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Protein

Tetratricopeptide repeat protein 5

Gene

Ttc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI

GO - Biological processi

  • DNA repair Source: UniProtKB-KW
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6804760. Regulation of TP53 Activity through Methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Gene namesi
Name:Ttc5
Synonyms:Strap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2683584. Ttc5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063821 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203Phosphoserine; by ATM2 Publications1
Modified residuei221Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LG4.
MaxQBiQ99LG4.
PaxDbiQ99LG4.
PRIDEiQ99LG4.

PTM databases

iPTMnetiQ99LG4.
PhosphoSitePlusiQ99LG4.

Expressioni

Inductioni

Sress-responsive protein. Induced upon UV or ionizing irradiation (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000006288.
CleanExiMM_TTC5.
GenevisibleiQ99LG4. MM.

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006451.

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 28Combined sources24
Helixi30 – 33Combined sources4
Helixi36 – 41Combined sources6
Helixi42 – 61Combined sources20
Helixi68 – 78Combined sources11
Beta strandi80 – 83Combined sources4
Helixi86 – 98Combined sources13
Helixi103 – 116Combined sources14
Helixi119 – 130Combined sources12
Helixi136 – 146Combined sources11
Helixi154 – 174Combined sources21
Helixi179 – 195Combined sources17
Helixi200 – 216Combined sources17
Helixi218 – 222Combined sources5
Helixi224 – 236Combined sources13
Helixi240 – 253Combined sources14
Helixi258 – 280Combined sources23
Turni281 – 283Combined sources3
Helixi286 – 294Combined sources9
Helixi299 – 301Combined sources3
Turni304 – 307Combined sources4
Helixi324 – 326Combined sources3
Beta strandi329 – 331Combined sources3
Beta strandi335 – 345Combined sources11
Beta strandi352 – 362Combined sources11
Beta strandi365 – 369Combined sources5
Beta strandi383 – 388Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi401 – 411Combined sources11
Helixi413 – 415Combined sources3
Helixi425 – 427Combined sources3
Beta strandi428 – 430Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ABNX-ray2.05A/B1-440[»]
ProteinModelPortaliQ99LG4.
SMRiQ99LG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 11 PublicationAdd BLAST55
Repeati68 – 98TPR 21 PublicationAdd BLAST31
Repeati103 – 130TPR 31 PublicationAdd BLAST28
Repeati136 – 174TPR 41 PublicationAdd BLAST39
Repeati179 – 216TPR 51 PublicationAdd BLAST38
Repeati224 – 253TPR 61 PublicationAdd BLAST30

Sequence similaritiesi

Contains 6 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ99LG4.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
TreeFamiTF316804.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEAK HVLQKLQGLV DRLYCFRDSY FETHSVEDAG RKQQDVQEEM
60 70 80 90 100
EKTLQQMEEV LGSAQVEAQA LMLKGKALNV TPDYSPEAEV LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA SAHTCFSGAL THCKNKVSLQ NLSMVLRQLQ
160 170 180 190 200
TDSGDEHSRH VMDSVRQAKL AVQMDVLDGR SWYILGNAYL SLYFNTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSQA
260 270 280 290 300
AALDPVWPEP QQREQQLLEF LSRLTSLLES KGKTKPKKLQ SMLGSLRPAH
310 320 330 340 350
LGPCGDGRYQ SASGQKMTLE LKPLSTLQPG VNSGTVVLGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NVVQSWGVLI GDSVAIPEPN LRHHQIRHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQNSSSQAS ATVASRPQCE
Length:440
Mass (Da):48,795
Last modified:July 27, 2011 - v2
Checksum:i07CB475AD1CEA370
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → T in AAH03272 (PubMed:15489334).Curated1
Sequence conflicti120A → T in AAH25610 (PubMed:15489334).Curated1
Sequence conflicti120A → T in AAH92074 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH03272 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH25610 (PubMed:15489334).Curated1
Sequence conflicti256V → A in AAH92074 (PubMed:15489334).Curated1
Sequence conflicti430S → Y in BAE34192 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157777 mRNA. Translation: BAE34192.1.
AK161279 mRNA. Translation: BAE36290.1.
BC003272 mRNA. Translation: AAH03272.1.
BC025610 mRNA. Translation: AAH25610.1.
BC092074 mRNA. Translation: AAH92074.1.
CCDSiCCDS36905.1.
RefSeqiNP_001074418.1. NM_001080949.2.
UniGeneiMm.276362.

Genome annotation databases

EnsembliENSMUST00000006451; ENSMUSP00000006451; ENSMUSG00000006288.
GeneIDi219022.
KEGGimmu:219022.
UCSCiuc007tlm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157777 mRNA. Translation: BAE34192.1.
AK161279 mRNA. Translation: BAE36290.1.
BC003272 mRNA. Translation: AAH03272.1.
BC025610 mRNA. Translation: AAH25610.1.
BC092074 mRNA. Translation: AAH92074.1.
CCDSiCCDS36905.1.
RefSeqiNP_001074418.1. NM_001080949.2.
UniGeneiMm.276362.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ABNX-ray2.05A/B1-440[»]
ProteinModelPortaliQ99LG4.
SMRiQ99LG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006451.

PTM databases

iPTMnetiQ99LG4.
PhosphoSitePlusiQ99LG4.

Proteomic databases

EPDiQ99LG4.
MaxQBiQ99LG4.
PaxDbiQ99LG4.
PRIDEiQ99LG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006451; ENSMUSP00000006451; ENSMUSG00000006288.
GeneIDi219022.
KEGGimmu:219022.
UCSCiuc007tlm.2. mouse.

Organism-specific databases

CTDi91875.
MGIiMGI:2683584. Ttc5.

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ99LG4.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
TreeFamiTF316804.

Enzyme and pathway databases

ReactomeiR-MMU-6804760. Regulation of TP53 Activity through Methylation.

Miscellaneous databases

PROiQ99LG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006288.
CleanExiMM_TTC5.
GenevisibleiQ99LG4. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC5_MOUSE
AccessioniPrimary (citable) accession number: Q99LG4
Secondary accession number(s): Q3TTN5, Q3TZL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.