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Protein

MAP3K12-binding inhibitory protein 1

Gene

Mbip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP3K12-binding inhibitory protein 1
Alternative name(s):
MAPK upstream kinase-binding inhibitory protein
Short name:
MUK-binding inhibitory protein
Gene namesi
Name:Mbip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1918320. Mbip.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shows a cytoplasmic localization when co-expressed with MAP3K12.By similarity

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  • cytoplasm Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962701 – 341MAP3K12-binding inhibitory protein 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei299N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99LQ1.
MaxQBiQ99LQ1.
PaxDbiQ99LQ1.
PeptideAtlasiQ99LQ1.
PRIDEiQ99LQ1.

PTM databases

iPTMnetiQ99LQ1.
PhosphoSitePlusiQ99LQ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021028.
CleanExiMM_MBIP.
GenevisibleiQ99LQ1. MM.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.By similarity

Protein-protein interaction databases

BioGridi229926. 3 interactors.
IntActiQ99LQ1. 4 interactors.
MINTiMINT-4101403.
STRINGi10090.ENSMUSP00000021416.

Structurei

3D structure databases

ProteinModelPortaliQ99LQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni170 – 341Interaction with MAP3K12Add BLAST172
Regioni269 – 283Leucine-zipper 1Sequence analysisAdd BLAST15
Regioni312 – 327Leucine-zipper 2Sequence analysisAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFXK. Eukaryota.
ENOG410Y0HB. LUCA.
GeneTreeiENSGT00510000047831.
HOGENOMiHOG000113491.
HOVERGENiHBG052420.
InParanoidiQ99LQ1.
OMAiVKITIDW.
OrthoDBiEOG091G0CV5.
PhylomeDBiQ99LQ1.
TreeFamiTF331763.

Family and domain databases

InterProiIPR026062. MBIP.
[Graphical view]
PANTHERiPTHR23404:SF3. PTHR23404:SF3. 2 hits.

Sequencei

Sequence statusi: Complete.

Q99LQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAELSSS SGSERSLEQC SSPLLTREVL CEVFRSLHTL TRQLNLRDDV
60 70 80 90 100
VKITIDWNRL QSLSASQPAL LLTALEQHVL YLQPFLAKLQ SLMKENSTAT
110 120 130 140 150
EIRQTEAETK SELRAIHPTE DLQDEGKPKD CDVGDVKKTQ NLFDPEVVQI
160 170 180 190 200
KAGKAEIDRR ISAFIERKQA EINENNVREF CNVIDCNQEN SCARTDAVFT
210 220 230 240 250
PYPGFKSHVK VSRVVNTYGP QTRPEGIAGS GHKPTGMLRD CGNQAVEERL
260 270 280 290 300
QNIEAHLRLQ TGGPVPRDIY QRIKKLEDKI LELEGISPEY FQSVNFSGKR
310 320 330 340
RKVQPPQQNY SLAELDEKIS ALKRALLRKS READSMAAHL P
Length:341
Mass (Da):38,333
Last modified:June 1, 2001 - v1
Checksum:iC83C4DDA6CBABCDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077125 mRNA. Translation: BAC36628.1.
AK154318 mRNA. Translation: BAE32511.1.
AK171164 mRNA. Translation: BAE42286.1.
BC002277 mRNA. Translation: AAH02277.1.
CCDSiCCDS25920.1.
RefSeqiNP_663417.1. NM_145442.2.
UniGeneiMm.25656.

Genome annotation databases

EnsembliENSMUST00000021416; ENSMUSP00000021416; ENSMUSG00000021028.
GeneIDi217588.
KEGGimmu:217588.
UCSCiuc007npc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077125 mRNA. Translation: BAC36628.1.
AK154318 mRNA. Translation: BAE32511.1.
AK171164 mRNA. Translation: BAE42286.1.
BC002277 mRNA. Translation: AAH02277.1.
CCDSiCCDS25920.1.
RefSeqiNP_663417.1. NM_145442.2.
UniGeneiMm.25656.

3D structure databases

ProteinModelPortaliQ99LQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229926. 3 interactors.
IntActiQ99LQ1. 4 interactors.
MINTiMINT-4101403.
STRINGi10090.ENSMUSP00000021416.

PTM databases

iPTMnetiQ99LQ1.
PhosphoSitePlusiQ99LQ1.

Proteomic databases

EPDiQ99LQ1.
MaxQBiQ99LQ1.
PaxDbiQ99LQ1.
PeptideAtlasiQ99LQ1.
PRIDEiQ99LQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021416; ENSMUSP00000021416; ENSMUSG00000021028.
GeneIDi217588.
KEGGimmu:217588.
UCSCiuc007npc.2. mouse.

Organism-specific databases

CTDi51562.
MGIiMGI:1918320. Mbip.

Phylogenomic databases

eggNOGiENOG410IFXK. Eukaryota.
ENOG410Y0HB. LUCA.
GeneTreeiENSGT00510000047831.
HOGENOMiHOG000113491.
HOVERGENiHBG052420.
InParanoidiQ99LQ1.
OMAiVKITIDW.
OrthoDBiEOG091G0CV5.
PhylomeDBiQ99LQ1.
TreeFamiTF331763.

Miscellaneous databases

ChiTaRSiMbip. mouse.
PROiQ99LQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021028.
CleanExiMM_MBIP.
GenevisibleiQ99LQ1. MM.

Family and domain databases

InterProiIPR026062. MBIP.
[Graphical view]
PANTHERiPTHR23404:SF3. PTHR23404:SF3. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMBIP1_MOUSE
AccessioniPrimary (citable) accession number: Q99LQ1
Secondary accession number(s): Q3TBM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.