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Protein

RCC1 and BTB domain-containing protein 2

Gene

Rcbtb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 2
Alternative name(s):
Chromosome condensation 1-like
Regulator of chromosome condensation and BTB domain-containing protein 2
Gene namesi
Name:Rcbtb2
Synonyms:Chc1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917200. Rcbtb2.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551RCC1 and BTB domain-containing protein 2PRO_0000206645Add
BLAST

Proteomic databases

MaxQBiQ99LJ7.
PaxDbiQ99LJ7.
PRIDEiQ99LJ7.

PTM databases

PhosphoSiteiQ99LJ7.

Expressioni

Gene expression databases

BgeeiQ99LJ7.
ExpressionAtlasiQ99LJ7. baseline and differential.
GenevestigatoriQ99LJ7.

Interactioni

Protein-protein interaction databases

BioGridi222895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ7.
SMRiQ99LJ7. Positions 62-338, 374-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 11552RCC1 1Add
BLAST
Repeati117 – 16953RCC1 2Add
BLAST
Repeati171 – 22252RCC1 3Add
BLAST
Repeati223 – 27452RCC1 4Add
BLAST
Repeati276 – 32651RCC1 5Add
BLAST
Repeati328 – 38255RCC1 6Add
BLAST
Domaini394 – 45764BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini489 – 51931BTB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
Contains 6 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5184.
GeneTreeiENSGT00780000121841.
HOGENOMiHOG000065752.
HOVERGENiHBG053261.
InParanoidiQ99LJ7.
KOiK11494.
OMAiGQMCSMA.
OrthoDBiEOG7HTHGW.
PhylomeDBiQ99LJ7.
TreeFamiTF329478.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99LJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV
60 70 80 90 100
FGSAGNEVLY TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI
110 120 130 140 150
ASLSYGSGPH IVLATTDGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS
160 170 180 190 200
NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTA NQPIPRRVTG
210 220 230 240 250
CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG SSGNQPTPCR
260 270 280 290 300
VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP
310 320 330 340 350
TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF
360 370 380 390 400
CCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV
410 420 430 440 450
DGKYIYAHKV LLKIRCEHFR SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT
460 470 480 490 500
DNISLSPEEA VGLLDLATFY SETRLKKLCQ QTIKQGICEE NAIALLSAAV
510 520 530 540 550
KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK

N
Length:551
Mass (Da):60,164
Last modified:June 1, 2001 - v1
Checksum:i6D54A19067688609
GO
Isoform 2 (identifier: Q99LJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.

Show »
Length:527
Mass (Da):57,608
Checksum:iDE8B721290A36F38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111A → S in BAC27316 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424Missing in isoform 2. 1 PublicationVSP_016724Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031242 mRNA. Translation: BAC27316.1.
AK031248 mRNA. Translation: BAC27319.1.
AK160881 mRNA. Translation: BAE36068.1.
BC003224 mRNA. Translation: AAH03224.1.
CCDSiCCDS27266.1. [Q99LJ7-1]
RefSeqiNP_001164165.1. NM_001170694.1. [Q99LJ7-1]
NP_598844.3. NM_134083.4. [Q99LJ7-1]
XP_006518445.1. XM_006518382.2. [Q99LJ7-1]
XP_006518446.1. XM_006518383.1. [Q99LJ7-1]
XP_006518447.1. XM_006518384.1. [Q99LJ7-1]
XP_006518448.1. XM_006518385.2. [Q99LJ7-1]
XP_006518449.1. XM_006518386.2. [Q99LJ7-2]
UniGeneiMm.280068.

Genome annotation databases

EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
GeneIDi105670.
KEGGimmu:105670.
UCSCiuc007upj.2. mouse. [Q99LJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031242 mRNA. Translation: BAC27316.1.
AK031248 mRNA. Translation: BAC27319.1.
AK160881 mRNA. Translation: BAE36068.1.
BC003224 mRNA. Translation: AAH03224.1.
CCDSiCCDS27266.1. [Q99LJ7-1]
RefSeqiNP_001164165.1. NM_001170694.1. [Q99LJ7-1]
NP_598844.3. NM_134083.4. [Q99LJ7-1]
XP_006518445.1. XM_006518382.2. [Q99LJ7-1]
XP_006518446.1. XM_006518383.1. [Q99LJ7-1]
XP_006518447.1. XM_006518384.1. [Q99LJ7-1]
XP_006518448.1. XM_006518385.2. [Q99LJ7-1]
XP_006518449.1. XM_006518386.2. [Q99LJ7-2]
UniGeneiMm.280068.

3D structure databases

ProteinModelPortaliQ99LJ7.
SMRiQ99LJ7. Positions 62-338, 374-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222895. 1 interaction.

PTM databases

PhosphoSiteiQ99LJ7.

Proteomic databases

MaxQBiQ99LJ7.
PaxDbiQ99LJ7.
PRIDEiQ99LJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
GeneIDi105670.
KEGGimmu:105670.
UCSCiuc007upj.2. mouse. [Q99LJ7-1]

Organism-specific databases

CTDi1102.
MGIiMGI:1917200. Rcbtb2.

Phylogenomic databases

eggNOGiCOG5184.
GeneTreeiENSGT00780000121841.
HOGENOMiHOG000065752.
HOVERGENiHBG053261.
InParanoidiQ99LJ7.
KOiK11494.
OMAiGQMCSMA.
OrthoDBiEOG7HTHGW.
PhylomeDBiQ99LJ7.
TreeFamiTF329478.

Miscellaneous databases

ChiTaRSiRcbtb2. mouse.
NextBioi357822.
PROiQ99LJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LJ7.
ExpressionAtlasiQ99LJ7. baseline and differential.
GenevestigatoriQ99LJ7.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Forelimb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRCBT2_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ7
Secondary accession number(s): Q3TUA3, Q8BMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.