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Protein

Tissue alpha-L-fucosidase

Gene

Fuca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei282May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 3474.
ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-975578. Reactions specific to the complex N-glycan synthesis pathway.
SABIO-RKiQ99LJ1.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:Fuca1
Synonyms:Fuca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95593. Fuca1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001031018 – 452Tissue alpha-L-fucosidaseAdd BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ99LJ1.
MaxQBiQ99LJ1.
PaxDbiQ99LJ1.
PRIDEiQ99LJ1.

PTM databases

iPTMnetiQ99LJ1.
PhosphoSitePlusiQ99LJ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028673.
GenevisibleiQ99LJ1. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030434.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ1.
SMRiQ99LJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ99LJ1.
KOiK01206.
OMAiCLIGNNH.
OrthoDBiEOG091G085V.
PhylomeDBiQ99LJ1.
TreeFamiTF313034.

Family and domain databases

InterProiView protein in InterPro
IPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF36. PTHR10030:SF36. 1 hit.
PfamiView protein in Pfam
PF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiView protein in SMART
SM00812. Alpha_L_fucos. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00385. ALPHA_L_FUCOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLLLLV AAAQAVALAP RRFTPDWQSL DSRPLPSWFD EAKFGVFVHW
60 70 80 90 100
GVFSVPAWGS EWFWWHWQGD RMPAYQRFMT ENYPPGFSYA DFAPQFTARF
110 120 130 140 150
FHPDQWAELF QAAGAKYVVL TTKHHEGFTN WPSPVSWNWN SKDVGPHRDL
160 170 180 190 200
VGELGAAVRK RNIRYGLYHS LLEWFHPLYL LDKKNGFKTQ HFVRAKTMPE
210 220 230 240 250
LYDLVNSYKP DLIWSDGEWE CPDTYWNSTS FLAWLYNDSP VKDEVIVNDR
260 270 280 290 300
WGQNCSCHHG GYYNCQDKYK PQSLPDHKWE MCTSMDRASW GYRKDMTMST
310 320 330 340 350
IAKENEIIEE LVQTVSLGGN YLLNIGPTKD GLIVPIFQER LLAVGKWLQI
360 370 380 390 400
NGEAIYASKP WRVQSEKNKT VVWYTTKNAT VYATFLYWPE NGIVNLKSPK
410 420 430 440 450
TTSATKITML GLEGDLSWTQ DPLEGVLISL PQLPPTVLPV EFAWTLKLTK

VN
Length:452
Mass (Da):52,281
Last modified:June 1, 2001 - v1
Checksum:i41B319A040152B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379A → T in BAC41012 (PubMed:16141072).Curated1
Sequence conflicti396L → F in BAB21949 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002230 mRNA. Translation: BAB21949.1.
AK053323 mRNA. Translation: BAC35346.1.
AK089958 mRNA. Translation: BAC41012.1.
AK151258 mRNA. Translation: BAE30247.1.
AK151361 mRNA. Translation: BAE30336.1.
AK151879 mRNA. Translation: BAE30765.1.
AK151908 mRNA. Translation: BAE30789.1.
AK165604 mRNA. Translation: BAE38288.1.
AL672076 Genomic DNA. Translation: CAM15900.1.
BC003235 mRNA. Translation: AAH03235.1.
CCDSiCCDS18794.1.
RefSeqiNP_077205.3. NM_024243.4.
UniGeneiMm.439940.

Genome annotation databases

EnsembliENSMUST00000030434; ENSMUSP00000030434; ENSMUSG00000028673.
GeneIDi71665.
KEGGimmu:71665.
UCSCiuc008vhi.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFUCO_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ1
Secondary accession number(s): B1AV51
, Q3UAH8, Q8BN13, Q9DD22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families