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Protein

Glutathione peroxidase 7

Gene

Gpx7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity).By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Protein family/group databases

PeroxiBasei3720. MmGPx07.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 7 (EC:1.11.1.9)
Short name:
GPx-7
Short name:
GSHPx-7
Gene namesi
Name:Gpx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914555. Gpx7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 186168Glutathione peroxidase 7PRO_0000013085Add
BLAST

Proteomic databases

MaxQBiQ99LJ6.
PaxDbiQ99LJ6.
PRIDEiQ99LJ6.

PTM databases

PhosphoSiteiQ99LJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028597.
CleanExiMM_GPX7.
ExpressionAtlasiQ99LJ6. baseline and differential.
GenevisibleiQ99LJ6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99LJ6. 1 interaction.
MINTiMINT-4096598.
STRINGi10090.ENSMUSP00000030332.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ6.
SMRiQ99LJ6. Positions 22-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ99LJ6.
KOiK00432.
OMAiCAQREQD.
OrthoDBiEOG091G0OJG.
PhylomeDBiQ99LJ6.
TreeFamiTF331942.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAAVATAWL LLWAAACAQS EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV
60 70 80 90 100
NVASECGFTD QNYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDTNREIE
110 120 130 140 150
NFARRTYSVS FPMFSKIAVT GTGAHPAFKY LTQTSGKEPT WNFWKYLVDP
160 170 180
DGKVVGAWDP TVPVAEIKPR ITEQVMKLIL RKREDL
Length:186
Mass (Da):21,061
Last modified:June 1, 2001 - v1
Checksum:iD20211218380A1BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003228 mRNA. Translation: AAH03228.1.
CCDSiCCDS18450.1.
RefSeqiNP_077160.1. NM_024198.3.
UniGeneiMm.20164.

Genome annotation databases

EnsembliENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597.
GeneIDi67305.
KEGGimmu:67305.
UCSCiuc008ubc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003228 mRNA. Translation: AAH03228.1.
CCDSiCCDS18450.1.
RefSeqiNP_077160.1. NM_024198.3.
UniGeneiMm.20164.

3D structure databases

ProteinModelPortaliQ99LJ6.
SMRiQ99LJ6. Positions 22-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99LJ6. 1 interaction.
MINTiMINT-4096598.
STRINGi10090.ENSMUSP00000030332.

Protein family/group databases

PeroxiBasei3720. MmGPx07.

PTM databases

PhosphoSiteiQ99LJ6.

Proteomic databases

MaxQBiQ99LJ6.
PaxDbiQ99LJ6.
PRIDEiQ99LJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597.
GeneIDi67305.
KEGGimmu:67305.
UCSCiuc008ubc.1. mouse.

Organism-specific databases

CTDi2882.
MGIiMGI:1914555. Gpx7.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ99LJ6.
KOiK00432.
OMAiCAQREQD.
OrthoDBiEOG091G0OJG.
PhylomeDBiQ99LJ6.
TreeFamiTF331942.

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiQ99LJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028597.
CleanExiMM_GPX7.
ExpressionAtlasiQ99LJ6. baseline and differential.
GenevisibleiQ99LJ6. MM.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX7_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.