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Q99LI2

- CLCC1_MOUSE

UniProt

Q99LI2 - CLCC1_MOUSE

Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Seems to act as a chloride ion channel.By similarity

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloride channel CLIC-like protein 1
    Gene namesi
    Name:Clcc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2385186. Clcc1.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 539521Chloride channel CLIC-like protein 1PRO_0000297683Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei433 – 4331PhosphoserineBy similarity
    Modified residuei459 – 4591PhosphoserineBy similarity
    Modified residuei476 – 4761PhosphothreonineBy similarity
    Modified residuei498 – 4981PhosphoserineBy similarity
    Modified residuei513 – 5131PhosphoserineBy similarity
    Modified residuei521 – 5211PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99LI2.
    PaxDbiQ99LI2.
    PRIDEiQ99LI2.

    PTM databases

    PhosphoSiteiQ99LI2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99LI2.
    BgeeiQ99LI2.
    CleanExiMM_CLCC1.
    GenevestigatoriQ99LI2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99LI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chloride channel MCLC family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44384.
    GeneTreeiENSGT00390000016611.
    HOGENOMiHOG000231351.
    HOVERGENiHBG060364.
    InParanoidiQ99LI2.

    Family and domain databases

    InterProiIPR009231. Chloride_chnl_CLIC-like.
    [Graphical view]
    PfamiPF05934. MCLC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99LI2-1 [UniParc]FASTAAdd to Basket

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    MLCRLLLCEC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQVRSGTSE    50
    KKEVSPDSSE AEELSDCLHR LDSLTHKVDS CEKKKMKDYE SQSNPVFRRY 100
    LNKILIEAGK LGLPDENKVE MRYDAEILLS RQTLLEIQKF LSGEEWKPGA 150
    LDDALSDILI NFKCHDSEAW KWQFEDYFGV DPYNVFMVLL CLLCLVVLVA 200
    TELWTYVRWY TQMKRIFIIS FLLSLAWNWI YLYKMAFAQH QANIAGMEPF 250
    DNLCAKKMDW TGSLWEWFTS SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL 300
    AITFTNFVTE PLKHIGKGAG EFIKALMKEI PVLLQIPVLA ILALAVLSFC 350
    YGAGRSVPML RHFGGPDREP PRALEPDDRR RQKGLDYRLH GGAGDADFSY 400
    RGPAGSIEQG PYDKMHASKR DALRQRFHSG NKSPEVLRAF DLPDTEAQEH 450
    PEVVPSHKSP IMNTNLETGE LPGESTPTEY SQSAKDVSGQ VPSAGKSSPT 500
    VDKAQLKTDS ECSPPGGCPP SKEAAVAAHG TEPVSSPCG 539
    Length:539
    Mass (Da):60,621
    Last modified:June 1, 2001 - v1
    Checksum:i252A3E095B56C1C4
    GO

    Sequence cautioni

    The sequence CAM17753.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK169803 mRNA. Translation: BAE41377.1.
    AK171296 mRNA. Translation: BAE42376.1.
    AL671917 Genomic DNA. Translation: CAM17753.1. Sequence problems.
    AL671917 Genomic DNA. Translation: CAM17754.1.
    BC003247 mRNA. Translation: AAH03247.1.
    CCDSiCCDS17766.1.
    RefSeqiNP_001171242.1. NM_001177771.1.
    NP_663518.1. NM_145543.2.
    XP_006501479.1. XM_006501416.1.
    UniGeneiMm.214545.

    Genome annotation databases

    EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884.
    ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884.
    GeneIDi229725.
    KEGGimmu:229725.
    UCSCiuc008qzk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK169803 mRNA. Translation: BAE41377.1 .
    AK171296 mRNA. Translation: BAE42376.1 .
    AL671917 Genomic DNA. Translation: CAM17753.1 . Sequence problems.
    AL671917 Genomic DNA. Translation: CAM17754.1 .
    BC003247 mRNA. Translation: AAH03247.1 .
    CCDSi CCDS17766.1.
    RefSeqi NP_001171242.1. NM_001177771.1.
    NP_663518.1. NM_145543.2.
    XP_006501479.1. XM_006501416.1.
    UniGenei Mm.214545.

    3D structure databases

    ProteinModelPortali Q99LI2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99LI2.

    Proteomic databases

    MaxQBi Q99LI2.
    PaxDbi Q99LI2.
    PRIDEi Q99LI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029483 ; ENSMUSP00000029483 ; ENSMUSG00000027884 .
    ENSMUST00000106609 ; ENSMUSP00000102220 ; ENSMUSG00000027884 .
    GeneIDi 229725.
    KEGGi mmu:229725.
    UCSCi uc008qzk.2. mouse.

    Organism-specific databases

    CTDi 23155.
    MGIi MGI:2385186. Clcc1.

    Phylogenomic databases

    eggNOGi NOG44384.
    GeneTreei ENSGT00390000016611.
    HOGENOMi HOG000231351.
    HOVERGENi HBG060364.
    InParanoidi Q99LI2.

    Miscellaneous databases

    NextBioi 379649.
    PROi Q99LI2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99LI2.
    Bgeei Q99LI2.
    CleanExi MM_CLCC1.
    Genevestigatori Q99LI2.

    Family and domain databases

    InterProi IPR009231. Chloride_chnl_CLIC-like.
    [Graphical view ]
    Pfami PF05934. MCLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLCC1_MOUSE
    AccessioniPrimary (citable) accession number: Q99LI2
    Secondary accession number(s): A2AEK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3