Q99LJ6 (GPX7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase 7
Short name=GPx-7
Short name=GSHPx-7
EC=1.11.1.9

Gene names

Name:

Gpx7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 186	168	Glutathione peroxidase 7		PRO_0000013085
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99LJ6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D20211218380A1BA	FASTA	186	21,061
	10 20 30 40 50 60 MVAAVATAWL LLWAAACAQS EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV NVASECGFTD 70 80 90 100 110 120 QNYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDTNREIE NFARRTYSVS FPMFSKIAVT 130 140 150 160 170 180 GTGAHPAFKY LTQTSGKEPT WNFWKYLVDP DGKVVGAWDP TVPVAEIKPR ITEQVMKLIL RKREDL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC003228 mRNA. Translation: AAH03228.1.
IPI	IPI00116959.
RefSeq	NP_077160.1. NM_024198.3.
UniGene	Mm.20164.
3D structure databases
ProteinModelPortal	Q99LJ6.
SMR	Q99LJ6. Positions 22-175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99LJ6.
Protein family/group databases
PeroxiBase	3720. MmGPx07.
Proteomic databases
PRIDE	Q99LJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597.
GeneID	67305.
KEGG	mmu:67305.
NMPDR	fig|10090.3.peg.10061.
Organism-specific databases
CTD	2882.
MGI	MGI:1914555. Gpx7.
Phylogenomic databases
GeneTree	ENSGT00550000074312.
HOGENOM	HBG648990.
HOVERGEN	HBG004333.
InParanoid	Q99LJ6.
OMA	SECGFTE.
OrthoDB	EOG4Q2DGK.
PhylomeDB	Q99LJ6.
Gene expression databases
ArrayExpress	Q99LJ6.
Bgee	Q99LJ6.
CleanEx	MM_GPX7.
Genevestigator	Q99LJ6.
GermOnline	ENSMUSG00000028597. Mus musculus.
Family and domain databases
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02540. Gpx7. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	324182.
SOURCE	Search...

Entry information

Entry name

GPX7_MOUSE

Accession

Primary (citable) accession number: Q99LJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	June 1, 2001
Last modified:	November 16, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program