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Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Gene namesi
Name:Clcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2385186. Clcc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029768319 – 539Chloride channel CLIC-like protein 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei429PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei476PhosphothreonineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei513PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LI2.
MaxQBiQ99LI2.
PaxDbiQ99LI2.
PeptideAtlasiQ99LI2.
PRIDEiQ99LI2.

PTM databases

iPTMnetiQ99LI2.
PhosphoSitePlusiQ99LI2.
SwissPalmiQ99LI2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027884.
CleanExiMM_CLCC1.
ExpressionAtlasiQ99LI2. baseline and differential.
GenevisibleiQ99LI2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99LI2. 2 interactors.
STRINGi10090.ENSMUSP00000102224.

Structurei

3D structure databases

ProteinModelPortaliQ99LI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJAP. Eukaryota.
ENOG41108E0. LUCA.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ99LI2.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCRLLLCEC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQVRSGTSE
60 70 80 90 100
KKEVSPDSSE AEELSDCLHR LDSLTHKVDS CEKKKMKDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKVE MRYDAEILLS RQTLLEIQKF LSGEEWKPGA
160 170 180 190 200
LDDALSDILI NFKCHDSEAW KWQFEDYFGV DPYNVFMVLL CLLCLVVLVA
210 220 230 240 250
TELWTYVRWY TQMKRIFIIS FLLSLAWNWI YLYKMAFAQH QANIAGMEPF
260 270 280 290 300
DNLCAKKMDW TGSLWEWFTS SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL
310 320 330 340 350
AITFTNFVTE PLKHIGKGAG EFIKALMKEI PVLLQIPVLA ILALAVLSFC
360 370 380 390 400
YGAGRSVPML RHFGGPDREP PRALEPDDRR RQKGLDYRLH GGAGDADFSY
410 420 430 440 450
RGPAGSIEQG PYDKMHASKR DALRQRFHSG NKSPEVLRAF DLPDTEAQEH
460 470 480 490 500
PEVVPSHKSP IMNTNLETGE LPGESTPTEY SQSAKDVSGQ VPSAGKSSPT
510 520 530
VDKAQLKTDS ECSPPGGCPP SKEAAVAAHG TEPVSSPCG
Length:539
Mass (Da):60,621
Last modified:June 1, 2001 - v1
Checksum:i252A3E095B56C1C4
GO

Sequence cautioni

The sequence CAM17753 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169803 mRNA. Translation: BAE41377.1.
AK171296 mRNA. Translation: BAE42376.1.
AL671917 Genomic DNA. Translation: CAM17753.1. Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1.
BC003247 mRNA. Translation: AAH03247.1.
CCDSiCCDS17766.1.
RefSeqiNP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.3.
XP_017175050.1. XM_017319561.1.
UniGeneiMm.214545.

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884.
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884.
GeneIDi229725.
KEGGimmu:229725.
UCSCiuc008qzk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169803 mRNA. Translation: BAE41377.1.
AK171296 mRNA. Translation: BAE42376.1.
AL671917 Genomic DNA. Translation: CAM17753.1. Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1.
BC003247 mRNA. Translation: AAH03247.1.
CCDSiCCDS17766.1.
RefSeqiNP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.3.
XP_017175050.1. XM_017319561.1.
UniGeneiMm.214545.

3D structure databases

ProteinModelPortaliQ99LI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99LI2. 2 interactors.
STRINGi10090.ENSMUSP00000102224.

PTM databases

iPTMnetiQ99LI2.
PhosphoSitePlusiQ99LI2.
SwissPalmiQ99LI2.

Proteomic databases

EPDiQ99LI2.
MaxQBiQ99LI2.
PaxDbiQ99LI2.
PeptideAtlasiQ99LI2.
PRIDEiQ99LI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884.
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884.
GeneIDi229725.
KEGGimmu:229725.
UCSCiuc008qzk.2. mouse.

Organism-specific databases

CTDi23155.
MGIiMGI:2385186. Clcc1.

Phylogenomic databases

eggNOGiENOG410IJAP. Eukaryota.
ENOG41108E0. LUCA.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ99LI2.

Miscellaneous databases

ChiTaRSiClcc1. mouse.
PROiQ99LI2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027884.
CleanExiMM_CLCC1.
ExpressionAtlasiQ99LI2. baseline and differential.
GenevisibleiQ99LI2. MM.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCC1_MOUSE
AccessioniPrimary (citable) accession number: Q99LI2
Secondary accession number(s): A2AEK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.