ99LQ7.
TreeFamiTF106147.

Miscellaneous databases

ChiTaRSiTmem189. mouse.
PROiQ99LQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090213.
CleanExiMM_TMEM189.
GenevisibleiQ99LQ7. MM.

Family and domain databases

InterProiIPR019547. TMEM189_B_dmain.
[Graphical view]
PfamiPF10520. TMEM189_B_dmain. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM189_MOUSE
AccessioniPrimary (citable) accession number: Q99LQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.