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Q99LJ7

- RCBT2_MOUSE

UniProt

Q99LJ7 - RCBT2_MOUSE

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Protein
RCC1 and BTB domain-containing protein 2
Gene
Rcbtb2, Chc1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 2
Alternative name(s):
Chromosome condensation 1-like
Regulator of chromosome condensation and BTB domain-containing protein 2
Gene namesi
Name:Rcbtb2
Synonyms:Chc1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1917200. Rcbtb2.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551RCC1 and BTB domain-containing protein 2
PRO_0000206645Add
BLAST

Proteomic databases

PaxDbiQ99LJ7.
PRIDEiQ99LJ7.

PTM databases

PhosphoSiteiQ99LJ7.

Expressioni

Gene expression databases

ArrayExpressiQ99LJ7.
BgeeiQ99LJ7.
GenevestigatoriQ99LJ7.

Interactioni

Protein-protein interaction databases

BioGridi222895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ7.
SMRiQ99LJ7. Positions 62-338, 374-531.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 11552RCC1 1
Add
BLAST
Repeati117 – 16953RCC1 2
Add
BLAST
Repeati171 – 22252RCC1 3
Add
BLAST
Repeati223 – 27452RCC1 4
Add
BLAST
Repeati276 – 32651RCC1 5
Add
BLAST
Repeati328 – 38255RCC1 6
Add
BLAST
Domaini394 – 45764BTB 1
Add
BLAST
Domaini489 – 51931BTB 2
Add
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.
Contains 6 RCC1 repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5184.
GeneTreeiENSGT00740000114947.
HOGENOMiHOG000065752.
HOVERGENiHBG053261.
InParanoidiQ99LJ7.
KOiK11494.
OMAiGQMCSMA.
OrthoDBiEOG7HTHGW.
PhylomeDBiQ99LJ7.
TreeFamiTF329478.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99LJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV    50
FGSAGNEVLY TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI 100
ASLSYGSGPH IVLATTDGEV FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS 150
NKQVIEVACG SYHSLVLTSD GEVFAWGYNN SGQVGSGSTA NQPIPRRVTG 200
CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG SSGNQPTPCR 250
VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP 300
TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF 350
CCTDDVFACF ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV 400
DGKYIYAHKV LLKIRCEHFR SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT 450
DNISLSPEEA VGLLDLATFY SETRLKKLCQ QTIKQGICEE NAIALLSAAV 500
KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI SKASRVGAFK 550
N 551
Length:551
Mass (Da):60,164
Last modified:June 1, 2001 - v1
Checksum:i6D54A19067688609
GO
Isoform 2 (identifier: Q99LJ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.

Show »
Length:527
Mass (Da):57,608
Checksum:iDE8B721290A36F38
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424Missing in isoform 2.
VSP_016724Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111A → S in BAC27316. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031242 mRNA. Translation: BAC27316.1.
AK031248 mRNA. Translation: BAC27319.1.
AK160881 mRNA. Translation: BAE36068.1.
BC003224 mRNA. Translation: AAH03224.1.
CCDSiCCDS27266.1. [Q99LJ7-1]
RefSeqiNP_001164165.1. NM_001170694.1. [Q99LJ7-1]
NP_598844.3. NM_134083.4. [Q99LJ7-1]
XP_006518445.1. XM_006518382.1. [Q99LJ7-1]
XP_006518446.1. XM_006518383.1. [Q99LJ7-1]
XP_006518447.1. XM_006518384.1. [Q99LJ7-1]
XP_006518448.1. XM_006518385.1. [Q99LJ7-1]
XP_006518449.1. XM_006518386.1. [Q99LJ7-2]
UniGeneiMm.280068.

Genome annotation databases

EnsembliENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
GeneIDi105670.
KEGGimmu:105670.
UCSCiuc007upj.2. mouse. [Q99LJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031242 mRNA. Translation: BAC27316.1 .
AK031248 mRNA. Translation: BAC27319.1 .
AK160881 mRNA. Translation: BAE36068.1 .
BC003224 mRNA. Translation: AAH03224.1 .
CCDSi CCDS27266.1. [Q99LJ7-1 ]
RefSeqi NP_001164165.1. NM_001170694.1. [Q99LJ7-1 ]
NP_598844.3. NM_134083.4. [Q99LJ7-1 ]
XP_006518445.1. XM_006518382.1. [Q99LJ7-1 ]
XP_006518446.1. XM_006518383.1. [Q99LJ7-1 ]
XP_006518447.1. XM_006518384.1. [Q99LJ7-1 ]
XP_006518448.1. XM_006518385.1. [Q99LJ7-1 ]
XP_006518449.1. XM_006518386.1. [Q99LJ7-2 ]
UniGenei Mm.280068.

3D structure databases

ProteinModelPortali Q99LJ7.
SMRi Q99LJ7. Positions 62-338, 374-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222895. 1 interaction.

PTM databases

PhosphoSitei Q99LJ7.

Proteomic databases

PaxDbi Q99LJ7.
PRIDEi Q99LJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022702 ; ENSMUSP00000022702 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
ENSMUST00000110952 ; ENSMUSP00000106577 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
ENSMUST00000164822 ; ENSMUSP00000131588 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
ENSMUST00000169479 ; ENSMUSP00000126898 ; ENSMUSG00000022106 . [Q99LJ7-1 ]
ENSMUST00000169513 ; ENSMUSP00000128579 ; ENSMUSG00000022106 . [Q99LJ7-2 ]
ENSMUST00000170677 ; ENSMUSP00000126510 ; ENSMUSG00000022106 . [Q99LJ7-2 ]
GeneIDi 105670.
KEGGi mmu:105670.
UCSCi uc007upj.2. mouse. [Q99LJ7-1 ]

Organism-specific databases

CTDi 1102.
MGIi MGI:1917200. Rcbtb2.

Phylogenomic databases

eggNOGi COG5184.
GeneTreei ENSGT00740000114947.
HOGENOMi HOG000065752.
HOVERGENi HBG053261.
InParanoidi Q99LJ7.
KOi K11494.
OMAi GQMCSMA.
OrthoDBi EOG7HTHGW.
PhylomeDBi Q99LJ7.
TreeFami TF329478.

Miscellaneous databases

ChiTaRSi RCBTB2. mouse.
NextBioi 357822.
PROi Q99LJ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99LJ7.
Bgeei Q99LJ7.
Genevestigatori Q99LJ7.

Family and domain databases

Gene3Di 2.130.10.30. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00415. RCC1. 4 hits.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Forelimb.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRCBT2_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ7
Secondary accession number(s): Q3TUA3, Q8BMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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