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Protein
Submitted name:

Col1a1 protein

Gene

Col1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: MGI
  2. identical protein binding Source: MGI
  3. platelet-derived growth factor binding Source: MGI

GO - Biological processi

  1. blood vessel development Source: MGI
  2. bone trabecula formation Source: MGI
  3. cartilage development involved in endochondral bone morphogenesis Source: MGI
  4. cellular response to amino acid stimulus Source: MGI
  5. cellular response to epidermal growth factor stimulus Source: Ensembl
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to fluoride Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. cellular response to retinoic acid Source: Ensembl
  10. cellular response to transforming growth factor beta stimulus Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. cellular response to vitamin E Source: Ensembl
  13. collagen biosynthetic process Source: MGI
  14. collagen fibril organization Source: MGI
  15. embryonic skeletal system development Source: MGI
  16. endochondral ossification Source: MGI
  17. face morphogenesis Source: MGI
  18. intramembranous ossification Source: MGI
  19. negative regulation of cell-substrate adhesion Source: MGI
  20. positive regulation of canonical Wnt signaling pathway Source: MGI
  21. positive regulation of cell migration Source: MGI
  22. positive regulation of epithelial to mesenchymal transition Source: MGI
  23. positive regulation of transcription, DNA-templated Source: MGI
  24. protein heterotrimerization Source: MGI
  25. protein localization to nucleus Source: MGI
  26. protein transport Source: MGI
  27. response to cAMP Source: Ensembl
  28. response to corticosteroid Source: Ensembl
  29. response to drug Source: Ensembl
  30. response to estradiol Source: Ensembl
  31. response to hydrogen peroxide Source: Ensembl
  32. response to hyperoxia Source: Ensembl
  33. response to peptide hormone Source: Ensembl
  34. sensory perception of sound Source: MGI
  35. skeletal system development Source: MGI
  36. skeletal system morphogenesis Source: MGI
  37. skin development Source: MGI
  38. skin morphogenesis Source: MGI
  39. tooth eruption Source: Ensembl
  40. tooth mineralization Source: MGI
  41. visual perception Source: MGI
  42. wound healing Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Col1a1 proteinImported
Gene namesi
Name:Col1a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88467. Col1a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: MGI
  2. collagen type I trimer Source: MGI
  3. cytoplasm Source: MGI
  4. endoplasmic reticulum Source: Ensembl
  5. extracellular matrix Source: MGI
  6. extracellular space Source: MGI
  7. Golgi apparatus Source: Ensembl
  8. proteinaceous extracellular matrix Source: MGI
  9. secretory granule Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ99LL6.
ExpressionAtlasiQ99LL6. baseline and differential.
GenevestigatoriQ99LL6.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG103137.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 5 hits.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99LL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FPGAAGRVGP PGPSGNAGPP GPPGPVGKEG GKGPRGETGP AGRPGEVGPP
60 70 80 90 100
GPPGPAGEKG SPGADGPAGS PGTPGPQGIA GQRGVVGLPG QRGERGFPGL
110 120 130 140 150
PGPSGEPGKQ GPSGSSGERG PPGPMGPPGL AGPPGESGRE GSPGAEGSPG
160 170 180 190 200
RDGAPGAKGD RGETGPAGPP GAPGAPGAPG PVGPAGKNGD RGETGPAGPA
210 220 230 240 250
GPIGPAGARG PAGPQGPRGD KGETGEQGDR GIKGHRGFSG LQGPPGSPGS
260 270 280 290 300
PGEQGPSGAS GPAGPRGPPG SAGSPGKDGL NGLPGPIGPP GPRGRTGDSG
310 320 330 340 350
PAGPPGPPGP PGPPGPPSGG YDFSFLPQPP QEKSQDGGRY YRADDANVVR
360 370 380 390 400
DRDLEVDTTL KSLSQQIENI RSPEGSRKNP ARTCRDLKMC HSDWKSGEYW
410 420 430 440 450
IDPNQGCNLD AIKVYCNMET GQTCVFPTQP SVPQKNWYIS PNPKEKKHVW
460 470 480 490 500
FGESMTDGFP FEYGSEGSDP ADVAIQLTFL RLMSTEASQN ITYHCKNSVA
510 520 530 540 550
YMDQQTGNLK KALLLQGSNE IELRGEGNSR FTYSTLVDGC TSHTGTWGKT
560 570 580
VIEYKTTKTS RLPIIDVAPL DIGAPDQEFG LDIGPACFV
Length:589
Mass (Da):58,805
Last modified:June 1, 2001 - v1
Checksum:i81847495E5E05CEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003198 mRNA. Translation: AAH03198.1.
UniGeneiMm.277735.
Mm.458212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003198 mRNA. Translation: AAH03198.1.
UniGeneiMm.277735.
Mm.458212.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88467. Col1a1.

Phylogenomic databases

HOVERGENiHBG103137.

Miscellaneous databases

ChiTaRSiCol1a1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LL6.
ExpressionAtlasiQ99LL6. baseline and differential.
GenevestigatoriQ99LL6.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 5 hits.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ99LL6_MOUSE
AccessioniPrimary (citable) accession number: Q99LL6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.