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Q99LJ0 (CT2NL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTTNBP2 N-terminal-like protein
Gene names
Name:Cttnbp2nl
Synonyms:Kiaa1433
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

May form homomers By similarity. May interact with MOB4, MST4, PPP2R1A, PPP2CB, STK24, STK25, STRN4, STRIP1 and STRIP2 By similarity. Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers. Ref.6

Subcellular location

Cytoplasmcytoskeleton. Note: Colocalizes with stress fibers. Ref.6

Tissue specificity

Predominantly expressed in skin, also detectable in spleen and lung (at protein level). Very low levels, if any, in brain (at protein level).

Sequence caution

The sequence BAC98169.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentactin cytoskeleton

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638CTTNBP2 N-terminal-like protein
PRO_0000226998

Regions

Coiled coil87 – 284198 Potential

Amino acid modifications

Modified residue4811Phosphoserine Ref.5
Modified residue4881Phosphoserine By similarity
Modified residue5221Phosphoserine By similarity
Modified residue5261Phosphoserine By similarity
Modified residue5591Phosphoserine By similarity
Modified residue5621Phosphoserine By similarity
Modified residue5691Phosphothreonine By similarity
Modified residue5891Phosphothreonine By similarity
Modified residue5911Phosphoserine By similarity

Experimental info

Sequence conflict921N → D in BAC26964. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99LJ0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9E3CC4364E73972C

FASTA63869,841
        10         20         30         40         50         60 
MNLEKLSKPE LLTLFSILEG ELEARDLVIE ALKAQHRDTF IEERYGKYNI SDPLMALQRD 

        70         80         90        100        110        120 
FETLKEKNDS EKQPVCTNPL SVLKAVMKQC KNMQERMLSQ LAAAESRHRK VILDLEEERQ 

       130        140        150        160        170        180 
RHAQDTAEGD DVTYMLEKER ERLTQQLEFE KSQVKKFEKE QKKLSSQLEE ERTRHKQLSS 

       190        200        210        220        230        240 
MLVLECRKAT SKAAEEGQKA GELSLKLDKE KSRASKLEEE LAAERKRGLQ TEAQVEKQLS 

       250        260        270        280        290        300 
EFDIEREQLR AKLNREENRT RALKEEVESL KKLVKDLEAA QQHRSTSEQG REPVTMSRGT 

       310        320        330        340        350        360 
ATEPPMRVSA FCQTESVQTE RSHGSVITKL TDTGLPGPTT AAYSYAKANG HCDPEIQTTR 

       370        380        390        400        410        420 
ELTSDSSTEN QGPPREKSAV AAQEKPVENG GCPVGTETPV TMPSHLPSSG SSLSPSSTAS 

       430        440        450        460        470        480 
SSLTSSPCSS PVLTKRLLGS AASSPGYQSS YQVGINQRFH AARHKFQSQA DQDQQASGLQ 

       490        500        510        520        530        540 
SPPSRDLSPT LLDNSAAKQL ARNTVTQVLS RFTNQGPIKP VSPNSSPFGT DYRNLASTAS 

       550        560        570        580        590        600 
PRGDTSHSPT PGKVSSPLSP LSPGIKSPTI PRAERGNPPP IPPKKPGLTP SQSATTPVTK 

       610        620        630 
THSQASSLAA TEDLASSCSP SAVVANGKDV EILLPTSS 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryonic tail.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pituitary and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CTTN, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129359 mRNA. Translation: BAC98169.1. Different initiation.
AK029901 mRNA. Translation: BAC26666.1.
AK030438 mRNA. Translation: BAC26964.1.
BC003236 mRNA. Translation: AAH03236.1.
BC006952 mRNA. Translation: AAH06952.1.
CCDSCCDS17707.1.
RefSeqNP_001156804.1. NM_001163332.1.
NP_001156805.1. NM_001163333.1.
NP_084525.1. NM_030249.4.
UniGeneMm.200327.

3D structure databases

ProteinModelPortalQ99LJ0.
SMRQ99LJ0. Positions 5-38, 248-276.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000096359.

PTM databases

PhosphoSiteQ99LJ0.

Proteomic databases

MaxQBQ99LJ0.
PaxDbQ99LJ0.
PRIDEQ99LJ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077548; ENSMUSP00000076751; ENSMUSG00000062127.
ENSMUST00000098763; ENSMUSP00000096359; ENSMUSG00000062127.
GeneID80281.
KEGGmmu:80281.
UCSCuc008quv.2. mouse.

Organism-specific databases

CTD55917.
MGIMGI:1933137. Cttnbp2nl.
RougeSearch...

Phylogenomic databases

eggNOGNOG301745.
GeneTreeENSGT00680000099614.
HOGENOMHOG000112036.
HOVERGENHBG081371.
InParanoidQ99LJ0.
OMAFTSQQGP.
OrthoDBEOG77M8NN.
PhylomeDBQ99LJ0.
TreeFamTF325130.

Gene expression databases

ArrayExpressQ99LJ0.
BgeeQ99LJ0.
CleanExMM_CTTNBP2NL.
GenevestigatorQ99LJ0.

Family and domain databases

InterProIPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamPF09727. CortBP2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio349965.
PROQ99LJ0.
SOURCESearch...

Entry information

Entry nameCT2NL_MOUSE
AccessionPrimary (citable) accession number: Q99LJ0
Secondary accession number(s): Q6ZPR0, Q8BSV1, Q922L8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot