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Protein

Periodic tryptophan protein 1 homolog

Gene

Pwp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in cell growth and/or transcription.By similarity

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

GO - Biological processi

  • histone H4-K20 trimethylation Source: MGI
  • negative regulation of serine phosphorylation of STAT3 protein Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1 homolog
Gene namesi
Name:Pwp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914735. Pwp1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Periodic tryptophan protein 1 homologPRO_0000051172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphothreonineBy similarity
Modified residuei49 – 491PhosphoserineCombined sources
Modified residuei58 – 581PhosphoserineCombined sources
Modified residuei85 – 851PhosphothreonineBy similarity
Modified residuei484 – 4841PhosphoserineBy similarity
Modified residuei493 – 4931PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LL5.
MaxQBiQ99LL5.
PaxDbiQ99LL5.
PeptideAtlasiQ99LL5.
PRIDEiQ99LL5.

PTM databases

iPTMnetiQ99LL5.
PhosphoSiteiQ99LL5.

Expressioni

Gene expression databases

BgeeiQ99LL5.
CleanExiMM_PWP1.
ExpressionAtlasiQ99LL5. baseline and differential.
GenevisibleiQ99LL5. MM.

Interactioni

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

Protein-protein interaction databases

BioGridi222026. 3 interactions.
IntActiQ99LL5. 2 interactions.
MINTiMINT-4124271.
STRINGi10090.ENSMUSP00000001836.

Structurei

3D structure databases

ProteinModelPortaliQ99LL5.
SMRiQ99LL5. Positions 185-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 22945WD 1Add
BLAST
Repeati253 – 29341WD 2Add
BLAST
Repeati296 – 33641WD 3Add
BLAST
Repeati382 – 42241WD 4Add
BLAST
Repeati427 – 46741WD 5Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ99LL5.
KOiK14791.
OMAiCAACCPD.
OrthoDBiEOG7X3QR1.
PhylomeDBiQ99LL5.
TreeFamiTF314868.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSRQVTCV AWVRRGVAKE TPDKVELSKE EVNRLIAEAK GKLQEEGGSE
60 70 80 90 100
EEEAGNPSED GMQSGPTQAP PRESLEDGDP QDDRTLDDDE LAGYDLDNYD
110 120 130 140 150
EEDNPDAETI GESLLGLTVY GSNDQDPYVT LKDTEQYEHE DFLIKPTDNL
160 170 180 190 200
IVCGRAEQEQ CNLEVHVYNQ EEESFYVHHD ILLSAYPLSV EWLNFDPSPD
210 220 230 240 250
ASTGNYIAVG NMTPVIEVWD LDIVDSLEPV FTLGSKLSKK KKKKGKKSSS
260 270 280 290 300
AEGHTDAVLD LSWNKTVRNV LASASADSTV VLWDLSVGKS VARLTAHTDK
310 320 330 340 350
VQTLQFHPFE AQTLISGSYD KSVALYDCRD PSQNHRQWRF SGQIERVTWN
360 370 380 390 400
HFSPCHFLAS TDDGFVYNLD ARSDKPIFTL NAHNDEISGL DLSSQIKGCL
410 420 430 440 450
VTASADKFVK IWDILGDRPS LIHSRDMKMG VLFCSSCCPD LPFVYAFGGQ
460 470 480 490 500
KEGLRVWDIS TVSSVNEAFG RRERLVIGGT KGLSVSGPCG SRSPQQTPME

S
Length:501
Mass (Da):55,587
Last modified:June 1, 2001 - v1
Checksum:i704A050633F0C2B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471K → R in BAB26622 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009972 mRNA. Translation: BAB26622.1.
AK082158 mRNA. Translation: BAC38427.1.
BC003199 mRNA. Translation: AAH03199.1.
BC023137 mRNA. Translation: AAH23137.1.
CCDSiCCDS24092.1.
RefSeqiNP_598754.2. NM_133993.3.
UniGeneiMm.18834.

Genome annotation databases

EnsembliENSMUST00000001836; ENSMUSP00000001836; ENSMUSG00000001785.
GeneIDi103136.
KEGGimmu:103136.
UCSCiuc007gnc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009972 mRNA. Translation: BAB26622.1.
AK082158 mRNA. Translation: BAC38427.1.
BC003199 mRNA. Translation: AAH03199.1.
BC023137 mRNA. Translation: AAH23137.1.
CCDSiCCDS24092.1.
RefSeqiNP_598754.2. NM_133993.3.
UniGeneiMm.18834.

3D structure databases

ProteinModelPortaliQ99LL5.
SMRiQ99LL5. Positions 185-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222026. 3 interactions.
IntActiQ99LL5. 2 interactions.
MINTiMINT-4124271.
STRINGi10090.ENSMUSP00000001836.

PTM databases

iPTMnetiQ99LL5.
PhosphoSiteiQ99LL5.

Proteomic databases

EPDiQ99LL5.
MaxQBiQ99LL5.
PaxDbiQ99LL5.
PeptideAtlasiQ99LL5.
PRIDEiQ99LL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001836; ENSMUSP00000001836; ENSMUSG00000001785.
GeneIDi103136.
KEGGimmu:103136.
UCSCiuc007gnc.2. mouse.

Organism-specific databases

CTDi11137.
MGIiMGI:1914735. Pwp1.

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ99LL5.
KOiK14791.
OMAiCAACCPD.
OrthoDBiEOG7X3QR1.
PhylomeDBiQ99LL5.
TreeFamiTF314868.

Miscellaneous databases

ChiTaRSiPwp1. mouse.
PROiQ99LL5.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LL5.
CleanExiMM_PWP1.
ExpressionAtlasiQ99LL5. baseline and differential.
GenevisibleiQ99LL5. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-58 AND SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPWP1_MOUSE
AccessioniPrimary (citable) accession number: Q99LL5
Secondary accession number(s): Q9D6T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.