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Reviewed, UniProtKB/Swiss-Prot Q99LJ6 (GPX7_MOUSE)

Last modified February 9, 2010. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione peroxidase 7
      Short name=GSHPx-7
      Short name=GPx-7
    EC=1.11.1.9
Gene names
Name: Gpx7
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the glutathione peroxidase family.

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Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 186168Glutathione peroxidase 7
PRO_0000013085

Sites

Active site561 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q99LJ6-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D20211218380A1BA

FASTA18621,061
        10         20         30         40         50         60 
MVAAVATAWL LLWAAACAQS EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV NVASECGFTD 

        70         80         90        100        110        120 
QNYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDTNREIE NFARRTYSVS FPMFSKIAVT 

       130        140        150        160        170        180 
GTGAHPAFKY LTQTSGKEPT WNFWKYLVDP DGKVVGAWDP TVPVAEIKPR ITEQVMKLIL 


RKREDL

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC003228 mRNA. Translation: AAH03228.1.
IPIIPI00116959.
RefSeqNP_077160.1.
UniGeneMm.20164

3D structure databases

SMRQ99LJ6. Positions 22-175.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ99LJ6.

Protein family/group databases

PeroxiBase3720. MmGPx07.

Proteomic databases

PRIDEQ99LJ6.

Genome annotation databases

EnsemblENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597; Mus musculus. [Genome view]
GeneID67305.
KEGGmmu:67305.
NMPDRfig|10090.3.peg.10061.
UCSCuc008ubc.1. mouse.

Organism-specific databases

CTD67305.
MGIMGI:1914555. Gpx7.

Phylogenomic databases

HOGENOMHBG648990.
HOVERGENQ99LJ6.
InParanoidQ99LJ6.
OMAKYLTETS.
PhylomeDBQ99LJ6.

Enzyme and pathway databases

BRENDA1.11.1.9. 244.

Gene expression databases

ArrayExpressQ99LJ6.
BgeeQ99LJ6.
CleanExMM_GPX7.
GenevestigatorQ99LJ6.
GermOnlineENSMUSG00000028597. Mus musculus.

Family and domain databases

InterProIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
TIGRFAMsTIGR02540. gpx7. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio324182.
SOURCESearch...

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Entry information

Entry nameGPX7_MOUSE
AccessionPrimary (citable) accession number: Q99LJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2001
Last modified: February 9, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents