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Q99LJ7

- RCBT2_MOUSE

UniProt

Q99LJ7 - RCBT2_MOUSE

Protein

RCC1 and BTB domain-containing protein 2

Gene

Rcbtb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RCC1 and BTB domain-containing protein 2
    Alternative name(s):
    Chromosome condensation 1-like
    Regulator of chromosome condensation and BTB domain-containing protein 2
    Gene namesi
    Name:Rcbtb2
    Synonyms:Chc1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1917200. Rcbtb2.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551RCC1 and BTB domain-containing protein 2PRO_0000206645Add
    BLAST

    Proteomic databases

    PaxDbiQ99LJ7.
    PRIDEiQ99LJ7.

    PTM databases

    PhosphoSiteiQ99LJ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99LJ7.
    BgeeiQ99LJ7.
    GenevestigatoriQ99LJ7.

    Interactioni

    Protein-protein interaction databases

    BioGridi222895. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99LJ7.
    SMRiQ99LJ7. Positions 62-338, 374-531.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 11552RCC1 1Add
    BLAST
    Repeati117 – 16953RCC1 2Add
    BLAST
    Repeati171 – 22252RCC1 3Add
    BLAST
    Repeati223 – 27452RCC1 4Add
    BLAST
    Repeati276 – 32651RCC1 5Add
    BLAST
    Repeati328 – 38255RCC1 6Add
    BLAST
    Domaini394 – 45764BTB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini489 – 51931BTB 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
    Contains 6 RCC1 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5184.
    GeneTreeiENSGT00740000114947.
    HOGENOMiHOG000065752.
    HOVERGENiHBG053261.
    InParanoidiQ99LJ7.
    KOiK11494.
    OMAiGQMCSMA.
    OrthoDBiEOG7HTHGW.
    PhylomeDBiQ99LJ7.
    TreeFamiTF329478.

    Family and domain databases

    Gene3Di2.130.10.30. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00415. RCC1. 4 hits.
    [Graphical view]
    PRINTSiPR00633. RCCNDNSATION.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF50985. SSF50985. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00626. RCC1_2. 1 hit.
    PS50012. RCC1_3. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99LJ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV    50
    FGSAGNEVLY TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI 100
    ASLSYGSGPH IVLATTDGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS 150
    NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTA NQPIPRRVTG 200
    CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG SSGNQPTPCR 250
    VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP 300
    TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF 350
    CCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV 400
    DGKYIYAHKV LLKIRCEHFR SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT 450
    DNISLSPEEA VGLLDLATFY SETRLKKLCQ QTIKQGICEE NAIALLSAAV 500
    KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK 550
    N 551
    Length:551
    Mass (Da):60,164
    Last modified:June 1, 2001 - v1
    Checksum:i6D54A19067688609
    GO
    Isoform 2 (identifier: Q99LJ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:527
    Mass (Da):57,608
    Checksum:iDE8B721290A36F38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2111A → S in BAC27316. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2424Missing in isoform 2. 1 PublicationVSP_016724Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031242 mRNA. Translation: BAC27316.1.
    AK031248 mRNA. Translation: BAC27319.1.
    AK160881 mRNA. Translation: BAE36068.1.
    BC003224 mRNA. Translation: AAH03224.1.
    CCDSiCCDS27266.1. [Q99LJ7-1]
    RefSeqiNP_001164165.1. NM_001170694.1. [Q99LJ7-1]
    NP_598844.3. NM_134083.4. [Q99LJ7-1]
    XP_006518445.1. XM_006518382.1. [Q99LJ7-1]
    XP_006518446.1. XM_006518383.1. [Q99LJ7-1]
    XP_006518447.1. XM_006518384.1. [Q99LJ7-1]
    XP_006518448.1. XM_006518385.1. [Q99LJ7-1]
    XP_006518449.1. XM_006518386.1. [Q99LJ7-2]
    UniGeneiMm.280068.

    Genome annotation databases

    EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
    ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
    ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
    ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
    ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
    ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
    GeneIDi105670.
    KEGGimmu:105670.
    UCSCiuc007upj.2. mouse. [Q99LJ7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK031242 mRNA. Translation: BAC27316.1 .
    AK031248 mRNA. Translation: BAC27319.1 .
    AK160881 mRNA. Translation: BAE36068.1 .
    BC003224 mRNA. Translation: AAH03224.1 .
    CCDSi CCDS27266.1. [Q99LJ7-1 ]
    RefSeqi NP_001164165.1. NM_001170694.1. [Q99LJ7-1 ]
    NP_598844.3. NM_134083.4. [Q99LJ7-1 ]
    XP_006518445.1. XM_006518382.1. [Q99LJ7-1 ]
    XP_006518446.1. XM_006518383.1. [Q99LJ7-1 ]
    XP_006518447.1. XM_006518384.1. [Q99LJ7-1 ]
    XP_006518448.1. XM_006518385.1. [Q99LJ7-1 ]
    XP_006518449.1. XM_006518386.1. [Q99LJ7-2 ]
    UniGenei Mm.280068.

    3D structure databases

    ProteinModelPortali Q99LJ7.
    SMRi Q99LJ7. Positions 62-338, 374-531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222895. 1 interaction.

    PTM databases

    PhosphoSitei Q99LJ7.

    Proteomic databases

    PaxDbi Q99LJ7.
    PRIDEi Q99LJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022702 ; ENSMUSP00000022702 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
    ENSMUST00000110952 ; ENSMUSP00000106577 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
    ENSMUST00000164822 ; ENSMUSP00000131588 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
    ENSMUST00000169479 ; ENSMUSP00000126898 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
    ENSMUST00000169513 ; ENSMUSP00000128579 ; ENSMUSG00000022106 . [Q99LJ7-2 ]
    ENSMUST00000170677 ; ENSMUSP00000126510 ; ENSMUSG00000022106 . [Q99LJ7-2 ]
    GeneIDi 105670.
    KEGGi mmu:105670.
    UCSCi uc007upj.2. mouse. [Q99LJ7-1 ]

    Organism-specific databases

    CTDi 1102.
    MGIi MGI:1917200. Rcbtb2.

    Phylogenomic databases

    eggNOGi COG5184.
    GeneTreei ENSGT00740000114947.
    HOGENOMi HOG000065752.
    HOVERGENi HBG053261.
    InParanoidi Q99LJ7.
    KOi K11494.
    OMAi GQMCSMA.
    OrthoDBi EOG7HTHGW.
    PhylomeDBi Q99LJ7.
    TreeFami TF329478.

    Miscellaneous databases

    ChiTaRSi RCBTB2. mouse.
    NextBioi 357822.
    PROi Q99LJ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99LJ7.
    Bgeei Q99LJ7.
    Genevestigatori Q99LJ7.

    Family and domain databases

    Gene3Di 2.130.10.30. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00415. RCC1. 4 hits.
    [Graphical view ]
    PRINTSi PR00633. RCCNDNSATION.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50985. SSF50985. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00626. RCC1_2. 1 hit.
    PS50012. RCC1_3. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Forelimb.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiRCBT2_MOUSE
    AccessioniPrimary (citable) accession number: Q99LJ7
    Secondary accession number(s): Q3TUA3, Q8BMG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3