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Protein

MAP3K12-binding inhibitory protein 1

Gene

Mbip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MAP3K12-binding inhibitory protein 1
Alternative name(s):
MAPK upstream kinase-binding inhibitory protein
Short name:
MUK-binding inhibitory protein
Gene namesi
Name:Mbip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1918320 Mbip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962701 – 341MAP3K12-binding inhibitory protein 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei299N6-acetyllysine; alternateCombined sources1
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99LQ1
MaxQBiQ99LQ1
PaxDbiQ99LQ1
PeptideAtlasiQ99LQ1
PRIDEiQ99LQ1

PTM databases

iPTMnetiQ99LQ1
PhosphoSitePlusiQ99LQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000021028
CleanExiMM_MBIP
ExpressionAtlasiQ99LQ1 baseline and differential
GenevisibleiQ99LQ1 MM

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229926, 3 interactors
IntActiQ99LQ1, 4 interactors
MINTiQ99LQ1
STRINGi10090.ENSMUSP00000021416

Structurei

3D structure databases

ProteinModelPortaliQ99LQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni170 – 341Interaction with MAP3K12Add BLAST172
Regioni269 – 283Leucine-zipper 1Sequence analysisAdd BLAST15
Regioni312 – 327Leucine-zipper 2Sequence analysisAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFXK Eukaryota
ENOG410Y0HB LUCA
GeneTreeiENSGT00510000047831
HOGENOMiHOG000113491
HOVERGENiHBG052420
InParanoidiQ99LQ1
OMAiVKITIDW
OrthoDBiEOG091G0CV5
PhylomeDBiQ99LQ1
TreeFamiTF331763

Family and domain databases

InterProiView protein in InterPro
IPR026062 MBIP
PANTHERiPTHR23404:SF3 PTHR23404:SF3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99LQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAELSSS SGSERSLEQC SSPLLTREVL CEVFRSLHTL TRQLNLRDDV
60 70 80 90 100
VKITIDWNRL QSLSASQPAL LLTALEQHVL YLQPFLAKLQ SLMKENSTAT
110 120 130 140 150
EIRQTEAETK SELRAIHPTE DLQDEGKPKD CDVGDVKKTQ NLFDPEVVQI
160 170 180 190 200
KAGKAEIDRR ISAFIERKQA EINENNVREF CNVIDCNQEN SCARTDAVFT
210 220 230 240 250
PYPGFKSHVK VSRVVNTYGP QTRPEGIAGS GHKPTGMLRD CGNQAVEERL
260 270 280 290 300
QNIEAHLRLQ TGGPVPRDIY QRIKKLEDKI LELEGISPEY FQSVNFSGKR
310 320 330 340
RKVQPPQQNY SLAELDEKIS ALKRALLRKS READSMAAHL P
Length:341
Mass (Da):38,333
Last modified:June 1, 2001 - v1
Checksum:iC83C4DDA6CBABCDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077125 mRNA Translation: BAC36628.1
AK154318 mRNA Translation: BAE32511.1
AK171164 mRNA Translation: BAE42286.1
BC002277 mRNA Translation: AAH02277.1
CCDSiCCDS25920.1
RefSeqiNP_663417.1, NM_145442.2
UniGeneiMm.25656

Genome annotation databases

EnsembliENSMUST00000021416; ENSMUSP00000021416; ENSMUSG00000021028
GeneIDi217588
KEGGimmu:217588
UCSCiuc007npc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMBIP1_MOUSE
AccessioniPrimary (citable) accession number: Q99LQ1
Secondary accession number(s): Q3TBM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health