Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetratricopeptide repeat protein 5

Gene

Ttc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI

GO - Biological processi

  • DNA repair Source: UniProtKB-KW
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6804760 Regulation of TP53 Activity through Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Gene namesi
Name:Ttc5
Synonyms:Strap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2683584 Ttc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063821 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203Phosphoserine; by ATM2 Publications1
Modified residuei221Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LG4
MaxQBiQ99LG4
PaxDbiQ99LG4
PRIDEiQ99LG4

PTM databases

iPTMnetiQ99LG4
PhosphoSitePlusiQ99LG4

Expressioni

Inductioni

Stress-responsive protein. Induced upon UV or ionizing irradiation (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000006288
CleanExiMM_TTC5
GenevisibleiQ99LG4 MM

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006451

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 28Combined sources24
Helixi30 – 33Combined sources4
Helixi36 – 41Combined sources6
Helixi42 – 61Combined sources20
Helixi68 – 78Combined sources11
Beta strandi80 – 83Combined sources4
Helixi86 – 98Combined sources13
Helixi103 – 116Combined sources14
Helixi119 – 130Combined sources12
Helixi136 – 146Combined sources11
Helixi154 – 174Combined sources21
Helixi179 – 195Combined sources17
Helixi200 – 216Combined sources17
Helixi218 – 222Combined sources5
Helixi224 – 236Combined sources13
Helixi240 – 253Combined sources14
Helixi258 – 280Combined sources23
Turni281 – 283Combined sources3
Helixi286 – 294Combined sources9
Helixi299 – 301Combined sources3
Turni304 – 307Combined sources4
Helixi324 – 326Combined sources3
Beta strandi329 – 331Combined sources3
Beta strandi335 – 345Combined sources11
Beta strandi352 – 362Combined sources11
Beta strandi365 – 369Combined sources5
Beta strandi383 – 388Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi401 – 411Combined sources11
Helixi413 – 415Combined sources3
Helixi425 – 427Combined sources3
Beta strandi428 – 430Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ABNX-ray2.05A/B1-440[»]
ProteinModelPortaliQ99LG4
SMRiQ99LG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 11 PublicationAdd BLAST55
Repeati68 – 98TPR 21 PublicationAdd BLAST31
Repeati103 – 130TPR 31 PublicationAdd BLAST28
Repeati136 – 174TPR 41 PublicationAdd BLAST39
Repeati179 – 216TPR 51 PublicationAdd BLAST38
Repeati224 – 253TPR 61 PublicationAdd BLAST30

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9 Eukaryota
ENOG410XP1F LUCA
GeneTreeiENSGT00390000006227
HOGENOMiHOG000006922
HOVERGENiHBG054388
InParanoidiQ99LG4
OMAiNMVQSWG
OrthoDBiEOG091G0ARR
TreeFamiTF316804

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.50.550, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR032076 TTC5_OB
IPR038645 TTC5_OB_sf
PfamiView protein in Pfam
PF16669 TTC5_OB, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q99LG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEAK HVLQKLQGLV DRLYCFRDSY FETHSVEDAG RKQQDVQEEM
60 70 80 90 100
EKTLQQMEEV LGSAQVEAQA LMLKGKALNV TPDYSPEAEV LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA SAHTCFSGAL THCKNKVSLQ NLSMVLRQLQ
160 170 180 190 200
TDSGDEHSRH VMDSVRQAKL AVQMDVLDGR SWYILGNAYL SLYFNTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSQA
260 270 280 290 300
AALDPVWPEP QQREQQLLEF LSRLTSLLES KGKTKPKKLQ SMLGSLRPAH
310 320 330 340 350
LGPCGDGRYQ SASGQKMTLE LKPLSTLQPG VNSGTVVLGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NVVQSWGVLI GDSVAIPEPN LRHHQIRHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQNSSSQAS ATVASRPQCE
Length:440
Mass (Da):48,795
Last modified:July 27, 2011 - v2
Checksum:i07CB475AD1CEA370
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → T in AAH03272 (PubMed:15489334).Curated1
Sequence conflicti120A → T in AAH25610 (PubMed:15489334).Curated1
Sequence conflicti120A → T in AAH92074 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH03272 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH25610 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH92074 (PubMed:15489334).Curated1
Sequence conflicti430S → Y in BAE34192 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157777 mRNA Translation: BAE34192.1
AK161279 mRNA Translation: BAE36290.1
BC003272 mRNA Translation: AAH03272.1
BC025610 mRNA Translation: AAH25610.1
BC092074 mRNA Translation: AAH92074.1
CCDSiCCDS36905.1
RefSeqiNP_001074418.1, NM_001080949.2
UniGeneiMm.276362

Genome annotation databases

EnsembliENSMUST00000006451; ENSMUSP00000006451; ENSMUSG00000006288
GeneIDi219022
KEGGimmu:219022
UCSCiuc007tlm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTTC5_MOUSE
AccessioniPrimary (citable) accession number: Q99LG4
Secondary accession number(s): Q3TTN5, Q3TZL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health