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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 1

Gene

Abtb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 1
Gene namesi
Name:Abtb1Imported
Synonyms:Bpoz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933148. Abtb1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Ankyrin repeat and BTB/POZ domain-containing protein 1PRO_0000248268Add
BLAST

Proteomic databases

EPDiQ99LJ2.
MaxQBiQ99LJ2.
PaxDbiQ99LJ2.
PRIDEiQ99LJ2.

PTM databases

iPTMnetiQ99LJ2.
PhosphoSiteiQ99LJ2.

Expressioni

Gene expression databases

BgeeiQ99LJ2.

Interactioni

Protein-protein interaction databases

BioGridi219771. 3 interactions.
STRINGi10090.ENSMUSP00000032169.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ2.
SMRiQ99LJ2. Positions 4-90, 106-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131ANK 1Sequence analysisAdd
BLAST
Repeati35 – 6430ANK 2Sequence analysisAdd
BLAST
Domaini115 – 18268BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini272 – 34675BTB 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili451 – 47727Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0511. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000253956.
HOVERGENiHBG059559.
InParanoidiQ99LJ2.
KOiK10520.
OrthoDBiEOG7VX8VM.
PhylomeDBiQ99LJ2.
TreeFamiTF329194.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50097. BTB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE
60 70 80 90 100
LVRYLLANGA RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY
110 120 130 140 150
YDDFLQRLLE QGIHSDVVFV VHGKPFRAHR CILGARSTYF ANMLDTKWKG
160 170 180 190 200
KSVVVLRHPL INPVAFGALL QYLYTGRLDI GVEHVSDCER LAKQCQLWDL
210 220 230 240 250
LDDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRAD MALLADCALP
260 270 280 290 300
SELRGDLGEL PFPCPDGFSS CPDICFRVAD SSFLCHKAFF CGRSDYFRAL
310 320 330 340 350
LDDHFQESEE PAASGDPPVV TLHDISPDIF IHVLYYVYSD HTELPPELAY
360 370 380 390 400
DVLSVADMYL LPGLKRLCGR SLAQLLEEDS VVGVWRIAKM FRLARLEDQC
410 420 430 440 450
TEYMAKVIEK LVEREDFVEA VREEAAAVAA RQETDSIPLV DDIRFHVAST
460 470
VQTYSAIEEA QQRLRALEDL LVSIGLDC
Length:478
Mass (Da):54,058
Last modified:June 1, 2001 - v1
Checksum:i65AAB8C27E179553
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921T → A in BAC40352 (PubMed:16141072).Curated
Sequence conflicti286 – 2861H → Y in BAB55652 (PubMed:11494141).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053477 mRNA. Translation: BAB55652.1.
AK088437 mRNA. Translation: BAC40352.1.
BC003234 mRNA. Translation: AAH03234.1.
CCDSiCCDS20339.1.
RefSeqiNP_084527.2. NM_030251.3.
UniGeneiMm.166858.

Genome annotation databases

GeneIDi80283.
KEGGimmu:80283.
UCSCiuc009cvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053477 mRNA. Translation: BAB55652.1.
AK088437 mRNA. Translation: BAC40352.1.
BC003234 mRNA. Translation: AAH03234.1.
CCDSiCCDS20339.1.
RefSeqiNP_084527.2. NM_030251.3.
UniGeneiMm.166858.

3D structure databases

ProteinModelPortaliQ99LJ2.
SMRiQ99LJ2. Positions 4-90, 106-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219771. 3 interactions.
STRINGi10090.ENSMUSP00000032169.

PTM databases

iPTMnetiQ99LJ2.
PhosphoSiteiQ99LJ2.

Proteomic databases

EPDiQ99LJ2.
MaxQBiQ99LJ2.
PaxDbiQ99LJ2.
PRIDEiQ99LJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80283.
KEGGimmu:80283.
UCSCiuc009cvs.2. mouse.

Organism-specific databases

CTDi80325.
MGIiMGI:1933148. Abtb1.

Phylogenomic databases

eggNOGiKOG0511. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000253956.
HOVERGENiHBG059559.
InParanoidiQ99LJ2.
KOiK10520.
OrthoDBiEOG7VX8VM.
PhylomeDBiQ99LJ2.
TreeFamiTF329194.

Miscellaneous databases

NextBioi349969.
PROiQ99LJ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LJ2.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50097. BTB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway."
    Unoki M., Nakamura Y.
    Oncogene 20:4457-4465(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6NJclImported.
    Tissue: LungImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NODImported.
    Tissue: ThymusImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiABTB1_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ2
Secondary accession number(s): Q8C2K7, Q91XU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.