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Q99LI2

- CLCC1_MOUSE

UniProt

Q99LI2 - CLCC1_MOUSE

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Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Gene namesi
Name:Clcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2385186. Clcc1.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Nucleus By similarity

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. Golgi apparatus Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 539521Chloride channel CLIC-like protein 1PRO_0000297683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei459 – 4591PhosphoserineBy similarity
Modified residuei476 – 4761PhosphothreonineBy similarity
Modified residuei498 – 4981PhosphoserineBy similarity
Modified residuei513 – 5131PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99LI2.
PaxDbiQ99LI2.
PRIDEiQ99LI2.

PTM databases

PhosphoSiteiQ99LI2.

Expressioni

Gene expression databases

BgeeiQ99LI2.
CleanExiMM_CLCC1.
ExpressionAtlasiQ99LI2. baseline and differential.
GenevestigatoriQ99LI2.

Structurei

3D structure databases

ProteinModelPortaliQ99LI2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44384.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ99LI2.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCRLLLCEC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQVRSGTSE
60 70 80 90 100
KKEVSPDSSE AEELSDCLHR LDSLTHKVDS CEKKKMKDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKVE MRYDAEILLS RQTLLEIQKF LSGEEWKPGA
160 170 180 190 200
LDDALSDILI NFKCHDSEAW KWQFEDYFGV DPYNVFMVLL CLLCLVVLVA
210 220 230 240 250
TELWTYVRWY TQMKRIFIIS FLLSLAWNWI YLYKMAFAQH QANIAGMEPF
260 270 280 290 300
DNLCAKKMDW TGSLWEWFTS SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL
310 320 330 340 350
AITFTNFVTE PLKHIGKGAG EFIKALMKEI PVLLQIPVLA ILALAVLSFC
360 370 380 390 400
YGAGRSVPML RHFGGPDREP PRALEPDDRR RQKGLDYRLH GGAGDADFSY
410 420 430 440 450
RGPAGSIEQG PYDKMHASKR DALRQRFHSG NKSPEVLRAF DLPDTEAQEH
460 470 480 490 500
PEVVPSHKSP IMNTNLETGE LPGESTPTEY SQSAKDVSGQ VPSAGKSSPT
510 520 530
VDKAQLKTDS ECSPPGGCPP SKEAAVAAHG TEPVSSPCG
Length:539
Mass (Da):60,621
Last modified:June 1, 2001 - v1
Checksum:i252A3E095B56C1C4
GO

Sequence cautioni

The sequence CAM17753.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK169803 mRNA. Translation: BAE41377.1.
AK171296 mRNA. Translation: BAE42376.1.
AL671917 Genomic DNA. Translation: CAM17753.1. Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1.
BC003247 mRNA. Translation: AAH03247.1.
CCDSiCCDS17766.1.
RefSeqiNP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.1.
UniGeneiMm.214545.

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884.
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884.
GeneIDi229725.
KEGGimmu:229725.
UCSCiuc008qzk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK169803 mRNA. Translation: BAE41377.1 .
AK171296 mRNA. Translation: BAE42376.1 .
AL671917 Genomic DNA. Translation: CAM17753.1 . Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1 .
BC003247 mRNA. Translation: AAH03247.1 .
CCDSi CCDS17766.1.
RefSeqi NP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.1.
UniGenei Mm.214545.

3D structure databases

ProteinModelPortali Q99LI2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99LI2.

Proteomic databases

MaxQBi Q99LI2.
PaxDbi Q99LI2.
PRIDEi Q99LI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029483 ; ENSMUSP00000029483 ; ENSMUSG00000027884 .
ENSMUST00000106609 ; ENSMUSP00000102220 ; ENSMUSG00000027884 .
GeneIDi 229725.
KEGGi mmu:229725.
UCSCi uc008qzk.2. mouse.

Organism-specific databases

CTDi 23155.
MGIi MGI:2385186. Clcc1.

Phylogenomic databases

eggNOGi NOG44384.
GeneTreei ENSGT00390000016611.
HOGENOMi HOG000231351.
HOVERGENi HBG060364.
InParanoidi Q99LI2.

Miscellaneous databases

NextBioi 379649.
PROi Q99LI2.
SOURCEi Search...

Gene expression databases

Bgeei Q99LI2.
CleanExi MM_CLCC1.
ExpressionAtlasi Q99LI2. baseline and differential.
Genevestigatori Q99LI2.

Family and domain databases

InterProi IPR009231. Chloride_chnl_CLIC-like.
[Graphical view ]
Pfami PF05934. MCLC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLCC1_MOUSE
AccessioniPrimary (citable) accession number: Q99LI2
Secondary accession number(s): A2AEK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3