Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99LJ0

- CT2NL_MOUSE

UniProt

Q99LJ0 - CT2NL_MOUSE

Protein

CTTNBP2 N-terminal-like protein

Gene

Cttnbp2nl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. protein dephosphorylation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTTNBP2 N-terminal-like protein
    Gene namesi
    Name:Cttnbp2nl
    Synonyms:Kiaa1433
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1933137. Cttnbp2nl.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication
    Note: Colocalizes with stress fibers.

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cytoplasm Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638CTTNBP2 N-terminal-like proteinPRO_0000226998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei481 – 4811Phosphoserine1 Publication
    Modified residuei488 – 4881PhosphoserineBy similarity
    Modified residuei522 – 5221PhosphoserineBy similarity
    Modified residuei526 – 5261PhosphoserineBy similarity
    Modified residuei559 – 5591PhosphoserineBy similarity
    Modified residuei562 – 5621PhosphoserineBy similarity
    Modified residuei569 – 5691PhosphothreonineBy similarity
    Modified residuei589 – 5891PhosphothreonineBy similarity
    Modified residuei591 – 5911PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99LJ0.
    PaxDbiQ99LJ0.
    PRIDEiQ99LJ0.

    PTM databases

    PhosphoSiteiQ99LJ0.

    Expressioni

    Tissue specificityi

    Predominantly expressed in skin, also detectable in spleen and lung (at protein level). Very low levels, if any, in brain (at protein level).

    Gene expression databases

    ArrayExpressiQ99LJ0.
    BgeeiQ99LJ0.
    CleanExiMM_CTTNBP2NL.
    GenevestigatoriQ99LJ0.

    Interactioni

    Subunit structurei

    May form homomers By similarity. May interact with MOB4, MST4, PPP2R1A, PPP2CB, STK24, STK25, STRN4, STRIP1 and STRIP2 By similarity. Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000096359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99LJ0.
    SMRiQ99LJ0. Positions 5-38, 248-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili87 – 284198Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG301745.
    GeneTreeiENSGT00680000099614.
    HOGENOMiHOG000112036.
    HOVERGENiHBG081371.
    InParanoidiQ99LJ0.
    OMAiFTSQQGP.
    OrthoDBiEOG77M8NN.
    PhylomeDBiQ99LJ0.
    TreeFamiTF325130.

    Family and domain databases

    InterProiIPR019131. Cortactin-binding_p2_N.
    [Graphical view]
    PfamiPF09727. CortBP2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99LJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI    50
    SDPLMALQRD FETLKEKNDS EKQPVCTNPL SVLKAVMKQC KNMQERMLSQ 100
    LAAAESRHRK VILDLEEERQ RHAQDTAEGD DVTYMLEKER ERLTQQLEFE 150
    KSQVKKFEKE QKKLSSQLEE ERTRHKQLSS MLVLECRKAT SKAAEEGQKA 200
    GELSLKLDKE KSRASKLEEE LAAERKRGLQ TEAQVEKQLS EFDIEREQLR 250
    AKLNREENRT RALKEEVESL KKLVKDLEAA QQHRSTSEQG REPVTMSRGT 300
    ATEPPMRVSA FCQTESVQTE RSHGSVITKL TDTGLPGPTT AAYSYAKANG 350
    HCDPEIQTTR ELTSDSSTEN QGPPREKSAV AAQEKPVENG GCPVGTETPV 400
    TMPSHLPSSG SSLSPSSTAS SSLTSSPCSS PVLTKRLLGS AASSPGYQSS 450
    YQVGINQRFH AARHKFQSQA DQDQQASGLQ SPPSRDLSPT LLDNSAAKQL 500
    ARNTVTQVLS RFTNQGPIKP VSPNSSPFGT DYRNLASTAS PRGDTSHSPT 550
    PGKVSSPLSP LSPGIKSPTI PRAERGNPPP IPPKKPGLTP SQSATTPVTK 600
    THSQASSLAA TEDLASSCSP SAVVANGKDV EILLPTSS 638
    Length:638
    Mass (Da):69,841
    Last modified:June 1, 2001 - v1
    Checksum:i9E3CC4364E73972C
    GO

    Sequence cautioni

    The sequence BAC98169.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921N → D in BAC26964. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129359 mRNA. Translation: BAC98169.1. Different initiation.
    AK029901 mRNA. Translation: BAC26666.1.
    AK030438 mRNA. Translation: BAC26964.1.
    BC003236 mRNA. Translation: AAH03236.1.
    BC006952 mRNA. Translation: AAH06952.1.
    CCDSiCCDS17707.1.
    RefSeqiNP_001156804.1. NM_001163332.1.
    NP_001156805.1. NM_001163333.1.
    NP_084525.1. NM_030249.4.
    UniGeneiMm.200327.

    Genome annotation databases

    EnsembliENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127.
    ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127.
    GeneIDi80281.
    KEGGimmu:80281.
    UCSCiuc008quv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129359 mRNA. Translation: BAC98169.1 . Different initiation.
    AK029901 mRNA. Translation: BAC26666.1 .
    AK030438 mRNA. Translation: BAC26964.1 .
    BC003236 mRNA. Translation: AAH03236.1 .
    BC006952 mRNA. Translation: AAH06952.1 .
    CCDSi CCDS17707.1.
    RefSeqi NP_001156804.1. NM_001163332.1.
    NP_001156805.1. NM_001163333.1.
    NP_084525.1. NM_030249.4.
    UniGenei Mm.200327.

    3D structure databases

    ProteinModelPortali Q99LJ0.
    SMRi Q99LJ0. Positions 5-38, 248-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000096359.

    PTM databases

    PhosphoSitei Q99LJ0.

    Proteomic databases

    MaxQBi Q99LJ0.
    PaxDbi Q99LJ0.
    PRIDEi Q99LJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077548 ; ENSMUSP00000076751 ; ENSMUSG00000062127 .
    ENSMUST00000098763 ; ENSMUSP00000096359 ; ENSMUSG00000062127 .
    GeneIDi 80281.
    KEGGi mmu:80281.
    UCSCi uc008quv.2. mouse.

    Organism-specific databases

    CTDi 55917.
    MGIi MGI:1933137. Cttnbp2nl.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG301745.
    GeneTreei ENSGT00680000099614.
    HOGENOMi HOG000112036.
    HOVERGENi HBG081371.
    InParanoidi Q99LJ0.
    OMAi FTSQQGP.
    OrthoDBi EOG77M8NN.
    PhylomeDBi Q99LJ0.
    TreeFami TF325130.

    Miscellaneous databases

    NextBioi 349965.
    PROi Q99LJ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99LJ0.
    Bgeei Q99LJ0.
    CleanExi MM_CTTNBP2NL.
    Genevestigatori Q99LJ0.

    Family and domain databases

    InterProi IPR019131. Cortactin-binding_p2_N.
    [Graphical view ]
    Pfami PF09727. CortBP2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
      Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
      Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTTN, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCT2NL_MOUSE
    AccessioniPrimary (citable) accession number: Q99LJ0
    Secondary accession number(s): Q6ZPR0, Q8BSV1, Q922L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3