Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GrpE protein homolog 1, mitochondrial

Gene

Grpel1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Gene namesi
Name:Grpel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1334417. Grpel1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000001305028 – 217GrpE protein homolog 1, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateCombined sources1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei120N6-succinyllysineCombined sources1
Modified residuei215N6-acetyllysine; alternateCombined sources1
Modified residuei215N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LP6.
MaxQBiQ99LP6.
PaxDbiQ99LP6.
PeptideAtlasiQ99LP6.
PRIDEiQ99LP6.

2D gel databases

UCD-2DPAGEQ99LP6.

PTM databases

iPTMnetiQ99LP6.
PhosphoSitePlusiQ99LP6.
SwissPalmiQ99LP6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029198.
CleanExiMM_GRPEL1.
GenevisibleiQ99LP6. MM.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99LP6. 3 interactors.
MINTiMINT-1842443.
STRINGi10090.ENSMUSP00000031099.

Structurei

3D structure databases

ProteinModelPortaliQ99LP6.
SMRiQ99LP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ99LP6.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG091G0O5D.
PhylomeDBiQ99LP6.
TreeFamiTF105284.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCVRLAR RSLPALALSF RPSPRLLCTA TKQKNNGQNL DEDLGHCEPK
60 70 80 90 100
TDPPSADKTL LEEKAKLEEQ LRETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQSVPKEEI SNNNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLDPIGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKDA
Length:217
Mass (Da):24,307
Last modified:June 1, 2001 - v1
Checksum:iBE7A6D26A9C5B329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048732 mRNA. Translation: BAC33437.1.
AK050445 mRNA. Translation: BAC34257.1.
AK089113 mRNA. Translation: BAC40758.1.
AK161688 mRNA. Translation: BAE36532.1.
BC002284 mRNA. Translation: AAH02284.1.
CCDSiCCDS19238.1.
RefSeqiNP_077798.1. NM_024478.2.
UniGeneiMm.21535.

Genome annotation databases

EnsembliENSMUST00000031099; ENSMUSP00000031099; ENSMUSG00000029198.
GeneIDi17713.
KEGGimmu:17713.
UCSCiuc008xep.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048732 mRNA. Translation: BAC33437.1.
AK050445 mRNA. Translation: BAC34257.1.
AK089113 mRNA. Translation: BAC40758.1.
AK161688 mRNA. Translation: BAE36532.1.
BC002284 mRNA. Translation: AAH02284.1.
CCDSiCCDS19238.1.
RefSeqiNP_077798.1. NM_024478.2.
UniGeneiMm.21535.

3D structure databases

ProteinModelPortaliQ99LP6.
SMRiQ99LP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99LP6. 3 interactors.
MINTiMINT-1842443.
STRINGi10090.ENSMUSP00000031099.

PTM databases

iPTMnetiQ99LP6.
PhosphoSitePlusiQ99LP6.
SwissPalmiQ99LP6.

2D gel databases

UCD-2DPAGEQ99LP6.

Proteomic databases

EPDiQ99LP6.
MaxQBiQ99LP6.
PaxDbiQ99LP6.
PeptideAtlasiQ99LP6.
PRIDEiQ99LP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031099; ENSMUSP00000031099; ENSMUSG00000029198.
GeneIDi17713.
KEGGimmu:17713.
UCSCiuc008xep.1. mouse.

Organism-specific databases

CTDi80273.
MGIiMGI:1334417. Grpel1.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ99LP6.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG091G0O5D.
PhylomeDBiQ99LP6.
TreeFamiTF105284.

Miscellaneous databases

PROiQ99LP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029198.
CleanExiMM_GRPEL1.
GenevisibleiQ99LP6. MM.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE1_MOUSE
AccessioniPrimary (citable) accession number: Q99LP6
Secondary accession number(s): Q3TSZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.