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Protein

Nucleolar GTP-binding protein 2

Gene

Gnl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3248GTPSequence analysis
Nucleotide bindingi361 – 3655GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Gene namesi
Name:Gnl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385207. Gnl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Nucleolar GTP-binding protein 2PRO_0000215807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei504 – 5041PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99LH1.
MaxQBiQ99LH1.
PaxDbiQ99LH1.
PRIDEiQ99LH1.

PTM databases

iPTMnetiQ99LH1.
PhosphoSiteiQ99LH1.

Expressioni

Gene expression databases

BgeeiQ99LH1.
ExpressionAtlasiQ99LH1. baseline and differential.
GenevisibleiQ99LH1. MM.

Interactioni

Protein-protein interaction databases

BioGridi231010. 1 interaction.
IntActiQ99LH1. 2 interactions.
MINTiMINT-4103943.
STRINGi10090.ENSMUSP00000030684.

Structurei

3D structure databases

ProteinModelPortaliQ99LH1.
SMRiQ99LH1. Positions 218-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 368162CP-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2423. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00810000125524.
HOGENOMiHOG000189714.
HOVERGENiHBG052643.
InParanoidiQ99LH1.
KOiK14537.
OMAiNSKVHIL.
OrthoDBiEOG7HXCQ7.
TreeFamiTF105668.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKPKYKGRS TINRSAASTN PDRVQGAGGQ NMRDRGTIRR LNMYRQKERR
60 70 80 90 100
NSRGKVIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQA SLQKFQEEMD
110 120 130 140 150
KVMKDPYKVV MKQSKLPMSL LHDRIQPHNA KVHILDTESF ESTFGPKSQR
160 170 180 190 200
KRPNLFASDM QSLLENAEMS TESYDQGKDR DLVMEDTGVR NEAQEEIYKK
210 220 230 240 250
GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIEAY LKKEKPWKHL
260 270 280 290 300
IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ
310 320 330 340 350
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY
360 370 380 390 400
ITLMRRIFLI DCPGVVYPSE DSETDIVLKG VVQVEKIKAP QDHIGAVLER
410 420 430 440 450
AKPEYISKTY KIESWENAED FLEKLALRTG KLLKGGEPDM LTVSKMVLND
460 470 480 490 500
WQRGRIPFFV KPPNAELPTD SQLPPSSPLE VPTETTQNNP EEETTETEVE
510 520 530 540 550
RSDSITEKEP EGDCSQDRNS EMQQILARVR QNFGKINVGP QFSADDLVPV
560 570 580 590 600
EMSDLEDLES SGEEEEQEQE QPGEDAEEER SPDTQEEPVG NDTKAVLRAL
610 620 630 640 650
DEKIAKYQRF LNKAKAKKFS AVRISKDLSE KVFAKYKEEK KTSAEDSDAA
660 670 680 690 700
PTKKARKWDA QMEEEPSNKT QRMLTCKERR RAARQQQSKK VGVRYYETHN
710 720
VKNRNRNKKK TSDSEGQKHR RNKFRQKQ
Length:728
Mass (Da):83,345
Last modified:July 27, 2011 - v2
Checksum:iAB449483ABEFE956
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761Q → K in BAC36850 (PubMed:16141072).Curated
Sequence conflicti467 – 4671L → I in AAH03262 (PubMed:15489334).Curated
Sequence conflicti530 – 5301R → S in BAC36850 (PubMed:16141072).Curated
Sequence conflicti646 – 6461D → V in AAH03262 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077532 mRNA. Translation: BAC36850.1.
AL626775 Genomic DNA. Translation: CAM20897.1.
BC003262 mRNA. Translation: AAH03262.1.
CCDSiCCDS18634.1.
RefSeqiNP_663527.2. NM_145552.2.
UniGeneiMm.90760.

Genome annotation databases

EnsembliENSMUST00000030684; ENSMUSP00000030684; ENSMUSG00000028869.
GeneIDi230737.
KEGGimmu:230737.
UCSCiuc008uro.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077532 mRNA. Translation: BAC36850.1.
AL626775 Genomic DNA. Translation: CAM20897.1.
BC003262 mRNA. Translation: AAH03262.1.
CCDSiCCDS18634.1.
RefSeqiNP_663527.2. NM_145552.2.
UniGeneiMm.90760.

3D structure databases

ProteinModelPortaliQ99LH1.
SMRiQ99LH1. Positions 218-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231010. 1 interaction.
IntActiQ99LH1. 2 interactions.
MINTiMINT-4103943.
STRINGi10090.ENSMUSP00000030684.

PTM databases

iPTMnetiQ99LH1.
PhosphoSiteiQ99LH1.

Proteomic databases

EPDiQ99LH1.
MaxQBiQ99LH1.
PaxDbiQ99LH1.
PRIDEiQ99LH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030684; ENSMUSP00000030684; ENSMUSG00000028869.
GeneIDi230737.
KEGGimmu:230737.
UCSCiuc008uro.2. mouse.

Organism-specific databases

CTDi29889.
MGIiMGI:2385207. Gnl2.

Phylogenomic databases

eggNOGiKOG2423. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00810000125524.
HOGENOMiHOG000189714.
HOVERGENiHBG052643.
InParanoidiQ99LH1.
KOiK14537.
OMAiNSKVHIL.
OrthoDBiEOG7HXCQ7.
TreeFamiTF105668.

Miscellaneous databases

ChiTaRSiGnl2. mouse.
PROiQ99LH1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LH1.
ExpressionAtlasiQ99LH1. baseline and differential.
GenevisibleiQ99LH1. MM.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiNOG2_MOUSE
AccessioniPrimary (citable) accession number: Q99LH1
Secondary accession number(s): B1ASC3, Q8BIF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.