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Protein

Periodic tryptophan protein 1 homolog

Gene

Pwp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in cell growth and/or transcription.By similarity

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

GO - Biological processi

  • histone H4-K20 trimethylation Source: MGI
  • negative regulation of serine phosphorylation of STAT3 protein Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1 homolog
Gene namesi
Name:Pwp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914735. Pwp1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511721 – 501Periodic tryptophan protein 1 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei493PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LL5.
MaxQBiQ99LL5.
PaxDbiQ99LL5.
PeptideAtlasiQ99LL5.
PRIDEiQ99LL5.

PTM databases

iPTMnetiQ99LL5.
PhosphoSitePlusiQ99LL5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001785.
CleanExiMM_PWP1.
ExpressionAtlasiQ99LL5. baseline and differential.
GenevisibleiQ99LL5. MM.

Interactioni

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: MGI

Protein-protein interaction databases

BioGridi222026. 3 interactors.
IntActiQ99LL5. 2 interactors.
MINTiMINT-4124271.
STRINGi10090.ENSMUSP00000001836.

Structurei

3D structure databases

ProteinModelPortaliQ99LL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 229WD 1Add BLAST45
Repeati253 – 293WD 2Add BLAST41
Repeati296 – 336WD 3Add BLAST41
Repeati382 – 422WD 4Add BLAST41
Repeati427 – 467WD 5Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ99LL5.
KOiK14791.
OMAiCVEWLDI.
OrthoDBiEOG091G07TA.
PhylomeDBiQ99LL5.
TreeFamiTF314868.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSRQVTCV AWVRRGVAKE TPDKVELSKE EVNRLIAEAK GKLQEEGGSE
60 70 80 90 100
EEEAGNPSED GMQSGPTQAP PRESLEDGDP QDDRTLDDDE LAGYDLDNYD
110 120 130 140 150
EEDNPDAETI GESLLGLTVY GSNDQDPYVT LKDTEQYEHE DFLIKPTDNL
160 170 180 190 200
IVCGRAEQEQ CNLEVHVYNQ EEESFYVHHD ILLSAYPLSV EWLNFDPSPD
210 220 230 240 250
ASTGNYIAVG NMTPVIEVWD LDIVDSLEPV FTLGSKLSKK KKKKGKKSSS
260 270 280 290 300
AEGHTDAVLD LSWNKTVRNV LASASADSTV VLWDLSVGKS VARLTAHTDK
310 320 330 340 350
VQTLQFHPFE AQTLISGSYD KSVALYDCRD PSQNHRQWRF SGQIERVTWN
360 370 380 390 400
HFSPCHFLAS TDDGFVYNLD ARSDKPIFTL NAHNDEISGL DLSSQIKGCL
410 420 430 440 450
VTASADKFVK IWDILGDRPS LIHSRDMKMG VLFCSSCCPD LPFVYAFGGQ
460 470 480 490 500
KEGLRVWDIS TVSSVNEAFG RRERLVIGGT KGLSVSGPCG SRSPQQTPME

S
Length:501
Mass (Da):55,587
Last modified:June 1, 2001 - v1
Checksum:i704A050633F0C2B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247K → R in BAB26622 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009972 mRNA. Translation: BAB26622.1.
AK082158 mRNA. Translation: BAC38427.1.
BC003199 mRNA. Translation: AAH03199.1.
BC023137 mRNA. Translation: AAH23137.1.
CCDSiCCDS24092.1.
RefSeqiNP_598754.2. NM_133993.3.
UniGeneiMm.18834.

Genome annotation databases

EnsembliENSMUST00000001836; ENSMUSP00000001836; ENSMUSG00000001785.
GeneIDi103136.
KEGGimmu:103136.
UCSCiuc007gnc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009972 mRNA. Translation: BAB26622.1.
AK082158 mRNA. Translation: BAC38427.1.
BC003199 mRNA. Translation: AAH03199.1.
BC023137 mRNA. Translation: AAH23137.1.
CCDSiCCDS24092.1.
RefSeqiNP_598754.2. NM_133993.3.
UniGeneiMm.18834.

3D structure databases

ProteinModelPortaliQ99LL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222026. 3 interactors.
IntActiQ99LL5. 2 interactors.
MINTiMINT-4124271.
STRINGi10090.ENSMUSP00000001836.

PTM databases

iPTMnetiQ99LL5.
PhosphoSitePlusiQ99LL5.

Proteomic databases

EPDiQ99LL5.
MaxQBiQ99LL5.
PaxDbiQ99LL5.
PeptideAtlasiQ99LL5.
PRIDEiQ99LL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001836; ENSMUSP00000001836; ENSMUSG00000001785.
GeneIDi103136.
KEGGimmu:103136.
UCSCiuc007gnc.2. mouse.

Organism-specific databases

CTDi11137.
MGIiMGI:1914735. Pwp1.

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ99LL5.
KOiK14791.
OMAiCVEWLDI.
OrthoDBiEOG091G07TA.
PhylomeDBiQ99LL5.
TreeFamiTF314868.

Miscellaneous databases

ChiTaRSiPwp1. mouse.
PROiQ99LL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001785.
CleanExiMM_PWP1.
ExpressionAtlasiQ99LL5. baseline and differential.
GenevisibleiQ99LL5. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPWP1_MOUSE
AccessioniPrimary (citable) accession number: Q99LL5
Secondary accession number(s): Q9D6T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.