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Protein

Periodic tryptophan protein 1 homolog

Gene

Pwp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in cell growth and/or transcription.By similarity

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

GO - Biological processi

  • histone H4-K20 trimethylation Source: MGI
  • negative regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1 homolog
Gene namesi
Name:Pwp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914735 Pwp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511721 – 501Periodic tryptophan protein 1 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei493PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LL5
MaxQBiQ99LL5
PaxDbiQ99LL5
PeptideAtlasiQ99LL5
PRIDEiQ99LL5

PTM databases

iPTMnetiQ99LL5
PhosphoSitePlusiQ99LL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000001785
CleanExiMM_PWP1
ExpressionAtlasiQ99LL5 baseline and differential
GenevisibleiQ99LL5 MM

Interactioni

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

Protein-protein interaction databases

BioGridi222026, 4 interactors
IntActiQ99LL5, 2 interactors
MINTiQ99LL5
STRINGi10090.ENSMUSP00000001836

Structurei

3D structure databases

ProteinModelPortaliQ99LL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 229WD 1Add BLAST45
Repeati253 – 293WD 2Add BLAST41
Repeati296 – 336WD 3Add BLAST41
Repeati382 – 422WD 4Add BLAST41
Repeati427 – 467WD 5Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0270 Eukaryota
ENOG410XT1V LUCA
GeneTreeiENSGT00390000017324
HOGENOMiHOG000212580
HOVERGENiHBG001543
InParanoidiQ99LL5
KOiK14791
OMAiPLCVEWL
OrthoDBiEOG091G07TA
PhylomeDBiQ99LL5
TreeFamiTF314868

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q99LL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSRQVTCV AWVRRGVAKE TPDKVELSKE EVNRLIAEAK GKLQEEGGSE
60 70 80 90 100
EEEAGNPSED GMQSGPTQAP PRESLEDGDP QDDRTLDDDE LAGYDLDNYD
110 120 130 140 150
EEDNPDAETI GESLLGLTVY GSNDQDPYVT LKDTEQYEHE DFLIKPTDNL
160 170 180 190 200
IVCGRAEQEQ CNLEVHVYNQ EEESFYVHHD ILLSAYPLSV EWLNFDPSPD
210 220 230 240 250
ASTGNYIAVG NMTPVIEVWD LDIVDSLEPV FTLGSKLSKK KKKKGKKSSS
260 270 280 290 300
AEGHTDAVLD LSWNKTVRNV LASASADSTV VLWDLSVGKS VARLTAHTDK
310 320 330 340 350
VQTLQFHPFE AQTLISGSYD KSVALYDCRD PSQNHRQWRF SGQIERVTWN
360 370 380 390 400
HFSPCHFLAS TDDGFVYNLD ARSDKPIFTL NAHNDEISGL DLSSQIKGCL
410 420 430 440 450
VTASADKFVK IWDILGDRPS LIHSRDMKMG VLFCSSCCPD LPFVYAFGGQ
460 470 480 490 500
KEGLRVWDIS TVSSVNEAFG RRERLVIGGT KGLSVSGPCG SRSPQQTPME

S
Length:501
Mass (Da):55,587
Last modified:June 1, 2001 - v1
Checksum:i704A050633F0C2B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247K → R in BAB26622 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009972 mRNA Translation: BAB26622.1
AK082158 mRNA Translation: BAC38427.1
BC003199 mRNA Translation: AAH03199.1
BC023137 mRNA Translation: AAH23137.1
CCDSiCCDS24092.1
RefSeqiNP_598754.2, NM_133993.3
UniGeneiMm.18834

Genome annotation databases

EnsembliENSMUST00000001836; ENSMUSP00000001836; ENSMUSG00000001785
GeneIDi103136
KEGGimmu:103136
UCSCiuc007gnc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPWP1_MOUSE
AccessioniPrimary (citable) accession number: Q99LL5
Secondary accession number(s): Q9D6T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health