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Protein

CTTNBP2 N-terminal-like protein

Gene

Cttnbp2nl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CTTNBP2 N-terminal-like protein
Gene namesi
Name:Cttnbp2nl
Synonyms:Kiaa1433
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1933137. Cttnbp2nl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269981 – 638CTTNBP2 N-terminal-like proteinAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineBy similarity1
Modified residuei481PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei522PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei559PhosphoserineBy similarity1
Modified residuei562PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Modified residuei589PhosphothreonineBy similarity1
Modified residuei591PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99LJ0.
PaxDbiQ99LJ0.
PeptideAtlasiQ99LJ0.
PRIDEiQ99LJ0.

PTM databases

iPTMnetiQ99LJ0.
PhosphoSitePlusiQ99LJ0.

Expressioni

Tissue specificityi

Predominantly expressed in skin, also detectable in spleen and lung (at protein level). Very low levels, if any, in brain (at protein level).

Gene expression databases

BgeeiENSMUSG00000062127.
CleanExiMM_CTTNBP2NL.
ExpressionAtlasiQ99LJ0. baseline and differential.
GenevisibleiQ99LJ0. MM.

Interactioni

Subunit structurei

May form homomers (By similarity). May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2 (By similarity). Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076751.

Structurei

3D structure databases

ProteinModelPortaliQ99LJ0.
SMRiQ99LJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 284Sequence analysisAdd BLAST198

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1103. Eukaryota.
ENOG410YR8R. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112036.
HOVERGENiHBG081371.
InParanoidiQ99LJ0.
OMAiSSPGYQS.
OrthoDBiEOG091G0CSA.
PhylomeDBiQ99LJ0.
TreeFamiTF325130.

Family and domain databases

InterProiIPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF09727. CortBP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI
60 70 80 90 100
SDPLMALQRD FETLKEKNDS EKQPVCTNPL SVLKAVMKQC KNMQERMLSQ
110 120 130 140 150
LAAAESRHRK VILDLEEERQ RHAQDTAEGD DVTYMLEKER ERLTQQLEFE
160 170 180 190 200
KSQVKKFEKE QKKLSSQLEE ERTRHKQLSS MLVLECRKAT SKAAEEGQKA
210 220 230 240 250
GELSLKLDKE KSRASKLEEE LAAERKRGLQ TEAQVEKQLS EFDIEREQLR
260 270 280 290 300
AKLNREENRT RALKEEVESL KKLVKDLEAA QQHRSTSEQG REPVTMSRGT
310 320 330 340 350
ATEPPMRVSA FCQTESVQTE RSHGSVITKL TDTGLPGPTT AAYSYAKANG
360 370 380 390 400
HCDPEIQTTR ELTSDSSTEN QGPPREKSAV AAQEKPVENG GCPVGTETPV
410 420 430 440 450
TMPSHLPSSG SSLSPSSTAS SSLTSSPCSS PVLTKRLLGS AASSPGYQSS
460 470 480 490 500
YQVGINQRFH AARHKFQSQA DQDQQASGLQ SPPSRDLSPT LLDNSAAKQL
510 520 530 540 550
ARNTVTQVLS RFTNQGPIKP VSPNSSPFGT DYRNLASTAS PRGDTSHSPT
560 570 580 590 600
PGKVSSPLSP LSPGIKSPTI PRAERGNPPP IPPKKPGLTP SQSATTPVTK
610 620 630
THSQASSLAA TEDLASSCSP SAVVANGKDV EILLPTSS
Length:638
Mass (Da):69,841
Last modified:June 1, 2001 - v1
Checksum:i9E3CC4364E73972C
GO

Sequence cautioni

The sequence BAC98169 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92N → D in BAC26964 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129359 mRNA. Translation: BAC98169.1. Different initiation.
AK029901 mRNA. Translation: BAC26666.1.
AK030438 mRNA. Translation: BAC26964.1.
BC003236 mRNA. Translation: AAH03236.1.
BC006952 mRNA. Translation: AAH06952.1.
CCDSiCCDS17707.1.
RefSeqiNP_001156804.1. NM_001163332.1.
NP_001156805.1. NM_001163333.1.
NP_084525.1. NM_030249.4.
XP_011238590.1. XM_011240288.2.
UniGeneiMm.200327.

Genome annotation databases

EnsembliENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127.
ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127.
GeneIDi80281.
KEGGimmu:80281.
UCSCiuc008quv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129359 mRNA. Translation: BAC98169.1. Different initiation.
AK029901 mRNA. Translation: BAC26666.1.
AK030438 mRNA. Translation: BAC26964.1.
BC003236 mRNA. Translation: AAH03236.1.
BC006952 mRNA. Translation: AAH06952.1.
CCDSiCCDS17707.1.
RefSeqiNP_001156804.1. NM_001163332.1.
NP_001156805.1. NM_001163333.1.
NP_084525.1. NM_030249.4.
XP_011238590.1. XM_011240288.2.
UniGeneiMm.200327.

3D structure databases

ProteinModelPortaliQ99LJ0.
SMRiQ99LJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076751.

PTM databases

iPTMnetiQ99LJ0.
PhosphoSitePlusiQ99LJ0.

Proteomic databases

MaxQBiQ99LJ0.
PaxDbiQ99LJ0.
PeptideAtlasiQ99LJ0.
PRIDEiQ99LJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127.
ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127.
GeneIDi80281.
KEGGimmu:80281.
UCSCiuc008quv.2. mouse.

Organism-specific databases

CTDi55917.
MGIiMGI:1933137. Cttnbp2nl.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1103. Eukaryota.
ENOG410YR8R. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112036.
HOVERGENiHBG081371.
InParanoidiQ99LJ0.
OMAiSSPGYQS.
OrthoDBiEOG091G0CSA.
PhylomeDBiQ99LJ0.
TreeFamiTF325130.

Miscellaneous databases

ChiTaRSiCttnbp2nl. mouse.
PROiQ99LJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062127.
CleanExiMM_CTTNBP2NL.
ExpressionAtlasiQ99LJ0. baseline and differential.
GenevisibleiQ99LJ0. MM.

Family and domain databases

InterProiIPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF09727. CortBP2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCT2NL_MOUSE
AccessioniPrimary (citable) accession number: Q99LJ0
Secondary accession number(s): Q6ZPR0, Q8BSV1, Q922L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.