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Q99LJ7 (RCBT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RCC1 and BTB domain-containing protein 2
Alternative name(s):
Chromosome condensation 1-like
Regulator of chromosome condensation and BTB domain-containing protein 2
Gene names
Name:Rcbtb2
Synonyms:Chc1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 BTB (POZ) domains.

Contains 6 RCC1 repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentacrosomal vesicle

Inferred from direct assay PubMed 22768142. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99LJ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99LJ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551RCC1 and BTB domain-containing protein 2
PRO_0000206645

Regions

Repeat64 – 11552RCC1 1
Repeat117 – 16953RCC1 2
Repeat171 – 22252RCC1 3
Repeat223 – 27452RCC1 4
Repeat276 – 32651RCC1 5
Repeat328 – 38255RCC1 6
Domain394 – 45764BTB 1
Domain489 – 51931BTB 2

Natural variations

Alternative sequence1 – 2424Missing in isoform 2.
VSP_016724

Experimental info

Sequence conflict2111A → S in BAC27316. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6D54A19067688609

FASTA55160,164
        10         20         30         40         50         60 
MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY 

        70         80         90        100        110        120 
TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI ASLSYGSGPH IVLATTDGEV 

       130        140        150        160        170        180 
FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN 

       190        200        210        220        230        240 
SGQVGSGSTA NQPIPRRVTG CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG 

       250        260        270        280        290        300 
SSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP 

       310        320        330        340        350        360 
TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF CCTDDVFACF 

       370        380        390        400        410        420 
ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR 

       430        440        450        460        470        480 
SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT DNISLSPEEA VGLLDLATFY SETRLKKLCQ 

       490        500        510        520        530        540 
QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI 

       550 
SKASRVGAFK N 

« Hide

Isoform 2 [UniParc].

Checksum: DE8B721290A36F38
Show »

FASTA52757,608

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Forelimb.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK031242 mRNA. Translation: BAC27316.1.
AK031248 mRNA. Translation: BAC27319.1.
AK160881 mRNA. Translation: BAE36068.1.
BC003224 mRNA. Translation: AAH03224.1.
CCDSCCDS27266.1. [Q99LJ7-1]
RefSeqNP_001164165.1. NM_001170694.1. [Q99LJ7-1]
NP_598844.3. NM_134083.4. [Q99LJ7-1]
XP_006518445.1. XM_006518382.1. [Q99LJ7-1]
XP_006518446.1. XM_006518383.1. [Q99LJ7-1]
XP_006518447.1. XM_006518384.1. [Q99LJ7-1]
XP_006518448.1. XM_006518385.1. [Q99LJ7-1]
XP_006518449.1. XM_006518386.1. [Q99LJ7-2]
UniGeneMm.280068.

3D structure databases

ProteinModelPortalQ99LJ7.
SMRQ99LJ7. Positions 62-338, 374-531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid222895. 1 interaction.

PTM databases

PhosphoSiteQ99LJ7.

Proteomic databases

PaxDbQ99LJ7.
PRIDEQ99LJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
GeneID105670.
KEGGmmu:105670.
UCSCuc007upj.2. mouse. [Q99LJ7-1]

Organism-specific databases

CTD1102.
MGIMGI:1917200. Rcbtb2.

Phylogenomic databases

eggNOGCOG5184.
GeneTreeENSGT00740000114947.
HOGENOMHOG000065752.
HOVERGENHBG053261.
InParanoidQ99LJ7.
KOK11494.
OMAGQMCSMA.
OrthoDBEOG7HTHGW.
PhylomeDBQ99LJ7.
TreeFamTF329478.

Gene expression databases

ArrayExpressQ99LJ7.
BgeeQ99LJ7.
GenevestigatorQ99LJ7.

Family and domain databases

Gene3D2.130.10.30. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRCBTB2. mouse.
NextBio357822.
PROQ99LJ7.
SOURCESearch...

Entry information

Entry nameRCBT2_MOUSE
AccessionPrimary (citable) accession number: Q99LJ7
Secondary accession number(s): Q3TUA3, Q8BMG2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot