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Q99LI2

- CLCC1_MOUSE

UniProt

Q99LI2 - CLCC1_MOUSE

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Protein
Chloride channel CLIC-like protein 1
Gene
Clcc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Gene namesi
Name:Clcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2385186. Clcc1.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Nucleus By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei185 – 20521Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 539521Chloride channel CLIC-like protein 1
PRO_0000297683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei433 – 4331Phosphoserine By similarity
Modified residuei459 – 4591Phosphoserine By similarity
Modified residuei476 – 4761Phosphothreonine By similarity
Modified residuei498 – 4981Phosphoserine By similarity
Modified residuei513 – 5131Phosphoserine By similarity
Modified residuei521 – 5211Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99LI2.
PaxDbiQ99LI2.
PRIDEiQ99LI2.

PTM databases

PhosphoSiteiQ99LI2.

Expressioni

Gene expression databases

ArrayExpressiQ99LI2.
BgeeiQ99LI2.
CleanExiMM_CLCC1.
GenevestigatoriQ99LI2.

Structurei

3D structure databases

ProteinModelPortaliQ99LI2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44384.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ99LI2.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99LI2-1 [UniParc]FASTAAdd to Basket

« Hide

MLCRLLLCEC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQVRSGTSE    50
KKEVSPDSSE AEELSDCLHR LDSLTHKVDS CEKKKMKDYE SQSNPVFRRY 100
LNKILIEAGK LGLPDENKVE MRYDAEILLS RQTLLEIQKF LSGEEWKPGA 150
LDDALSDILI NFKCHDSEAW KWQFEDYFGV DPYNVFMVLL CLLCLVVLVA 200
TELWTYVRWY TQMKRIFIIS FLLSLAWNWI YLYKMAFAQH QANIAGMEPF 250
DNLCAKKMDW TGSLWEWFTS SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL 300
AITFTNFVTE PLKHIGKGAG EFIKALMKEI PVLLQIPVLA ILALAVLSFC 350
YGAGRSVPML RHFGGPDREP PRALEPDDRR RQKGLDYRLH GGAGDADFSY 400
RGPAGSIEQG PYDKMHASKR DALRQRFHSG NKSPEVLRAF DLPDTEAQEH 450
PEVVPSHKSP IMNTNLETGE LPGESTPTEY SQSAKDVSGQ VPSAGKSSPT 500
VDKAQLKTDS ECSPPGGCPP SKEAAVAAHG TEPVSSPCG 539
Length:539
Mass (Da):60,621
Last modified:June 1, 2001 - v1
Checksum:i252A3E095B56C1C4
GO

Sequence cautioni

The sequence CAM17753.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK169803 mRNA. Translation: BAE41377.1.
AK171296 mRNA. Translation: BAE42376.1.
AL671917 Genomic DNA. Translation: CAM17753.1. Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1.
BC003247 mRNA. Translation: AAH03247.1.
CCDSiCCDS17766.1.
RefSeqiNP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.1.
UniGeneiMm.214545.

Genome annotation databases

EnsembliENSMUST00000029483; ENSMUSP00000029483; ENSMUSG00000027884.
ENSMUST00000106609; ENSMUSP00000102220; ENSMUSG00000027884.
GeneIDi229725.
KEGGimmu:229725.
UCSCiuc008qzk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK169803 mRNA. Translation: BAE41377.1 .
AK171296 mRNA. Translation: BAE42376.1 .
AL671917 Genomic DNA. Translation: CAM17753.1 . Sequence problems.
AL671917 Genomic DNA. Translation: CAM17754.1 .
BC003247 mRNA. Translation: AAH03247.1 .
CCDSi CCDS17766.1.
RefSeqi NP_001171242.1. NM_001177771.1.
NP_663518.1. NM_145543.2.
XP_006501479.1. XM_006501416.1.
UniGenei Mm.214545.

3D structure databases

ProteinModelPortali Q99LI2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99LI2.

Proteomic databases

MaxQBi Q99LI2.
PaxDbi Q99LI2.
PRIDEi Q99LI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029483 ; ENSMUSP00000029483 ; ENSMUSG00000027884 .
ENSMUST00000106609 ; ENSMUSP00000102220 ; ENSMUSG00000027884 .
GeneIDi 229725.
KEGGi mmu:229725.
UCSCi uc008qzk.2. mouse.

Organism-specific databases

CTDi 23155.
MGIi MGI:2385186. Clcc1.

Phylogenomic databases

eggNOGi NOG44384.
GeneTreei ENSGT00390000016611.
HOGENOMi HOG000231351.
HOVERGENi HBG060364.
InParanoidi Q99LI2.

Miscellaneous databases

NextBioi 379649.
PROi Q99LI2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99LI2.
Bgeei Q99LI2.
CleanExi MM_CLCC1.
Genevestigatori Q99LI2.

Family and domain databases

InterProi IPR009231. Chloride_chnl_CLIC-like.
[Graphical view ]
Pfami PF05934. MCLC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLCC1_MOUSE
AccessioniPrimary (citable) accession number: Q99LI2
Secondary accession number(s): A2AEK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi